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Eastern Panama Vacation Rentals

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Our top choices for Eastern Panama vacation rentals

San Blas Private Beach Cabin

San Blas Private Beach Cabin
2.5 star property
Narganá
$233 nightly
The price is $256
Jan 14 - Jan 15
Total with taxes and fees
San Blas Private Beach Cabin

Private Over-Water Cabins on San Blas Island

Private Over-Water Cabins on San Blas Island
2.5 star property
Narganá
$309 nightly
The price is $330
Jan 14 - Jan 15
Total with taxes and fees
Private Over-Water Cabins on San Blas Island

San Blas Private Oceanfront Cabin

San Blas Private Oceanfront Cabin
2.5 star property
Narganá
$359 nightly
The price is $385
Jan 14 - Jan 15
Total with taxes and fees
San Blas Private Oceanfront Cabin

San Blas Tour Aridub

San Blas Tour Aridub
2.0 star property
Narganá
$226 nightly
The price is $249
Jan 14 - Jan 15
Total with taxes and fees
San Blas Tour Aridub

Caribbean getaway: beach cottage just on the sand

Caribbean getaway: beach cottage just on the sand
Palenque
10.0 out of 10, Exceptional, (1 review)
"The beach view was perfect! I loved hearing the waves all day and throughout the night. My dog and I enjoyed everything and felt very comfortable. "
United States
Beth N.
$287 nightly
The price is $287
Jan 18 - Jan 19
Total with taxes and fees
Caribbean getaway: beach cottage just on the sand

Private Over-the-Water Cabin in San Blas including Meals

Private Over-the-Water Cabin in San Blas including Meals
2.5 star property
Mirladub
Private Over-the-Water Cabin in San Blas including Meals

Cabaña La Punta op het Strand!!

Cabaña La Punta op het Strand!!
Colón Province
$170 nightly
The price is $170
Jan 14 - Jan 15
Total with taxes and fees
Cabaña La Punta op het Strand!!

Exclusive sailboat for 2 people all inclusive in San Blas islands

Exclusive sailboat for 2 people all inclusive in San Blas islands
Guna Yala
10.0 out of 10, Exceptional, (1 review)
"Anita e Federico sono state il valore aggiunto in queste isole meravigliose. La loro disponibilita, le loro attenzioni, i sorridenti contatti di Anita con la popolazione dei Guna e la cucina superlativa di Federico hanno reso speciale la nostra vacanza che ha soddisfatto appieno le nostre aspettative. Discreta e deliziosa la presenza della gattina (la principessa di bordo) Shanu. Grazie di tutto!"
United States
Grazia B.
$605 nightly
The price is $605
Jan 26 - Jan 27
Total with taxes and fees
Exclusive sailboat for 2 people all inclusive in San Blas islands

Despierta sobre el mar

Despierta sobre el mar
2.0 star property
Garrote
6.0 out of 10, (1 review)
$100 nightly
The price is $108
Jan 15 - Jan 16
Total with taxes and fees
Despierta sobre el mar

All inclusive 4-bedroom Catamaran up to 8 people in San Blas Panama

All inclusive 4-bedroom Catamaran up to 8 people in San Blas Panama
Guna Yala Comarca
$937 nightly
The price is $937
Jan 17 - Jan 18
Total with taxes and fees
All inclusive 4-bedroom Catamaran up to 8 people in San Blas Panama

Catamaran experience in paradise

Catamaran experience in paradise
Guna Yala Comarca
$1,196 nightly
The price is $1,196
Jan 14 - Jan 15
Total with taxes and fees
Catamaran experience in paradise

Private cabin in San Blas

Private cabin in San Blas
Panama , Betania
$302 nightly
The price is $302
Jan 14 - Jan 15
Total with taxes and fees
Private cabin in San Blas

Deluxe Beachfront 4-bedroom house in Colón Province

Deluxe Beachfront 4-bedroom house in Colón Province
Colón Province
$387 nightly
The price is $387
Jan 16 - Jan 17
Total with taxes and fees
Deluxe Beachfront 4-bedroom house in Colón Province

San Blas Private Over-the-Water Cabin

San Blas Private Over-the-Water Cabin
2.5 star property
Narganá
8.0 out of 10, Very Good, (2 reviews)
"I liked the modern payment system that was used for booking the trip, the food was great, the location was as described. I disliked the communication with the reseller this booking goes through. They dropped the ball on communicating pickup time and itinerary confirmation, even when i tried calling and emailing them. I also disliked the value of what you get with this trip. Id expect better cleanliness and standards for this trip. I also disliked when the staff on the island said i needed to pay...
United States
Andrew
$351 nightly
The price is $376
Jan 14 - Jan 15
Total with taxes and fees
San Blas Private Over-the-Water Cabin

Jacuzy, pool and lake at the same house.

