South Central Houston Vacations from $209
Book a Hotel + Flight or Car together to unlock savings
Your South Central Houston Vacation
Leave the stress of travel planning behind with a South Central Houston vacation package. With all the details locked in before you go, all you have to do is enjoy this university neighborhood's nightlife, history and dining. Some nearby attractions to visit during your trip to South Central Houston include Toyota Center, Minute Maid Park and Houston Zoo. Stop dreaming and start doing. When you're ready to book your next vacation to South Central Houston, Expedia will help get you there.
The Latest South Central Houston Vacation Packages
Price found within the past 48 hours. Click for updated prices.
Heritage Place Houston Brookhollow
Lazybrook/Timbergrove
$215
per person
Dec 9 - Dec 13
found 1 day ago
Roundtrip flight included
Atlanta (ATL) to Houston (IAH)
9/10 Wonderful! (218 reviews)
I liked everything about my stay here. The staff are super friendly and helpful. The rooms are clean and modern. I had everything I needed. It was quiet and there was security. Everything a solo traveler needs!
Reviewed on Oct 22, 2026
Where to stay in South Central Houston
Find the best South Central Houston areas and neighborhoods for the activities you enjoy most. Learn more about South Central Houston
Downtown Houston
3 out of top 10 points of interest in this area
Largest central business district in Texas, this area boasts major league sports venues, a vibrant Theater District, and shopping options like GreenStreet. Easily navigate with public transportation options like METRORail and bus lines.
The Galleria
Travelers to The Galleria praise its popular shops. If you've got some more time to explore, be sure to make a stop by The Galleria and Williams Tower.
Texas Medical Center
1 out of top 10 points of interest in this area
Boasting the world's largest medical complex, this Houston neighborhood offers access to over 60 medical institutions and is served by the METRORail Red Line. Explore the John P. McGovern Historical Collections and Research Center for a unique experience.
Montrose
Unique features of Montrose include the theaters and museums. Make a stop by Rothko Chapel or Menil Collection while you're exploring the area.
Houston Central Business District
If you're spending time in Houston Central Business District, check out sights like Toyota Center or House of Blues Houston and hop on the metro to see more the city at Bell Station or Downtown Transit Center Station.
South Central Houston Hotel Deals
Hilton Houston Plaza/Medical Center
6633 Travis St Houston TX
Fully refundableReserve now, pay when you stay
$89 nightly
$104 total
Nov 1 - Nov 2
Total with taxes and fees
8.6/10 Excellent! (2,210 reviews)
"I expected the room to be cleaner and the refrigerator was very noisy and kept us up at night"
Reviewed on Oct 23, 2026
The Westin Houston Medical Center/Museum District
1709 DRYDEN ROAD Houston TX
Fully refundableReserve now, pay when you stay
$183 nightly
$212 total
Nov 8 - Nov 9
Total with taxes and fees
Hotel Zaza Houston Museum District
5701 Main Street Houston TX
Fully refundableReserve now, pay when you stay
$286 nightly
$333 total
Oct 24 - Oct 25
Total with taxes and fees
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Stay near popular South Central Houston attractions
Photo by Michael Lore
University of Houston
8.2/10 (2,247 reviews)
Enjoy the collegiate vibe when you visit University of Houston, during your travels in Houston. Experience the great live music and lively festivals in this vibrant area.
Houston Zoo
8.6/10 (4,550 reviews)
Feed a giraffe, catch a 4-D movie or cool off in the water park at this extraordinary zoo.
Texas Southern University
10.0/10 (1 review)
Take a campus tour or just explore the area of Texas Southern University, during your travels in Houston. Experience the acclaimed art scene and lively festivals in this vibrant area.
Houston Natural Science Museum
9.2/10 (1,036 reviews)
You can spend time studying the exhibits at Houston Natural Science Museum in Houston. Experience the area's acclaimed theater scene and great live music.
Hermann Park
9.4/10 (13 reviews)
This expansive green space in the heart of the city offers places for exercising and relaxing, as well as a zoo and the Museum of Natural Science.
