A modern glass building with a curved facade and a sign reading "The Kentucky Center".

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Check availability on Southern Indiana 4 Star Hotels

Tonight
Oct 15 - Oct 16
Tomorrow
Oct 16 - Oct 17
This weekend
Oct 16 - Oct 18
Next weekend
Oct 23 - Oct 25

Our top choices for Southern Indiana 4-star hotels

A modern interior with large windows offering a city view, a circular light fixture, and leather seating.
A modern bar with a long counter, multiple shelves of liquor bottles, and cushioned bar stools.
A spacious room with a large dining table, comfortable seating, a sofa, and a view of a bridge.
A nighttime view of The GALT and The Galthouse buildings with illuminated signage, a busy street with light trails from moving vehicles, and a modern urban setting.

1. Galt House Hotel Trademark Collection by Wyndham

Galt House Hotel Trademark Collection by Wyndham
Downtown Louisville
United States
Mark
$140 nightly
$165 total
Nov 8 - Nov 9
Total with taxes and fees
Galt House Hotel Trademark Collection by Wyndham
A spacious lobby with a high ceiling, a central chandelier, and seating areas with tables and chairs.
A modern interior with a fireplace, bookshelves, and seating areas.
A modern building entrance with a glass facade, wooden ceiling, and illuminated fixtures.
A rooftop bar with outdoor seating, including sofas and chairs, and a bar area with a television screen.

2. Omni Louisville Hotel

Omni Louisville Hotel
Downtown Louisville
United States
Samantha
$125 nightly
$148 total
Oct 18 - Oct 19
Total with taxes and fees
Omni Louisville Hotel
A grand lobby with ornate columns, plush seating, and a chandelier.
A grand lobby with ornate ceiling, large windows, and classic furniture.
A grand lobby with ornate ceiling, multiple seating areas, and a staircase.
A grand lobby with ornate ceiling and chandeliers, a large vase, and a seating area with multiple sofas and armchairs.

3. The Brown Hotel

The Brown Hotel
Downtown Louisville
United States
John
$156 nightly
$183 total
Oct 28 - Oct 29
Total with taxes and fees
The Brown Hotel
A spacious lobby with a blue sofa, a wooden coffee table, and a chandelier.
An indoor swimming pool with clear water, surrounded by white marble walls and columns, and furnished with lounge chairs and tables.
A hotel dining area with long tables, booths, and a bar.
A modern bar area with a long counter, multiple chairs, and a bookshelf filled with bottles.

4. Embassy Suites Louisville Downtown

Embassy Suites Louisville Downtown
Downtown Louisville
United States
Frances
$130 nightly
$153 total
Nov 15 - Nov 16
Total with taxes and fees
Embassy Suites Louisville Downtown
A modern lobby with a curved metallic structure, a seating area with a sofa and a small table, and an escalator in the background.
A modern indoor swimming pool with clear glass walls, lounge chairs, and a wooden wall in the background.
A reception area with a wooden wall and a neon sign that reads "Sway LOCAL SOUTHERN EATERY".
A bar area with wooden paneling, multiple seating arrangements, and a variety of liquor bottles displayed on shelves.

5. Hyatt Regency Louisville

Hyatt Regency Louisville
Downtown Louisville
United States
Lester
$165 nightly
$194 total
Oct 29 - Oct 30
Total with taxes and fees
Hyatt Regency Louisville
A modern building with a restaurant on the ground floor, featuring large windows and outdoor seating.
A reception area with marble counters, modern pendant lighting, and potted orchids.
A modern bar area with glass partitions, bar stools, and a variety of bottles.
A modern hotel room with a large window offering a city view, a cozy seating area with a sofa and chairs, a dining table with lamps, and a wooden floor.

6. Louisville Marriott Downtown

Louisville Marriott Downtown
Downtown Louisville
United States
Jason
$137 nightly
$162 total
Nov 13 - Nov 14
Total with taxes and fees
Louisville Marriott Downtown
A classical gold statue in front of a multi-story building with large windows and a brick facade.
A cozy room with wooden walls, a table with a lamp, and shelves displaying books and decorative items.
A steam fountain in a brick alleyway.
A restaurant with multiple dining tables, a long bench seating area, and framed artwork on the walls.

7. 21c Museum Hotel Louisville

21c Museum Hotel Louisville
Downtown Louisville
United States
Matt
$156 nightly
$184 total
Nov 8 - Nov 9
Total with taxes and fees
21c Museum Hotel Louisville
A room with a checkered floor, leather armchairs, a sofa, and a small table with a glass. There are windows with arched tops and a view of buildings outside.
A brightly lit grocery store with yellow shelving and a central checkout counter.
A bar area with a wooden bar counter, two stools, a chandelier, and a mirror.
A bedroom with a bed, a chair, a TV, and a window with curtains.

