Upstate South Carolina Vacations
Book a Hotel + Flight or Car together to unlock savings
- Plan, book, travel with confidence
- Better togetherSave up to $2,000 when you book a flight and hotel together*
- Find the right fitWith over 300,000 hotels worldwide, it's easy to create a perfect package
- Rest easyPlan, book, and manage your trip all in one place
Your Upstate South Carolina Vacation
When adventure calls, answer it with a tailor-made vacation package to Upstate South Carolina. Wherever it is you're going and whatever your plans are, prepare to experience a destination with plenty to offer. Start your trip to Upstate South Carolina with a few nights in Greenville visiting popular sights like Falls Park on the Reedy and Bon Secours Wellness Arena. Spartanburg is another city that draws crowds from far and wide. WestGate Mall and Tyger River Park are two of the top places to see in this destination. Find some travel buddies and start packing, because your Upstate South Carolina vacation is just a few clicks away with Expedia.
Where to stay in Upstate South Carolina
Greenville Downtown
The ample dining options and beautiful river views are top of the list for many visitors to Greenville Downtown. A stop by The Peace Center or Bon Secours Wellness Arena might round out your trip.
Discover the most popular places to visit in Upstate South Carolina
Clemson University
Enjoy the collegiate vibe when you visit Clemson University, during your travels in Clemson. Experience the area's theater scene or attend a football game.
Falls Park on the Reedy
Falls Park on the Reedy is just one of the places to see in Greenville, so why not enjoy the other things to explore during your travels? Experience the acclaimed theater scene or attend a sporting event in this family-friendly area.
Fred W. Symmes Chapel
You can find out about the history of Cleveland when you stop by Fred W. Symmes Chapel. Wander the lakeside and forest in this relaxing area.
What to do in Upstate South Carolina
Guided E-Bike Tour in Greenville South Carolina with Brunch
Upstate South Carolina Hotel Deals
Hilton Greenville
The staff that hosted the 50th birthday was also
Reviewed on Apr 27, 2026
Embassy Suites Greenville Golf Resort & Conference Center
Great trip… close to golfing
Reviewed on Apr 27, 2026
Hyatt Place Greenville/Haywood
The elevators need a lot of work done to them. The doors open slow or half way at very slow speed.
Reviewed on Apr 27, 2026
Find the Best Upstate South Carolina Vacation Packages
Upstate South Carolina Essential Information
Language | English |
|---|---|
Currency | U.S dollars |
Closest Airport | Charlotte-Douglas Intl. Airport (CLT) |
More vacations you might like
Explore a world of travel with Expedia
- Hotels near Conestee Nature Preserve
- Mauldin Hotels
- Hotels near Donaldson Center
- Marriott Hotels & Resorts in Mauldin
- Hotels with Restaurants in Mauldin
- Motels in Mauldin
- Hotels on the Lake in Mauldin
- Hotels with Hot Tubs in Mauldin
- Cabin Rentals in Mauldin
- Pet-Friendly Hotels in Mauldin
- Apartments in Mauldin
- Rv Parks in Mauldin
- 4 Star Hotels in Mauldin
- Hotels with Free Breakfast in Mauldin
- Hilton Hotels in Mauldin
- La Quinta Inn & Suites Hotels in Mauldin
- B&B in Mauldin
- Extended Stay America Hotels in Mauldin
- Luxury Hotels in Mauldin
- Cottages in Mauldin
- Family Hotels in Mauldin
- Greenville Hotels
- Hotels near Discovery Island Water Park
- Hotels near Terrace Shopping Center
- Hotels near Gatlin Park
- Hotels near Golden Lanes and Golden Skate
- Gantt Hotels
- Hotels near Augusta Road Park
- Hotels near Rockwood Park
- Hotels near Greenville Technical College
- Hotels near Frankie's Fun Park
- Hotels near The Shops at Greenridge
- Hotels near Green Forest Park
- Hotels near McAlister Square
- Hotels near Greenville Downtown
- Flights from Donaldson Center
- Flights from Pickens (LQK) to Greenville (GDC)
- Flights to Donaldson Center
- Flights from Tampa (TPA) to Greenville (GDC)
- Flights from Atlanta (ATL) to Greenville (GDC)
- Flights from Dallas (DFW) to Greenville (GDC)
- Flights from Chicago (ORD) to Greenville (GDC)
- Flights from New York (JFK) to Greenville (GDC)
- Flights from Miami (MIA) to Greenville (GDC)
- Flights from Greenville (GSP) to Greenville (GDC)
- Flights from Clemson (CEU) to Greenville (GDC)
- Flights from Newburgh (SWF) to Greenville (GDC)
- Flights from Fort Lauderdale (FLL) to Greenville (GDC)
- Flights from Portland (PDX) to Greenville (GDC)
- Flights from Denver (DEN) to Greenville (GDC)
- Flights from San Francisco (SFO) to Greenville (GDC)
- Flights from Washington (IAD) to Greenville (GDC)
- Flights from Greenwood (GRD) to Greenville (GDC)
- Flights from Austin (AUS) to Greenville (GDC)
- Flights from Auburn (AUO) to Greenville (GDC)
- Flights from Indianapolis (IND) to Greenville (GDC)
- Flights from Atlantic City (ACY) to Greenville (GDC)
- Flights from Copenhagen (CPH) to Greenville (GDC)
- Flights from Norfolk (ORF) to Greenville (GDC)
- Flights from Hong Kong (HKG) to Greenville (GDC)
- Flights from Philadelphia (PHL) to Greenville (GDC)
- Flights from Birmingham (BHM) to Greenville (GDC)
- Flights from Kansas City (MCI) to Greenville (GDC)
- Flights from Pittsburgh (PIT) to Greenville (GDC)
- Flights from Houston (IAH) to Greenville (GDC)
- Flights from Milwaukee (MKE) to Greenville (GDC)
- Flights from Washington (DCA) to Greenville (GDC)
- Flights to Mauldin
- Flights from Mauldin
- Flights from Gantt
- Flights to Greenville - Spartanburg
- Conestee Nature Preserve
- Mauldin Vacations
- Visit Mauldin
- Cu Intl. Center for Automotive Research
- Discovery Island Water Park
- Terrace Shopping Center
- Gatlin Park
- Golden Lanes and Golden Skate
- Rockwood Park
- Frankie's Fun Park
- Gravitopia Trampoline Arena
- Green Forest Park
- Mcalister Square
- Old Towne Shopping Center
- 7th Inning Splash Waterpark
- Lakeside Park
- Lewis Plaza Shopping Center
- Runway Park at GMU
- Prisma Health Greenville Memorial Hospital
- Roper Mountain Science Center