Houston Museum of Fine Arts
9.4/10 (258 reviews)
Architecturally stunning and filled with pieces by renowned artists of the world, this museum is a must-see for art lovers.
Main Street Theater - Rice Village
You can enjoy a show at Main Street Theater - Rice Village during your trip to Houston. Attend a sporting event or simply enjoy the top-notch restaurants while you're in the area.
Photo by Mariam Ahmed
Children's Museum of Houston
8.8/10 (495 reviews)
You can take time to visit Children's Museum of Houston during your travels to Houston. Experience the area's acclaimed art scene and great live music.
Things to do
Houston: Space Center Houston Admission Ticket
$30
per adult
92% of travellers recommend
Houston Museum of Natural Science: Butterfly Center Ticket
$15
per adult
100% of travellers recommend
Houston: Houston Botanic Garden Entry Ticket
$12
per adult
74% of travellers recommend
Explore a world of travel with Expedia
- Flights from Boston (BOS) to Houston (IAH)
- Flights from Miami (MIA) to Houston (IAH)
- Flights from Los Angeles (LAX) to Houston (IAH)
- Flights from New Orleans (MSY) to Houston (HOU)
- Flights from Newark Liberty Intl. Airport (EWR) to Houston (IAH)
- Flights from New York (NYC) to Houston (HOU)
- Flights from William P. Hobby
- Flights from San Diego (SAN) to Houston (HOU)
- Flights from Washington (DCA) to Houston (HOU)
- Flights from Phoenix (PHX) to Houston (HOU)
- Flights from Austin (AUS) to Houston (IAH)
- Flights from Detroit (DTW) to Houston (IAH)
- Flights from Chicago (ORD) to Houston (HOU)
- Flights from George Bush Intercontinental
- Flights from Orlando (MCO) to Houston (IAH)
- Flights from Seattle (SEA) to Houston (IAH)
- Flights from Philadelphia (PHL) to Houston (HOU)
- Flights from Atlanta (ATL) to Houston (HOU)
- Flights from Tampa (TPA) to Houston (HOU)
- Flights from Dallas (DFW) to Houston (HOU)
- Flights from Houston
- Flights from Charlotte (CLT) to Houston (HOU)
- Flights to Houston
- Downtown Aquarium
- Highland Village
- Saint Arnold Brewery
- Harris Health System - Ben Taub General Hospital
- Greenway Plaza
- Houston Police Officer Memorial
- North Houston Vacations
- Menil Collection
- Texas Southern University
- Jesse H. Jones Hall
- Alley Theater
- Discovery Green
- Bayou Bend Collection and Gardens
- Main Street Theater - Rice Village
- Rice University
- Space Center Houston
- Gerald D. Hines Waterwall Park
- Sylvan Beach Park
- Rothko Chapel
- Kinder Lake
- Buffalo Bayou Park
- The Chapel of St. Basil
- Health Museum
- Continental Club
- Buffalo Soldiers National Museum
- Color Factory Houston
- Houston Natural Science Museum
- Cy Twombly Gallery
- Midtown Vacations
- Christ Church Cathedral
- Nrg Stadium
- Houston JPMorgan Chase Tower
- Six Flags Hurricane Harbor
- Allen's Landing Park
- Visit Houston
- Hermann Park
- Hobby Center for the Performing Arts
- Cullen Sculpture Garden
- Bayou Place
- Houston Museum of Fine Arts
- Downtown Houston Vacations
- Children's Museum of Houston
- River Oaks Country Club
- Houston Zoo
- Kemah Boardwalk
- Wortham Center
- Holocaust Museum Houston
- Houston City Hall
- Traders Village
- Theatre Under The Stars
- Houston Arboretum and Nature Center
- House of Blues Houston
- Giant Beatles Statues
- Houston Sports Museum
- Houston Vacations
- Daikin Park
- Memorial Vacations
- Shell Energy Stadium
- University of Houston
- George R. Brown Convention Center
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.