Title: Upstate South Carolina Vacation Packages 2026 from $576 | Expedia.com [Upstate South Carolina Travel Guide](https://expedia.com/Upstate-South-Carolina.dx6057939)[Hotels in Upstate South Carolina](https://expedia.com/Upstate-South-Carolina-Hotels.d6057939.Travel-Guide-Hotels)[Vacation Rentals in Upstate South Carolina](https://expedia.com/Upstate-South-Carolina-Vacation-Rentals.d6057939.Travel-Guide-VacationRentals)[Flights to Upstate South Carolina](https://expedia.com/Cheap-Flights-To-Upstate-South-Carolina.d6057939.Travel-Guide-Flights)[Things to do in Upstate South Carolina](https://expedia.com/Things-To-Do-In-Upstate-South-Carolina.d6057939.Travel-Guide-Activities)[Car Rentals in Upstate South Carolina](https://expedia.com/Car-Rentals-In-Upstate-South-Carolina.d6057939.Car-Rental-Guide) ![](https://images.trvl-media.com/place/144669/e945b35d-16b4-408c-818b-68622e164446.jpg?impolicy=fcrop&w=1200&h=300&q=medium) # Upstate South Carolina Vacations from $576 ## Book a Hotel + Flight or Car together to unlock savings Photo by RVLuckyorWhat - ## Plan, book, travel with confidence - ### Better together Save up to $1,045 when you book a flight and hotel together\* - ### Find the right fit With over 300,000 hotels worldwide, it's easy to create a perfect package - ### Rest easy Plan, book, and manage your trip all in one place ### Your Upstate South Carolina Vacation When adventure calls, answer it with a tailor-made vacation package to Upstate South Carolina. Wherever it is you're going and whatever your plans are, prepare to experience a destination with plenty to offer. Start your trip to Upstate South Carolina with a few nights in [Greenville](https://www.expedia.com/Greenville.d1388.Destination-Travel-Guides) visiting popular sights like Falls Park on the Reedy and Bon Secours Wellness Arena. [Spartanburg](https://www.expedia.com/Spartanburg.d9787.Destination-Travel-Guides) is another city that draws crowds from far and wide. WestGate Mall and Tyger River Park are two of the top places to see in this destination. Find some travel buddies and start packing, because your Upstate South Carolina vacation is just a few clicks away with Expedia. ## The Latest Upstate South Carolina vacation packages Price found within the past 48 hours. Click for updated prices. ![The Radical Asheville, Tapestry Collection by Hilton](https://images.trvl-media.com/lodging/91000000/90810000/90809800/90809737/0732ad16_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### The Radical Asheville, Tapestry Collection by Hilton River Arts District $576 per person May 8 - May 10 found 21 hours ago Roundtrip non-stop flight included Boston (BOS) to Asheville (AVL) 9.6/10 Exceptional! (516 reviews) I love the individually designed rooms. The decor is awesome almost club like we will absolutely stay there again. Staff was very friendly and helpful. Reviewed on Mar 23, 2026 ![Pinners Compound- 4 BR hot tub fire pit](https://images.trvl-media.com/lodging/96000000/95360000/95353500/95353482/c9f58154_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Pinners Compound- 4 BR hot tub fire pit South Asheville $1,033 per person May 8 - May 10 found 21 hours ago Roundtrip non-stop flight included Boston (BOS) to Asheville (AVL) No reviews ![The Restoration Asheville](https://images.trvl-media.com/lodging/76000000/75610000/75600300/75600240/2af742a7_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### The Restoration Asheville Downtown Asheville $658 per person May 31 - Jun 3 found 1 day ago Roundtrip flight included Boston (BOS) to Asheville (AVL) 9.8/10 Exceptional! (1,156 reviews) An excellent hotel in the center of town, easy walking, great staff, parking is easy, and the room was just great. Would come back again in a heartbeat. Reviewed