Upstate South Carolina Vacation Packages 2026 from $599

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Your Upstate South Carolina Vacation

When adventure calls, answer it with a tailor-made vacation package to Upstate South Carolina. Wherever it is you're going and whatever your plans are, prepare to experience a destination with plenty to offer. Start your trip to Upstate South Carolina with a few nights in Greenville visiting popular sights like Falls Park on the Reedy and Bon Secours Wellness Arena. Spartanburg is another city that draws crowds from far and wide. WestGate Mall and Tyger River Park are two of the top places to see in this destination. Find some travel buddies and start packing, because your Upstate South Carolina vacation is just a few clicks away with Expedia.

The Latest Upstate South Carolina vacation packages

Price found within the past 48 hours. Click for updated prices.

AutoCamp Asheville

$599

per person

Nov 12 - Nov 15

found 1 day ago

Roundtrip non-stop flight included

Orlando (MCO) to Asheville (AVL)

9.6/10 Exceptional! (11 reviews)

Fun and different lodging experience, well suited to people who like to be closer to nature without the hassle of hauling your own camper. A little pricey, and amenities more suited to families (we were three buddies on a trip). Overall, a great experience.

Reviewed on Aug 23, 2026

The Windsor Boutique Hotel

Downtown Asheville

Save 100% on your flight

$937

per person

Nov 21 - Nov 25

found 1 day ago

Roundtrip flight included

Fort Lauderdale (FLL) to Asheville (AVL)

9.8/10 Exceptional! (612 reviews)

This is an amazingly beautiful hotel. The staff are so friendly and helpful. Everything you need is here. There’s free coffee, tea, bottled water, sodas, snacks, etc. down stairs, and coffee in your room. My room was beautifully decorated. I had a free bottle of wine waiting for me, comfy robes and towels in the closet, a new package of coffee in the kitchen, and coasters exactly where I needed them. The flow from the shower head was a good flow. If I come back to Asheville, I will book again . Why mess with perfection? This hotel is perfect!

Reviewed on Aug 31, 2026

Htd Pool-hot Tub-fire Pit-fenced Yard-dogs Welcome

Save 100% on your flight

$2,606

per person

Nov 20 - Nov 25

found 1 day ago

Roundtrip flight included

Miami (MIA) to Greenville (GSP)

No reviews

Backwoods Bungalow

Save 100% on your flight

$913

per person

Oct 30 - Nov 2

found 1 day ago

Roundtrip flight included

Fort Lauderdale (FLL) to Asheville (AVL)

10/10 Exceptional! (1 review)

Really unique, amazing find.

Reviewed on Jun 10, 2024

Blind Tiger Asheville

North Downtown

$693

per person

Nov 21 - Nov 25

found 1 day ago

Roundtrip flight included

Fort Lauderdale (FLL) to Asheville (AVL)

9.2/10 Wonderful! (251 reviews)

This hotel was exactly what we were looking for in Asheville. The Blind Tiger is a property where you can feel as removed or involved with the other guests and staff as you desire. We had an awesome little cottage to ourselves, would visit the main house for breakfast and to chat with the staff, but overall felt pleasantly unbothered in our accommodation and were able top easily come and go and walk downtown as we pleased. This is a definite recommended stay!

Reviewed on Jul 31, 2026

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Where to stay in Upstate South Carolina

Find the best Upstate South Carolina areas and neighborhoods for the activities you enjoy most. Learn more about Upstate South Carolina

A pedestrian bridge with colorful lights, surrounded by trees and a distant building.

Greenville Downtown

2 out of top 10 points of interest in this area

The ample dining options and beautiful river views are top of the list for many visitors to Greenville Downtown. A stop by The Peace Center or Bon Secours Wellness Arena might round out your trip.

Nicholtown

If you're spending some time in Nicholtown, Swamp Rabbit Trail and Pleasantburg Shopping Center are top sights worth seeing.

An aerial view of a park with a winding path, trees in autumn colors, and a bridge.

