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Our top choices for Lyon hotels

Lobby
Front of property
Lobby sitting area
Casino

1. Isle Casino Hotel Lula Hotel & Casino - A Caesars Rewards Destination

Isle Casino Hotel Lula Hotel & Casino - A Caesars Rewards Destination
Lula
United States
Ernest
$69 nightly
$75 total
Sep 13 - Sep 14
Total with taxes and fees
Isle Casino Hotel Lula Hotel & Casino - A Caesars Rewards Destination
Reception
Room
Exterior
Reception

2. Hampton Inn Clarksdale

Hampton Inn Clarksdale
Clarksdale
United States
James
$134 nightly
$147 total
Sep 6 - Sep 7
Total with taxes and fees
Hampton Inn Clarksdale
Lobby sitting area
Room
Breakfast area
Lobby lounge

3. Quality Inn Clarksdale

Quality Inn Clarksdale
Clarksdale
United States
William
$83 nightly
$91 total
Sep 23 - Sep 24
Total with taxes and fees
Quality Inn Clarksdale
Exterior
Lobby
Front of property
Lobby sitting area

4. Travelers Hotel

Travelers Hotel
Clarksdale
United States
Carl
$142 nightly
$155 total
Sep 28 - Sep 29
Total with taxes and fees
Travelers Hotel
Lobby
Room, 2 Double Beds, Smoking
Breakfast area
Room, 1 King Bed, Smoking

5. Americas Best Value Inn & Suites Clarksdale

Americas Best Value Inn & Suites Clarksdale
Clarksdale
United States
Iesha
$78 nightly
$86 total
Sep 24 - Sep 25
Total with taxes and fees
Americas Best Value Inn & Suites Clarksdale
Room
Lobby
Exterior
Property entrance

6. Delta Inn West Helena US 49 AR

Delta Inn West Helena US 49 AR
West Helena
United States
Yvonne
$54 nightly
$61 total
Sep 1 - Sep 2
Total with taxes and fees
Delta Inn West Helena US 49 AR
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Where to stay near Lyon

Lyon offers a delightful blend of outdoor adventures and scenic beauty. Explore family-friendly neighborhoods and enjoy romantic strolls amidst nature. Whether hiking, picnicking, or simply soaking in the atmosphere, you'll find plenty of opportunities for unforgettable experiences in and around this charming city.
A colorful car parked in front of a mural on a city street.
Photo by Alice Andersen
A blue guitar with road signs 61 and 49 mounted on top.
A red electric guitar leaning against a speaker in a room with a piano in the background.
A blue guitar leaning against a signpost with route numbers 61 and 49.
A cotton field under a blue sky with scattered clouds.

Clarksdale

Discover Clarksdale, a vibrant destination perfectly suited for cultural enthusiasts and music lovers seeking an authentic Southern experience. Explore the rich heritage at the Delta Blues Museum, enjoy live performances at the iconic Ground Zero Blues Club, and immerse yourself in the local scene around Coahoma Community College. Just about a 2-mile drive from Lyon, Clarksdale offers easy access for visitors. With its unique blend of music, culture, and outdoor activities, Clarksdale is a smart choice for your next getaway.

Jonestown

Plan your stay in Jonestown, a top-rated choice for families and budget travelers looking for a mix of outdoor adventures and cultural experiences. This charming village offers easy access to attractions like Coahoma Community College and the Rock N' Roll & Blues Heritage Museum, perfect for those wanting to explore the local arts scene. With a drive of about 14 miles from Lyon, Jonestown is a smart choice for your next vacation getaway.

Coahoma

Make your vacation planning effortless by staying in Coahoma, a haven for family and budget travelers thanks to its diverse attractions. Enjoy the vibrant local culture at the Rock N' Roll & Blues Heritage Museum, relax in the scenic Freedom Park, and explore Coahoma Community College. With its welcoming atmosphere and recreational options, Coahoma is a smart choice for travelers seeking both entertainment and relaxation. Plus, it's only about a 10-mile drive from Lyon, making it easy to reach.

Alligator

Ideally situated for budget-conscious families and nature enthusiasts, Alligator offers a charming escape just about 16 miles by car from Lyon. Here, visitors can immerse themselves in outdoor adventures, explore the scenic beauty of nearby state parks, and enjoy local landmarks like the Delta Blues Museum and Ground Zero Blues Club. With a blend of education and recreation, Alligator provides a welcoming atmosphere for travelers looking to experience the best of Mississippi's culture and scenery. It's a smart choice for your vacation stay.

Lambert

Travelers visiting the area often choose Lambert, especially families and outdoor enthusiasts seeking a charming village atmosphere. With attractions like the Hobson Plantation bar, the Coahoma Community College, and the Rock N' Roll & Blues Heritage Museum, Lambert offers a blend of cultural and recreational experiences. Located about 24 miles by car from Lyon, it provides easy access to a peaceful getaway while still being close to urban conveniences. Lambert is a smart choice for those looking to unwind and explore Mississippi's unique offerings.