on Mar 28, 2026 ![Grand Bohemian Lodge Asheville, Autograph Collection®](https://images.trvl-media.com/lodging/3000000/2210000/2201800/2201799/0a0ae2ec_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Grand Bohemian Lodge Asheville, Autograph Collection® Biltmore Village $926 per person Jun 22 - Jun 26 found 1 day ago Roundtrip flight included Newark Liberty Intl. Airport (EWR) to Asheville (AVL) 9.2/10 Wonderful! (918 reviews) Beautiful property and very close to Biltmore Estate. Reviewed on Mar 24, 2026 ![Elevation Lofts Hotel](https://images.trvl-media.com/lodging/90000000/89230000/89222200/89222104/d97a2324_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Elevation Lofts Hotel Downtown Asheville $1,247 per person May 22 - May 25 found 1 day ago Roundtrip flight included Chicago (CHI) to Asheville (AVL) 9.6/10 Exceptional! (7 reviews) Modern 2 bed room 2 bath loft located near downtown Asheville with reserved parking. Short drive to Biltmore. All the modern conveniences. Everything you could want for a visit to Asheville. Reviewed on Nov 18, 2025 Don't see what you're looking for? See all available trips from Columbus to Upstate South Carolina [View all trips](https://expedia.com/go/package/search/FlightHotel/2026-04-30/2026-05-07/?FromAirport=Columbus,%20Ohio,%20United%20States%20of%20America&Destination=GSP&NumRoom=1&NumAdult=2&NumChild=0&paandie=true) ## Where to stay in Upstate South Carolina Find the best Upstate South Carolina areas and neighborhoods for the activities you enjoy most. [Learn more about Upstate South Carolina](https://expedia.com/Upstate-South-Carolina.dx6057939) ![Greenville Downtown](https://images.trvl-media.com/place/1388/cd6e82af-6f0e-4f28-bd90-dc864c25ddac.jpg?impolicy=fcrop&w=350&h=192&q=medium) ### Greenville Downtown 2 out of top 10 points of interest in this area 5/5(657 area reviews) The ample dining options and beautiful river views are top of the list for many visitors to Greenville Downtown. A stop by The Peace Center or Bon Secours Wellness Arena might round out your trip. [Find hotel + flight trips in Greenville Downtown](https://expedia.com/go/package/search/FlightHotel/?FromAirport=Downtown%20Columbus,%20Columbus,%20Ohio,%20United%20States%20of%20America&Destination=Greenville%20Downtown&DestID=6348006&DaysInFuture=30&StayLength=7&rfrr=TG.LP.Dest.PKG.Neighborhoods) ![Default Image](https://images.trvl-media.com/media/content/expus/graphics/deals/TE_Clouds_card_r1.jpg?impolicy=fcrop&w=350&h=192&q=medium) ### Nicholtown If you're spending some time in Nicholtown, Pleasantburg Shopping Center and Swamp Rabbit Trail are top sights worth seeing. [Find hotel + flight trips in Nicholtown](https://expedia.com/go/package/search/FlightHotel/?FromAirport=Downtown%20Columbus,%20Columbus,%20Ohio,%20United%20States%20of%20America&Destination=Nicholtown&DestID=944322769370443776&DaysInFuture=30&StayLength=7&rfrr=TG.LP.Dest.PKG.Neighborhoods) ![Overbrook Historic District](https://images.trvl-media.com/place/6035267/cb556cb0-09f4-48a1-92a0-474aceebaeea.jpg?impolicy=fcrop&w=350&h=192&q=medium) ### Overbrook Historic District While Overbrook Historic District might not have many sights to explore, venturing just a little farther will lead you to top things to see and do like Bon Secours Wellness Arena and Beattie House. [Find hotel + flight trips in Overbrook Historic District](https://expedia.com/go/package/search/FlightHotel/?FromAirport=Downtown%20Columbus,%20Columbus,%20Ohio,%20United%20States%20of%20America&Destination=Overbrook%20Historic%20District&DestID=944230627130175488&DaysInFuture=30&StayLength=7&rfrr=TG.LP.Dest.PKG.Neighborhoods) ![Krissy Simmons](https://images.trvl-media.com/place/6348163/68b54b76-2321-4a98-9351-703daf9d97e1.jpg?impolicy=fcrop&w=350&h=192&q=medium) ### West