Punta Paitilla

Panama City

A cityscape at sunset with tall buildings silhouetted against the sky.
A coastal cityscape with high-rise buildings, a marina, and a beach.
A cityscape with modern skyscrapers, a prominent green building, and a clear blue sky.
A cityscape with a distinctive twisted skyscraper, a busy highway, and surrounding modern buildings.
A cityscape at sunset with a prominent skyscraper and a river.

Stay near popular Punta Paitilla attractions

Pacific Center

You can enjoy retail therapy at Pacific Center during your visit to Panama City. You can enjoy the restaurants while in the area.
See properties

Things to do

Panama Canal: The Most Complete Monkey Island Experience

Panama Canal: The Most Complete Wildlife Experience

$36
per adult
100% of travellers recommend
Panama Canal: The Most Complete Wildlife Experience
Picture 3 for Activity Panama City: All-Inclusive Catamaran Cruise to Taboga Island

Panama City: All-Inclusive Catamaran Cruise to Taboga Island

$99
per adult
94% of travellers recommend
Panama City: All-Inclusive Catamaran Cruise to Taboga Island
From Panama City: San Blas Islands Tour with Island Hopping

From Panama City: San Blas Islands Tour with Island Hopping

$145
per adult
98% of travellers recommend
From Panama City: San Blas Islands Tour with Island Hopping
Panama: Monkey and Sloth Jungle Habitat Panama Tour

Panama: Monkey and Sloth Jungle Habitat Panama Tour

$60
per adult
100% of travellers recommend
Panama: Monkey and Sloth Jungle Habitat Panama Tour
Panama City: Poin Glass Observation Deck Ticket with VR Tour

Panama City: Poin Glass Observation Deck Ticket with VR Tour

$32
per adult
100% of travellers recommend
Panama City: Poin Glass Observation Deck Ticket with VR Tour
Panama City: Poin Full Package Experience

Panama City: Poin Full Package Experience

$155
per adult
98% of travellers recommend
Panama City: Poin Full Package Experience
See all activities in Panama City

Punta Paitilla Hotel Deals

Megapolis Hotel Panamá

Megapolis Hotel Panamá

4.5 out of 5
Avenida Balboa Panama City
$129 nightly
The price is $144 total per night from Nov 7 to Nov 8
$144 total
Nov 7 - Nov 8
Total with taxes and fees
Book a stay at this luxury hotel in Panama City. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in ...
8.6/10 Excellent! (1,831 reviews)
"Excellent"

Reviewed on Nov 2, 2026

Megapolis Hotel Panamá
Decapolis Hotel Panama City

Decapolis Hotel Panama City

4 out of 5
Avenida Balboa Con Multicentro Panama City Panama
$94 nightly
The price is $104 total per night from Nov 29 to Nov 30
$104 total
Nov 29 - Nov 30
Total with taxes and fees
Book a stay at this spa hotel in Panama City. Enjoy free breakfast, free WiFi, and free valet parking. Our guests praise the breakfast and the helpful staff ...
8.6/10 Excellent! (1,731 reviews)
"We always stay there and have a good experience, good breakfast and very nice staff"

Reviewed on Nov 2, 2026

Decapolis Hotel Panama City
Las Americas Golden Tower Panama

Las Americas Golden Tower Panama

4 out of 5
Av. Balboa con Calle 53 Panama City Panama
$150 nightly
The price is $165 total per night from Nov 8 to Nov 9
$165 total
Nov 8 - Nov 9
Total with taxes and fees
Book a stay at this spa hotel in Panama City. Enjoy free WiFi, free parking, and a full-service spa. Our guests praise the breakfast and the helpful staff in ...
Las Americas Golden Tower Panama
Residence Inn by Marriott Panama City

Residence Inn by Marriott Panama City

4 out of 5
CALLE RAMON H JURADO EDIFICO P Panama City
$206 nightly
The price is $227 total per night from Dec 2 to Dec 3
$227 total
Dec 2 - Dec 3
Total with taxes and fees
Book a stay at this business-friendly hotel in Panama City. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
9.2/10 Wonderful! (693 reviews)
"Excellent stay at the Residence Inn by Marriott. The staff members were very friendly and accommodating and the room was very clean. The breakfast spread was wonderful and the location was great to visit the main tourist attractions."

Reviewed on Oct 29, 2026

Residence Inn by Marriott Panama City
Plaza Paitilla Inn Hotel

Plaza Paitilla Inn Hotel

3.5 out of 5
Italy Avenue, Punta Paitilla Panama City Panama
$121 nightly
The price is $135 total per night from Dec 3 to Dec 4
$135 total
Dec 3 - Dec 4
Total with taxes and fees
Book a stay at this business-friendly hotel in Panama City. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the pool in ...
9.4/10 Exceptional! (2,239 reviews)
"Clean and modern room! Great view! We loved the included breakfast. I highly recommend!"

Reviewed on Nov 2, 2026

Plaza Paitilla Inn Hotel
Hotel Riu Plaza Panama

Hotel Riu Plaza Panama

5 out of 5
Calle 50, Urb. Marbella Panama City Panama
$118 nightly
The price is $130 total per night from Dec 1 to Dec 2
$130 total
Dec 1 - Dec 2
Total with taxes and fees
Book a stay at this luxury hotel in Panama City. Enjoy free breakfast, free WiFi, and 3 restaurants. Our guests praise the breakfast and the pool in our reviews. ...
9/10 Wonderful! (6,166 reviews)
"The hotel is very well located, and the breakfast is decent. However, our room had a strong mildew smell and seemed poorly ventilated. The air conditioning appeared to have been left off before our arrival. Although it was turned on as soon as we arrived, the unpleasant smell persisted and kept me ..."

Reviewed on Nov 2, 2026

Hotel Riu Plaza Panama
See all 1,800 properties in Punta Paitilla
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Where to stay in Punta Paitilla

Find the best Punta Paitilla areas and neighborhoods for the activities you enjoy most. Learn more about Punta Paitilla
Learn more about Punta Paitilla
A coastal cityscape with a prominent church tower, a river, and distant mountains.

Casco Viejo

Unique features of Casco Viejo include the historic sites and bars. Make a stop by Independence Square or Interoceanic Canal Museum while you're exploring the area.

A modern, spiraling skyscraper with a unique design, surrounded by other buildings in an urban setting.
Photo by Fabiola Tile
Open Photo by Fabiola Tile

Bella Vista

Bella Vista is highly notable for its popular shops, and you might want to visit top sights like Via Espana and Iglesia del Carmen. See more of Panama City by jumping on the metro at Iglesia del Carmen Station or Vía Argentina Station.

A city skyline with modern high-rise buildings and a river in the foreground.

El Cangrejo

The abundant dining options and casinos are top of the list for many visitors to El Cangrejo. A stop by Via Espana or Crown Casino might round out your trip.

A bridge over a body of water with several boats.

San Francisco

San Francisco is noteworthy for its restaurants, and you can make a stop at top attractions like Multiplaza Pacific Mall and Calle 50.

A building with three arched windows, a balcony with wrought iron railings, and a tiled roof.

San Felipe

If you're spending some time in San Felipe, Independence Square and Interoceanic Canal Museum are top sights worth seeing.

Punta Paitilla

Choose one or more items to build your trip:

Explore a world of travel with Expedia