Santa Fe

Travel Guide

A lush forest with a stream, moss-covered rocks, and dense foliage.
A waterfall in a lush forest with dense foliage and a clear stream below.
A dense forest with a mountain in the background partially covered by clouds.
Hotel Anachoreo

Hotel Anachoreo

3 out of 5
Calle Chinita Santa Fe Veraguas Province
$85 nightly
The price is $93 total per night from Oct 31 to Nov 1
$93 total
Oct 31 - Nov 1
Total with taxes and fees
Stay at this B&B in Santa Fe. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Town Square and Orchid House are located nearby.
9.6/10 Exceptional! (46 reviews)
"Light"

Reviewed on Aug 26, 2026

Hotel Anachoreo
La Qhia Eco Retreat

La Qhia Eco Retreat

2.5 out of 5
Barriada el Cerro A 100 Mts De Santa Fe Veraguas
Stay at this hostal in Santa Fe. Enjoy free parking, breakfast (surcharge), and onsite spa services. Popular attractions Town Square and Orchid House are located ...
8.2/10 Very Good! (22 reviews)
"This is a beautiful property but remember it is somewhat rustic. The neighborhood roosters make sure to wake you. The rooms are comfortable and with the mountain air and ceiling fan you don’t miss AC. Free breakfast was tasty. Dinner was good but lunch is not available. The best part is the well ..."

Reviewed on Sep 11, 2026

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La Qhia Eco Retreat
Rainforest Yasmin Hotel

Rainforest Yasmin Hotel

2.5 out of 5
Veraguas Santa Fe Provincia de Veraguas
Stay at this hotel in Santa Fe. Enjoy free WiFi, free parking, and a 24-hour front desk. Popular attractions Town Square and Orchid House are located ...
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Rainforest Yasmin Hotel
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Private Over the Water Cabin on San Blas Island

Private Over the Water Cabin on San Blas Island

2 out of 5
9.542876, -78.899058 Las Huacas San Blas
Book a stay at this beach cabin in Las Huacas. Enjoy free breakfast, a beach locale, and an airport shuttle (surcharge).
7.6/10 Good! (7 reviews)
"Very nice. And I liked the food"

Reviewed on Aug 14, 2025

Private Over the Water Cabin on San Blas Island
Perfect 1-bedroom bungalow with AC in peaceful Playa reina

Perfect 1-bedroom bungalow with AC in peaceful Playa reina

Santiago Provincia de Veraguas
Stay at this vacation home in Canto del Llano. Enjoy air conditioning. Popular attractions Parque Acuatico Italia Guadalupe Panama and Plaza Banconal are located ...
Perfect 1-bedroom bungalow with AC in peaceful Playa reina
2-Bedroom Cinta Costera Retreat

2-Bedroom Cinta Costera Retreat

Panama
Stay at this apartment in Las Huacas. Enjoy laundry facilities and air conditioning.
2-Bedroom Cinta Costera Retreat
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Stay near popular Santa Fe attractions

Alto de Piedra Waterfall

7.6/10 (7 reviews)
Commune with nature and explore the great outdoors at Alto de Piedra Waterfall during your travels in Santa Fe. While you're in the area, wander around the natural setting.
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Frequently asked questions

Is Santa Fe worth visiting?
Santa Fe is worth visiting for its relaxing attractions, including Quebrada Las Trancas Spa and the central Town Square. Travelers can also enjoy diverse dining experiences, from Latin American dishes like tacos and enchiladas to classic Italian cuisine such as pasta and pizza.
When is the best time to visit Santa Fe?
The best time to visit Santa Fe is from July through November, when the climate is pleasant for exploring. For fewer crowds and better value, consider the quieter months of February through May. This period offers mild temperatures, allowing travelers to enjoy Santa Fe before the peak summer season.
What is Santa Fe known for?
Santa Fe is known for its Quebrada Las Trancas Spa, Town Square, and the Catholic Church of Santa Fe. This city in Panama also features a Latin American food culture, where travelers can find diverse culinary options.
What is a good itinerary length for Santa Fe?
A good itinerary length for Santa Fe is two to three days to explore key highlights like Quebrada Las Trancas Spa, the Town Square, and the Catholic Church of Santa Fe. For a more relaxed trip, consider four to five days, allowing you to enjoy the local atmosphere and diverse Latin American, Italian, and North American cuisine.
What are the top things to do in and around Santa Fe?
Santa Fe offers natural beauty and local landmarks for travelers to explore:


How do I plan a trip to Santa Fe?
To plan your trip to Santa Fe, search for places to stay and book flights early. Consider a rental car for getting around. When planning activities, remember to schedule outdoor experiences like visiting Quebrada Las Trancas Spa for early morning or late afternoon. Don't miss exploring the Town Square and Catholic Church of Santa Fe.
What cuisines can you find in Santa Fe?
In Santa Fe you can find Mexican cuisine, with dishes like tacos, burritos, enchiladas, and chiles rellenos. Travelers also have options for Italian fare, New American dishes, and various Asian flavors including Japanese and Chinese.
Can I book a refundable hotel in Santa Fe?
Yes, Expedia offers many flexible booking options, and you can look for refundable hotels in Santa Fe by entering your dates and using the refundable or fully refundable filter. Always check the hotel's cancellation policy before you book, since terms can vary by hotel, and visit Expedia help center for further details.
Why book a trip to Santa Fe with Expedia?
Expedia makes it easier to plan your Santa Fe trip with travel tools, flexible search options, and bookable trip components all in one place. You can organize your plans in one account and use Expedia to help build a trip that fits your budget and travel style. Find out more about how by visiting Expedia's Trip Planner page.
Should I stay in a hotel or vacation rental in Santa Fe?
The best choice depends on your travel style. Hotels in Santa Fe can be a good fit for convenience, on-site amenities, and shorter stays, while vacation rentals may offer more space, privacy, and home-style amenities for longer trips, families, or groups. With Expedia, you can compare both options side by side, read traveler reviews, and filter by amenities to find the right fit for your trip.
How can I manage my Santa Fe trip on Expedia?
Once you've booked your Santa Fe trip, you can manage it through your Expedia account or the Expedia app. You can view your itinerary, access booking details, make eligible changes, and check for updates in My Trips. The Expedia app can also help you stay organized while you travel.
What if I need help during my Santa Fe trip?
Expedia offers customer support before, during, and after your Santa Fe trip. If your plans change or something unexpected happens, you can review your booking in My Trips and use Expedia help center channels for help with eligible changes, cancellations, or travel issues.
How can Expedia help me plan my first trip to Santa Fe?
If it's your first trip to Santa Fe, Expedia can help you plan by bringing together stays, flights, activities, traveler reviews, and trip-planning tools in one place. With Expedia's Trip Planner you can compare options, read reviews from other travelers, and build an itinerary that matches your interests and budget.
How can I save on my Santa Fe hotel booking with Expedia?
Join One Key™ for free to unlock instant discounts with Member Prices on select hotels. You can also earn and use OneKeyCash™* on eligible bookings on Expedia. Booking in advance is usually another great way to save on your Santa Fe hotel.

*Excludes taxes and fees. OneKeyCash is not redeemable for cash and can only be used on Expedia and other participating brands.

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