Southeastern Indiana Vacations from $398

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Your Southeastern Indiana Vacation

Head off on your next big adventure with a Southeastern Indiana vacation package, and leave knowing all the details are organized. And with the ability to customize your getaway, you know it'll be one to remember. Your trip to Southeastern Indiana wouldn't be complete without getting to some of its most well-known cities, starting with Louisville. A couple of the top attractions here include KFC Yum Center and Kentucky Kingdom. Radcliff should also be on the itineraries of all Southeastern Indiana travelers. Visitors to this exciting city love Freeman Lake Park and General George Patton Museum. Whether you're planning to travel for a few days or a few weeks, Expedia are here to help you tailor-make your next dream Southeastern Indiana vacation.

The Latest Southeastern Indiana vacation packages

Price found within the past 48 hours. Click for updated prices.
Hyatt Regency Cincinnati
Hilton Cincinnati Netherland Plaza
Caesars Southern Indiana
The Cincinnatian Hotel Curio Collection by Hilton
21c Museum Hotel Cincinnati
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Where to stay in Southeastern Indiana

Find the best Southeastern Indiana areas and neighborhoods for the activities you enjoy most. Learn more about Southeastern Indiana

Discover the most popular places to visit in Southeastern Indiana

Southeastern Indiana Hotel Deals

Radisson Hotel Louisville North

Radisson Hotel Louisville North

3 out of 5
505 Marriott Drive, Clarksville, IN
Fully refundable
$63 nightly
The price is $71 total per night from Aug 9 to Aug 10
$71 total
Aug 9 - Aug 10
Total includes taxes and fees
6.8/10 (2,236 reviews)
"Chai and Kimberly up at the front are great people and treat you with the outmost respect and kindness. They are really helpful and quick to process your request. Been staying a couple nights and have not had a single issue. Super recommended."

Reviewed on Aug 1, 2025

Radisson Hotel Louisville North
Comfort Inn & Suites Clarksville - Louisville North

Comfort Inn & Suites Clarksville - Louisville North

2.5 out of 5
1485 Broadway St, Clarksville, IN
Fully refundableReserve now, pay when you stay
$97 nightly
The price is $109 total per night from Sep 1 to Sep 2
$109 total
Sep 1 - Sep 2
Total includes taxes and fees
8.8/10 Excellent! (950 reviews)
"The rooms were comfortable and clean. Lobby was welcoming. Unfortunately, the pool was closed on our visit and parking is awkward. But those were the only 2 negatives, overall a really great property at a great price."

Reviewed on Aug 1, 2025

Comfort Inn & Suites Clarksville - Louisville North
Sheraton Louisville Riverside by Marriott

Sheraton Louisville Riverside by Marriott

3.5 out of 5
700 West Riverside Drive, Jeffersonville, IN
Fully refundableReserve now, pay when you stay
$93 nightly
The price is $105 total per night from Aug 11 to Aug 12
$105 total
Aug 11 - Aug 12
Total includes taxes and fees
8.2/10 Very Good! (1,000 reviews)
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Reviewed on Jul 15, 2025

Sheraton Louisville Riverside by Marriott
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.