Title: Upstate South Carolina Vacation Packages 2026 from $772 | Expedia.com [Upstate South Carolina Travel Guide](https://expedia.com/Upstate-South-Carolina.dx6057939)[Hotels in Upstate South Carolina](https://expedia.com/Upstate-South-Carolina-Hotels.d6057939.Travel-Guide-Hotels)[Vacation Rentals in Upstate South Carolina](https://expedia.com/Upstate-South-Carolina-Vacation-Rentals.d6057939.Travel-Guide-VacationRentals)[Flights to Upstate South Carolina](https://expedia.com/Cheap-Flights-To-Upstate-South-Carolina.d6057939.Travel-Guide-Flights)[Things to do in Upstate South Carolina](https://expedia.com/Things-To-Do-In-Upstate-South-Carolina.d6057939.Travel-Guide-Activities)[Car Rentals in Upstate South Carolina](https://expedia.com/Car-Rentals-In-Upstate-South-Carolina.d6057939.Car-Rental-Guide) ![](https://images.trvl-media.com/place/144669/e945b35d-16b4-408c-818b-68622e164446.jpg?impolicy=fcrop&w=1200&h=300&q=medium) # Upstate South Carolina Vacations from $772 ## Book a Hotel + Flight or Car together to unlock savings Photo by RVLuckyorWhat - ## Plan, book, travel with confidence - ### Better together Save up to $1,045 when you book a flight and hotel together\* - ### Find the right fit With over 300,000 hotels worldwide, it's easy to create a perfect package - ### Rest easy Plan, book, and manage your trip all in one place ### Your Upstate South Carolina Vacation When adventure calls, answer it with a tailor-made vacation package to Upstate South Carolina. Wherever it is you're going and whatever your plans are, prepare to experience a destination with plenty to offer. Start your trip to Upstate South Carolina with a few nights in [Greenville](https://www.expedia.com/Greenville.d1388.Destination-Travel-Guides) visiting popular sights like Falls Park on the Reedy and Bon Secours Wellness Arena. [Spartanburg](https://www.expedia.com/Spartanburg.d9787.Destination-Travel-Guides) is another city that draws crowds from far and wide. WestGate Mall and Tyger River Park are two of the top places to see in this destination. Find some travel buddies and start packing, because your Upstate South Carolina vacation is just a few clicks away with Expedia. ## The Latest Upstate South Carolina vacation packages Price found within the past 48 hours. Click for updated prices. ![Element Asheville Downtown](https://images.trvl-media.com/lodging/49000000/48970000/48967200/48967159/w3997h2662x0y0-fed56a1e_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Element Asheville Downtown Downtown Asheville $772 per person May 22 - May 27 found 17 hours ago Roundtrip non-stop flight included New Orleans (MSY) to Asheville (AVL) 9.4/10 Exceptional! (487 reviews) Nice clean room. The breakfast was beautifully tended by conscientious staff. Easy walking distance to restaurants and bars. Reviewed on Mar 30, 2026 ![The Restoration Asheville](https://images.trvl-media.com/lodging/76000000/75610000/75600300/75600240/2af742a7_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### The Restoration Asheville Downtown Asheville Save 100% on your flight $960 per person May 22 - May 27 found 17 hours ago Roundtrip non-stop flight included New Orleans (MSY) to Asheville (AVL) 9.8/10 Exceptional! (1,156 reviews) Everyone at the hotel was super friendly and helpful! Top notch service all the way around! Loved sitting on the patio at the watch and people watching in the evening! Then the rooftop for sunset and cocktails, then the lower level for live music and arcade games! It was a special treat to have a breakfast bag delivered to the door in the morning as well as afternoon, charcuterie, cheese, and wine that was complementary. The location was wonderful and using the valet made everything so easy! Reviewed on Apr 4, 2026 ![The Radical Asheville, Tapestry Collection by Hilton](https://images.trvl-media.com/lodging/91000000/90810000/90809800/90809737/0732ad16_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### The Radical Asheville, Tapestry Collection by Hilton River Arts District $849 per person May 22 - May 27 found 17 hours ago Roundtrip non-stop flight included New Orleans (MSY) to Asheville (AVL) 9.6/10 Exceptional! (516 reviews) Great staff, hotel is nice and beds are comfortable, baths are great. Best shower. 