Stay near popular attractions around Lyon

Nestled in the heart of Mississippi, Lyon offers a perfect blend of outdoor adventures and cultural experiences. Discover local museums and galleries, and admire beautiful monuments. Whether you seek scenic hikes or family-friendly attractions, Lyon promises an unforgettable getaway for every traveler.

Delta Blues Museum

9.0/10 (83 reviews)
Set the stage for your exploration of American music at the Delta Blues Museum, a vibrant tribute to the rich heritage of blues music. Located about 2 miles by car from Lyon, this museum offers an immersive experience into the culture and history of the Delta blues. Staying nearby makes it easy to soak in the musical legacy of the region.
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Rock N' Roll & Blues Heritage Museum

8.8/10 (19 reviews)
Often cited as a favorite among music lovers, the Rock N' Roll & Blues Heritage Museum in Clarksdale celebrates the rich cultural history of American music. Located about 2 miles by car from Lyon, this museum offers a unique glimpse into the roots of rock and blues, making it a convenient stop for an enriching day out.
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Hambone Art Gallery

9.0/10 (22 reviews)
Ideal for travelers interested in local art and culture, Hambone Art Gallery showcases unique works that reflect the vibrant spirit of the area. Located about 2 miles by car from Lyon, this gallery offers a convenient stop to immerse yourself in the local art scene.
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Carnegie Public Library

10.0/10 (4 reviews)
No trip is complete without a visit to Carnegie Public Library, a charming spot for families and culture seekers. This inviting library offers a welcoming atmosphere and a wealth of resources. It’s about a 2-mile drive from Lyon, making it a convenient stop to enrich your visit.
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The Crossroads

An essential stop for cultural explorers, The Crossroads in Clarksdale, Mississippi, embodies the rich musical heritage of the region. This iconic monument, located about 2 miles by car from Lyon, offers a unique glimpse into the birthplace of blues. Staying nearby allows for easy access to this historic site and the vibrant local scene.
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Top Lyon Hotel Reviews

Hampton Inn Clarksdale

Hampton Inn Clarksdale

10/10 Excellent
"Room had a faint odor"
Ternarian 1-night trip
Posted 20 hours ago
Hampton Inn Clarksdale
Travelers Hotel

Travelers Hotel

10/10 Excellent
"It’s a unique hotel with lots of character. A great place to stay!"
Carl 3-night trip
Posted 6 days ago
Travelers Hotel
Casa D’Amore!!!! Adorable home less than 1/2 mile from downtown Clarksdale

Casa D’Amore!!!! Adorable home less than 1/2 mile from downtown Clarksdale

10/10 Excellent
"The home was immaculate, accommodating and accessible. Everything we ever need was available including snacks and beverages."
Kathy 3-night trip
Posted 13 days ago
Casa D’Amore!!!! Adorable home less than 1/2 mile from downtown Clarksdale
Auberge Clarksdale Blues Hostel

Auberge Clarksdale Blues Hostel

10/10 Excellent
"My first time in a hostel and was sort of dreading it, but it was lovely. Shared bathroom was more like a locker room. Great location to walk everywhere."
Shelly 2-night trip
Posted 13 days ago
Auberge Clarksdale Blues Hostel
Sunset Log Cabin

Sunset Log Cabin

10/10 Excellent
"Clean and comfortable accommodation. Great location. reasonable price. I'll be back!"
Don G. 3-night trip
Posted 2 weeks ago
Sunset Log Cabin
Only a mile from historic downtown Clarksdale!

Only a mile from historic downtown Clarksdale!

10/10 Excellent
"Great spot. Excellent host"
Todd G. 2-night trip
Posted 1 month ago
Only a mile from historic downtown Clarksdale!
Cottage on riverbank one mile from Clarksdale in gated community

Cottage on riverbank one mile from Clarksdale in gated community

10/10 Excellent
"The property was very clean, comfortable and check in was so easy, the hospitality was amazing, we really enjoyed ourselves and will be visiting again!!!"
Bridget I. 3-night trip
Posted 2 months ago
Cottage on riverbank one mile from Clarksdale in gated community
Get to BLUES-in' at Rusty's Roost, adjacent to downtown Clarksdale, MS

Get to BLUES-in' at Rusty's Roost, adjacent to downtown Clarksdale, MS

10/10 Excellent
"The location was so perfect for us on our volunteer trip. The house was clean and easily accessible. Kitchen stocked with everything you need. Great shower. We loved the house and the front porch too. Parking is easy. The owner communicated so well in regards to any questions we had. She told us places to eat on days when a lot of restaurant were closed, told us about the farmers market and where to find groceries. Thank you."
Neil g. 5-night trip
Posted 2 months ago
Get to BLUES-in' at Rusty's Roost, adjacent to downtown Clarksdale, MS
The Governors Mansion in Clarksdale Mississippi. A Step Back in Time

