A cityscape with a park, a river, and a large building with a red roof.

Texas Medical Center Vacations from $211

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Your Texas Medical Center Vacation

Texas Medical Center is calling! Whatever type of break you're organizing, you can see and experience the best of this neighborhood with a Texas Medical Center vacation package. Your trip to Texas Medical Center wouldn't be complete without a stop at top attractions nearby such as Houston Zoo, Houston Natural Science Museum and Childrens Museum of Houston. Whatever your travel plans or the size of your budget, booking a perfect Texas Medical Center vacation is quick and easy with Expedia.

The Latest Texas Medical Center Vacation Packages

Price found within the past 48 hours. Click for updated prices.

Dec 19 - Dec 22
Tx Home Group- Houston + Flight
Northside
3 nights
2.0 star property
Roundtrip • Atlanta (ATL) - Houston (IAH)
ATL - IAH • Nonstop IAH - ATL • Nonstop
Save 100% on your flight
~~$330~~
$211
per traveler
found 17 hours ago
Tx Home Group- Houston
Jan 8 - Jan 13
Heritage Place Houston Brookhollow + Flight
Lazybrook/Timbergrove
5 nights
3.0 star property
8.8/10 - Excellent (299 reviews)
"There was basically no staff working at the hotel although all facets were excellent. I chose not to have my room cleaned daily because the staff was short handed."
Reviewed November 7, 2026
Roundtrip • Atlanta (ATL) - Houston (IAH)
ATL - IAH • Nonstop IAH - ATL • Nonstop
~~$420~~
$238
per traveler
found 1 day ago
Heritage Place Houston Brookhollow
Jan 13 - Jan 18
Dejs' Modern Retreat + Flight
Southeast Houston
5 nights
2.0 star property
10/10 - Exceptional (1 review)
Roundtrip • Atlanta (ATL) - Houston (IAH)
ATL - IAH • Nonstop IAH - ATL • Nonstop
Save 100% on your flight
~~$749~~
$429
per traveler
found 1 day ago
Dejs' Modern Retreat
Jan 8 - Jan 13
Moxy Houston Downtown + Flight
Downtown Houston
5 nights
3.0 star property
8.6/10 - Excellent (1,206 reviews)
"The service was very accommodating. The 2 black ladies at the counter were really sweet and helped with any questions and concerns we had. Restaurants are close and next door to the hotel. I would stay here again"
Reviewed November 6, 2026
Roundtrip • Atlanta (ATL) - Houston (IAH)
ATL - IAH • Nonstop IAH - ATL • Nonstop
~~$491~~
$295
per traveler
found 1 day ago
Moxy Houston Downtown
Jan 21 - Jan 24
Experience a First Class Stay - 2 BDRM + Flight
Humble
3 nights
3.5 star property
8.0/10 - Very good (5 reviews)
"This people have water that smells like poop. Sewage water is what they use for water. Remnants of trash, sticky nastiness in drawers, air vents falling off ceilings. Random kids belts found? Candy stuck to floor? Trash wasn’t even taken out. Mind you I have kids that found these things as well. Oh and don’t even try and ask for them to refund you for their disgusting rental. They will give you the run around and then IGNORE YOU. Awful establishment and these people NEED TO BE SHUTDOWN."
Reviewed March 11, 2022
Roundtrip • Atlanta (ATL) - Houston (IAH)
ATL - IAH • Nonstop IAH - ATL • Nonstop
~~$883~~
$539
per traveler
found 1 day ago
Experience a First Class Stay - 2 BDRM

Where to stay in Texas Medical Center

Find the best Texas Medical Center areas and neighborhoods for the activities you enjoy most. Learn more about Texas Medical Center

Downtown Houston

Largest central business district in Texas, this area boasts major league sports venues, a vibrant Theater District, and shopping options like GreenStreet. Easily navigate with public transportation options like METRORail and bus lines.

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A tall, modern building with a unique, vertical design, surrounded by trees and a partly cloudy sky.

The Galleria

Travelers to The Galleria praise its popular shops. If you've got some more time to explore, be sure to make a stop by The Galleria and Williams Tower.

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A city skyline with modern skyscrapers and a river flowing through a park.

Montrose

Unique features of Montrose include the theaters and museums. Make a stop by Rothko Chapel or Menil Collection while you're exploring the area.

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A modern cityscape with a tram and tall buildings.

Houston Central Business District

If you're spending time in Houston Central Business District, check out sights like Toyota Center or House of Blues Houston and hop on the metro to see more the city at Bell Station or Downtown Transit Center Station.

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