Title: Southeastern Indiana Guest Houses from $66 | Expedia.com [Southeastern Indiana Travel Guide](https://expedia.com/Southeastern-Indiana.dx6233889)[Hotels in Southeastern Indiana](https://expedia.com/Southeastern-Indiana-Hotels.d6233889.Travel-Guide-Hotels)[Vacation Rentals in Southeastern Indiana](https://expedia.com/Southeastern-Indiana-Vacation-Rentals.d6233889.Travel-Guide-VacationRentals)[Flights to Southeastern Indiana](https://expedia.com/Cheap-Flights-To-Southeastern-Indiana.d6233889.Travel-Guide-Flights)[Car Rentals in Southeastern Indiana](https://expedia.com/Car-Rentals-In-Southeastern-Indiana.d6233889.Car-Rental-Guide)[Southeastern Indiana Vacation Packages](https://expedia.com/Southeastern-Indiana.d6233889.Destination-Travel-Guides) ![Lodging Image](https://a.travel-assets.com/travel-assets-manager/bex-affinities/lodging.jpg?impolicy=fcrop&w=1200&h=500&q=medium) ![](https://a.travel-assets.com/travel-assets-manager/bex-affinities/lodging.jpg?impolicy=fcrop&w=1200&h=500&q=medium) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light_bundle_and_save.svg) ### Bundle & Save Get more, spend less whenever you see Bundle & Save deals - ![](https://a.travel-assets.com/travel-assets-manager/pictograms-expedia/light__onekey.svg) ### OneKeyCash Earn OneKeyCash on all your eligible bookings - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light_ftc.svg) ### Upfront pricing We are not like the others - we include taxes and fees ## Check prices for these dates Next weekend [Mar 6 - Mar 8](https://www.expedia.com/Hotel-Search?regionId=6233889&startDate=2026-03-06&endDate=2026-03-08&adults=2&lodging=GUEST_HOUSE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In two weeks [Mar 13 - Mar 15](https://www.expedia.com/Hotel-Search?regionId=6233889&startDate=2026-03-13&endDate=2026-03-15&adults=2&lodging=GUEST_HOUSE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In one month [Mar 27 - Mar 29](https://www.expedia.com/Hotel-Search?regionId=6233889&startDate=2026-03-27&endDate=2026-03-29&adults=2&lodging=GUEST_HOUSE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In two months [Apr 24 - Apr 26](https://www.expedia.com/Hotel-Search?regionId=6233889&startDate=2026-04-24&endDate=2026-04-26&adults=2&lodging=GUEST_HOUSE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Our top choices for Southeastern Indiana guest houses ![Front of property](https://images.trvl-media.com/lodging/5000000/4490000/4486800/4486724/3566d32f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Deluxe Room, 1 Queen Bed, River View | Private kitchen | Shared fridge, microwave](https://images.trvl-media.com/lodging/5000000/4490000/4486800/4486724/90db027c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 2 Bedrooms | Living area | 32-inch flat-screen TV with cable channels, TV](https://images.trvl-media.com/lodging/5000000/4490000/4486800/4486724/7ec58500.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Deluxe Room, 1 Queen Bed, River View | Free WiFi](https://images.trvl-media.com/lodging/5000000/4490000/4486800/4486724/9651a901.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Empire House Hotel [](https://www.expedia.com/Lawrenceburg-Hotels-Empire-House-Hotel.h4486724.Hotel-Information) Rising Sun 9.2/10 Wonderful (328 reviews) "Marsha, the hostess was wonderful. To be able to sit on the porch and look at the river was amazing. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Charlene $58 nightly $66 total Feb 28 - Mar 1 Total with taxes and fees [](https://www.expedia.com/Lawrenceburg-Hotels-Empire-House-Hotel.h4486724.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/33000000/32870000/32867700/32867647/a11c341c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/33000000/32870000/32867700/32867647/4eab0dc1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/33000000/32870000/32867700/32867647/2e778310.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/33000000/32870000/32867700/32867647/w2396h1598x0y2-10232419.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Spacious Carriage House with Park Views Near Frankfort Ave & Downtown [](https://www.expedia.com/Louisville-Hotels-Park-Carriage-House-Rest-Explore-With-Hollyhock.h32867647.Hotel-Information) Crescent Hill 9.8/10 Exceptional (51 reviews) "Great location and great space! Host response was excellent and everything as advertised. Thank you for a great stay for our family. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Catherine B. $263 nightly $308 total Feb 25 - Feb 26 Total with taxes and fees [](https://www.expedia.com/Louisville-Hotels-Park-Carriage-House-Rest-Explore-With-Hollyhock.h32867647.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/64000000/63350000/63347500/63347477/563e5e5e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/64000000/63350000/63347500/63347477/w1288h959x1y0-929b4f52.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Full-size fridge, microwave, coffee/tea maker, toaster](https://images.trvl-media.com/lodging/64000000/63350000/63347500/63347477/e758669e_edited_417a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Dining](https://images.trvl-media.com/lodging/64000000/63350000/63347500/63347477/3e92d764.