Opelousas Vacation Rentals

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Check prices for these dates

In two weeks
Nov 27 - Nov 29
In two months
Jan 8 - Jan 10
In three months
Feb 5 - Feb 7
In four months
Mar 5 - Mar 7

Our top choices for Opelousas vacation rentals

A small, single-story house with a porch and a wooden fence.

1. Maison D'Memoire Bed & Breakfast Cottages

Maison D'Memoire Bed & Breakfast Cottages
4.0 star property
Rayne
9.8 out of 10, Exceptional, (98 reviews)
"Delightful bed and breakfast venue. Real Southern charm and Lynn (the owner) was a fantastic host. Far exceeded our expectations and genuinely wished we could have stayed longer."
United Kingdom
Paul
$189 nightly
The price is $214
Nov 16 - Nov 17
Total with taxes and fees
Maison D'Memoire Bed & Breakfast Cottages
A modern kitchen with white cabinetry, a round dining table, and a blue door.

2. KING Bed Central

KING Bed Central
2.0 star property
Lafayette
$218 nightly
The price is $251
Dec 2 - Dec 3
Total with taxes and fees
KING Bed Central
A modern two-story building with a dark facade, large windows, and a central entrance with a small tree.

3. Enclave 1 Bedroom Suites

Enclave 1 Bedroom Suites
3.0 star property
Lafayette
9.6 out of 10, Exceptional, (37 reviews)
"We had a great stay here! Nice location and had everything we needed for a long weekend."
United States
Mackenzie
$172 nightly
The price is $187
Nov 19 - Nov 20
Total with taxes and fees
Enclave 1 Bedroom Suites
A modern kitchen with grey cabinets, a central island with a sink, and a dining area with wicker chairs.

4. Enclave 3 Bedroom Luxury Homes

Enclave 3 Bedroom Luxury Homes
4.0 star property
Lafayette
10.0 out of 10, Exceptional, (3 reviews)
"Great Value! I highly recommend this property over hotels in the area."
United States
Roderick
$253 nightly
The price is $276
Nov 15 - Nov 16
Total with taxes and fees
Enclave 3 Bedroom Luxury Homes
A modern living room with a ceiling fan, a sofa, a chair, a small table, and a potted plant.

5. Cozy 1BR Cottage w Kitchen Laundry

Cozy 1BR Cottage w Kitchen Laundry
2.0 star property
Downtown Lafayette
$78 nightly
The price is $90
Nov 12 - Nov 13
Total with taxes and fees
Cozy 1BR Cottage w Kitchen Laundry
A modern kitchen with white cabinets, a central island with bar stools, a stainless steel refrigerator, and a brick backsplash.

6. Enclave 2 Bedroom Luxury Homes

Enclave 2 Bedroom Luxury Homes
3.0 star property
Lafayette
10.0 out of 10, Exceptional, (11 reviews)
"One of my favorite places I’ve stayed"
United States
Willie
$233 nightly
The price is $268
Nov 19 - Nov 20
Total with taxes and fees
Enclave 2 Bedroom Luxury Homes
A modern kitchen with grey cabinets, a central island, stainless steel appliances, and pendant lighting.

7. Cafe House

Cafe House
2.0 star property
Lafayette
$197 nightly
The price is $227
Nov 15 - Nov 16
Total with taxes and fees
Cafe House
A spacious living area with a dining table, sofa, and a ceiling fan.

8. The Royal Inn

The Royal Inn
4.0 star property
Lafayette
10.0 out of 10, Exceptional, (1 review)
"Una estancia maravillosa de principio a fin. La casa es preciosa, elegantemente decorada y extremadamente limpia. Desde que entras se siente un olor delicioso y una sensación de limpieza, tranquilidad y cuidado en cada detalle. La decoración en blanco con los detalles dorados es hermosa, especialmente los baños, y todo está impecablemente mantenido. La habitación principal fue una de mis partes favoritas: la cama es increíblemente cómoda, perfecta para descansar después de un día largo. En...
United States
Yudeika
$273 nightly
The price is $298
Nov 16 - Nov 17
Total with taxes and fees
The Royal Inn
A modern kitchen with white cabinets, stainless steel appliances, a dishwasher, and a dining area with wicker chairs.

9. Iberville Inn

Iberville Inn
4.0 star property
Lafayette
$255 nightly
The price is $278
Nov 22 - Nov 23
Total with taxes and fees
Iberville Inn
A modern kitchen with white cabinetry, a central island with seating, a microwave, stove, and refrigerator.