🙂 Reviewed on Apr 5, 2026 ![The Windsor Boutique Hotel](https://images.trvl-media.com/lodging/10000000/9490000/9487700/9487610/761229c3_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### The Windsor Boutique Hotel Downtown Asheville Save 100% on your flight $1,197 per person May 22 - May 27 found 17 hours ago Roundtrip non-stop flight included New Orleans (MSY) to Asheville (AVL) 9.8/10 Exceptional! (578 reviews) Rooms are spacious, wonderfully appointed with soft robes and good coffee. Very comfortable beds. The location is perfect, close to shops, spas, breweries, restaurants. Staff is friendly and helpful. Would absolutely stay here again. Reviewed on Apr 4, 2026 ![The Omni Grove Park Inn & Spa](https://images.trvl-media.com/lodging/1000000/440000/438200/438107/1e0517b2_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### The Omni Grove Park Inn & Spa Grove Park- Sunset Save 100% on your flight $1,263 per person May 22 - May 27 found 1 day ago Roundtrip non-stop flight included New Orleans (MSY) to Asheville (AVL) 9.2/10 Wonderful! (1,007 reviews) The property is beautiful! I loved the spa and sitting outside looking at Black Mountain. Reviewed on Apr 3, 2026 Don't see what you're looking for? See all available trips from Columbus to Upstate South Carolina [View all trips](https://expedia.com/go/package/search/FlightHotel/2026-05-06/2026-05-13/?FromAirport=Columbus,%20Ohio,%20United%20States%20of%20America&Destination=GSP&NumRoom=1&NumAdult=2&NumChild=0&paandie=true) ## Where to stay in Upstate South Carolina Find the best Upstate South Carolina areas and neighborhoods for the activities you enjoy most. [Learn more about Upstate South Carolina](https://expedia.com/Upstate-South-Carolina.dx6057939) ![Greenville Downtown](https://images.trvl-media.com/place/1388/cd6e82af-6f0e-4f28-bd90-dc864c25ddac.jpg?impolicy=fcrop&w=350&h=192&q=medium) ### Greenville Downtown 2 out of top 10 points of interest in this area 5/5(657 area reviews) The ample dining options and beautiful river views are top of the list for many visitors to Greenville Downtown. A stop by The Peace Center or Bon Secours Wellness Arena might round out your trip. [Find hotel + flight trips in Greenville Downtown](https://expedia.com/go/package/search/FlightHotel/?FromAirport=Downtown%20Columbus,%20Columbus,%20Ohio,%20United%20States%20of%20America&Destination=Greenville%20Downtown&DestID=6348006&DaysInFuture=30&StayLength=7&rfrr=TG.LP.Dest.PKG.Neighborhoods) ![Default Image](https://images.trvl-media.com/media/content/expus/graphics/deals/TE_Clouds_card_r1.jpg?impolicy=fcrop&w=350&h=192&q=medium) ### Nicholtown If you're spending some time in Nicholtown, Pleasantburg Shopping Center and Swamp Rabbit Trail are top sights worth seeing. [Find hotel + flight trips in Nicholtown](https://expedia.com/go/package/search/FlightHotel/?FromAirport=Downtown%20Columbus,%20Columbus,%20Ohio,%20United%20States%20of%20America&Destination=Nicholtown&DestID=944322769370443776&DaysInFuture=30&StayLength=7&rfrr=TG.LP.Dest.PKG.Neighborhoods) ![Overbrook Historic District](https://images.trvl-media.com/place/6035267/cb556cb0-09f4-48a1-92a0-474aceebaeea.jpg?impolicy=fcrop&w=350&h=192&q=medium) ### Overbrook Historic District While Overbrook Historic District might not have many sights to explore, venturing just a little farther will lead you to top things to see and do like Bon Secours Wellness Arena and Beattie House. [Find hotel + flight trips in Overbrook Historic