Upstate South Carolina Vacations from $422
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Your Upstate South Carolina Vacation
When adventure calls, answer it with a tailor-made vacation package to Upstate South Carolina. Wherever it is you're going and whatever your plans are, prepare to experience a destination with plenty to offer. Start your trip to Upstate South Carolina with a few nights in Greenville visiting popular sights like Falls Park on the Reedy and Bon Secours Wellness Arena. Spartanburg is another city that draws crowds from far and wide. WestGate Mall and Tyger River Park are two of the top places to see in this destination. Find some travel buddies and start packing, because your Upstate South Carolina vacation is just a few clicks away with Expedia.
The Latest Upstate South Carolina vacation packages
Price found within the past 48 hours. Click for updated prices.
La Quinta Inn & Suites by Wyndham Greenville Woodruff Rd.
Price was $565, price is now $422 per person
$422
per person
Jun 26 - Jun 29
found 1 day ago
Roundtrip flight included
New York (LGA) to Greenville (GSP)
8.8/10 Excellent! (162 reviews)
Clean room, staff great, only complaint was the last night of stay, whoever was above us started making non-stop noise. After complaint was made to front desk noise subsided
Reviewed on Apr 12, 2026
Hotel Hartness
Price was $853, price is now $603 per person
$603
per person
Jun 26 - Jun 29
found 1 day ago
Roundtrip flight included
New York (LGA) to Greenville (GSP)
9.8/10 Exceptional! (685 reviews)
Beautiful property. Almost hate to give a great review since it’s a hidden gem that I selfishly want to keep that way.
Reviewed on Apr 13, 2026
The Radical Asheville, Tapestry Collection by Hilton
River Arts District
Price was $924, price is now $677 per person
$677
per person
Jun 21 - Jun 26
found 1 day ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to Asheville (AVL)
9.6/10 Exceptional! (527 reviews)
We liked the hotel very much and great location is you are looking to be a little away from the noise of downtown.
Reviewed on Apr 16, 2026
The Windsor Boutique Hotel
Downtown Asheville
Save 100% on your flight
Price was $1,480, price is now $1,090 per person
$1,090
per person
Jun 21 - Jun 26
found 1 day ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to Asheville (AVL)
9.8/10 Exceptional! (583 reviews)
Rooms are spacious, wonderfully appointed with soft robes and good coffee. Very comfortable beds. The location is perfect, close to shops, spas, breweries, restaurants. Staff is friendly and helpful. Would absolutely stay here again.
Reviewed on Apr 4, 2026
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View all tripsWhere to stay in Upstate South Carolina
Find the best Upstate South Carolina areas and neighborhoods for the activities you enjoy most. Learn more about Upstate South Carolina
Greenville Downtown
2 out of top 10 points of interest in this area
5/5(657 area reviews)
The ample dining options and beautiful river views are top of the list for many visitors to Greenville Downtown. A stop by The Peace Center or Bon Secours Wellness Arena might round out your trip.
Discover the most popular places to visit in Upstate South Carolina
Clemson University
5/5(423 reviews)
Enjoy the collegiate vibe when you visit Clemson University, during your travels in Clemson. Experience the area's theater scene or attend a football game.
Falls Park on the Reedy
4.5/5(594 reviews)
Falls Park on the Reedy is just one of the places to see in Greenville, so why not enjoy the other things to explore during your travels? Experience the acclaimed theater scene or attend a sporting event in this family-friendly area.
Fred W. Symmes Chapel
5/5(12 reviews)
You can find out about the history of Cleveland when you stop by Fred W. Symmes Chapel. Wander the lakeside and forest in this relaxing area.
What to do in Upstate South Carolina
Guided E-Bike Tour in Greenville South Carolina with Brunch
$105
per adult
Upstate South Carolina Hotel Deals
Crowne Plaza Hotel Greenville-I-385-Roper Mtn Rd by IHG
851 Congaree Rd Greenville SC
Fully refundable
$101 nightly
The price is $111 total per night from Apr 18 to Apr 19
$111 total
Apr 18 - Apr 19
Total with taxes and fees
8.6/10 Excellent! (1,004 reviews)
Overall the hotel was nice. We cam because it had an indoor pool. We went down several times with the kids but it was always ice cold. We generally pick hotels that out kids will like so we won't return here. Other than that it was a very nice place.
Reviewed on Apr 16, 2026
Hilton Greenville
45 W Orchard Park Dr Greenville SC
Fully refundableReserve now, pay when you stay
$110 nightly
The price is $121 total per night from Apr 26 to Apr 27
$121 total
Apr 26 - Apr 27
Total with taxes and fees
8.2/10 Very Good! (1,002 reviews)
Room did not have hand soap, body wash, and the bathroom light was inoperable.
Reviewed on Apr 16, 2026
Embassy Suites Greenville Golf Resort & Conference Center
670 Verdae Blvd Greenville SC
Fully refundableReserve now, pay when you stay
$121 nightly
The price is $133 total per night from Apr 19 to Apr 20
$133 total
Apr 19 - Apr 20
Total with taxes and fees
9/10 Wonderful! (1,154 reviews)
Staff is friendly and helpful! Clean room. Easy access to airport.
Reviewed on Apr 13, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Find the Best Upstate South Carolina Vacation Packages
Upstate South Carolina Essential Information
Language | English |
|---|---|
Currency | U.S dollars |
Closest Airport | Charlotte-Douglas Intl. Airport (CLT) |
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- Visit Mauldin
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- Gravitopia Trampoline Arena
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- Mcalister Square
- Old Towne Shopping Center
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- Lakeside Park
- Lewis Plaza Shopping Center
- Runway Park at GMU
- Prisma Health Greenville Memorial Hospital
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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.