South Central Houston, TX
Houston
Visit South Central Houston
Stay near popular South Central Houston attractions
Things to do
Houston: Space Center Houston Admission Ticket
$30
per adult
92% of travellers recommend
Houston Museum of Natural Science: Butterfly Center Ticket
$15
per adult
100% of travellers recommend
Houston: Houston Botanic Garden Entry Ticket
$12
per adult
74% of travellers recommend
Houston: Guided City Tour by an Open-Top Double Decker Bus
$40
per adult
98% of travellers recommend
Houston's Official City & Mural Tour!
$40
per adult
88% of travellers recommend
South Central Houston Hotel Deals
Hilton Houston Plaza/Medical Center
6633 Travis St Houston TX
$110 nightly
The price is $128 total per night from Nov 6 to Nov 7
$128 total
Nov 6 - Nov 7
Total with taxes and fees
Book a stay at this luxury hotel in Houston. Enjoy free WiFi, 2 restaurants, and 2 bars/lounges. Our guests praise the helpful staff and the clean rooms in our ...
Hotel Zaza Houston Museum District
5701 Main Street Houston TX
$264 nightly
The price is $307 total per night from Oct 22 to Oct 23
$307 total
Oct 22 - Oct 23
Total with taxes and fees
Book a stay at this luxury hotel in Houston. Enjoy free WiFi, a full-service spa, and breakfast (surcharge). Our guests praise the helpful staff in our reviews. ...
9.2/10 Wonderful! (1,007 reviews)
"Fabulous hotel, but avoid the restaurant at all costs. Hotel staff were incredibly helpful (particularly Kevin from valet), beds were comfortable, the decor was fun. The restaurant was beyond horrible. Slow, terrible service, the "steel cut oats" were not steel cut oats, no one cared, no one even ..."
Reviewed on Oct 18, 2026
The Westin Houston Medical Center/Museum District
1709 DRYDEN ROAD Houston TX
$183 nightly
The price is $212 total per night from Oct 25 to Oct 26
$212 total
Oct 25 - Oct 26
Total with taxes and fees
Book a stay at this business-friendly hotel in Houston. Enjoy breakfast (surcharge), room service, and a 24-hour health club. Our guests praise the helpful staff ...
InterContinental Houston by IHG
6750 Main St Houston TX
$186 nightly
The price is $218 total per night from Nov 7 to Nov 8
$218 total
Nov 7 - Nov 8
Total with taxes and fees
Book a stay at this business-friendly hotel in Houston. Enjoy free WiFi, breakfast (surcharge), and a free area shuttle. Our guests praise the helpful staff ...
9.4/10 Exceptional! (1,011 reviews)
"Horrible mattresses horrible woke up with back aches every morning and then in your restaurant ordered from the Menu with understaffed people it took an hour to get food. All they had to do is tell us that you have to use the buffet and the food. Everything was cold when it came."
Reviewed on Oct 17, 2026
Extended Stay America Suites Houston Med Ctr Braeswood Bl
1301 Braeswood Blvd Houston TX
$79 nightly
The price is $93 total per night from Nov 6 to Nov 7
$93 total
Nov 6 - Nov 7
Total with taxes and fees
Book a stay at this business-friendly hotel in Houston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the clean rooms in our reviews. ...
Houston Marriott Medical Center/Museum District
6580 Fannin Street Houston TX
$198 nightly
The price is $231 total per night from Nov 14 to Nov 15
$231 total
Nov 14 - Nov 15
Total with taxes and fees
Book a stay at this business-friendly hotel in Houston. Enjoy breakfast (surcharge), a free area shuttle, and room service. Our guests praise the helpful staff ...
9/10 Wonderful! (1,001 reviews)
"Always appreciate staying at this property when visiting MD Anderson - the staff is excellent, rooms are great, and the shuttle is especially helpful"
Reviewed on Oct 15, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Where to stay in South Central Houston
Find the best South Central Houston areas and neighborhoods for the activities you enjoy most. Learn more about South Central Houston
Learn more about South Central Houston
Downtown Houston
Known for its abundant dining options and live music, there's plenty to explore in Downtown Houston. Top attractions like Daikin Park and Toyota Center are major draws, and you can catch the metro at Central Station Main or Main Street Square Station to see more of the city.
The Galleria
Travelers to The Galleria praise its popular shops. If you've got some more time to explore, be sure to make a stop by The Galleria and Williams Tower.
Texas Medical Center
Well-liked for its restaurants, museums, and shopping, there's plenty to explore in Texas Medical Center. Attractions like Houston Zoo is a major draw, and you can hop on the metro at TMC Transit Center or Dryden/TMC Station to see more of the city.
Montrose
Unique features of Montrose include the theaters and museums. Make a stop by Rothko Chapel or Menil Collection while you're exploring the area.
Photo by George Zimzores
Open Photo by George Zimzores
Houston Central Business District
If you're spending time in Houston Central Business District, check out sights like Toyota Center or House of Blues Houston and hop on the metro to see more the city at Bell Station or Downtown Transit Center Station.
South Central Houston, TX
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- Visit Greenway Plaza-Upper Kirby
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- Where to stay in Houston
- Visit Museum District
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- Houston Vacations
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