Overbrook Historic District

While Overbrook Historic District might not have many sights to explore, venturing just a little farther will lead you to top things to see and do like Beattie House and Bon Secours Wellness Arena.

A cityscape with a mix of modern and historic buildings, a large parking lot, and a highway.

West End

Arts and entertainment thrive in this Greenville neighborhood, with cultural events at the Peace Center and baseball games at Fluor Field at the West End. Don't miss Falls Park on the Reedy and the picturesque Liberty Bridge crossing the river.

Hampton-Pinckney Historic District

Hampton-Pinckney Historic District is well-liked for its historic sites. If you'd like to do some sightseeing in the greater Greenville area, you might plan a trip to The Children’s Museum of the Upstate or The Peace Center.

Stay near popular Upstate South Carolina attractions

A historic building with a clock tower, surrounded by a well-maintained lawn with a paw print design.

Clemson University

9.6/10 (1,439 reviews)

Enjoy the collegiate vibe when you visit Clemson University, during your travels in Clemson. Experience the area's theater scene or attend a football game.

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Falls Park on the Reedy

9.6/10 (2,661 reviews)

Falls Park on the Reedy is just one of the places to see in Greenville, so why not enjoy the other things to explore during your travels? Experience the acclaimed theater scene or attend a sporting event in this family-friendly area.

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Bon Secours Wellness Arena

8.6/10 (1,219 reviews)

Catch an event at Bon Secours Wellness Arena during your trip to Greenville. Stroll along the riverfront or experience the great live music in this family-friendly area.

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Greenville Convention Center

8.4/10 (571 reviews)

Learn about the events happening at Greenville Convention Center during your trip to Greenville. Attend a sporting event or visit the shops in this family-friendly area.

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Memorial Stadium

9.6/10 (410 reviews)

Catch an event at Memorial Stadium during your trip to Clemson. Experience the area's theater scene or attend a football game.

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BMW Performance Center

9.0/10 (90 reviews)

You can spend an afternoon browsing the exhibits at BMW Performance Center during your travels in Greer. While in this family-friendly area, you can savor the charming coffeehouses.

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Haywood Mall

8.8/10 (1,681 reviews)

During your trip to Greenville, you can browse for the perfect souvenirs at Haywood Mall. Experience the great live music or attend a sporting event in this family-friendly area.

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What to do in Upstate South Carolina

Spooky & Haunted Paranormal Bar Crawl Downtown Greenville

Greenville Haunted Bar Tour

$28

per adult

100% of travellers recommend

Just Desserts Tour In Greenville

$95

per adult

Gorgeous loop around Swan Lake at Furman University.

Guided E-Bike Tour in Greenville South Carolina with Brunch

$105

per adult

See all activities in Upstate South Carolina

Upstate South Carolina Hotel Deals

Crowne Plaza Hotel Greenville-I-385-Roper Mtn Rd by IHG

851 Congaree Rd Greenville SC

Fully refundableReserve now, pay when you stay

$84 nightly

$93 total

Sep 13 - Sep 14

Total with taxes and fees

8.6/10 Excellent! (1,008 reviews)

"The place is clean, well run and managed. I very much recommend this hotel."

Reviewed on Sep 7, 2026

Hilton Greenville

45 W Orchard Park Dr Greenville SC

Fully refundableReserve now, pay when you stay

$117 nightly

$129 total

Sep 20 - Sep 21

Total with taxes and fees

8.4/10 Very Good! (1,011 reviews)

"Great location and wonderful stay!"

Reviewed on Sep 7, 2026

Embassy Suites Greenville Golf Resort & Conference Center

670 Verdae Blvd Greenville SC

Fully refundableReserve now, pay when you stay

$105 nightly

$116 total

Sep 20 - Sep 21

Total with taxes and fees

9/10 Wonderful! (1,382 reviews)

"As always, Embassy Suites is one of the greatest hotels and the rooms are really nice. The staff did a great job and the room lived up to its reputation. For the price this place is a no brainer. Stay here when you can!!"

Reviewed on Sep 8, 2026

See all 3,071 properties in Upstate South Carolina

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.