South Central Houston, TX
Houston
Visit South Central Houston
Stay near popular South Central Houston attractions
Things to do
Houston: Space Center Houston Admission Ticket
$30
per adult
92% of travellers recommend
Houston Museum of Natural Science: Butterfly Center Ticket
$15
per adult
100% of travellers recommend
Houston: Houston Botanic Garden Entry Ticket
$12
per adult
74% of travellers recommend
Houston: Guided City Tour by an Open-Top Double Decker Bus
$40
per adult
98% of travellers recommend
Houston's Official City & Mural Tour!
$40
per adult
88% of travellers recommend
South Central Houston Hotel Deals
Hilton Houston Plaza/Medical Center
6633 Travis St Houston TX
Fully refundableReserve now, pay when you stay
$94 nightly
The price is $110 total per night from Nov 15 to Nov 16
$110 total
Nov 15 - Nov 16
Total with taxes and fees
Book a stay at this luxury hotel in Houston. Enjoy free WiFi, 2 restaurants, and 2 bars/lounges. Our guests praise the helpful staff and the clean rooms in our ...
The Westin Houston Medical Center/Museum District
1709 DRYDEN ROAD Houston TX
$183 nightly
The price is $212 total per night from Nov 8 to Nov 9
$212 total
Nov 8 - Nov 9
Total with taxes and fees
Book a stay at this business-friendly hotel in Houston. Enjoy breakfast (surcharge), room service, and a 24-hour health club. Our guests praise the helpful staff ...
9.2/10 Wonderful! (1,265 reviews)
"Very nice. I just dont like when the balcony was closed."
Reviewed on Oct 21, 2026
Hotel Zaza Houston Museum District
5701 Main Street Houston TX
$264 nightly
The price is $307 total per night from Oct 22 to Oct 23
$307 total
Oct 22 - Oct 23
Total with taxes and fees
Book a stay at this luxury hotel in Houston. Enjoy free WiFi, a full-service spa, and breakfast (surcharge). Our guests praise the helpful staff in our reviews. ...
InterContinental Houston by IHG
6750 Main St Houston TX
$184 nightly
The price is $215 total per night from Nov 20 to Nov 21
$215 total
Nov 20 - Nov 21
Total with taxes and fees
Book a stay at this business-friendly hotel in Houston. Enjoy free WiFi, breakfast (surcharge), and a free area shuttle. Our guests praise the helpful staff ...
9.4/10 Exceptional! (1,003 reviews)
"Horrible mattresses horrible woke up with back aches every morning and then in your restaurant ordered from the Menu with understaffed people it took an hour to get food. All they had to do is tell us that you have to use the buffet and the food. Everything was cold when it came."
Reviewed on Oct 17, 2026
Extended Stay America Suites Houston Med Ctr Braeswood Bl
1301 Braeswood Blvd Houston TX
$75 nightly
The price is $88 total per night from Oct 29 to Oct 30
$88 total
Oct 29 - Oct 30
Total with taxes and fees
Book a stay at this business-friendly hotel in Houston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the clean rooms in our reviews. ...
Houston Marriott Medical Center/Museum District
6580 Fannin Street Houston TX
$198 nightly
The price is $231 total per night from Nov 13 to Nov 14
$231 total
Nov 13 - Nov 14
Total with taxes and fees
Book a stay at this business-friendly hotel in Houston. Enjoy breakfast (surcharge), a free area shuttle, and room service. Our guests praise the helpful staff ...
9/10 Wonderful! (1,001 reviews)
"Breakfast was to be included for our stay per our booking. The Hotel staff confirmed our free breakfast at registration. We were charged for the two free breakfasts. The fees were outrageous. $ 160 for the two breakfasts for two people. We each had coffee, orange juice, and a yogurt parfait. DON'T ..."
Reviewed on Oct 21, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Check South Central Houston hotel availability
Where to stay in South Central Houston
Find the best South Central Houston areas and neighborhoods for the activities you enjoy most. Learn more about South Central Houston
Learn more about South Central Houston
Downtown Houston
Known for its abundant dining options and live music, there's plenty to explore in Downtown Houston. Top attractions like Daikin Park and Toyota Center are major draws, and you can catch the metro at Central Station Main or Main Street Square Station to see more of the city.
The Galleria
Travelers to The Galleria praise its popular shops. If you've got some more time to explore, be sure to make a stop by The Galleria and Williams Tower.
Texas Medical Center
Well-liked for its restaurants, museums, and shopping, there's plenty to explore in Texas Medical Center. Attractions like Houston Zoo is a major draw, and you can hop on the metro at TMC Transit Center or Dryden/TMC Station to see more of the city.
