Upstate South Carolina Vacations from $648
Book a Hotel + Flight or Car together to unlock savings
Photo by RVLuckyorWhat
- Plan, book, travel with confidence
- Better togetherSave up to $1,045 when you book a flight and hotel together*
- Find the right fitWith over 300,000 hotels worldwide, it's easy to create a perfect package
- Rest easyPlan, book, and manage your trip all in one place
Your Upstate South Carolina Vacation
When adventure calls, answer it with a tailor-made vacation package to Upstate South Carolina. Wherever it is you're going and whatever your plans are, prepare to experience a destination with plenty to offer. Start your trip to Upstate South Carolina with a few nights in Greenville visiting popular sights like Falls Park on the Reedy and Bon Secours Wellness Arena. Spartanburg is another city that draws crowds from far and wide. WestGate Mall and Tyger River Park are two of the top places to see in this destination. Find some travel buddies and start packing, because your Upstate South Carolina vacation is just a few clicks away with Expedia.
The Latest Upstate South Carolina vacation packages
Price found within the past 48 hours. Click for updated prices.
Hotel Hartness
Price was $822, price is now $648 per person
$648
per person
Jun 26 - Jun 28
found 1 day ago
Roundtrip non-stop flight included
Boston (BOS) to Greenville (GSP)
9.8/10 Exceptional! (696 reviews)
Although this is an exceptional property to stay at as far as cleanliness and great scenery, this time around service wasn’t as great as it usually has been, and they’ve taken away the full continental breakfast that was one of the major amenities that this hotel offered. Also the friendliness of the staff just wasn’t there like it always has been.
Reviewed on Apr 20, 2026
The Restoration Asheville
Downtown Asheville
Price was $1,375, price is now $887 per person
$887
per person
May 22 - May 25
found 1 day ago
Roundtrip non-stop flight included
Boston (BOS) to Asheville (AVL)
9.8/10 Exceptional! (1,184 reviews)
First, the staff was very welcoming and friendly for our two day stay. In addition, the area near the hotel is prime for a low key vibe, surrounded by good choices of food and live entertainment.
Reviewed on Apr 14, 2026
The Windsor Boutique Hotel
Downtown Asheville
Save 100% on your flight
Price was $1,231, price is now $911 per person
$911
per person
May 23 - May 27
found 5 hours ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to Asheville (AVL)
9.8/10 Exceptional! (583 reviews)
Rooms are spacious, wonderfully appointed with soft robes and good coffee. Very comfortable beds. The location is perfect, close to shops, spas, breweries, restaurants. Staff is friendly and helpful. Would absolutely stay here again.
Reviewed on Apr 4, 2026
Don't see what you're looking for?
See all available trips from Columbus to Upstate South Carolina
View all tripsWhere to stay in Upstate South Carolina
Find the best Upstate South Carolina areas and neighborhoods for the activities you enjoy most. Learn more about Upstate South Carolina
Greenville Downtown
2 out of top 10 points of interest in this area
5/5(657 area reviews)
The ample dining options and beautiful river views are top of the list for many visitors to Greenville Downtown. A stop by The Peace Center or Bon Secours Wellness Arena might round out your trip.
Discover the most popular places to visit in Upstate South Carolina
Clemson University
Enjoy the collegiate vibe when you visit Clemson University, during your travels in Clemson. Experience the area's theater scene or attend a football game.
Falls Park on the Reedy
Falls Park on the Reedy is just one of the places to see in Greenville, so why not enjoy the other things to explore during your travels? Experience the acclaimed theater scene or attend a sporting event in this family-friendly area.
Fred W. Symmes Chapel
You can find out about the history of Cleveland when you stop by Fred W. Symmes Chapel. Wander the lakeside and forest in this relaxing area.
What to do in Upstate South Carolina
Guided E-Bike Tour in Greenville South Carolina with Brunch
$105
per adult
Upstate South Carolina Hotel Deals
Hilton Greenville
45 W Orchard Park Dr Greenville SC
Fully refundableReserve now, pay when you stay
$110 nightly
The price is $121 total per night from Apr 26 to Apr 27
$121 total
Apr 26 - Apr 27
Total with taxes and fees
8.2/10 Very Good! (1,010 reviews)
Will stay again
Reviewed on Apr 21, 2026
Embassy Suites Greenville Golf Resort & Conference Center
670 Verdae Blvd Greenville SC
$128 nightly
The price is $141 total per night from Apr 26 to Apr 27
$141 total
Apr 26 - Apr 27
Total with taxes and fees
9/10 Wonderful! (1,163 reviews)
Great breakfast assortment. Clean restrooms
Reviewed on Apr 20, 2026
Hyatt Place Greenville/Haywood
40 W Orchard Park Dr Greenville SC
Fully refundableReserve now, pay when you stay
$101 nightly
The price is $111 total per night from Apr 27 to Apr 28
$111 total
Apr 27 - Apr 28
Total with taxes and fees
7.8/10 Good! (1,012 reviews)
Breakfast service consistently ended 30–45 minutes earlier than the posted closing time, which was frustrating and inconvenient. The hotel also does not provide extra pillows, and any additional sheets or towels require guests to go down to the lobby themselves—even when these items should have been ...
