Search Vacation Homes in Upstate South Carolina

    price find illustration

    Upfront pricing

    Our total price for your stay includes taxes and fees
    deals illustration

    Treat yourself

    Save 10% or more on over 100,000 hotels worldwide with Member Prices
    bed illustration

    Be picky

    Search almost a million properties worldwide

Check prices for these dates

Next weekend
In two weeks
In one month
In two months

Vacation Homes in Upstate South Carolina

Keowee Key Townhome - Pet Friendly, View of Golf Course plus Amenities

9.8 out of 10, Exceptional, (72)
"Had a great stay, Ann and team thought and provided everything!"
Keowee Key Townhome - Pet Friendly, View of Golf Course plus Amenities

Grand Greenville Estate ~ walk to Furman & Swamp Rabbit Trail!

10.0 out of 10, Exceptional, (17)
"My family stayed here while attending a wedding. It was a perfect place for us. It was close to downtown and lots of restaurants."
$432 nightly
The price is $475
Aug 11 - Aug 12
Total includes taxes and fees
Grand Greenville Estate ~ walk to Furman & Swamp Rabbit Trail!

New Construction Townhome Less Than 1 Mile From The Heart Of Downtown Greenville

9.6 out of 10, Exceptional, (58)
"This property was clean and everyone had their own space. The shopping and dining were very close so it was easy to get downtown Overall I would recommend this vacation home a 10"
New Construction Townhome Less Than 1 Mile From The Heart Of Downtown Greenville

Lake Jocassee retreat on two acres!! New hot tub, Devil’s Fork State Park

10.0 out of 10, Exceptional, (14)
"Very clean, beautiful and serene views, great location, extremely accommodating hosts, comfy beds, perfect getaway to the beautiful Lake Jocassee, this was a trip for the books"
Lake Jocassee retreat on two acres!! New hot tub, Devil’s Fork State Park

Luxury 4BR/4BA Lake Keowee Retreat- Mountain Cabin Vibes + Private Dock

10.0 out of 10, Exceptional, (2)
"The kitchen is spacious, kitchen is fully stocked, plenty of towels, and a PERFECT location to anchor down and enjoy the fireworks on the lake. We entered the lake through Cane Creek Landing Boat Ramp which is only 7 minutes away. If you prefer more privacy with your family, this location in the cove is ideal."
Luxury 4BR/4BA Lake Keowee Retreat- Mountain Cabin Vibes + Private Dock

Gameday Getaway! - Less than 2 miles from Death Valley!

2.0 star property
10.0 out of 10, Exceptional, (5)
"House was in perfect location.very clean.we have stayed there before and will definitely be back.would recommended to anyone looking for a place not far from downtown and great family spot."
Gameday Getaway! - Less than 2 miles from Death Valley!

2-bedroom vacation home just 7 minutes from Haywood Mall - Cleaning Fee Included

10.0 out of 10, Exceptional, (55)
"Great rates and very clean. Nice ptivate back yard. We will definitely book again next time we are in town. "
2-bedroom vacation home just 7 minutes from Haywood Mall - Cleaning Fee Included

New! Boutique Tiny Home on the Saluda River

9.8 out of 10, Exceptional, (72)
"This was a wonderful place to stay at over the weekend. "
New! Boutique Tiny Home on the Saluda River

Relaxing Multi-family waterfront home with private dock on Lake Hartwell!

10.0 out of 10, Exceptional, (106)
"Great house with everything you could possibly need!"
Relaxing Multi-family waterfront home with private dock on Lake Hartwell!

Lake Hartwell Waterfront w/Dock, Waterfall, Gameroom, Firepit, Pets, Fenced Yard

10.0 out of 10, Exceptional, (6)
Lake Hartwell Waterfront w/Dock, Waterfall, Gameroom, Firepit, Pets, Fenced Yard

Secluded cabin surrounded by mountains, waterfalls, wildlife, and 50,000 acres

10.0 out of 10, Exceptional, (50)
"Very secluded relaxing getaway. Tons to do nearby and plenty to do right there on the property. Wonderful place for families ❤️"
Secluded cabin surrounded by mountains, waterfalls, wildlife, and 50,000 acres

Spacious house 3 mi from CU! Across from Patrick Square!

10.0 out of 10, Exceptional, (12)
"House was clean, spacious and a great location. Will use again if staying in Clemson!"
Spacious house 3 mi from CU! Across from Patrick Square!

Beautiful Home Close To Everything

9.6 out of 10, Exceptional, (165)
"House was close to everything but far enough away from the exit traffic. Very short drive to restaurants or Costco!"
Beautiful Home Close To Everything

Treetop Haven Clemson

10.0 out of 10, Exceptional, (20)
"It was an amazing stay. Beautiful home, lovely host and elegant decor and amenities. "
Treetop Haven Clemson

Travelers Rest Treasure - Pets Welcome Sleeps 8 - 3 Bedroom 2 Bath

10.0 out of 10, Exceptional, (19)
"Great location in Travelers Rest. House was clean, spacious, and very welcoming for a wonderful stay. Very dog friendly with a separate fenced area. Owner was very easy to communicate with and I highly recommend. "
Travelers Rest Treasure - Pets Welcome Sleeps 8 - 3 Bedroom 2 Bath

Cozy House Close To Everything Anderson Has To Offer

10.0 out of 10, Exceptional, (16)
"Nice cozy home, good central location. Good weekend getaway. Would stay again if in the area"
Cozy House Close To Everything Anderson Has To Offer

Mini Putting Green & Pool Access: Simpsonville Gem

10.0 out of 10, Exceptional, (1)
"The home is beautiful--great floor plan with up-to-date decor and comfortable furniture. Everything was clean. The location is great if your group wants to use the community pool, and the property has easy access to both Greenville and Simpsonville. We would definitely stay here again!"
Mini Putting Green & Pool Access: Simpsonville Gem

Relaxing Stay on Trade Street

10.0 out of 10, Exceptional, (12)
"Cozy, comfortable space for three women on an annual get-together. Loved its proximity to town."
Relaxing Stay on Trade Street

The Westfield - Cozy Downtown Greer Retreat

8.0 out of 10, Very Good, (1)
"We enjoyed our stay at the westfeild cottage. The home is very comfortable and pets being welcome is a bonus. The only issue we experienced was not being able to walk our dogs in peace because everytime we went outsode, within 2 minutes the neighbor let her 4 dogs out and they didnt seem like the friendliest on the opposite side of the fence. Things did seem a little rushed before our arrival,cleaning wise. There was a dead fly in the fridge, sheets in the dryer, and the soaps were running low...
$188 nightly
The price is $205
Aug 12 - Aug 13
Total includes taxes and fees
The Westfield - Cozy Downtown Greer Retreat

Near Downtown 3 Bedroom Home with King beds+ Parking+Deck

10.0 out of 10, Exceptional, (7)
"The weekend stay at this property was overall AMAZING! There was so much space and the house was very very clean ! We ended up cooking both nights and everything we needed was there including seasonings! Let’s just say 10/10 will definitely book again. "
$271 nightly
The price is $298
Aug 18 - Aug 19
Total includes taxes and fees
Near Downtown 3 Bedroom Home with King beds+ Parking+Deck
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Save an average of 15% on thousands of hotels when you're signed in

Top Upstate South Carolina Hotel Reviews