Southeastern Indiana Vacation Packages 2026 from $333

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Your Southeastern Indiana Vacation

Head off on your next big adventure with a Southeastern Indiana vacation package, and leave knowing all the details are organized. And with the ability to customize your getaway, you know it'll be one to remember. Your trip to Southeastern Indiana wouldn't be complete without getting to some of its most well-known cities, starting with Louisville. A couple of the top attractions here include KFC Yum Center and Kentucky Kingdom. Radcliff should also be on the itineraries of all Southeastern Indiana travelers. Visitors to this exciting city love Freeman Lake Park and General George Patton Museum. Whether you're planning to travel for a few days or a few weeks, Expedia are here to help you tailor-make your next dream Southeastern Indiana vacation.

The Latest Southeastern Indiana vacation packages

Price found within the past 48 hours. Click for updated prices.

21c Museum Hotel Cincinnati

Downtown Cincinnati

Save 100% on your flight

$333

per person

Oct 31 - Nov 3

found 1 day ago

Roundtrip flight included

Atlanta (ATL) to Cincinnati (CVG)

8.6/10 Excellent! (1,011 reviews)

Hotel Covington Cincinnati Riverfront

Central Business District

Save 100% on your flight

$391

per person

Oct 31 - Nov 3

found 1 day ago

Roundtrip flight included

Atlanta (ATL) to Cincinnati (CVG)

9.6/10 Exceptional! (1,004 reviews)

Louisville Marriott Downtown

Downtown Louisville

$1,185

per person

Oct 26 - Nov 1

found 1 day ago

Roundtrip flight included

Boston (BOS) to Louisville (SDF)

9/10 Wonderful! (1,003 reviews)

Property was nice! Room was as expected! Valet/service was much to be desired! Room service snd bar service was some of the worst I’ve ever encountered! Was told by room service they had water; but if I wanted then I had to come get them myself! She wasn’t delivering them! Bartender in the hotel lounge was so bad it was laughable!! Told us she was doing us a favor by waiting on us! Lost her mind when I ask for 3 small bowls to put nuts in so our party of eight didn’t have to pass around the same cardboard cup she put them in!

Reviewed on Aug 16, 2026

River View by Avantstay Pool + Deck Dining + BBQ Kayaks + EV Charger Catskills View

Save 100% on your flight

$2,587

per person

Oct 15 - Oct 18

found 1 day ago

Roundtrip flight included

Atlanta (ATL) to Cincinnati (CVG)

No reviews

Hotel Distil, Autograph Collection

Downtown Louisville

$1,317

per person

Oct 26 - Nov 1

found 1 day ago

Roundtrip flight included

Boston (BOS) to Louisville (SDF)

9.6/10 Exceptional! (491 reviews)

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Where to stay in Southeastern Indiana

Find the best Southeastern Indiana areas and neighborhoods for the activities you enjoy most. Learn more about Southeastern Indiana

The entrance to the Kentucky Science Center with a large circular structure in the foreground.

West Main Historic District

Boasting the largest collection of cast iron façades outside New York's SoHo district, this historic area features "Museum Row" with attractions like the Louisville Slugger Museum and Muhammad Ali Center.

A bridge with a metal truss structure and a highway with vehicles.

Portland

While visiting Portland, you might make a stop by sights like Portland Museum and Lannan Park Trailhead.

A weathered tower with a metal sign reading "Better By Far" and a metal structure with the number "3" on top.

California

If you're spending some time in California, Ohio River Valley and Union Station are top sights worth seeing.

An aerial view of a park with manicured lawns, a central fountain, and a large building with a red dome.

Downtown French Lick

While Downtown French Lick might not have many sights to explore, venturing just a little farther will lead you to top things to see and do like French Lick Springs Hotel and French Lick Casino.

Russell

If you're spending some time in Russell, Ohio River Valley and I. Willis Cole Residence are top sights worth seeing.

Stay near popular Southeastern Indiana attractions

A river with a bridge, a stadium, and modern buildings.

KFC Yum Center

8.8/10 (1,621 reviews)

Catch an event at KFC Yum Center during your trip to Louisville. Stroll along the riverfront or attend a sporting event in the area.

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A wall of wooden baseball bats organized by size and weight.

Louisville Slugger Museum

9.2/10 (2,299 reviews)

Baseball is part of the American fabric. See where one important tool for this sport is produced in the factory that makes ball games possible.

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A wooden barrel room with barrels lined up on both sides and a wooden floor.

Whiskey Row

9.2/10 (11 reviews)

Find out about the history of Louisville when you spend time at Whiskey Row. Attend a sporting event or simply enjoy the top-notch restaurants while you're in the area.

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A city street with a large building labeled "FOURTH STREET" and a neon sign for "JIM BEAM."

Fourth Street Live!

8.4/10 (2,560 reviews)

You can do some window-shopping at Fourth Street Live! during your stay in Louisville. Experience the area's great live music and acclaimed theater scene.

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A bridge with illuminated blue lights at night.

Louisville Waterfront Park

8.8/10 (668 reviews)

After visiting Louisville Waterfront Park, make a plan to see the other sights and activities in Louisville. Stroll along the area's riverfront or experience its great live music.

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A waterfall cascading over a rocky cliff surrounded by dense green foliage.

Clifty Falls State Park

9.2/10 (183 reviews)

You can take time to visit Clifty Falls State Park during your travels to Madison. Stroll along the riverfront or discover the area's waterfalls.

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Kentucky International Convention Center

8.4/10 (763 reviews)

Learn about the events happening at Kentucky International Convention Center during your trip to Louisville. Amble around the area's riverfront or attend a sporting event.

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Kentucky Bourbon Trail Visitor Center

Kentucky Bourbon Trail Visitor Center is just one of the places to see in Louisville, so why not enjoy the other things to explore during your travels? Attend a sporting event or simply enjoy the top-notch restaurants while you're in the area.

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Southeastern Indiana Hotel Deals

Radisson Hotel Louisville North

505 Marriott Drive Clarksville IN

Fully refundableReserve now, pay when you stay

$60 nightly

$68 total

Sep 1 - Sep 2

Total with taxes and fees

Derby Hotel & Suites

505 K Marriot Dr Clarksville IN

Fully refundableReserve now, pay when you stay

$56 nightly

$63 total

Sep 6 - Sep 7

Total with taxes and fees

Big Splash Adventure Indoor Water Park & Resort

8505 W State Road 56 French Lick IN

$88 nightly

$98 total

Aug 27 - Aug 28

Total with taxes and fees

7.8/10 Good! (206 reviews)

"It's a very Kool place everything was great food was good people were polite water park was Kool but be ready for a saltwater pool not a chlorine pool"

Reviewed on Aug 12, 2026

See all 1,177 properties in Southeastern Indiana

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.