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Ladys Island Vacation Rentals

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Our top choices for Ladys Island vacation rentals

Relax under the Shade of a Live Oak! MCRD Paris Island and MCAS 10 Minute Drive

Relax under the Shade of a Live Oak! MCRD Paris Island and MCAS 10 Minute Drive
2.0 star property
Beaufort
10.0 out of 10, Exceptional, (4)
"I had success a wonderful stay !!!"
United States
Jasminee L.
$279 nightly
The price is $307
Jan 3 - Jan 4, 2026
Total with taxes and fees
Relax under the Shade of a Live Oak! MCRD Paris Island and MCAS 10 Minute Drive

Amazing Airstream, Beaufort, SC-Enjoy the Journey!

Amazing Airstream, Beaufort, SC-Enjoy the Journey!
Beaufort
9.6 out of 10, Exceptional, (24)
"We love this place. I stay here frequently and enjoy every time. Close and convenient to everything Beaufort has to offer."
United States
Nate P.
$159 nightly
The price is $175
Dec 28 - Dec 29
Total with taxes and fees
Amazing Airstream, Beaufort, SC-Enjoy the Journey!

Marriott's Barony Beach Club

Marriott's Barony Beach Club
3.5 star property
Mid Island
9.6 out of 10, Exceptional, (243)
"Great place for vacation on the beach, nice, clean and quiet areas "
United States
Larisa
$186 nightly
The price is $205
Jan 4 - Jan 5, 2026
Total with taxes and fees
Marriott's Barony Beach Club

Marriott's Harbour Club

Marriott's Harbour Club
3.5 star property
Sea Pines
9.2 out of 10, Wonderful, (61)
"The staff was extremely inviting, professional, and kind. Parking was extremely easy we stayed in villa 3939. It was very large, clean, and had a great view. The property was conveniently located within the area and very walkable. It is very dark at night but we felt safe walking back from dinner. I’d definitely recommend this property for a quiet and peaceful getaway."
United States
ANGELEE
$163 nightly
The price is $179
Jan 3 - Jan 4, 2026
Total with taxes and fees
Marriott's Harbour Club

522 Sunsuite - New to VRBO! Resort Access Included!

522 Sunsuite - New to VRBO! Resort Access Included!
Fripp Island
9.6 out of 10, Exceptional, (4)
"Relaxation was much needed and host was very accommodating and made check in easy. The room was clean, and perfect for our stay. The location was perfect. "
United States
Felicia R.
$307 nightly
The price is $337
Dec 31 - Jan 1, 2026
Total with taxes and fees
522 Sunsuite - New to VRBO! Resort Access Included!

Bright Ocean View Condo Steps From Dining, Golf, Pool, & Beach

Bright Ocean View Condo Steps From Dining, Golf, Pool, & Beach
3.5 star property
Fripp Island
10.0 out of 10, Exceptional, (2)
"Amazing location and views. Very nice. Definitely recommend!"
United States
Christopher
$552 nightly
The price is $607
Dec 29 - Dec 30
Total with taxes and fees
Bright Ocean View Condo Steps From Dining, Golf, Pool, & Beach

Tranquility by the Beach 1st Fl Sleeps 6,King Bed

Tranquility by the Beach 1st Fl Sleeps 6,King Bed
Mid Island
9.4 out of 10, Exceptional, (53)
"Relaxing and comfortable stay"
United States
cheryl j.
$262 nightly
The price is $288
Jan 4 - Jan 5, 2026
Total with taxes and fees
Tranquility by the Beach 1st Fl Sleeps 6,King Bed

501 Sunsuite - New to VRBO! Resort Access Included!

501 Sunsuite - New to VRBO! Resort Access Included!
Fripp Island
9.8 out of 10, Exceptional, (11)
"This was a super getaway. From the friendly gate greeting, the comfortable, attractive room, the quick walk to the beach and everything for a wonderful 2 night stay! We hope to visit again!"
United States
Robbie
$328 nightly
The price is $361
Dec 28 - Dec 29
Total with taxes and fees
501 Sunsuite - New to VRBO! Resort Access Included!

Disney's Hilton Head Island Resort

Disney's Hilton Head Island Resort
3.5 star property
Mid Island
9.6 out of 10, Exceptional, (127)
"While the rooms are overdue a refurbishment, this place is a wondeful resort. "
United States
Chad
$160 nightly
The price is $176
Jan 6 - Jan 7, 2026
Total with taxes and fees
Disney's Hilton Head Island Resort

A Room With a View-1 BR Efficiency Condo Close to Everything.

A Room With a View-1 BR Efficiency Condo Close to Everything.
Edisto Beach
9.8 out of 10, Exceptional, (130)
"Very clean and convenient place to stay. Check in and out were very easy. Communication with host was good!"
United States
Robert S.
$180 nightly
The price is $201
Dec 28 - Dec 29
Total with taxes and fees
A Room With a View-1 BR Efficiency Condo Close to Everything.

Mariners' Nautical Nest on Port Royal's Battery Creek

Mariners' Nautical Nest on Port Royal's Battery Creek
Beaufort
9.8 out of 10, Exceptional, (24)
"We so loved our stay! Our stay was AMAZING! Great location, great views, and the downtown area is very close and easy to get to. Cannot wait to rebook your place!! "
United States
Glenn G.
$189 nightly
The price is $208
Jan 4 - Jan 5, 2026
Total with taxes and fees
Mariners' Nautical Nest on Port Royal's Battery Creek

The Coral Pelican - 1 Block to Sand and Ocean!