8. Hotel Genevieve part of JdV by Hyatt

Hotel Genevieve part of JdV by Hyatt
Downtown Louisville
United States
Tyler
$135 nightly
$159 total
Oct 25 - Oct 26
Total with taxes and fees
Hotel Genevieve part of JdV by Hyatt
An indoor dining area with tables set for guests, surrounded by potted plants and hanging lights.
A multi-story hotel with a classic facade, large windows, and a modern glass building adjacent to it.
A bar with shelves of liquor bottles and a bartender preparing drinks.
A modern living room with a leather sectional sofa, a glass coffee table, and a view of the city skyline through large windows.

9. Hotel Distil, Autograph Collection

Hotel Distil, Autograph Collection
Downtown Louisville
United States
Heather
$228 nightly
$268 total
Nov 8 - Nov 9
Total with taxes and fees
Hotel Distil, Autograph Collection
A modern interior with a fireplace, bookshelves, a green sofa, and leather chairs.
A multi-level interior with a staircase, bookshelves, and a prominent sign reading "THE GRADY".
A building with a sign reading "THE GRADY" at the entrance.
A modern hotel room with a large bed, a desk with a flat-screen TV, a green armchair, and a view of the city through large windows.

10. The Grady

The Grady
Downtown Louisville
United States
Donna
$173 nightly
$204 total
Nov 15 - Nov 16
Total with taxes and fees
The Grady
An outdoor seating area with sofas and tables, a fire feature, and a clock tower in the background.
A modern lobby with a central reception desk, seating area, and a large abstract wall art piece.
A hotel with a prominent sign, a central courtyard with a sculpture, and a dome structure in the background.
A modern living room with a sofa, a coffee table, a side table with a plant, and a view of a building with a clock tower.

11. Hotel Bourré Bonne Louisville, Curio Collection by Hilton

Hotel Bourré Bonne Louisville, Curio Collection by Hilton
Downtown Louisville
United States
Cameron
$180 nightly
$211 total
Oct 25 - Oct 26
Total with taxes and fees
Hotel Bourré Bonne Louisville, Curio Collection by Hilton
A modern hotel entrance with a covered walkway, a parking area, and a building with multiple floors.
A fountain with multiple jets of water in front of a building with a curved facade and large windows.
A neatly made breakfast tray on a bed with a coffee pot, croissant, and fruit bowl.
An outdoor seating area with wicker chairs and a central fire feature, surrounded by potted plants and a brick wall.

12. DoubleTree by Hilton Evansville

DoubleTree by Hilton Evansville
Downtown Evansville
United States
CheyAnne
$101 nightly
$116 total
Oct 25 - Oct 26
Total with taxes and fees
DoubleTree by Hilton Evansville
A historic hotel with ornate architecture, a grand entrance, and a red carpet leading to the doors.
A grand lobby with marble floors, a staircase, and a reception desk.
A grand staircase with ornate railings and a marble floor, leading to a high-ceilinged lobby with decorative moldings and a chandelier.
A bakery display with pastries and bread, a coffee station, and a Christmas tree in the background.

13. Seelbach Hilton Louisville Downtown

Seelbach Hilton Louisville Downtown
Downtown Louisville
United States
Colleen
$165 nightly
$194 total
Oct 29 - Oct 30
Total with taxes and fees
Seelbach Hilton Louisville Downtown
A modern hotel lobby with a reception desk, seating area, and a staircase leading to the upper floor.
A modern KFC building with large glass windows, a prominent sign, and a well-lit entrance area.
A modern interior with a green wall, black chairs, and a ceiling with exposed beams and lights.
A modern, well-lit room with a large bed, a green sofa, a small round table, and a kitchen area in the background.

14. Stellar Suites

Stellar Suites
Downtown Louisville
United States
Kevin
$163 nightly
$189 total
Nov 1 - Nov 2
Total with taxes and fees
Stellar Suites
A grand entrance with a staircase leading to a door, flanked by two lamp posts and a bench.
A long table set with white tablecloths, gold chargers, and clear glassware.
A grand hallway with a wooden floor, a staircase, a chandelier, and a large mirror.
A covered porch with a brick wall, a wooden door, and a hanging light fixture.

15. The Pepin Mansion Historic B&B

The Pepin Mansion Historic B&B
New Albany
United States
David
$115 nightly
$130 total
Nov 9 - Nov 10
Total with taxes and fees
The Pepin Mansion Historic B&B
A modern lounge with leather sofas, a coffee table, and a view of a classical building.
A building with a sign reading "Pursuit Spirits Co." and a large window display.
A modern interior with a wooden dining table, leather sofas, and a bar area with shelves.
A narrow corridor with exposed brick walls, wooden flooring, and a seating area with tables and chairs.

