$244 Cheap Flights from St. Louis (STL) to Key West (EYW)

View $244 flight on Tue, Dec 30, 2025Opens in a new window

Popular airlines from St. Louis Lambert Intl. Airport (STL) to Key West Intl. Airport (EYW)

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Cheap Flights from St. Louis to Key West (STL-EYW)

Prices were available within the past 7 days and start at $244 for one-way flights and $223 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Delta
Tue, Oct 21 - Wed, Oct 29
STL
St. Louis
EYW
Key West
$223 Roundtrip, found 2 hours ago
$223
Roundtrip
found 2 hours ago
Select Delta flight, departing Tue, Oct 21 from St. Louis to Key West, returning Wed, Oct 29, priced at $223 found 2 hours ago
American Airlines
Sat, Nov 1 - Tue, Nov 4
STL
St. Louis
EYW
Key West
$228 Roundtrip, found 10 hours ago
$228
Roundtrip
found 10 hours ago
Select American Airlines flight, departing Sat, Nov 1 from St. Louis to Key West, returning Tue, Nov 4, priced at $228 found 10 hours ago
Delta
Wed, Dec 24 - Thu, Dec 25
STL
St. Louis
EYW
Key West
$240 Roundtrip, found 6 days ago
$240
Roundtrip
found 6 days ago
Select Delta flight, departing Wed, Dec 24 from St. Louis to Key West, returning Thu, Dec 25, priced at $240 found 6 days ago
United
Sat, May 9 - Fri, May 15
STL
St. Louis
EYW
Key West
$241 Roundtrip, found 3 days ago
$241
Roundtrip
found 3 days ago
Select United flight, departing Sat, May 9 from St. Louis to Key West, returning Fri, May 15, priced at $241 found 3 days ago
American Airlines
Mon, Jan 19 - Sat, Jan 24
STL
St. Louis
EYW
Key West
$246 Roundtrip, found 1 day ago
$246
Roundtrip
found 1 day ago
Select American Airlines flight, departing Mon, Jan 19 from St. Louis to Key West, returning Sat, Jan 24, priced at $246 found 1 day ago
Delta
Sat, Nov 8 - Thu, Nov 13
STL
St. Louis
EYW
Key West
$256 Roundtrip, just found
$256
Roundtrip
just found
Select Delta flight, departing Sat, Nov 8 from St. Louis to Key West, returning Thu, Nov 13, priced at $256 just found
Delta
Fri, Oct 31 - Thu, Nov 6
STL
St. Louis
EYW
Key West
$258 Roundtrip, found 1 day ago
$258
Roundtrip
found 1 day ago
Select Delta flight, departing Fri, Oct 31 from St. Louis to Key West, returning Thu, Nov 6, priced at $258 found 1 day ago
American Airlines
Thu, Jan 29 - Mon, Feb 9
STL
St. Louis
EYW
Key West
$259 Roundtrip, found 4 hours ago
$259
Roundtrip
found 4 hours ago
Select American Airlines flight, departing Thu, Jan 29 from St. Louis to Key West, returning Mon, Feb 9, priced at $259 found 4 hours ago
American Airlines
Sat, Oct 11 - Wed, Oct 15
STL
St. Louis
EYW
Key West
$264 Roundtrip, found 1 day ago
$264
Roundtrip
found 1 day ago
Select American Airlines flight, departing Sat, Oct 11 from St. Louis to Key West, returning Wed, Oct 15, priced at $264 found 1 day ago
American Airlines
Sat, Feb 21 - Wed, Feb 25
STL
St. Louis
EYW
Key West
$266 Roundtrip, found 3 hours ago
$266
Roundtrip
found 3 hours ago
Select American Airlines flight, departing Sat, Feb 21 from St. Louis to Key West, returning Wed, Feb 25, priced at $266 found 3 hours ago

Find the cheapest month to fly from St. Louis (STL) to Key West (EYW)

April is typically the cheapest month to fly

From $204 - $518 per traveler.

Frequently asked questions

How much does a flight from Lambert-St. Louis Intl. Airport (STL) to Key West Intl. Airport (EYW) cost?
Lock in a cheap one-way flight from $244 or cheap return flight from $223 from Lambert-St. Louis Intl. Airport (STL) to Key West Intl. Airport (EYW) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to find our cheapest flight offers on this route.
What is the cheapest month to fly from Lambert-St. Louis Intl. Airport (STL) to Key West Intl. Airport (EYW)?
Traveling in October is a great way to save, as it's the cheapest month for flights between STL and EYW. You'll often find the lowest prices during off-peak months.
What is the cheapest airline that flies from Lambert-St. Louis Intl. Airport (STL) to Key West Intl. Airport (EYW)?
Expedia's filter tool lets you easily compare different airlines, travel time and fares all in one place. Choose your preferences, then sort by "Price (lowest to highest)" to find the carrier with the cheapest STL to EYW flight.
How many flights per day from Lambert-St. Louis Intl. Airport (STL) to Key West Intl. Airport (EYW)?
Direct flights from Lambert-St. Louis Intl. Airport (STL) to Key West Intl. Airport (EYW) aren't available daily, so you'll need to take a flight with a layover. Explore your options with Expedia's filters. Enter your travel dates and select either "1 Stop" or "2+ Stops."
What day of the week has the most flights from STL to EYW?
Friday is typically the busiest day for flights, while Tuesday tends to be the quietest.* Keep in mind that flight schedules can change based on various factors, including the time of year and airline.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Lambert-St. Louis Intl. Airport (STL) to Key West Intl. Airport (EYW)?
To land at Key West Intl. Airport (EYW) without delays, select a flight that takes off from Lambert-St. Louis Intl. Airport (STL) before 3 PM. The likelihood of cancellations is 22% higher, on average, for departures after this time.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Lambert-St. Louis Intl. Airport (STL) to Key West Intl. Airport (EYW) last-minute?
Waiting until just before your trip to book a ticket from STL to EYW generally means paying more. While you may find some last-minute deals, they aren't always guaranteed. Allow some flexibility in your schedule to maximize your chances of scoring a bargain.
Is it cheaper to book a STL to EYW flight and hotel package?
Compared with arranging flights and hotels separately, booking a STL to EYW flight and hotel package with Expedia could result in significant savings. Better still, having everything in one convenient place takes the hassle out of travel planning. Just pick your flights and choose from our extensive range of stays, then personalize your trip with other add-ons like tours, car rentals and activities.
Can I cancel or change the date of my flight from Lambert-St. Louis Intl. Airport (STL) to Key West Intl. Airport (EYW)?
It's generally possible to cancel or reschedule your STL to EYW flight. However, if it's been more than 24 hours since booking, additional fees may apply. Check your airline's policies in your itinerary to see what changes are allowed and if any costs are involved. You'll also find more details on our Customer Service portal.

Travel information

Travel information

Origin airport
Lambert-St. Louis Intl.
Destination airport
Key West Intl.
Airlines serving
American Airlines, Delta, United
Roundtrip price
$222
Distance
1102 mi

Book with confidence

Book with confidence

St. Louis to Key West Flights

The cheapest times to fly from St. Louis to Key West

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from St. Louis to Key West are during the month of October. You can find some of the cheapest flights from St. Louis to Key West with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from St. Louis to Key West

Sunday is one of the best days to book for cheap flights from St. Louis to Key West: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from St. Louis to Key West

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from St. Louis to Key West in 2025. You can also book with separate airlines for your outbound and return journeys, from $244 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap St. Louis to Key West flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your St. Louis to Key West airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

St. Louis to Key West Flights

Explore a world of travel with Expedia

Explore a world of travel with Expedia

*Available to One Key members.