End Arts and entertainment thrive in this Greenville neighborhood, with cultural events at the Peace Center and baseball games at Fluor Field at the West End. Don't miss Falls Park on the Reedy and the picturesque Liberty Bridge crossing the river. [Find hotel + flight trips in West End](https://expedia.com/go/package/search/FlightHotel/?FromAirport=Downtown%20Columbus,%20Columbus,%20Ohio,%20United%20States%20of%20America&Destination=West%20End&DestID=6348163&DaysInFuture=30&StayLength=7&rfrr=TG.LP.Dest.PKG.Neighborhoods) ![Default Image](https://images.trvl-media.com/media/content/expus/graphics/deals/TE_Clouds_card_r1.jpg?impolicy=fcrop&w=350&h=192&q=medium) ### Hampton-Pinckney Historic District Hampton-Pinckney Historic District is well-liked for its historic sites. If you'd like to do some sightseeing in the greater Greenville area, you might plan a trip to The Children’s Museum of the Upstate or The Peace Center. [Find hotel + flight trips in Hampton-Pinckney Historic District](https://expedia.com/go/package/search/FlightHotel/?FromAirport=Downtown%20Columbus,%20Columbus,%20Ohio,%20United%20States%20of%20America&Destination=Hampton-Pinckney%20Historic%20District&DestID=6348164&DaysInFuture=30&StayLength=7&rfrr=TG.LP.Dest.PKG.Neighborhoods) ### Discover the most popular places to visit in Upstate South Carolina !["Clemson University is an American public, coeducational, land-grant and sea-grant research university located in Clemson, South Carolina, United States.More clemson images:"](https://images.trvl-media.com/place/6127431/81e51bd8-6dfc-4739-9fb0-b15a1329fa3d.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Clemson University 5/5(422 reviews) Enjoy the collegiate vibe when you visit Clemson University, during your travels in Clemson. Experience the area's theater scene or attend a football game. [](https://expedia.com/Clemson-University-Clemson.d6127431.Vacation-Attraction) ![Falls Park on the Reedy](https://images.trvl-media.com/place/1388/9768cca7-241b-46cc-9044-0389ae1e8a0a.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Falls Park on the Reedy 4.5/5(594 reviews) Falls Park on the Reedy is just one of the places to see in Greenville, so why not enjoy the other things to explore during your travels? Experience the acclaimed theater scene or attend a sporting event in this family-friendly area. [](https://expedia.com/Falls-Park-On-The-Reedy-Greenville-Downtown.d6082697.Vacation-Attraction) ![Fred W. Symmes Chapel](https://images.trvl-media.com/place/553248621532656718/82a12a54-2b7c-457d-b071-556ed8fd587d.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Fred W. Symmes Chapel 5/5(12 reviews) You can find out about the history of Cleveland when you stop by Fred W. Symmes Chapel. Wander the lakeside and forest in this relaxing area. [](https://expedia.com/Fred-W-Symmes-Chapel-Cleveland.d553248621532656718.Vacation-Attraction) ### What to do in Upstate South Carolina ![Just Desserts Tour In Greenville](https://mediaim.expedia.com/localexpert/1351196/8e9eb85a-4aa7-4b2f-88cd-57bc5d997f04.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Just Desserts Tour In Greenville $95 per adult [](https://expedia.com/things-to-do/just-desserts-tour-in-greenville.a1351196.activity-details) ![Greenville: Saturday Morning Breakfast Tour](https://mediaim.expedia.com/localexpert/4536544/2424efd7-807a-4b7b-8d92-2a0a78490524.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Greenville: Saturday Morning Breakfast Tour $90 per adult [](https://expedia.com/things-to-do/greenville-saturday-morning-breakfast-tour.a4536544.activity-details) ![Gorgeous loop around Swan Lake at Furman University.](https://mediaim.expedia.com/localexpert/47647166/7d9e46d8-4054-43e9-85db-de9971fd7898.