16. The Reserve on Main

The Reserve on Main
Downtown Louisville
United States
De'Carlon
The Reserve on Main
A rooftop pool area with multiple lounge chairs and umbrellas, surrounded by a high-rise building with balconies.
A gym with exercise equipment, mirrors, and a TV screen.
A modern kitchen with white cabinets, stainless steel appliances, and a dining area with a table and chairs.
A modern living room with a dining area, a blue sofa, a ceiling fan, and a view of a balcony.

17. CozySuites at Nulu

CozySuites at Nulu
Downtown Louisville
United States
Jennifer
$194 nightly
$225 total
Oct 18 - Oct 19
Total with taxes and fees
CozySuites at Nulu
A modern hotel with a 'Stay Apt Suites' sign, featuring a brick facade, large windows, and a parking lot.
Terrace/patio
In-room dining
Private kitchen

18. stayAPT Suites Louisville North-Clarksville

stayAPT Suites Louisville North-Clarksville
Clarksville
Canada
Darlene
$149 nightly
$168 total
Oct 27 - Oct 28
Total with taxes and fees
stayAPT Suites Louisville North-Clarksville
A large, multi-story building with a prominent tower and multiple windows.
A spacious living area with a large, ornate rug, a wooden bench, and a staircase with white balusters.
A large outdoor swimming pool with a Ferris wheel in the background.
A dining table set with placemats, folded napkins, cutlery, and a coffee cup.

19. Bourbon Barrel Inn Bed & Breakfast

Bourbon Barrel Inn Bed & Breakfast
Old Louisville
United States
jonathan
Bourbon Barrel Inn Bed & Breakfast
A modern kitchen with wooden cabinets, a black microwave, and a stainless steel refrigerator.
A living room with a sofa, a coffee table, and a ceiling fan. There is a dining area with a table and chairs.
A kitchen with wooden cabinets, a refrigerator, a coffee maker, and a tiled backsplash.
A kitchen with a black refrigerator, a dining area with a table and chairs, and a living room with a blue sofa.

20. Spacious 3 BR Ranch House W Patio Yard in a Quiet Suburb

Spacious 3 BR Ranch House W Patio Yard in a Quiet Suburb
Sellersburg
United States
Tammy
Spacious 3 BR Ranch House W Patio Yard in a Quiet Suburb
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Learn more about Southern Indiana

Hoosier traditions add a unique slant to your trip to the towns of this region, while the forest offers a serene spot for a picnic beside old buffalo grounds.

See all hotels in Southern Indiana
A riverboat with multiple decks and passengers, docked near a bridge.

Top Southern Indiana Hotel Reviews

Find out more about Southern Indiana

Southern Indiana Four Star Hotel Information

When you need to book a room with luxurious amazing amenities and the best rates, the 4 star hotels in Southern Indiana, United States of America are incredible options. Known for their extra perks, first-rate service, and fantastic locations, each of the Southern Indiana 4 star hotels offers the ultimate experience for globe-trotting travelers. Relax in your expertly designed room. Kick back with around-the-clock room service.

Get a good night’s sleep with the ultra-plush bedding, and freshen up in the morning with designer-inspired body products. It’s all available when you stay at one of the top book a four star hotels in Southern Indiana. What’s more, thanks to Expedia you might even score a cheap great deal on a 4 star hotel in Southern Indiana, United States of America, areas near the hottest attractions, so you can plan a sightseeing adventure and take advantage of unbeatable discounts in one fell swoop.

Whether you’re putting together a serene getaway or want to revel in the most vibrant entertainment district, 4 star Southern Indiana hotels offer everything your heart desires.

Frequently asked questions

What are the best 4-star hotels in Southern Indiana?
If your Southern Indiana vacation leads you to Louisville, consider Galt House Hotel Trademark Collection by Wyndham. With lots of amenities such as massage services and a swimming pool, it scores top marks from many Expedia customers. Another popular pick here is Hyatt Regency Louisville. It also has 4 stars and offers designer toiletries and a swimming pool.
How much does it cost to stay in a 4-star hotel in Southern Indiana?
To book a 4-star hotel in Southern Indiana that's within your budget, use Expedia's handy filter tool. Browse the availability during your chosen dates and use our pricing filter to set your limit. You can also sort your results by the cheapest option first.
  • Search for the lowest price from $116
What's the difference between 5-star and 4-star hotels in Southern Indiana?
Offering an inviting traveler experience and upscale décor, 4-star hotels are an excellent option for your Southern Indiana break. These kinds of accommodations generally feature loads of handy amenities that make it easy to unpack and recharge — think pillowtop mattresses, restaurants and pools. Or live in the lap of luxury at a 5-star hotel designed to spoil you with exclusive perks and amenities. 24-hour front desk, oversized bathrooms and gourmet dining are typically featured at these swanky properties.

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