Upstate South Carolina Vacations from $251
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Your Upstate South Carolina Vacation
When adventure calls, answer it with a tailor-made vacation package to Upstate South Carolina. Wherever it is you're going and whatever your plans are, prepare to experience a destination with plenty to offer. Start your trip to Upstate South Carolina with a few nights in Greenville visiting popular sights like Falls Park on the Reedy and Bon Secours Wellness Arena. Spartanburg is another city that draws crowds from far and wide. WestGate Mall and Tyger River Park are two of the top places to see in this destination. Find some travel buddies and start packing, because your Upstate South Carolina vacation is just a few clicks away with Expedia.
The Latest Upstate South Carolina vacation packages
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Greenville Downtown
3 out of top 10 points of interest in this area
The ample dining options and beautiful river views are top of the list for many visitors to Greenville Downtown. A stop by The Peace Center or Bon Secours Wellness Arena might round out your trip.
Stay near popular Upstate South Carolina attractions
What to do in Upstate South Carolina
Guided E-Bike Tour in Greenville South Carolina with Brunch
$105
per adult
Upstate South Carolina Hotel Deals
Best Western Plus Greenville I-385 Inn & Suites
831 Congaree Rd Greenville SC
Fully refundableReserve now, pay when you stay
$75 nightly
The price is $83 total per night from Dec 6 to Dec 7
$83 total
Dec 6 - Dec 7
Total with taxes and fees
9.2/10 Wonderful! (1,616 reviews)
"Room was nice and tidy. Breakfast was good. Parking was convenient. Overall a very good experience."
Reviewed on Nov 8, 2026
Crowne Plaza Hotel Greenville-I-385-Roper Mtn Rd by IHG
851 Congaree Rd Greenville SC
Fully refundable
$99 nightly
The price is $110 total per night from Nov 22 to Nov 23
$110 total
Nov 22 - Nov 23
Total with taxes and fees
Days Inn by Wyndham Greenville
60 Roper Mountain Rd Greenville SC
Fully refundableReserve now, pay when you stay
$62 nightly
The price is $68 total per night from Nov 29 to Nov 30
$68 total
Nov 29 - Nov 30
Total with taxes and fees
5.6/10 (1,001 reviews)
"Always a great stay"
Reviewed on Nov 6, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Find the Best Upstate South Carolina Vacation Packages
Upstate South Carolina Essential Information
Language | English |
|---|---|
Currency | U.S dollars |
Closest Airport | Charlotte-Douglas Intl. Airport (CLT) |
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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.