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Guided E-Bike Tour in Greenville South Carolina with Brunch $105 per adult [](https://expedia.com/things-to-do/guided-e-bike-tour-in-greenville-south-carolina-with-brunch.a47647166.activity-details) [See all activities in Upstate South Carolina](https://expedia.com/things-to-do/search?rid=6057939) ## Upstate South Carolina Hotel Deals ![Hilton Greenville](https://images.trvl-media.com/lodging/1000000/30000/23200/23172/8017eeff_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Hilton Greenville 45 W Orchard Park Dr Greenville SC Fully refundableReserve now, pay when you stay $99 nightly $109 total Apr 12 - Apr 13 Total with taxes and fees 8.2/10 Very Good! (1,003 reviews) Yes the room were clean and everything was great to include the staff as they were very accommodating. The property was nice as well and everything was awesome. I have stayed here before and was happy I was able to do so again Reviewed on Mar 30, 2026 [](https://expedia.com/Hotel-Search?startDate=4%2F12%2F2026&endDate=4%2F13%2F2026&selected=23172&PinnedHotelID=23172&HadPinnedHotel=true®ionId=6057939) ![Embassy Suites Greenville Golf Resort & Conference Center](https://images.trvl-media.com/lodging/1000000/10000/3300/3223/b0e15e12_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Embassy Suites Greenville Golf Resort & Conference Center 670 Verdae Blvd Greenville SC Fully refundableReserve now, pay when you stay $98 nightly $107 total Apr 5 - Apr 6 Total with taxes and fees 9/10 Wonderful! (1,129 reviews) Nice clean property. Breakfast was repetitive but I love the option of fresh omelette on the menu! Reviewed on Mar 29, 2026 [](https://expedia.com/Hotel-Search?startDate=4%2F5%2F2026&endDate=4%2F6%2F2026&selected=3223&PinnedHotelID=3223&HadPinnedHotel=true®ionId=6057939) ![Grand Bohemian Lodge Greenville, Autograph Collection](https://images.trvl-media.com/lodging/72000000/71770000/71762700/71762652/6f048029_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Grand Bohemian Lodge Greenville, Autograph Collection 44 EAST CAMPERDOWN WAY Greenville SC Fully refundableReserve now, pay when you stay $349 nightly $383 total Apr 2 - Apr 3 Total with taxes and fees 9.6/10 Exceptional! (467 reviews) Beautiful place Reviewed on Mar 26, 2026 [](https://expedia.com/Hotel-Search?startDate=4%2F2%2F2026&endDate=4%2F3%2F2026&selected=71762652&PinnedHotelID=71762652&HadPinnedHotel=true®ionId=6057939) [See all 2,955 properties in Upstate South Carolina](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.Package&startDate=3%2F31%2F2026&endDate=4%2F1%2F2026®ionId=6057939) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. ## Find the Best Upstate South Carolina Vacation Packages ## Upstate South Carolina Essential Information | Language | English | | --------------- | ------------------------------------- | | Currency | U.S dollars | | Closest Airport | Charlotte-Douglas Intl. Airport (CLT) | ## More vacations you might like ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/06/08/all-inclusive_holidays_US.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh) All Inclusive Vacations [](https://expedia.com/lp/theme-vacations/all-inclusive-vacations?rfrr=editorial.All_Inclusive%20Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/10/17/XPC_Beach_Overview_HR_v3.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Beach Vacations [](https://expedia.com/lp/theme-vacations/beach-vacations?rfrr=editorial.Beach_Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/06/08/Family_holidays_US_3_.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Kid Friendly Vacations [](https://expedia.com/lp/theme-vacations/kid-friendly-vacations?rfrr=editorial.Kid_Friendly%20Vacations.click) 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