South Central Houston, TX
Houston
Visit South Central Houston
Stay near popular South Central Houston attractions
Things to do
Houston: Space Center Houston Admission Ticket
$30
per adult
92% of travellers recommend
Houston Museum of Natural Science: Butterfly Center Ticket
$15
per adult
100% of travellers recommend
Houston: Houston Botanic Garden Entry Ticket
$12
per adult
74% of travellers recommend
Houston: Guided City Tour by an Open-Top Double Decker Bus
$40
per adult
98% of travellers recommend
Houston's Official City & Mural Tour!
$40
per adult
88% of travellers recommend
South Central Houston Hotel Deals
Hilton Houston Plaza/Medical Center
6633 Travis St Houston TX
$101 nightly
The price is $119 total per night from Oct 18 to Oct 19
$119 total
Oct 18 - Oct 19
Total with taxes and fees
Book a stay at this luxury hotel in Houston. Enjoy free WiFi, 2 restaurants, and 2 bars/lounges. Our guests praise the helpful staff and the clean rooms in our ...
The Westin Houston Medical Center/Museum District
1709 DRYDEN ROAD Houston TX
$155 nightly
The price is $180 total per night from Oct 11 to Oct 12
$180 total
Oct 11 - Oct 12
Total with taxes and fees
Book a stay at this business-friendly hotel in Houston. Enjoy breakfast (surcharge), room service, and a 24-hour health club. Our guests praise the helpful staff ...
Hotel Zaza Houston Museum District
5701 Main Street Houston TX
Fully refundableReserve now, pay when you stay
$281 nightly
The price is $327 total per night from Oct 8 to Oct 9
$327 total
Oct 8 - Oct 9
Total with taxes and fees
Book a stay at this luxury hotel in Houston. Enjoy free WiFi, a full-service spa, and breakfast (surcharge). Our guests praise the helpful staff in our reviews. ...
InterContinental Houston by IHG
6750 Main St Houston TX
$186 nightly
The price is $218 total per night from Oct 25 to Oct 26
$218 total
Oct 25 - Oct 26
Total with taxes and fees
Book a stay at this business-friendly hotel in Houston. Enjoy free WiFi, breakfast (surcharge), and a free area shuttle. Our guests praise the helpful staff ...
9.4/10 Exceptional! (1,009 reviews)
"Comfflean comfy rooms and delicious restaurant."
Reviewed on Oct 5, 2026
Extended Stay America Suites Houston Med Ctr Braeswood Bl
1301 Braeswood Blvd Houston TX
$81 nightly
The price is $95 total per night from Oct 11 to Oct 12
$95 total
Oct 11 - Oct 12
Total with taxes and fees
Book a stay at this business-friendly hotel in Houston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the clean rooms in our reviews. ...
Houston Marriott Medical Center/Museum District
6580 Fannin Street Houston TX
$207 nightly
The price is $242 total per night from Oct 18 to Oct 19
$242 total
Oct 18 - Oct 19
Total with taxes and fees
Book a stay at this business-friendly hotel in Houston. Enjoy breakfast (surcharge), a free area shuttle, and room service. Our guests praise the helpful staff ...
9/10 Wonderful! (1,002 reviews)
"Very safe and secure place to stay as a solo female traveller .. Shuttle to museum district was wonderful !!! Vanessa shuttle driver was very helpful ..The valet said I could use shuttle to get to Galleria but then she said she was no longer allowed to take gusts that far. She helped me find the ..."
Reviewed on Oct 5, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Check South Central Houston hotel availability
Where to stay in South Central Houston
Find the best South Central Houston areas and neighborhoods for the activities you enjoy most. Learn more about South Central Houston
Learn more about South Central Houston
Downtown Houston
Known for its abundant dining options and live music, there's plenty to explore in Downtown Houston. Top attractions like Daikin Park and Toyota Center are major draws, and you can catch the metro at Central Station Main or Main Street Square Station to see more of the city.
The Galleria
Travelers to The Galleria praise its popular shops. If you've got some more time to explore, be sure to make a stop by The Galleria and Williams Tower.
Texas Medical Center
Well-liked for its restaurants, museums, and shopping, there's plenty to explore in Texas Medical Center. Attractions like Houston Zoo is a major draw, and you can hop on the metro at TMC Transit Center or Dryden/TMC Station to see more of the city.
Montrose
Unique features of Montrose include the theaters and museums. Make a stop by Rothko Chapel or Menil Collection while you're exploring the area.