Reviewed on Apr 20, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Find the Best Upstate South Carolina Vacation Packages
Upstate South Carolina Essential Information
Language | English |
|---|---|
Currency | U.S dollars |
Closest Airport | Charlotte-Douglas Intl. Airport (CLT) |
More vacations you might like
Explore a world of travel with Expedia
- Hotels near Conestee Nature Preserve
- Mauldin Hotels
- Hotels near Donaldson Center
- Marriott Hotels & Resorts in Mauldin
- Hotels with Restaurants in Mauldin
- Motels in Mauldin
- Hotels on the Lake in Mauldin
- Hotels with Hot Tubs in Mauldin
- Cabin Rentals in Mauldin
- Pet-Friendly Hotels in Mauldin
- Apartments in Mauldin
- Rv Parks in Mauldin
- 4 Star Hotels in Mauldin
- Hotels with Free Breakfast in Mauldin
- Hilton Hotels in Mauldin
- La Quinta Inn & Suites Hotels in Mauldin
- B&B in Mauldin
- Extended Stay America Hotels in Mauldin
- Luxury Hotels in Mauldin
- Cottages in Mauldin
- Family Hotels in Mauldin
- Greenville Hotels
- Hotels near Discovery Island Water Park
- Hotels near Terrace Shopping Center
- Hotels near Gatlin Park
- Hotels near Golden Lanes and Golden Skate
- Gantt Hotels
- Hotels near Augusta Road Park
- Hotels near Rockwood Park
- Hotels near Greenville Technical College
- Hotels near Frankie's Fun Park
- Hotels near The Shops at Greenridge
- Hotels near Green Forest Park
- Hotels near McAlister Square
- Hotels near Greenville Downtown
- Flights from Donaldson Center
- Flights from Pickens (LQK) to Greenville (GDC)
- Flights to Donaldson Center
- Flights from Tampa (TPA) to Greenville (GDC)
- Flights from Atlanta (ATL) to Greenville (GDC)
- Flights from Dallas (DFW) to Greenville (GDC)
- Flights from Chicago (ORD) to Greenville (GDC)
- Flights from New York (JFK) to Greenville (GDC)
- Flights from Miami (MIA) to Greenville (GDC)
- Flights from Greenville (GSP) to Greenville (GDC)
- Flights from Clemson (CEU) to Greenville (GDC)
- Flights from Newburgh (SWF) to Greenville (GDC)
- Flights from Fort Lauderdale (FLL) to Greenville (GDC)
- Flights from Portland (PDX) to Greenville (GDC)
- Flights from Denver (DEN) to Greenville (GDC)
- Flights from San Francisco (SFO) to Greenville (GDC)
- Flights from Washington (IAD) to Greenville (GDC)
- Flights from Greenwood (GRD) to Greenville (GDC)
- Flights from Austin (AUS) to Greenville (GDC)
- Flights from Auburn (AUO) to Greenville (GDC)
- Flights from Indianapolis (IND) to Greenville (GDC)
- Flights from Atlantic City (ACY) to Greenville (GDC)
- Flights from Copenhagen (CPH) to Greenville (GDC)
- Flights from Norfolk (ORF) to Greenville (GDC)
- Flights from Hong Kong (HKG) to Greenville (GDC)
- Flights from Philadelphia (PHL) to Greenville (GDC)
- Flights from Birmingham (BHM) to Greenville (GDC)
- Flights from Kansas City (MCI) to Greenville (GDC)
- Flights from Pittsburgh (PIT) to Greenville (GDC)
- Flights from Houston (IAH) to Greenville (GDC)
- Flights from Milwaukee (MKE) to Greenville (GDC)
- Flights from Washington (DCA) to Greenville (GDC)
- Flights to Mauldin
- Flights from Mauldin
- Flights from Gantt
- Flights to Greenville - Spartanburg
- Conestee Nature Preserve
- Mauldin Vacations
- Visit Mauldin
- Cu Intl. Center for Automotive Research
- Discovery Island Water Park
- Terrace Shopping Center
- Gatlin Park
- Golden Lanes and Golden Skate
- Rockwood Park
- Frankie's Fun Park
- Gravitopia Trampoline Arena
- Green Forest Park
- Mcalister Square
- Old Towne Shopping Center
- 7th Inning Splash Waterpark
- Lakeside Park
- Lewis Plaza Shopping Center
- Runway Park at GMU
- Prisma Health Greenville Memorial Hospital
- Roper Mountain Science Center
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.
