Southeastern Indiana Vacation Packages 2026 from $587

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Your Southeastern Indiana Vacation

Head off on your next big adventure with a Southeastern Indiana vacation package, and leave knowing all the details are organized. And with the ability to customize your getaway, you know it'll be one to remember. Your trip to Southeastern Indiana wouldn't be complete without getting to some of its most well-known cities, starting with Louisville. A couple of the top attractions here include KFC Yum Center and Kentucky Kingdom. Radcliff should also be on the itineraries of all Southeastern Indiana travelers. Visitors to this exciting city love Freeman Lake Park and General George Patton Museum. Whether you're planning to travel for a few days or a few weeks, Expedia are here to help you tailor-make your next dream Southeastern Indiana vacation.

The Latest Southeastern Indiana vacation packages

Price found within the past 48 hours. Click for updated prices.

Hyatt Regency Louisville

Downtown Louisville

$587

per person

Dec 30 - Jan 3

found 1 day ago

Roundtrip flight included

New York (LGA) to Louisville (SDF)

8.8/10 Excellent! (1,004 reviews)

The Grady

Downtown Louisville

$703

per person

Dec 30 - Jan 3

found 1 day ago

Roundtrip flight included

New York (LGA) to Louisville (SDF)

9.4/10 Exceptional! (1,011 reviews)

The Lytle Park Hotel, Autograph Collection

Downtown Cincinnati

$1,150

per person

Nov 22 - Nov 27

found 1 day ago

Roundtrip flight included

Dallas (DFW) to Cincinnati (CVG)

9.6/10 Exceptional! (316 reviews)

Hotel Covington Cincinnati Riverfront

Central Business District

$891

per person

Dec 13 - Dec 18

found 1 day ago

Roundtrip flight included

Dallas (DFW) to Cincinnati (CVG)

9.6/10 Exceptional! (1,004 reviews)

I can’t even trust you cause I don’t think you let her out last night cause the leash was right where I left it. You have to give her time to pee and

Reviewed on Oct 10, 2026

Hotel Distil, Autograph Collection

Downtown Louisville

$855

per person

Dec 30 - Jan 3

found 1 day ago

Roundtrip flight included

New York (LGA) to Louisville (SDF)

9.6/10 Exceptional! (507 reviews)

The room exceeded expectations! All of the restaurants had exceptional food! Beautiful hotel, great location, and very friendly staff!

Reviewed on Oct 11, 2026

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Where to stay in Southeastern Indiana

Find the best Southeastern Indiana areas and neighborhoods for the activities you enjoy most. Learn more about Southeastern Indiana

The entrance to the Kentucky Science Center with a large circular structure in the foreground.

West Main Historic District

Boasting the largest collection of cast iron façades outside New York's SoHo district, this historic area features "Museum Row" with attractions like the Louisville Slugger Museum and Muhammad Ali Center.

Madison Historic District

If you're spending some time in Madison Historic District, Historic District and Schofield House are top sights worth seeing.

A bridge with a metal truss structure and a highway with vehicles.

Portland

While visiting Portland, you might make a stop by sights like Portland Museum and Lannan Park Trailhead.

A weathered tower with a metal sign reading "Better By Far" and a metal structure with the number "3" on top.

California

If you're spending some time in California, Ohio River Valley and Union Station are top sights worth seeing.

An aerial view of a park with manicured lawns, a central fountain, and a large building with a red dome.

Downtown French Lick

While Downtown French Lick might not have many sights to explore, venturing just a little farther will lead you to top things to see and do like French Lick Springs Hotel and French Lick Casino.

Stay near popular Southeastern Indiana attractions

A river with a bridge, a stadium, and modern buildings.

KFC Yum Center

8.8/10 (1,621 reviews)

Catch an event at KFC Yum Center during your trip to Louisville. Stroll along the riverfront or attend a sporting event in the area.

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A tall wooden baseball bat leaning against a brick building with a sign reading "Hillerich & Brassler Co."

Louisville Slugger Museum

9.2/10 (2,299 reviews)

Baseball is part of the American fabric. See where one important tool for this sport is produced in the factory that makes ball games possible.

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A wooden barrel room with barrels lined up on both sides and a wooden floor.

Whiskey Row

9.2/10 (11 reviews)

Find out about the history of Louisville when you spend time at Whiskey Row. Attend a sporting event or simply enjoy the lively bars while you're in the area.

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A city street with a large building labeled "FOURTH STREET" and a neon sign for "JIM BEAM."

Fourth Street Live!

8.4/10 (2,560 reviews)

You can do some window-shopping at Fourth Street Live! during your stay in Louisville. Experience the area's entertainment choices and lively festivals.

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A waterfall cascading over a rocky cliff surrounded by dense green foliage.

Clifty Falls State Park

9.2/10 (183 reviews)

You can take time to visit Clifty Falls State Park during your travels to Madison. Stroll along the riverfront or discover the area's waterfalls.

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A nighttime cityscape with a lit bridge reflecting on the water.

Louisville Waterfront Park

8.8/10 (668 reviews)

After visiting Louisville Waterfront Park, make a plan to see the other sights and activities in Louisville. Stroll along the area's riverfront or experience its acclaimed art scene.

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Kentucky International Convention Center

8.4/10 (763 reviews)

Learn about the events happening at Kentucky International Convention Center during your trip to Louisville. Amble around the area's riverfront or attend a sporting event.

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Louisville Palace

8.2/10 (488 reviews)

You can get tickets for a performance at Louisville Palace on your trip to Louisville. Experience the area's acclaimed theater scene or attend a sporting event.

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Southeastern Indiana Hotel Deals

Radisson Hotel Louisville North

505 Marriott Drive Clarksville IN

Fully refundable

$67 nightly

$75 total

Nov 11 - Nov 12

Total with taxes and fees

7.2/10 Good! (3,439 reviews)

"Maintenance crew needs to check the rooms on a weekly basis to see what need to be fixed or maintained."

Reviewed on Oct 10, 2026

Derby Hotel & Suites

505 K Marriot Dr Clarksville IN

Fully refundableReserve now, pay when you stay

$54 nightly

$61 total

Oct 12 - Oct 13

Total with taxes and fees

Hampton Inn New Albany Louisville West

411 W Spring Street New Albany IN

$93 nightly

$105 total

Oct 26 - Oct 27

Total with taxes and fees

See all 1,150 properties in Southeastern Indiana

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.