Photo by George Zimzores
Open Photo by George Zimzores
Houston Central Business District
If you're spending time in Houston Central Business District, check out sights like Toyota Center or House of Blues Houston and hop on the metro to see more the city at Bell Station or Downtown Transit Center Station.
South Central Houston, TX
Explore a world of travel with Expedia
- Hotels near NRG Stadium
- Apartments in Houston
- Cheap Hotels in Houston
- Romantic Hotels in Houston
- Galveston Hotels
- All-Inclusive Resorts in Houston
- Hotels near George R. Brown Convention Center
- Hotels near Daikin Park
- Houston Hotels
- Hotels near George Bush Intercontinental
- Hotels near MD Anderson Cancer Center
- The Galleria Hotels
- Extended Stay Hotels in Houston
- Hotels with Hot Tubs in Houston
- Downtown Houston Hotels
- Cabin Rentals in Houston
- Pet-Friendly Hotels in Houston
- Hotels with Free Airport Shuttle in Houston
- Flights from Washington (DCA) to Houston (HOU)
- Flights from Seattle (SEA) to Houston (IAH)
- Flights from Miami (MIA) to Houston (IAH)
- Flights from San Antonio (SAT) to Houston (IAH)
- Flights from Richmond (RIC) to Houston (HOU)
- Flights from Houston
- Flights from Austin (AUS) to Houston (IAH)
- Flights from Jacksonville (JAX) to Houston (HOU)
- Flights from Detroit (DTW) to Houston (IAH)
- Flights from Kansas City (MCI) to Houston (HOU)
- Flights from Charlotte (CLT) to Houston (HOU)
- Flights from Oklahoma City (OKC) to Houston (HOU)
- Flights from San Diego (SAN) to Houston (HOU)
- Flights from Los Angeles (LAX) to Houston (IAH)
- Flights to Houston
- Flights from Boston (BOS) to Houston (IAH)
- Flights from El Paso (ELP) to Houston (HOU)
- Flights from Memphis (MEM) to Houston (HOU)
- Flights from Tampa (TPA) to Houston (HOU)
- Flights from Dallas (DFW) to Houston (HOU)
- Flights from Minneapolis (MSP) to Houston (IAH)
- Flights from Raleigh (RDU) to Houston (IAH)
- Flights from St. Louis (STL) to Houston (HOU)
- Flights from Sacramento (SMF) to Houston (HOU)
- Flights from Pittsburgh (PIT) to Houston (HOU)
- Flights from Phoenix (PHX) to Houston (HOU)
- Flights from Columbus (CMH) to Houston (HOU)
- Flights from George Bush Intercontinental
- Flights from New York (NYC) to Houston (HOU)
- Flights from William P. Hobby
- Flights from Orlando (MCO) to Houston (IAH)
- Flights from New Orleans (MSY) to Houston (HOU)
- Flights from Indianapolis (IND) to Houston (HOU)
- Flights from Philadelphia (PHL) to Houston (HOU)
- Flights from Fort Lauderdale (FLL) to Houston (IAH)
- Flights from Cincinnati (CVG) to Houston (HOU)
- Flights from Atlanta (ATL) to Houston (HOU)
- Flights from San Francisco (SFO) to Houston (IAH)
- Flights from Denver (DEN) to Houston (IAH)
- Flights from Baltimore (BWI) to Houston (IAH)
- Flights from Las Vegas (LAS) to Houston (IAH)
- Flights from Newark Liberty Intl. Airport (EWR) to Houston (IAH)
- Flights from Chicago (ORD) to Houston (HOU)
- Visit Greenway Plaza-Upper Kirby
- Visit Southwest Houston
- Visit Galveston
- Visit Downtown Houston
- Visit Houston
- Visit Midtown
- Visit Riverside Terrace
- Visit Houston Convention District
- Visit Houston Heights
- Visit East Downtown Houston
- Visit Texas Medical Center
- Visit The Galleria
- Visit West University Place
- Visit Foster Place
- Visit Houston Central Business District
- Visit Southeast Houston
- Visit Brookhollow
- Visit Jacinto City
- Visit Southside Place
- Visit East Houston
- Visit Uptown
- Visit Theater District
- Visit Magnolia Park
- Visit Greater Heights
- Visit Northside
- Visit Montrose
- Where to stay in Houston
- Visit Museum District
- Visit Astrodome
- Visit Bellaire
- Houston Vacations
- Visit Galena Park