District](https://expedia.com/go/package/search/FlightHotel/?FromAirport=Downtown%20Columbus,%20Columbus,%20Ohio,%20United%20States%20of%20America&Destination=Overbrook%20Historic%20District&DestID=944230627130175488&DaysInFuture=30&StayLength=7&rfrr=TG.LP.Dest.PKG.Neighborhoods) ![Krissy Simmons](https://images.trvl-media.com/place/6348163/68b54b76-2321-4a98-9351-703daf9d97e1.jpg?impolicy=fcrop&w=350&h=192&q=medium) ### West End Arts and entertainment thrive in this Greenville neighborhood, with cultural events at the Peace Center and baseball games at Fluor Field at the West End. Don't miss Falls Park on the Reedy and the picturesque Liberty Bridge crossing the river. [Find hotel + flight trips in West End](https://expedia.com/go/package/search/FlightHotel/?FromAirport=Downtown%20Columbus,%20Columbus,%20Ohio,%20United%20States%20of%20America&Destination=West%20End&DestID=6348163&DaysInFuture=30&StayLength=7&rfrr=TG.LP.Dest.PKG.Neighborhoods) ![Default Image](https://images.trvl-media.com/media/content/expus/graphics/deals/TE_Clouds_card_r1.jpg?impolicy=fcrop&w=350&h=192&q=medium) ### Hampton-Pinckney Historic District Hampton-Pinckney Historic District is well-liked for its historic sites. If you'd like to do some sightseeing in the greater Greenville area, you might plan a trip to The Children’s Museum of the Upstate or The Peace Center. [Find hotel + flight trips in Hampton-Pinckney Historic District](https://expedia.com/go/package/search/FlightHotel/?FromAirport=Downtown%20Columbus,%20Columbus,%20Ohio,%20United%20States%20of%20America&Destination=Hampton-Pinckney%20Historic%20District&DestID=6348164&DaysInFuture=30&StayLength=7&rfrr=TG.LP.Dest.PKG.Neighborhoods) ### Discover the most popular places to visit in Upstate South Carolina !["Clemson University is an American public, coeducational, land-grant and sea-grant research university located in Clemson, South Carolina, United States.More clemson images:"](https://images.trvl-media.com/place/6127431/81e51bd8-6dfc-4739-9fb0-b15a1329fa3d.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Clemson University Enjoy the collegiate vibe when you visit Clemson University, during your travels in Clemson. Experience the area's theater scene or attend a football game. [](https://expedia.com/Clemson-University-Clemson.d6127431.Vacation-Attraction) ![Fred W. Symmes Chapel](https://images.trvl-media.com/place/553248621532656718/82a12a54-2b7c-457d-b071-556ed8fd587d.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Fred W. Symmes Chapel You can find out about the history of Cleveland when you stop by Fred W. Symmes Chapel. Wander the lakeside and forest in this relaxing area. [](https://expedia.com/Fred-W-Symmes-Chapel-Cleveland.d553248621532656718.Vacation-Attraction) ![Falls Park on the Reedy](https://images.trvl-media.com/place/1388/9768cca7-241b-46cc-9044-0389ae1e8a0a.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Falls Park on the Reedy Falls Park on the Reedy is just one of the places to see in Greenville, so why not enjoy the other things to explore during your travels? Experience the acclaimed theater scene or attend a sporting event in this family-friendly area. [](https://expedia.com/Falls-Park-On-The-Reedy-Greenville-Downtown.d6082697.Vacation-Attraction) ### What to do in Upstate South Carolina ![Spooky & Haunted Paranormal Bar Crawl Downtown Greenville](https://mediaim.expedia.com/localexpert/44967258/bb9d33b6-ba2f-4d38-aa52-533ef9bcfd7e.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Greenville Haunted Bar Tour $35 per adult **100%** of travellers recommend [](https://expedia.com/things-to-do/greenville-haunted-bar-tour.a44967258.activity-details) ![Just Desserts Tour In Greenville](https://mediaim.expedia.com/localexpert/1351196/8e9eb85a-4aa7-4b2f-88cd-57bc5d997f04.