The Coral Pelican - 1 Block to Sand and Ocean!
Fripp Island
9.8 out of 10, Exceptional, (19)
"Enjoyed our stay here. Kids and husband loved it and we all had a great time on fripp. Would rent again. "
United States
Neely T.
$645 nightly
The price is $710
Jan 4 - Jan 5, 2026
Total with taxes and fees
The Coral Pelican - 1 Block to Sand and Ocean!

Marriott's Grande Ocean

Marriott's Grande Ocean
3.5 star property
South End
9.4 out of 10, Exceptional, (163)
"Great hotel"
United States
WOOJIN
$211 nightly
The price is $232
Jan 3 - Jan 4, 2026
Total with taxes and fees
Marriott's Grande Ocean

Marriott's Heritage Club

Marriott's Heritage Club
3.5 star property
Sea Pines
9.4 out of 10, Exceptional, (67)
"Another great Marriott, super clean and spacious with the comforts we needed to finish out a long trip (e.g. hot tub, laundry, kitchen). Friendly staff and convenient to the forest reserve."
United States
Landry
$163 nightly
The price is $179
Jan 7 - Jan 8, 2026
Total with taxes and fees
Marriott's Heritage Club

The Grey Pearl on Port Royal's Battery Creek

The Grey Pearl on Port Royal's Battery Creek
Beaufort
10.0 out of 10, Exceptional, (19)
"Great property "
United States
Caleb C.
$193 nightly
The price is $212
Dec 28 - Dec 29
Total with taxes and fees
The Grey Pearl on Port Royal's Battery Creek

Cozy 2-bedroom villa close to Coligny!

Cozy 2-bedroom villa close to Coligny!
2.0 star property
South End
10.0 out of 10, Exceptional, (4)
"Great central location for our trip, plenty of sleeping options (family of 5) and very clean. Host was excellent to coordinate with and check-in was a breeze!"
United States
Brian J.
$257 nightly
The price is $282
Jan 6 - Jan 7, 2026
Total with taxes and fees
Cozy 2-bedroom villa close to Coligny!

Charming Coastal Casa on Beaufort's Battery Creek

Charming Coastal Casa on Beaufort's Battery Creek
Beaufort
9.8 out of 10, Exceptional, (45)
"Great condo. Very clean, well maintained."
United States
Kenton A.
$193 nightly
The price is $212
Dec 28 - Dec 29
Total with taxes and fees
Charming Coastal Casa on Beaufort's Battery Creek

The Offbeat Oasis by the Marsh- State Park Pass Included🏖

The Offbeat Oasis by the Marsh- State Park Pass Included🏖
Saint Helena Island
10.0 out of 10, Exceptional, (15)
"Beautiful marsh views. Close to the beach and state park. Peaceful and well taken care of. "
United States
Dorothy T.
$290 nightly
The price is $319
Jan 1 - Jan 2, 2026
Total with taxes and fees
The Offbeat Oasis by the Marsh- State Park Pass Included🏖

All Inn on Edisto - Cozy Studio Condo Close to Everything

All Inn on Edisto - Cozy Studio Condo Close to Everything
Edisto Beach
9.8 out of 10, Exceptional, (151)
"The property was nice and comfortable. Perfect for a couples get away. We only stayed one night, but were impressed by the property. "
United States
Stephen F.
$175 nightly
The price is $196
Dec 28 - Dec 29
Total with taxes and fees
All Inn on Edisto - Cozy Studio Condo Close to Everything

Coastal Elegance. Poolside. Just steps from the beach! Cards available.

Coastal Elegance. Poolside. Just steps from the beach! Cards available.
Fripp Island
9.4 out of 10, Exceptional, (108)
"The property was great. We were close to all the amenities. "
United States
Dave W.
$287 nightly
The price is $316
Jan 5 - Jan 6, 2026
Total with taxes and fees
Coastal Elegance. Poolside. Just steps from the beach! Cards available.
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Ladys Island Hotel Reviews

Find out more about Ladys Island

Everything you need to know about Ladys Island vacation rentals

Whether you’re excited for the perfect family vacation, a romantic getaway for two, or the ultimate city break, we’ve got the Ladys Island vacation rental for you. At Expedia, you can take your pick from private vacation homes, apartments, condos, resorts, cabins, villas, motels. The list goes on, and on …and on.

There’s just as wide a choice of amenities, too. Maybe you’re dreaming of your own pool, long evenings in a hot tub, or watching the kids laugh through the day at a waterpark. Maybe you just want a quiet retreat in a pet-friendly apartment. Well, we can help you find it. Hunt out the perfect Ladys Island vacation rental for you by simply entering your desired dates. Then check your favorite filters to narrow down your search.

Ladys Island vacation rentals: An excellent choice for every season

Whenever you want to travel, a warm welcome awaits you in Ladys Island. If you’re looking for a little peace, consider booking during the quieter low season months. For more hustle and bustle, you may prefer to visit Ladys Island in high season.

Prices vary throughout the year. Your chosen location, property type, and amenities will impact the cost of your trip, too. The selection of properties we have chosen for you start as low as $175 per night. Rates vary depending on your travel dates, location, and amenities so make a search and you might find even better deals!

How to find incredible deals on Ladys Island rentals

At Expedia, we put the best Ladys Island vacation rentals in one place. All you need to do is take your pick. And as we offer book now, pay later options, as well as free cancellation on some properties, you can plan your trip with total peace of mind. You’ll always find a great deal with Expedia.

To find some top Ladys Island rental deals, enter your travel dates, and sort your search results by price. You can also filter by budget, so you only see accommodation in your ballpark. Next, add any filters you want—and just like that, you’ve built your dream Ladys Island vacation.

If you’re looking for a little inspiration, browse our latest incredible offers, or use the map to view all accommodation in and around Ladys Island. And to unlock even more fantastic deals, bundle your accommodation, flights, and car rental together to save and book with Expedia in complete confidence.