Upstate South Carolina Vacations from $325
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Your Upstate South Carolina Vacation
When adventure calls, answer it with a tailor-made vacation package to Upstate South Carolina. Wherever it is you're going and whatever your plans are, prepare to experience a destination with plenty to offer. Start your trip to Upstate South Carolina with a few nights in Greenville visiting popular sights like Falls Park on the Reedy and Bon Secours Wellness Arena. Spartanburg is another city that draws crowds from far and wide. WestGate Mall and Tyger River Park are two of the top places to see in this destination. Find some travel buddies and start packing, because your Upstate South Carolina vacation is just a few clicks away with Expedia.
The Latest Upstate South Carolina vacation packages
Price found within the past 48 hours. Click for updated prices.
The Windsor Boutique Hotel
Downtown Asheville
Save 100% on your flight
per person
Oct 23 - Oct 26
found 15 hours ago
Roundtrip non-stop flight included
Orlando (MCO) to Asheville (AVL)
9.8/10 Exceptional! (522 reviews)
We had a wonderful stay. The staff was friendly and helpful. We loved the complimentary snacks and drinks. We are definitely going back for another stay.
Reviewed on Jul 12, 2025
Foxhunt at Sapphire Valley
Save 100% on your flight
per person
Sep 3 - Sep 7
found 18 hours ago
Roundtrip flight included
Orlando (MCO) to Asheville (AVL)
9/10 Wonderful! (406 reviews)
Was such a beautiful condo with beautiful decks! Definitely a great price and close to everything! We would stay again!
Reviewed on Jul 27, 2025
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Find the best Upstate South Carolina areas and neighborhoods for the activities you enjoy most. Learn more about Upstate South Carolina
Greenville Downtown
3 out of top 10 points of interest in this area
5/5(654 area reviews)
The ample dining options and beautiful river views are top of the list for many visitors to Greenville Downtown. A stop by The Peace Center or Bon Secours Wellness Arena might round out your trip.
Discover the most popular places to visit in Upstate South Carolina
Clemson University
5/5(410 reviews)
Walk around the campus of Clemson University, a top university in Clemson. Experience the area's theater scene or attend a football game.
Lake Keowee
4.5/5(101 reviews)
Commune with nature and explore the great outdoors at Lake Keowee during your travels in Salem. While you're in the area, wander around the college campus.
Falls Park on the Reedy
4.5/5(583 reviews)
Falls Park on the Reedy is just one of the places to see in Greenville, so why not enjoy the other things to explore during your travels? Experience the acclaimed theater scene or attend a sporting event in this family-friendly area.
What to do in Upstate South Carolina
Epic City Scavenger Hunt in Garden Grove by Operation City Quest
$10
per adult
Greenville on the Go A 1 Hour Rydable Adventure
$59
per adult
Upstate South Carolina Hotel Deals
Hilton Greenville
45 W Orchard Park Dr, Greenville, SC
Fully refundableReserve now, pay when you stay
$106 nightly
The price is $117 total per night from Aug 3 to Aug 4
$117 total
Aug 3 - Aug 4
Total includes taxes and fees
8/10 Very Good! (1,006 reviews)
"One night stay passing through. Good price and location."
Reviewed on Jul 26, 2025
Crowne Plaza Hotel Greenville-I-385-Roper Mtn Rd by IHG
851 Congaree Rd, Greenville, SC
Fully refundable
$99 nightly
The price is $109 total per night from Aug 3 to Aug 4
$109 total
Aug 3 - Aug 4
Total includes taxes and fees
8.4/10 Very Good! (1,000 reviews)
"It was a nice hotel. Hoping the pool was warmer but it wasn't bad."
Reviewed on Jul 29, 2025
La Quinta Inn & Suites by Wyndham Greenville Haywood
65 W Orchard Park Dr, Greenville, SC
Fully refundableReserve now, pay when you stay
$67 nightly
The price is $74 total per night from Aug 3 to Aug 4
$74 total
Aug 3 - Aug 4
Total includes taxes and fees
7.2/10 Good! (1,023 reviews)
"The breakfast was very poor."
Reviewed on Jul 25, 2025
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Find the Best Upstate South Carolina Vacation Packages
Upstate South Carolina Essential Information
Language | English |
|---|---|
Currency | U.S dollars |
Closest Airport | Charlotte-Douglas Intl. Airport (CLT) |
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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.