A modern glass building with a curved facade and a sign reading "The Kentucky Center".

Find 4 Star Hotels in Southern Indiana from $100

  • Upfront pricing

    Our total price for your stay includes taxes and fees

  • Treat yourself

    Save 10% or more on over 100,000 hotels worldwide with Member Prices
    Learn about One Key

  • Be picky

    Search almost a million properties worldwide

Check availability on Southern Indiana 4 Star Hotels

Our top choices for Southern Indiana 4-star hotels

4 restaurants; breakfast, lunch, and dinner served

Galt House Hotel Trademark Collection by Wyndham

Galt House Hotel Trademark Collection by Wyndham
4.0 star property
Downtown Louisville
9.0 out of 10, Wonderful, (4,175 reviews)
"Great hotel & stay!"
United States
Jennifer
$147 nightly
The price is $173
Aug 1 - Aug 2
Total with taxes and fees
Galt House Hotel Trademark Collection by Wyndham
3 bars/lounges, cocktail bar, lobby lounge

Omni Louisville Hotel

Omni Louisville Hotel
4.0 star property
Downtown Louisville
9.4 out of 10, Exceptional, (1,992 reviews)
"Beautiful, clean property with many things to do at and around the hotel."
United States
Brittany
$159 nightly
The price is $187
Aug 2 - Aug 3
Total with taxes and fees
Omni Louisville Hotel
Lobby

Hyatt Regency Louisville

Hyatt Regency Louisville
4.0 star property
Downtown Louisville
8.8 out of 10, Excellent, (1,002 reviews)
"Beautiful Hotel!"
United States
Joseph
$127 nightly
The price is $149
Aug 1 - Aug 2
Total with taxes and fees
Hyatt Regency Louisville
Front of property

21c Museum Hotel Louisville

21c Museum Hotel Louisville
4.5 star property
Downtown Louisville
9.4 out of 10, Exceptional, (1,001 reviews)
"Beautiful property, on-site restaurant was delicious. Beds very nice."
United States
nicolle
$156 nightly
The price is $184
Aug 16 - Aug 17
Total with taxes and fees
21c Museum Hotel Louisville
Reception

Embassy Suites Louisville Downtown

Embassy Suites Louisville Downtown
4.0 star property
Downtown Louisville
9.0 out of 10, Wonderful, (1,298 reviews)
"We liked everything about our stay"
United States
Mark
$130 nightly
The price is $153
Jul 31 - Aug 1
Total with taxes and fees
Embassy Suites Louisville Downtown
Exterior

Louisville Marriott Downtown

Louisville Marriott Downtown
4.0 star property
Downtown Louisville
9.0 out of 10, Wonderful, (1,000 reviews)
"Great location and friendly staff. Loved their bar and lobby area."
United States
Bikash
$168 nightly
The price is $197
Aug 16 - Aug 17
Total with taxes and fees
Louisville Marriott Downtown
Lobby

The Grady

The Grady
4.0 star property
Downtown Louisville
9.4 out of 10, Exceptional, (1,015 reviews)
"Great place to stay!"
United States
Jennifer
$181 nightly
The price is $213
Aug 6 - Aug 7
Total with taxes and fees
The Grady
Lobby

The Brown Hotel

The Brown Hotel
4.5 star property
Downtown Louisville
9.4 out of 10, Exceptional, (1,281 reviews)
"Great people and hotel"
United States
Roland
$171 nightly
The price is $201
Aug 4 - Aug 5
Total with taxes and fees
The Brown Hotel
Terrace/patio

Hotel Bourré Bonne Louisville, Curio Collection by Hilton

Hotel Bourré Bonne Louisville, Curio Collection by Hilton
4.0 star property
Downtown Louisville
9.4 out of 10, Exceptional, (127 reviews)
"Great stay"
United States
Kristen
$177 nightly
The price is $208
Aug 16 - Aug 17
Total with taxes and fees
Hotel Bourré Bonne Louisville, Curio Collection by Hilton
Terrace/patio

Hotel Genevieve part of JdV by Hyatt

Hotel Genevieve part of JdV by Hyatt
4.0 star property
Downtown Louisville
9.2 out of 10, Wonderful, (1,111 reviews)
"Great place in NuLu"
United States
Fredrick
$135 nightly
The price is $159
Jul 26 - Jul 27
Total with taxes and fees
Hotel Genevieve part of JdV by Hyatt
Terrace/patio

Hotel Distil, Autograph Collection

Hotel Distil, Autograph Collection
4.0 star property
Downtown Louisville
9.6 out of 10, Exceptional, (483 reviews)
"Great hotel and great staff."
United States
Jasmine
$202 nightly
The price is $237
Aug 2 - Aug 3
Total with taxes and fees
Hotel Distil, Autograph Collection
Lobby

DoubleTree by Hilton Evansville

DoubleTree by Hilton Evansville
4.0 star property
Downtown Evansville
8.6 out of 10, Excellent, (1,000 reviews)
"The breakfast at the restaurant was very good. The hotel was very convenient for an event we attended at the Ford Center."
United States
Adrianna
$98 nightly
The price is $112
Jul 26 - Jul 27
Total with taxes and fees
DoubleTree by Hilton Evansville
Exterior

Seelbach Hilton Louisville Downtown

Seelbach Hilton Louisville Downtown
4.0 star property
Downtown Louisville
8.8 out of 10, Excellent, (1,000 reviews)
"Room was very clean."
United States
Whitney
$164 nightly
The price is $192
Jul 27 - Jul 28
Total with taxes and fees
Seelbach Hilton Louisville Downtown
Property entrance