Jacuzy, pool and lake at the same house.
Colon
10.0 out of 10, Exceptional, (1 review)
"Great. Please take care of the cat"
United States
KENNETH E.
$69 nightly
The price is $69
Jan 14 - Jan 15
Total with taxes and fees
Jacuzy, pool and lake at the same house.

Charming cottage with 2 separate beds and a beautiful view of the river

Charming cottage with 2 separate beds and a beautiful view of the river
Santa Rosa
10.0 out of 10, Exceptional, (1 review)
"Wir fanden die Unterkunft aufgrund der guten Wegbeschreibung sofort. Die Empfang war sehr nett. Das Haus war sehr sehr sauber und wir haben uns sehr wohl gefühlt. Alles war perfekt. Es war die sauberste/beste Unterkunft die wir bei unserer Panama Rundtour in Panama hatte. Erik und Alba alles Gute und vielen Dank."
Germany
Birgit U.
$146 nightly
The price is $146
Jan 14 - Jan 15
Total with taxes and fees
Charming cottage with 2 separate beds and a beautiful view of the river

Tranquil cabin with WiFi in Los Altos de Cerro Azul

Tranquil cabin with WiFi in Los Altos de Cerro Azul
Los Altos de Cerro Azul
$200 nightly
The price is $200
Jan 15 - Jan 16
Total with taxes and fees
Tranquil cabin with WiFi in Los Altos de Cerro Azul

Elegance and comfort in old town panama

Elegance and comfort in old town panama
Panamá
$90 nightly
The price is $90
Jan 14 - Jan 15
Total with taxes and fees
Elegance and comfort in old town panama

BEAUTIFUL APARTMENT IN FRONT OF THE SEA

BEAUTIFUL APARTMENT IN FRONT OF THE SEA
Portobelo
8.0 out of 10, Very Good, (3 reviews)
"All of it! Gabriel is a marvelous host; absolutely above and beyond. The house is lovely, very unique, and the location, right on the water, superb. We'll be back!"
United States
Rosa M.
$177 nightly
The price is $177
Jan 15 - Jan 16
Total with taxes and fees
BEAUTIFUL APARTMENT IN FRONT OF THE SEA

Charming 3-bedroom villa with AC and WiFi in soothing Río Hato

Charming 3-bedroom villa with AC and WiFi in soothing Río Hato
Río Hato
$469 nightly
The price is $496
Feb 2 - Feb 3
Total with taxes and fees
Charming 3-bedroom villa with AC and WiFi in soothing Río Hato
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Eastern Panama Hotel Reviews

Find out more about Eastern Panama

Everything you need to know about Eastern Panama vacation rentals

Whether you’re excited for the perfect family vacation, a romantic getaway for two, or the ultimate city break, we’ve got the Eastern Panama vacation rental for you. At Expedia, you can take your pick from private vacation homes, apartments, condos, resorts, cabins, villas, motels. The list goes on, and on …and on.

There’s just as wide a choice of amenities, too. Maybe you’re dreaming of your own pool, long evenings in a hot tub, or watching the kids laugh through the day at a waterpark. Maybe you just want a quiet retreat in a pet-friendly apartment. Well, we can help you find it. Hunt out the perfect Eastern Panama vacation rental for you by simply entering your desired dates. Then check your favorite filters to narrow down your search.

Eastern Panama vacation rentals: An excellent choice for every season

Whenever you want to travel, a warm welcome awaits you in Eastern Panama. If you’re looking for a little peace, consider booking during the quieter low season months. For more hustle and bustle, you may prefer to visit Eastern Panama in high season.

Prices vary throughout the year. Your chosen location, property type, and amenities will impact the cost of your trip, too. The selection of properties we have chosen for you start as low as $108 per night. Rates vary depending on your travel dates, location, and amenities so make a search and you might find even better deals!

How to find incredible deals on Eastern Panama rentals

At Expedia, we put the best Eastern Panama vacation rentals in one place. All you need to do is take your pick. And as we offer book now, pay later options, as well as free cancellation on some properties, you can plan your trip with total peace of mind. You’ll always find a great deal with Expedia.

To find some top Eastern Panama rental deals, enter your travel dates, and sort your search results by price. You can also filter by budget, so you only see accommodation in your ballpark. Next, add any filters you want—and just like that, you’ve built your dream Eastern Panama vacation.

If you’re looking for a little inspiration, browse our latest incredible offers, or use the map to view all accommodation in and around Eastern Panama. And to unlock even more fantastic deals, bundle your accommodation, flights, and car rental together to save and book with Expedia in complete confidence.