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Kentucky Derby Guest House < 16 guest !! [](https://www.expedia.com/Louisville-Hotels-Kentucky-Derby-Guest-House-16-Guest.h63347477.Hotel-Information) Mount Washington 9.0/10 Wonderful (48 reviews) "Property was in a good location and was clean." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Eric W M. $122 nightly $136 total Mar 1 - Mar 2 Total with taxes and fees [](https://www.expedia.com/Louisville-Hotels-Kentucky-Derby-Guest-House-16-Guest.h63347477.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.com/Hotel-Search?startDate=2026-03-09&endDate=2026-03-10®ionId=6233889&adults=2&lodging=GUEST_HOUSE&sort=RECOMMENDED&openPlayBack=true) ![](https://forever.travel-assets.com/flex/flexmanager/images/2026/02/06/expedia-sale-2026-desktop-us-ca.jpg?impolicy=fcrop&w=1400&h=600&q=mediumHigh) ## The Annual Vacation Sale Members save up to 40% on hotels and homes. Plan this year’s big trip and save. [Book now](https://expedia.com/deals?rfrr=AA_SPRING_PROMO_6233889) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in ](https://expedia.com/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FSoutheastern-Indiana-Guest-Houses.d6233889-aaGuestHouses.Travel-Guide-Accommodation)[ Sign up, it's free ](https://expedia.com/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FSoutheastern-Indiana-Guest-Houses.d6233889-aaGuestHouses.Travel-Guide-Accommodation) ## Top Southeastern Indiana Hotel Reviews ![Motel 6 Jeffersonville, In - Louisville](https://images.trvl-media.com/lodging/84000000/83090000/83085300/83085300/973d4bf9_y.jpg) ### Motel 6 Jeffersonville, In - Louisville 10/10 Excellent "The room was clean .. ..roomy" [](https://expedia.com/Louisville-Hotels-Motel-6-Jeffersonville.h83085300.Hotel-Information) ![Best Western Plus French Lick](https://images.trvl-media.com/lodging/11000000/10630000/10622000/10621919/814c5c73_y.jpg) ### Best Western Plus French Lick 10/10 Excellent "The staff there was excellent! The rooms were excellent! My only complaint is where you order food from. So there's a icon that the hotel suggest you order from. They were 3 hours late and it messed up my whole night waiting for my food." [](https://expedia.com/French-Lick-Hotels-Best-Western-Plus-French-Lick.h10621919.Hotel-Information) ![The Villas at French Lick Springs](https://images.trvl-media.com/lodging/19000000/18260000/18258400/18258353/18b116b3_y.jpg) ### The Villas at French Lick Springs 10/10 Excellent "Love this place" [](https://expedia.com/French-Lick-Hotels-The-Villas-At-French-Lick-Springs.h18258353.Hotel-Information) ![Ramada by Wyndham Sellersburg/Louisville North](https://images.trvl-media.com/lodging/1000000/660000/659000/658960/dbc92ac1_y.jpg) ### Ramada by Wyndham Sellersburg/Louisville North 10/10 Excellent "I want to commend the team for their outstanding hospitality. The attention to detail regarding room cleanliness and guest relations made my stay incredibly productive and relaxing. I will certainly be returning on my next trip to the area." [](https://expedia.com/Sellersburg-Hotels-Ramada-By-Wyndham-SellersburgLouisville-North.h658960.Hotel-Information) ![Hampton Inn New Albany Louisville West](https://images.trvl-media.com/lodging/1000000/30000/25400/25301/eb53eba8_y.jpg) ### Hampton Inn New Albany Louisville West 10/10 Excellent "Clean" [](https://expedia.com/Louisville-Hotels-Hampton-Inn-New-Albany-Louisville-West.h25301.Hotel-Information) ![Comfort Inn & Suites Clarksville - Louisville North](https://images.trvl-media.com/lodging/65000000/64420000/64410900/64410808/254e595c_y.jpg) ### Comfort Inn & Suites Clarksville - Louisville North 10/10 Excellent "Clean room, staff was very nice" [](https://expedia.com/Louisville-Hotels-Best-Western-Plus-Louisville-North.h64410808.Hotel-Information) ![Best Western Green Tree Inn](https://images.trvl-media.com/lodging/1000000/30000/21100/21059/80ec0958_y.jpg) ### Best Western Green Tree Inn 10/10 Excellent "Clean room, good breakfast " [](https://expedia.com/Louisville-Hotels-Best-Western-Green-Tree-Inn.h21059.Hotel-Information) ![Sheraton Louisville Riverside by Marriott](https://images.trvl-media.com/lodging/1000000/20000/17900/17862/14fa367c_y.jpg) ### Sheraton Louisville Riverside by Marriott 10/10 Excellent "Nice place. Restaurant attached was great too" [](https://expedia.com/Louisville-Hotels-Sheraton-Louisville-Riverside-Hotel.h17862.Hotel-Information) ![TownePlace Suites by Marriott Louisville North](https://images.trvl-media.com/lodging/21000000/20180000/20177600/20177563/2010f6e1_y.jpg) ### TownePlace Suites by Marriott Louisville North 10/10 Excellent "The room was so comfortable, and super clean. All of the staff were so friendly and welcoming. Would definitely recommend to anyone." [](https://expedia.com/Louisville-Hotels-TownePlace-Suites-By-Marriott-Louisville-North.h20177563.Hotel-Information) ## Find out more about Southeastern Indiana ## Southeastern Indiana Guest Houses information | Number of reviews | 427 | | ----------------- | -------------- | | Accommodation | 1 Guest Houses | | Lowest Price | $66 | | Highest Price | $308 | ## Frequently asked questions ### What is the nightly rate for a guest house in Southeastern Indiana? ### What's the difference between a Southeastern Indiana guest house and a B&B?