South Central Houston Vacations from $192

Book a Hotel + Flight or Car together to unlock savings

Your South Central Houston Vacation

Leave the stress of travel planning behind with a South Central Houston vacation package. With all the details locked in before you go, all you have to do is enjoy this university neighborhood's nightlife, history and dining. Some nearby attractions to visit during your trip to South Central Houston include Toyota Center, Minute Maid Park and Houston Zoo. Stop dreaming and start doing. When you're ready to book your next vacation to South Central Houston, Expedia will help get you there.

The Latest South Central Houston Vacation Packages

Price found within the past 48 hours. Click for updated prices.
Hilton Houston North
DoubleTree by Hilton Hotel & Suites Houston by the Galleria
Margaritaville Lake Resort, Lake Conroe/Houston
Hotel Saint Augustine
Le Meridien Houston Downtown

Where to stay in South Central Houston

Find the best South Central Houston areas and neighborhoods for the activities you enjoy most. Learn more about South Central Houston

South Central Houston Hotel Deals

Hotel Zaza Houston Museum District

Hotel Zaza Houston Museum District

4.5 out of 5
5701 Main Street, Houston, TX
Fully refundableReserve now, pay when you stay
$213 nightly
The price is $249 total per night from Nov 30 to Dec 1
$249 total
Nov 30 - Dec 1
Total with taxes and fees
8.8/10 Excellent! (1,803 reviews)
Outstanding services!

Reviewed on Oct 26, 2025

Hotel Zaza Houston Museum District
Hilton Houston Plaza/Medical Center

Hilton Houston Plaza/Medical Center

4.5 out of 5
6633 Travis St, Houston, TX
Fully refundableReserve now, pay when you stay
$83 nightly
The price is $97 total per night from Nov 30 to Dec 1
$97 total
Nov 30 - Dec 1
Total with taxes and fees
8.2/10 Very Good! (1,639 reviews)
I didn't eat at hotel . Had a great stay . Comfortable and clean

Reviewed on Oct 28, 2025

Hilton Houston Plaza/Medical Center
InterContinental Houston by IHG

InterContinental Houston by IHG

4 out of 5
6750 Main St, Houston, TX
Fully refundable
$156 nightly
The price is $183 total per night from Nov 28 to Nov 29
$183 total
Nov 28 - Nov 29
Total with taxes and fees
9.2/10 Wonderful! (1,001 reviews)
Always an incredible experience staying in this hotel

Reviewed on Oct 28, 2025

InterContinental Houston by IHG
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Discover the most popular places to visit in South Central Houston

Things to do

Explore a world of travel with Expedia

* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.