Title: The Best 5 Star Hotels in Mebane, NC from $95 | Expedia.com

[Mebane Travel Guide](https://expedia.com/Mebane.dx180961)[Hotels in Mebane](https://expedia.com/Mebane-Hotels.d180961.Travel-Guide-Hotels)[Vacation Rentals in Mebane](https://expedia.com/Mebane-Vacation-Rentals.d180961.Travel-Guide-VacationRentals)[Flights to Mebane](https://expedia.com/Cheap-Flights-To-Mebane.d180961.Travel-Guide-Flights)[Car Rentals in Mebane](https://expedia.com/Car-Rentals-In-Mebane.d180961.Car-Rental-Guide)[Mebane Vacation Packages](https://expedia.com/Mebane.d180961.Destination-Travel-Guides)

![Farm surrounded by a  harvested field](https://images.trvl-media.com/place/180961/5f702896-f7fc-45a7-9280-3872f62bf7f7.jpg?impolicy=fcrop&w=1200&h=500&q=medium)

![](https://images.trvl-media.com/place/180961/5f702896-f7fc-45a7-9280-3872f62bf7f7.jpg?impolicy=fcrop&w=1200&h=500&q=medium)

## Check availability on Mebane 5 Star Hotels

Tonight

[Feb 5 - Feb 6](https://www.expedia.com/Hotel-Search?regionId=180961&startDate=2026-02-05&endDate=2026-02-06&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

Tomorrow

[Feb 6 - Feb 7](https://www.expedia.com/Hotel-Search?regionId=180961&startDate=2026-02-06&endDate=2026-02-07&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

This weekend

[Feb 6 - Feb 8](https://www.expedia.com/Hotel-Search?regionId=180961&startDate=2026-02-06&endDate=2026-02-08&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

Next weekend

[Feb 13 - Feb 15](https://www.expedia.com/Hotel-Search?regionId=180961&startDate=2026-02-13&endDate=2026-02-15&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

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## Explore similar 4-star hotels

Many 4-star hotels have the same amenities as 5-star hotels. See all 4-star hotels in Mebane.

![JB Duke Hotel](https://images.trvl-media.com/lodging/16000000/15940000/15936000/15935986/22366c65_y.jpg?impolicy=resizecrop&rw=402&ra=fit)

### JB Duke Hotel

230 Science Drive Durham NC

$149 nightly

$169 total

Feb 10 - Feb 11

Total with taxes and fees

9.4/10 Exceptional! (564 reviews)

[](https://expedia.com/Raleigh-Hotels-JB-Duke-Hotel.h15935986.Hotel-Information)

![21c Museum Hotel Durham](https://images.trvl-media.com/lodging/9000000/8730000/8720800/8720744/a66cf407_y.jpg?impolicy=resizecrop&rw=402&ra=fit)

### 21c Museum Hotel Durham

111 North Corcoran Street Durham NC

$165 nightly

$187 total

Mar 8 - Mar 9

Total with taxes and fees

8.2/10 Very Good! (1,000 reviews)

[](https://expedia.com/Raleigh-Hotels-21c-Museum-Hotel-Durham.h8720744.Hotel-Information)

![DoubleTree Suites by Hilton Raleigh - Durham](https://images.trvl-media.com/lodging/1000000/20000/13200/13139/7fb5aa3f_y.jpg?impolicy=resizecrop&rw=402&ra=fit)

### DoubleTree Suites by Hilton Raleigh - Durham

2515 Meridian Pkwy Durham NC

$84 nightly

$95 total

Feb 22 - Feb 23

Total with taxes and fees

9/10 Wonderful! (1,007 reviews)

[](https://expedia.com/Raleigh-Hotels-DoubleTree-Suites-By-Hilton-Raleigh-Durham.h13139.Hotel-Information)

Still don't see what you're looking for?

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You can also use these popular filters to refine your search.

[Pool](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=2%2F6%2F2026&endDate=2%2F7%2F2026&regionId=180961&star=50&star=50&amenities=POOL)[Spa](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=2%2F6%2F2026&endDate=2%2F7%2F2026&regionId=180961&star=50&star=50&amenities=SPA_ON_SITE)[Hot tub](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=2%2F6%2F2026&endDate=2%2F7%2F2026&regionId=180961&star=50&star=50&amenities=HOT_TUB)[Breakfast included](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=2%2F6%2F2026&endDate=2%2F7%2F2026&regionId=180961&star=50&star=50&amenities=FREE_BREAKFAST)[Waterpark](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=2%2F6%2F2026&endDate=2%2F7%2F2026&regionId=180961&star=50&star=50&amenities=WATER_PARK)

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

## Learn more about Mebane

This charming small town boasts the Tanger Outlets where savvy shoppers find designer deals without the big-city crowds. Stroll through the historic downtown for local eateries, the Clay Street Mural, and weekend festivals where locals welcome visitors with genuine Southern hospitality.

[See all hotels in Mebane](https://www.expedia.com/Hotel-Search?startDate=2026-02-19&endDate=2026-02-20&adults=2&regionId=180961)

![Farm surrounded by a  harvested field](https://images.trvl-media.com/place/180961/5f702896-f7fc-45a7-9280-3872f62bf7f7.jpg?impolicy=fcrop&w=900&h=506&p=1&q=high)

## Top Mebane Hotel Reviews

## Find out more about Mebane

Ready for an incredible adventure? Add further enjoyment on your next trip to Mebane by treating yourself to the best of the best when it comes to accommodation. It's an ideal combination. After all, you love the finer things in life, both at home and when you book a getaway. You'll join the multitudes of vacationers who have made Mebane so popular in the last year. There's no reason to delay a getaway to Mebane any longer. Besides, the hotels in this area are known for guest services, so you know you'll be looked after during your getaway. Our 5-star hotels in Mebane are the perfect places to relax in when you really need to escape. You deserve the great vacation you're dreaming about.

### 5-Star Hotels in Mebane

Don't be afraid to live the high life while you're on vacation, along with the best conditions. Exceptional service, delicious meals, and one-on-one attention are all waiting for you. You're sure to find exactly the accommodation you need. Besides that, you'll find that these hotels are kept in fantastic condition and provide a fine place to kick back after your daily adventures. What kind of amenities will make your stay a wonderful one? A reflexology treatment that will leave you feeling refreshed and alive? 24-hour room service, so you can order that berry tart in the wee hours of the morning? A deep-tissue massage to help your cares fall away? Don't want to take our word for it? Plenty of visitors recommend this location. 

You won't sleep and order room service the entire time, though. We've got you covered. From doing a bit of shopping to embracing the great outdoors, you'll never be bored on this retreat. Whatever you plan to do, the 5-star hotels in Mebane are the perfect place to rest up after a busy day.

### Your Getaway Starts Today

The results are in, and Mebane 5-star hotels are the place to be when you book your next vacation. These beautiful hotels are highly rated by the guests who stay in them, and you're about to join their ranks. Your great getaway is just a mouse-click away -- Expedia can help you land a great deal on accommodation. Choose one of the 5-star hotels in Mebane today and settle down in the lap of luxury at your convenience.

## Frequently asked questions

### How much does it cost to stay in a 5-star hotel in Mebane?

> - Search for the lowest price per night from $95

### What makes a hotel 5 stars in Mebane?

### Are there any 5-star all-inclusive resorts in Mebane?

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