The Governors Mansion in Clarksdale Mississippi. A Step Back in Time

10/10 Excellent
"We had an incredible stay at this historic mansion in Clarksdale! Our large group had more than enough room to spread out comfortably, and the house itself is full of charm, character, and history. It was the perfect place to gather together while still having plenty of space for everyone.The pool was one of the highlights of our trip. It was large, well-maintained, and the perfect place to relax after a day of exploring.Our host was fantastic from start to finish. They were incredibly friendly, quick to respond to any questions, and gave us wonderful recommendations for local restaurants, attractions, and hidden gems that made our trip even more memorable.If you have the chance, be sure to spend some time exploring downtown Clarksdale. It's packed with history, incredible music culture, and so many unique places to discover. If you're a fan of the blues, this town is an absolute must-visit.We couldn't have asked for a better place to stay and would absolutely recommend it to anyone visiting Clarksdale, whether you're traveling with family, friends, or a large group. We would gladly stay here again!"
Nicole S. 8-night trip
Posted 2 months ago
The Governors Mansion in Clarksdale Mississippi. A Step Back in Time

More cheap stays in Lyon

Americas Best Value Inn & Suites Clarksdale

Americas Best Value Inn & Suites Clarksdale

350 South State Street Clarksdale MS
$78 nightly
$86 total
Sep 24 - Sep 25
Total with taxes and fees
6/10 (430 reviews)
Americas Best Value Inn & Suites Clarksdale
Quality Inn Clarksdale

Quality Inn Clarksdale

818 South State Street Clarksdale MS
$83 nightly
$91 total
Sep 23 - Sep 24
Total with taxes and fees
Quality Inn Clarksdale
Auberge Clarksdale Blues Hostel

Auberge Clarksdale Blues Hostel

164 Delta Ave Clarksdale MS
$92 nightly
$101 total
Aug 31 - Sep 1
Total with taxes and fees
9.6/10 Exceptional! (110 reviews)
Auberge Clarksdale Blues Hostel
Hampton Inn Clarksdale

Hampton Inn Clarksdale

15000 New Africa Rd Clarksdale MS
$134 nightly
$147 total
Sep 6 - Sep 7
Total with taxes and fees
8.2/10 Very Good! (401 reviews)
Hampton Inn Clarksdale
Travelers Hotel

Travelers Hotel

212 3rd St Clarksdale MS
$142 nightly
$155 total
Sep 28 - Sep 29
Total with taxes and fees
9.8/10 Exceptional! (316 reviews)
Travelers Hotel
High Cotton Condos

High Cotton Condos

249 Delta Ave Clarksdale MS
Get rates
8.8/10 Excellent! (6 reviews)
High Cotton Condos

Hotels in Lyon with star-rating

Frequently asked questions

What is the best area to stay in Lyon?
The best area to stay in Lyon, Mississippi, is near the intersection of Highway 61 and Highway 161, which provides convenient access to local amenities and the surrounding region.This area is the primary hub for visitors passing through Lyon. It offers easy access to the main roads, making it a practical choice for those exploring the Mississippi Delta. You'll find a few local eateries and essential services concentrated around these major thoroughfares.For solo travelers or couples on a road trip, this location is ideal.
When is the best time to go to Lyon?
The best time to visit Lyon, Mississippi, is during the spring (March to May) and fall (September to November) months, when the weather is most pleasant for exploring.Spring offers mild temperatures, typically ranging from the 60s to high 70s Fahrenheit, making it comfortable for outdoor activities and enjoying the natural beauty of the Mississippi Delta. This season is ideal for travelers who appreciate comfortable weather for sightseeing and general exploration without the intense heat of summer.Similarly, the fall season brings cooler temperatures, generally from the 60s to low 80s Fahrenheit, and lower humidity. This period is superb for those looking to experience the local culture and history in comfort.
Can I cancel my hotel reservation on Expedia?
You can cancel your hotel reservation on Expedia, though it depends on the cancellation policy of your booking. Most bookings are refundable if canceled within 24-48 hours of the scheduled arrival. Be sure to check your booking confirmation for the exact cancellation policy. If free cancellation is available, you can cancel directly through your Expedia account by logging in, going to "My Trips", and selecting your reservation. To find flexible deals, filter your search by "Fully refundable property" for hotels in Lyon.
How much is the nightly rate at a Lyon hotel?
Prices for hotels in Lyon often vary, but you can find a great deal from $86 on Expedia. All sorts of factors affect price, such as the time of year or the days of the week you choose for your stay. Find the best deals by being flexible with your dates, and sort search results by "Price: low to high" for the cheapest rate.

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