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Find 5 Star Hotels in Ladys Island, SC from $266

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Compare Ladys Island 5 Star Hotels with updated room rates, reviews, and availability. Most hotels are fully refundable.

2 outdoor pools, pool umbrellas, sun loungers

"Very friendly people, always ready to assist. Nice restaurants on the property. Beautiful nature! Very quiet. Special thanks to Carmela, concierge who did more than expected to provide us with maximum service."

$581 total

includes taxes & fees

Jun 27 - Jun 28

"The restaurant at the Anchorage 1770 has excellent food with seating on the patio. We made the mistake of not specifying outdoor seating when we made the dinner reservation. The hotel is beautiful and walkable within the historic district."

$425 total

includes taxes & fees

Jun 16 - Jun 17

Explore similar 4-star hotels

Many 4-star hotels have the same amenities as 5-star hotels. See all 4-star hotels in Ladys Island.

Sonesta Resort Hilton Head Island

130 Shipyard Drive, Hilton Head Island, SC

$330

$406 total

includes taxes & fees

Jul 7 - Jul 8

8/10 Very Good! (1,001 reviews)

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Pool Spa Hot tub Breakfast included Waterpark

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Why not ask for the best of accommodations on your excursion to Ladys Island? After all, you love the finer things in life, both at home and when you book a getaway. You'll join the multitudes of vacationers who have made Ladys Island so popular in the last year. There's no reason to delay a getaway to Ladys Island any longer. You can also expect excellent customer service from these hotels, so get ready to kick back and indulge. Our 5-star hotels in Ladys Island are the perfect places to relax in during your next escape. What are you waiting for?

Book the Best Ladys Island 5-Star Hotels

You'll have a wonderful time at one of these 5-star hotels. Top-notch service, delicious meals, and attentive guest service are all ready for you. You're sure to find exactly the accommodation you need. You can also expect excellent customer service from these hotels, so get ready to kick back and indulge. What kind of amenities will make your stay a wonderful one? A Swedish massage to help your cares fall away? A concierge to help you make reservations at that outstanding restaurant? Fluffy down pillows, piping hot coffees, and even space for your family pet in some cases...these hotels have it all. Don't want to take our word for it? Explore our listings and pick the perfect accommodation for your needs.

You won't sleep and order room service the entire time, though. We've got you covered. From doing a bit of shopping to embracing the great outdoors, you'll never be bored on this retreat. No matter what's on your agenda, the 5-star hotels in Ladys Island are waiting for you to relax after an exciting day.

Make Your Escape

The results are in, and Ladys Island 5-star hotels are the place to be when you book your next vacation. If you've been dreaming about a vacation set here, then go ahead and book it. Expedia can help you land a great deal on accommodation. Your great getaway is just a mouse-click away. Select one of Expedia's Ladys Island 5-star hotels today and settle down in total tranquility tomorrow.

Frequently asked questions

What are the best 5-star hotels in Ladys Island?

Anchorage 1770 is a favorite option around the Beaufort neighborhood of Ladys Island based on customer reviews. From its best-in-class services to its top-of-the-line amenities, this 5-star hotel promises a luxurious and comfortable stay.

How much does it cost to stay in a 5-star hotel in Ladys Island?

The amount you pay for a 5-star hotel in Ladys Island can vary depending on when you decide to travel and how long you plan to be away, among a number of factors. Use our price per night filter and other search tools to land the best rate on a luxurious getaway.

Search for the lowest price per night from $266

What makes a hotel 5 stars in Ladys Island?

From high-end restaurants and all-day gyms to swimming pools and premium bedding, the 5-star experience in Ladys Island is all about indulgence and comfort. But it calls for more than just top-notch perks to get a 5-star rating. Stays must also provide exceptional guest-focused services like beauty treatments, on-site laundry and room service any time night or day.

Are there any 5-star all-inclusive resorts in Ladys Island?

Our convenient filters are the quickest way to search for exactly what you’re looking for. Check the “All inclusive” and “5-star” boxes to show the most luxurious properties in Ladys Island where your meals, room, activities and entertainment are included in the upfront price. At these getaways, your trip is pure leisure from the moment you enter the lobby.

What are the top 5-star spa hotels in Ladys Island?

One of the best spa accommodations around Ladys Island, Anchorage 1770 is where you can escape the worries of everyday life. Select this 5-star stay and indulge in a variety of activities and treatments that are aimed at enhancing your overall health and well-being.

Are there any 5-star vacation rentals in Ladys Island?

You won’t find any 5-star vacation rentals in Ladys Island on our site, but there are a range of other highly rated options worth looking into. Browse our vacation rentals in Ladys Island to find the best place for your stay.