The Pepin Mansion Historic B&B

The Pepin Mansion Historic B&B
4.0 star property
New Albany
9.8 out of 10, Exceptional, (709 reviews)
"Lovely property and excellent breakfast"
United States
Jacob
$89 nightly
The price is $100
Jul 19 - Jul 20
Total with taxes and fees
The Pepin Mansion Historic B&B
Lounge

Stellar Suites

Stellar Suites
4.5 star property
Downtown Louisville
9.6 out of 10, Exceptional, (141 reviews)
"Great location. Lots to do in the area. Room was clean and very nice."
United States
Brad
$161 nightly
The price is $186
Aug 3 - Aug 4
Total with taxes and fees
Stellar Suites
Exterior

stayAPT Suites Louisville North-Clarksville

stayAPT Suites Louisville North-Clarksville
4.0 star property
Clarksville
9.8 out of 10, Exceptional, (53 reviews)
"Nice place to stay"
United States
Chauntel
$169 nightly
The price is $191
Jul 19 - Jul 20
Total with taxes and fees
stayAPT Suites Louisville North-Clarksville
Seasonal outdoor pool

CozySuites at Nulu

CozySuites at Nulu
4.0 star property
Downtown Louisville
7.6 out of 10, Good, (32 reviews)
"Wonderful stay - great spot and lots of great dining options and bars nearby "
United States
Roy
$173 nightly
The price is $201
Aug 3 - Aug 4
Total with taxes and fees
CozySuites at Nulu
32-inch Smart TV with cable channels

The Reserve on Main

The Reserve on Main
4.0 star property
Downtown Louisville
9.4 out of 10, Exceptional, (3 reviews)
"The room was great and clean. Great location. "
United States
De'Carlon
The Reserve on Main
Exterior

Bourbon Barrel Inn Bed & Breakfast

Bourbon Barrel Inn Bed & Breakfast
4.0 star property
Old Louisville
10.0 out of 10, Exceptional, (4 reviews)
"Inn Keepers were wonderful. "
United States
jonathan
Bourbon Barrel Inn Bed & Breakfast
Family House, Multiple Beds | Private kitchen | Fridge, microwave, oven, stovetop

Spacious 3 BR Ranch House W Patio Yard in a Quiet Suburb

Spacious 3 BR Ranch House W Patio Yard in a Quiet Suburb
4.0 star property
Sellersburg
9.4 out of 10, Exceptional, (10 reviews)
"Very nice house in a nice neighborhood, spacious home environmental, felt more that at home there,"
United States
Tammy
Spacious 3 BR Ranch House W Patio Yard in a Quiet Suburb
Save an average of 15% on thousands of hotels when you're signed in
Sign in
Sign up, it's free

Learn more about Southern Indiana

Hoosier traditions add a unique slant to your trip to the towns of this region, while the forest offers a serene spot for a picnic beside old buffalo grounds.

See all hotels in Southern Indiana
A riverboat with multiple decks and passengers, docked near a bridge.

Top Southern Indiana Hotel Reviews

Find out more about Southern Indiana

Southern Indiana Four Star Hotel Information

When you need to book a room with luxurious amazing amenities and the best rates, the 4 star hotels in Southern Indiana, United States of America are incredible options. Known for their extra perks, first-rate service, and fantastic locations, each of the Southern Indiana 4 star hotels offers the ultimate experience for globe-trotting travelers. Relax in your expertly designed room. Kick back with around-the-clock room service.

Get a good night’s sleep with the ultra-plush bedding, and freshen up in the morning with designer-inspired body products. It’s all available when you stay at one of the top book a four star hotels in Southern Indiana. What’s more, thanks to Expedia you might even score a cheap great deal on a 4 star hotel in Southern Indiana, United States of America, areas near the hottest attractions, so you can plan a sightseeing adventure and take advantage of unbeatable discounts in one fell swoop.

Whether you’re putting together a serene getaway or want to revel in the most vibrant entertainment district, 4 star Southern Indiana hotels offer everything your heart desires.

Frequently asked questions

What are the best 4-star hotels in Southern Indiana?
If your Southern Indiana vacation leads you to Louisville, consider Galt House Hotel Trademark Collection by Wyndham. With lots of amenities such as massage services and a swimming pool, it scores top marks from many Expedia customers. Another popular pick here is Hyatt Regency Louisville. It also has 4 stars and offers designer toiletries and a swimming pool.
How much does it cost to stay in a 4-star hotel in Southern Indiana?
To book a 4-star hotel in Southern Indiana that's within your budget, use Expedia's handy filter tool. Browse the availability during your chosen dates and use our pricing filter to set your limit. You can also sort your results by the cheapest option first.

  • Search for the lowest price from $100

What's the difference between 5-star and 4-star hotels in Southern Indiana?
Offering an inviting traveler experience and upscale décor, 4-star hotels are an excellent option for your Southern Indiana break. These kinds of accommodations generally feature loads of handy amenities that make it easy to unpack and recharge — think pillowtop mattresses, restaurants and pools. Or live in the lap of luxury at a 5-star hotel designed to spoil you with exclusive perks and amenities. 24-hour front desk, oversized bathrooms and gourmet dining are typically featured at these swanky properties.

Explore a world of travel with Expedia