South Central Houston Vacations from $173

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Your South Central Houston Vacation

Leave the stress of travel planning behind with a South Central Houston vacation package. With all the details locked in before you go, all you have to do is enjoy this university neighborhood's nightlife, history and dining. Some nearby attractions to visit during your trip to South Central Houston include Toyota Center, Minute Maid Park and Houston Zoo. Stop dreaming and start doing. When you're ready to book your next vacation to South Central Houston, Expedia will help get you there.

The Latest South Central Houston Vacation Packages

Price found within the past 48 hours. Click for updated prices.
Heritage Place Houston Brookhollow
Luxury 3BR for Families Nurses and Group
2824 Aeon Living
Experience a First Class Stay - 2 BDRM
Dejs' Modern Retreat

Where to stay in South Central Houston

Find the best South Central Houston areas and neighborhoods for the activities you enjoy most. Learn more about South Central Houston

South Central Houston Hotel Deals

Hilton Houston Plaza/Medical Center

Hilton Houston Plaza/Medical Center

4.5 out of 5
6633 Travis St Houston TX
Fully refundableReserve now, pay when you stay
$78 nightly
The price is $91 total per night from Nov 29 to Nov 30
$91 total
Nov 29 - Nov 30
Total with taxes and fees
Hilton Houston Plaza/Medical Center
Hotel Zaza Houston Museum District

Hotel Zaza Houston Museum District

4.5 out of 5
5701 Main Street Houston TX
Fully refundableReserve now, pay when you stay
$283 nightly
The price is $329 total per night from Nov 7 to Nov 8
$329 total
Nov 7 - Nov 8
Total with taxes and fees
9.2/10 Wonderful! (1,009 reviews)
"The staff is very professional."

Reviewed on Nov 1, 2026

Hotel Zaza Houston Museum District
The Westin Houston Medical Center/Museum District

The Westin Houston Medical Center/Museum District

4 out of 5
1709 DRYDEN ROAD Houston TX
Fully refundableReserve now, pay when you stay
$183 nightly
The price is $212 total per night from Nov 8 to Nov 9
$212 total
Nov 8 - Nov 9
Total with taxes and fees
9.2/10 Wonderful! (1,270 reviews)
"Clean rooms great staff nice amenities overall amazing experience"

Reviewed on Nov 1, 2026

The Westin Houston Medical Center/Museum District
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Stay near popular South Central Houston attractions

Things to do

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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.