Find 5 Star Hotels in Ladys Island, SC from $128
Check availability on Ladys Island 5 Star Hotels
Compare Ladys Island 5 Star Hotels with updated room rates, reviews, and availability. Most hotels are fully refundable.
Montage Palmetto Bluff
Anchorage 1770
Montage Palmetto Bluff Residences
Explore similar 4-star hotels
Hilton Beachfront Resort & Spa Hilton Head Island
Learn more about Ladys Island
Venture to sights like Coosaw Island and Cat Island Driving Range as you discover Ladys Island.
Top Ladys Island Hotel Reviews
Montage Palmetto Bluff
Find out more about Ladys Island
Why not ask for the best of accommodations on your excursion to Ladys Island? After all, you love the finer things in life, both at home and when you book a getaway. You'll join the multitudes of vacationers who have made Ladys Island so popular in the last year. There's no reason to delay a getaway to Ladys Island any longer. You can also expect excellent customer service from these hotels, so get ready to kick back and indulge. Our 5-star hotels in Ladys Island are the perfect places to relax in during your next escape. What are you waiting for?
Book the Best Ladys Island 5-Star Hotels
You'll have a wonderful time at one of these 5-star hotels. Top-notch service, delicious meals, and attentive guest service are all ready for you. You're sure to find exactly the accommodation you need. You can also expect excellent customer service from these hotels, so get ready to kick back and indulge. What kind of amenities will make your stay a wonderful one? A Swedish massage to help your cares fall away? A concierge to help you make reservations at that outstanding restaurant? Fluffy down pillows, piping hot coffees, and even space for your family pet in some cases...these hotels have it all. Don't want to take our word for it? Explore our listings and pick the perfect accommodation for your needs.
You won't sleep and order room service the entire time, though. We've got you covered. From doing a bit of shopping to embracing the great outdoors, you'll never be bored on this retreat. No matter what's on your agenda, the 5-star hotels in Ladys Island are waiting for you to relax after an exciting day.
Make Your Escape
The results are in, and Ladys Island 5-star hotels are the place to be when you book your next vacation. If you've been dreaming about a vacation set here, then go ahead and book it. Expedia can help you land a great deal on accommodation. Your great getaway is just a mouse-click away. Select one of Expedia's Ladys Island 5-star hotels today and settle down in total tranquility tomorrow.
Frequently asked questions
Explore a world of travel with Expedia
- Beaufort Hotels
- Hotels near Newpoint
- 5 Star Hotels in Beaufort
- 4 Star Hotels in Beaufort
- 3 Star Hotels in Beaufort
- Hotels near The Old Point
- Hotels near The Point
- Hotels near USCB Center for the Arts
- Hotels near University of South Carolina-Beaufort
- Cheap Hotels in Beaufort
- Hotels near Pigeon Point
- Beach Hotels in Beaufort
- Hotels near Uptown
- Hotels near Thomas Hepworth House
- Hotels near The Old Commons
- Hotels near Beaufort Museum
- Houseboats in Beaufort County
- Luxury Hotels in Beaufort County
- RV Parks in Beaufort County
- Beaufort County Hotels
- Motels in Beaufort County
- Hotels near Historic District
- Pet-friendly Hotels in Beaufort
- Historic Hotels in Beaufort
- Dataw Island Hotels
- Luxury Hotels in Beaufort
- B&B in Beaufort
- Hotels near Frogmore Intl.
- Flights to Beaufort
- Flights from Beaufort County
- Flights to Beaufort County
- Flights from Raleigh (RDU) to Beaufort (BFT)
- Flights from Charlotte (CLT) to Beaufort (BFT)
- Flights from Atlanta (ATL) to Beaufort (BFT)
- Flights from Savannah (SAV) to Beaufort (BFT)
- Flights from Nashville (BNA) to Beaufort (BFT)
- Flights from Orlando (MCO) to Beaufort (BFT)
- Flights from Knoxville (TYS) to Beaufort (BFT)
- Flights from Tampa (TPA) to Beaufort (BFT)
- Flights from Memphis (MEM) to Beaufort (BFT)
- Flights from New York (LGA) to Beaufort (BFT)
- Flights from Frogmore Intl.
- Flights from Washington (DCA) to Beaufort (BFT)
- Flights from Buffalo (BUF) to Beaufort (BFT)
- Flights from Philadelphia (PHL) to Beaufort (BFT)
- Flights from Miami (MIA) to Beaufort (BFT)
- Flights from Boston (BOS) to Beaufort (BFT)
- Flights from Baltimore (BWI) to Beaufort (BFT)
- Flights from Chicago (ORD) to Beaufort (BFT)
- Flights from Cleveland (CLE) to Beaufort (BFT)
- Flights from Dallas (DFW) to Beaufort (BFT)
- Flights from Hartford (BDL) to Beaufort (BFT)
- Flights from Pittsburgh (PIT) to Beaufort (BFT)
- Flights from Providence (PVD) to Beaufort (BFT)
- Flights from Detroit (DTW) to Beaufort (BFT)
- Flights from Phoenix (PHX) to Beaufort (BFT)
- Flights from New York (JFK) to Beaufort (BFT)
- Flights from Cincinnati (CVG) to Beaufort (BFT)
- Flights from Beaufort
- Flights from St. Louis (STL) to Beaufort (BFT)
- Flights from Austin (AUS) to Beaufort (BFT)
- Flights from Seattle (SEA) to Beaufort (BFT)
- Flights from Washington (IAD) to Beaufort (BFT)
- Flights from Indianapolis (IND) to Beaufort (BFT)
- Flights from Houston (IAH) to Beaufort (BFT)
- Flights from San Diego (SAN) to Beaufort (BFT)
- Flights from Los Angeles (LAX) to Beaufort (BFT)
- Flights from West Palm Beach (PBI) to Beaufort (BFT)
- Flights from New Orleans (MSY) to Beaufort (BFT)
- Flights from Syracuse (SYR) to Beaufort (BFT)
- Flights from Sarasota (SRQ) to Beaufort (BFT)
- Flights from Rochester (ROC) to Beaufort (BFT)
- Flights from Grand Rapids (GRR) to Beaufort (BFT)
- Flights from Fort Wayne (FWA) to Beaufort (BFT)
- Flights from Kansas City (MCI) to Beaufort (BFT)
- Flights from Huntsville (HSV) to Beaufort (BFT)
- Flights from Dayton (DAY) to Beaufort (BFT)
- Flights from Minneapolis (MSP) to Beaufort (BFT)
- Flights from Portland (PDX) to Beaufort (BFT)
- Flights from Johannesburg (JNB) to Beaufort (BFT)
- Flights from Augusta (AGS) to Beaufort (BFT)
- Flights from Madison (MSN) to Beaufort (BFT)
- Flights from Burlington (BTV) to Beaufort (BFT)
- Flights from Las Vegas (LAS) to Beaufort (BFT)
- Flights from Montreal (YUL) to Beaufort (BFT)
- Flights from Des Moines (DSM) to Beaufort (BFT)
- Flights from Hilton Head Island (HHH) to Beaufort (BFT)
- Flights from Baton Rouge (BTR) to Beaufort (BFT)