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Just Desserts Tour In Greenville $95 per adult [](https://expedia.com/things-to-do/just-desserts-tour-in-greenville.a1351196.activity-details) ![Greenville: Saturday Morning Breakfast Tour](https://mediaim.expedia.com/localexpert/4536544/2424efd7-807a-4b7b-8d92-2a0a78490524.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Greenville: Saturday Morning Breakfast Tour $90 per adult [](https://expedia.com/things-to-do/greenville-saturday-morning-breakfast-tour.a4536544.activity-details) [See all activities in Upstate South Carolina](https://expedia.com/things-to-do/search?rid=6057939) ## Upstate South Carolina Hotel Deals ![Crowne Plaza Hotel Greenville-I-385-Roper Mtn Rd by IHG](https://images.trvl-media.com/lodging/1000000/10000/1400/1379/605b3e5f_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Crowne Plaza Hotel Greenville-I-385-Roper Mtn Rd by IHG 851 Congaree Rd Greenville SC Fully refundable $105 nightly $116 total Apr 12 - Apr 13 Total with taxes and fees 8.6/10 Excellent! (1,005 reviews) Staff was wonderful Bresyln she was very helpful from the first call I made to check in early she made sure I had everything I needed and the room in the perfect spot!! Thanks so much we will definitely will be back!! Reviewed on Apr 5, 2026 [](https://expedia.com/Hotel-Search?startDate=4%2F12%2F2026&endDate=4%2F13%2F2026&selected=1379&PinnedHotelID=1379&HadPinnedHotel=true®ionId=6057939) ![Hilton Greenville](https://images.trvl-media.com/lodging/1000000/30000/23200/23172/8017eeff_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Hilton Greenville 45 W Orchard Park Dr Greenville SC Fully refundableReserve now, pay when you stay $99 nightly $109 total Apr 12 - Apr 13 Total with taxes and fees 8.2/10 Very Good! (1,005 reviews) Everything went smooth and the rooms were clean and spacious. The $10/night parking is a bit steep but what are you going to do Reviewed on Apr 4, 2026 [](https://expedia.com/Hotel-Search?startDate=4%2F12%2F2026&endDate=4%2F13%2F2026&selected=23172&PinnedHotelID=23172&HadPinnedHotel=true®ionId=6057939) ![Embassy Suites Greenville Golf Resort & Conference Center](https://images.trvl-media.com/lodging/1000000/10000/3300/3223/b0e15e12_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Embassy Suites Greenville Golf Resort & Conference Center 670 Verdae Blvd Greenville SC $134 nightly $148 total Apr 12 - Apr 13 Total with taxes and fees 9/10 Wonderful! (1,138 reviews) Clean and nice. Reviewed on Apr 5, 2026 [](https://expedia.com/Hotel-Search?startDate=4%2F12%2F2026&endDate=4%2F13%2F2026&selected=3223&PinnedHotelID=3223&HadPinnedHotel=true®ionId=6057939) [See all 2,970 properties in Upstate South Carolina](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.Package&startDate=4%2F7%2F2026&endDate=4%2F8%2F2026®ionId=6057939) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. ## Find the Best Upstate South Carolina Vacation Packages ## Upstate South Carolina Essential Information | Language | English | | --------------- | ------------------------------------- | | Currency | U.S dollars | | Closest Airport | Charlotte-Douglas Intl. Airport (CLT) | ## More vacations you might like ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/06/08/all-inclusive_holidays_US.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh) All Inclusive Vacations [](https://expedia.com/lp/theme-vacations/all-inclusive-vacations?rfrr=editorial.All_Inclusive%20Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/10/17/XPC_Beach_Overview_HR_v3.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Beach Vacations [](https://expedia.com/lp/theme-vacations/beach-vacations?rfrr=editorial.Beach_Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/06/08/Family_holidays_US_3_.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Kid Friendly Vacations [](https://expedia.com/lp/theme-vacations/kid-friendly-vacations?rfrr=editorial.Kid_Friendly%20Vacations.click) 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