Upstate South Carolina Vacation Packages 2026 from $406

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Your Upstate South Carolina Vacation

When adventure calls, answer it with a tailor-made vacation package to Upstate South Carolina. Wherever it is you're going and whatever your plans are, prepare to experience a destination with plenty to offer. Start your trip to Upstate South Carolina with a few nights in Greenville visiting popular sights like Falls Park on the Reedy and Bon Secours Wellness Arena. Spartanburg is another city that draws crowds from far and wide. WestGate Mall and Tyger River Park are two of the top places to see in this destination. Find some travel buddies and start packing, because your Upstate South Carolina vacation is just a few clicks away with Expedia.

The Latest Upstate South Carolina vacation packages

Price found within the past 48 hours. Click for updated prices.

The Highlands at Sugar

Save 100% on your flight

$406

per person

Dec 1 - Dec 6

found 1 day ago

Roundtrip flight included

Fort Lauderdale (FLL) to Asheville (AVL)

8.2/10 Very Good! (853 reviews)

Omg where can I start this was the most beautiful place and everything was perfectly fine I liked they had the heat on waiting for me and my key in the box awesome no check in line waited until I was done I will be back the location was the best

Reviewed on Oct 20, 2026

The Restoration Asheville

Downtown Asheville

Save 100% on your flight

$847

per person

Dec 26 - Dec 31

found 1 day ago

Roundtrip flight included

Newark Liberty Intl. Airport (EWR) to Asheville (AVL)

9.8/10 Exceptional! (1,216 reviews)

Wonderful stay! Close to everything- easy walking. Amenities were extremely thoughtful. The hotel was a perfect mix of charm and comfort- a great boutique hotel. Would stay here again in a heartbeat!!!!

Reviewed on Oct 22, 2026

Foxhunt at Sapphire Valley

$493

per person

Nov 26 - Nov 30

found 9 hours ago

Roundtrip flight included

Orlando (MCO) to Greenville (GSP)

9/10 Wonderful! (501 reviews)

Perfect family getaway mountain cabin.

Reviewed on Oct 11, 2026

The Windsor Boutique Hotel

Downtown Asheville

Save 100% on your flight

$1,242

per person

Dec 26 - Dec 31

found 1 day ago

Roundtrip flight included

Newark Liberty Intl. Airport (EWR) to Asheville (AVL)

9.8/10 Exceptional! (619 reviews)

Great location in downtown Asheville. Make sure to check out nearby Old Europe Pastries, which I think we visited every day. Rooms are spacious, and we loved having a full kitchen. Staff was incredibly helpful and welcoming. There was some noticeable outside street noise as you might expect with any historical building, but it wasn't too bad. Parking was in a nearby lot that was easy to get to.

Reviewed on Oct 22, 2026

Asheville Sunset 10min to Asheville + Ping Pong

Save 100% on your flight

$3,167

per person

Dec 23 - Dec 27

found 18 hours ago

Roundtrip flight included

Fort Lauderdale (FLL) to Asheville (AVL)

10/10 Exceptional! (2 reviews)

no complaints at all

Reviewed on Mar 2, 2026

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Where to stay in Upstate South Carolina

Find the best Upstate South Carolina areas and neighborhoods for the activities you enjoy most. Learn more about Upstate South Carolina

A pedestrian bridge with colorful lights, surrounded by trees and a distant building.

Greenville Downtown

3 out of top 10 points of interest in this area

The ample dining options and beautiful river views are top of the list for many visitors to Greenville Downtown. A stop by The Peace Center or Bon Secours Wellness Arena might round out your trip.

Nicholtown

If you're spending some time in Nicholtown, Swamp Rabbit Trail and Pleasantburg Shopping Center are top sights worth seeing.

An aerial view of a park with a winding path, trees in autumn colors, and a bridge.

Overbrook Historic District

While Overbrook Historic District might not have many sights to explore, venturing just a little farther will lead you to top things to see and do like Bon Secours Wellness Arena and Beattie House.

A cityscape with a mix of modern and historic buildings, a large parking lot, and a highway.

West End

Arts and entertainment thrive in this Greenville neighborhood, with cultural events at the Peace Center and baseball games at Fluor Field at the West End. Don't miss Falls Park on the Reedy and the picturesque Liberty Bridge crossing the river.

A cityscape with a mix of modern and historic buildings, a prominent bridge, and a river.

Green Avenue

If you're looking for some top things to see and do in Green Avenue and surrounding area, you can visit Fluor Field at the West End and The Peace Center.

Stay near popular Upstate South Carolina attractions

A historic building with a clock tower, surrounded by a well-maintained lawn with a paw print design.

Clemson University

9.6/10 (1,439 reviews)

Enjoy the collegiate vibe when you visit Clemson University, during your travels in Clemson. Experience the area's theater scene or attend a football game.

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Falls Park on the Reedy

9.6/10 (2,661 reviews)

Falls Park on the Reedy is just one of the places to see in Greenville, so why not enjoy the other things to explore during your travels? Experience the acclaimed theater scene or attend a sporting event in this family-friendly area.

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A bridge over a river with a waterfall, surrounded by trees and buildings.

The Peace Center

8.8/10 (940 reviews)

You can make plans for a show at The Peace Center during your stay in Greenville. Amble around this family-friendly area's riverfront or attend a sporting event.

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Bon Secours Wellness Arena

8.6/10 (1,219 reviews)

Catch an event at Bon Secours Wellness Arena during your trip to Greenville. Stroll along the riverfront or experience the great live music in this family-friendly area.

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Memorial Stadium

9.6/10 (410 reviews)

Catch an event at Memorial Stadium during your trip to Clemson. Experience the area's theater scene or attend a football game.

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Greenville Convention Center

8.4/10 (571 reviews)

Learn about the events happening at Greenville Convention Center during your trip to Greenville. Attend a sporting event or visit the shops in this family-friendly area.

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Haywood Mall

8.8/10 (1,681 reviews)

During your trip to Greenville, you can browse for the perfect souvenirs at Haywood Mall. Experience the great live music or attend a sporting event in this family-friendly area.

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BMW Performance Center

9.0/10 (90 reviews)

You can spend an afternoon browsing the exhibits at BMW Performance Center during your travels in Greer. While in this family-friendly area, you can savor the charming coffeehouses.

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What to do in Upstate South Carolina

Greenville Haunted Bar Tour

$35

per adult

100% of travellers recommend

Just Desserts Tour In Greenville

$95

per adult

Gorgeous loop around Swan Lake at Furman University.

Guided E-Bike Tour in Greenville South Carolina with Brunch

$105

per adult

See all activities in Upstate South Carolina

Upstate South Carolina Hotel Deals

Hyatt Place Greenville/Haywood

40 W Orchard Park Dr Greenville SC

Fully refundableReserve now, pay when you stay

$84 nightly

$93 total

Nov 23 - Nov 24

Total with taxes and fees

8/10 Very Good! (1,001 reviews)

"Very nice place"

Reviewed on Oct 23, 2026

Best Western Plus Greenville I-385 Inn & Suites

831 Congaree Rd Greenville SC

Fully refundableReserve now, pay when you stay

$76 nightly

$84 total

Nov 1 - Nov 2

Total with taxes and fees

Crowne Plaza Hotel Greenville-I-385-Roper Mtn Rd by IHG

851 Congaree Rd Greenville SC

Fully refundable

$89 nightly

$99 total

Nov 22 - Nov 23

Total with taxes and fees

See all 3,097 properties in Upstate South Carolina

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.