Montrose
Unique features of Montrose include the theaters and museums. Make a stop by Rothko Chapel or Menil Collection while you're exploring the area.
Photo by George Zimzores
Open Photo by George Zimzores
Houston Central Business District
If you're spending time in Houston Central Business District, check out sights like Toyota Center or House of Blues Houston and hop on the metro to see more the city at Bell Station or Downtown Transit Center Station.
South Central Houston, TX
Explore a world of travel with Expedia
- Hotels near NRG Stadium
- Apartments in Houston
- Cheap Hotels in Houston
- Romantic Hotels in Houston
- Galveston Hotels
- All-Inclusive Resorts in Houston
- Hotels near George R. Brown Convention Center
- Hotels near Daikin Park
- Houston Hotels
- Hotels near George Bush Intercontinental
- Hotels near MD Anderson Cancer Center
- The Galleria Hotels
- Extended Stay Hotels in Houston
- Hotels with Hot Tubs in Houston
- Downtown Houston Hotels
- Cabin Rentals in Houston
- Pet-Friendly Hotels in Houston
- Hotels with Free Airport Shuttle in Houston
- Flights from Washington (DCA) to Houston (HOU)
- Flights from Seattle (SEA) to Houston (IAH)
- Flights from Miami (MIA) to Houston (IAH)
- Flights from San Antonio (SAT) to Houston (IAH)
- Flights from Richmond (RIC) to Houston (HOU)
- Flights from Houston
- Flights from Austin (AUS) to Houston (IAH)
- Flights from Jacksonville (JAX) to Houston (HOU)
- Flights from Detroit (DTW) to Houston (IAH)
- Flights from Kansas City (MCI) to Houston (HOU)
- Flights from Charlotte (CLT) to Houston (HOU)
- Flights from Oklahoma City (OKC) to Houston (HOU)
- Flights from San Diego (SAN) to Houston (HOU)
- Flights from Los Angeles (LAX) to Houston (IAH)
- Flights to Houston
- Flights from Boston (BOS) to Houston (IAH)
- Flights from El Paso (ELP) to Houston (HOU)
- Flights from Memphis (MEM) to Houston (HOU)
- Flights from Tampa (TPA) to Houston (HOU)
- Flights from Dallas (DFW) to Houston (HOU)
- Flights from Minneapolis (MSP) to Houston (IAH)
- Flights from Raleigh (RDU) to Houston (IAH)
- Flights from St. Louis (STL) to Houston (HOU)
- Flights from Sacramento (SMF) to Houston (HOU)
- Flights from Pittsburgh (PIT) to Houston (HOU)
- Flights from Phoenix (PHX) to Houston (HOU)
- Flights from Columbus (CMH) to Houston (HOU)
- Flights from George Bush Intercontinental
- Flights from New York (NYC) to Houston (HOU)
- Flights from William P. Hobby
- Flights from Orlando (MCO) to Houston (IAH)
- Flights from New Orleans (MSY) to Houston (HOU)
- Flights from Indianapolis (IND) to Houston (HOU)
- Flights from Philadelphia (PHL) to Houston (HOU)
- Flights from Fort Lauderdale (FLL) to Houston (IAH)
- Flights from Cincinnati (CVG) to Houston (HOU)
- Flights from Atlanta (ATL) to Houston (HOU)
- Flights from San Francisco (SFO) to Houston (IAH)
- Flights from Denver (DEN) to Houston (IAH)
- Flights from Baltimore (BWI) to Houston (IAH)
- Flights from Las Vegas (LAS) to Houston (IAH)
- Flights from Newark Liberty Intl. Airport (EWR) to Houston (IAH)
- Flights from Chicago (ORD) to Houston (HOU)
- Visit Greenway Plaza-Upper Kirby
- Visit Southwest Houston
- Visit Galveston
- Visit Downtown Houston
- Visit Houston
- Visit Midtown
- Visit Riverside Terrace
- Visit Houston Convention District
- Visit Houston Heights
- Visit East Downtown Houston
- Visit Texas Medical Center
- Visit The Galleria
- Visit West University Place
- Visit Foster Place
- Visit Houston Central Business District
- Visit Southeast Houston
- Visit Brookhollow
- Visit Jacinto City
- Visit Southside Place
- Visit East Houston
- Visit Uptown
- Visit Theater District
- Visit Magnolia Park
- Visit Greater Heights
- Visit Northside
- Visit Montrose
- Where to stay in Houston
- Visit Museum District
- Visit Astrodome
- Visit Bellaire
- Houston Vacations
- Visit Galena Park