10. Poydras Inn

Poydras Inn
4.0 star property
Lafayette
$233 nightly
The price is $254
Nov 22 - Nov 23
Total with taxes and fees
Poydras Inn
A modern kitchen with white cabinetry, gold handles, a built-in microwave, and a stove.

11. Decatur Inn

Decatur Inn
4.0 star property
Lafayette
$253 nightly
The price is $276
Nov 17 - Nov 18
Total with taxes and fees
Decatur Inn
A modern kitchen with white cabinetry, a central island with seating, a microwave, stove, and refrigerator.

12. Esplanade Inn

Esplanade Inn
4.0 star property
Lafayette
$261 nightly
The price is $284
Nov 23 - Nov 24
Total with taxes and fees
Esplanade Inn
A modern kitchen with white cabinets, stainless steel appliances, and a round wooden table with wicker chairs.

13. Rampart Inn

Rampart Inn
4.0 star property
Lafayette
$271 nightly
The price is $295
Nov 16 - Nov 17
Total with taxes and fees
Rampart Inn
A spacious living area with a round dining table, a sofa, and a painting of a lake.

14. Canal Inn

Canal Inn
4.0 star property
Lafayette
$226 nightly
The price is $246
Nov 12 - Nov 13
Total with taxes and fees
Canal Inn
A modern living room with a sofa, a coffee table, and a dining area with chairs.

15. Modern Cozy Unit A Fast Wifi Near Downtown Lafayette

Modern Cozy Unit A Fast Wifi Near Downtown Lafayette
2.0 star property
McComb-Veazey
$150 nightly
The price is $172
Dec 7 - Dec 8
Total with taxes and fees
Modern Cozy Unit A Fast Wifi Near Downtown Lafayette
A bedroom with a brown leather sofa, a bed, a nightstand, a lamp, a ceiling fan, and a dining area with a table and chairs.

16. Charming 1BR Cottage Near Downtown Lafayette

Charming 1BR Cottage Near Downtown Lafayette
2.0 star property
Lafayette
$109 nightly
The price is $126
Nov 30 - Dec 1
Total with taxes and fees
Charming 1BR Cottage Near Downtown Lafayette
A living room with a sofa, a coffee table, a fireplace, a television, and a ceiling fan.

17. Private Bedroom in 4BR Home

Private Bedroom in 4BR Home
2.0 star property
Freetown - Port Rico
$84 nightly
The price is $96
Nov 15 - Nov 16
Total with taxes and fees
Private Bedroom in 4BR Home
A modern kitchen with white cabinetry, stainless steel appliances, a central island with stools, and a ceiling fan.

18. Budget-friendly Hostel-style Private Room

Budget-friendly Hostel-style Private Room
2.0 star property
Freetown - Port Rico
$59 nightly
The price is $68
Nov 15 - Nov 16
Total with taxes and fees
Budget-friendly Hostel-style Private Room
A spacious living room with a wooden floor, two grey sofas, a coffee table, and a TV mounted on a wooden cabinet.

19. Steps From Downtown Minutes to the Airport

Steps From Downtown Minutes to the Airport
2.0 star property
McComb-Veazey
6.8 out of 10, (3 reviews)
"great stay highly recommedrd"
United States
ROBERT
$219 nightly
The price is $252
Nov 16 - Nov 17
Total with taxes and fees
Steps From Downtown Minutes to the Airport
A hotel room with a bed, a desk, a chair, a clock, and a window with curtains.

20. Downtown Lafayette 4BR Home With Parking

Downtown Lafayette 4BR Home With Parking
2.0 star property
Downtown Lafayette
10.0 out of 10, Exceptional, (1 review)
"It is a beautiful home the house was"
United States
Destiny
$162 nightly
The price is $186
Nov 30 - Dec 1
Total with taxes and fees
Downtown Lafayette 4BR Home With Parking
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Find vacation rentals that suit your style

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Cabins
Cabins
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Aparthotels
Aparthotels

Top Opelousas Hotel Reviews

A spacious room with a blue sofa, leather armchairs, and a round table.
Hotel Klaus

Hotel Klaus

Hotel Klaus
Washington

10/10 Excellent

A historic gem! Quiet, excellent staff, and comfortable bed. Will be back!
United States
Ron
Reviewed September 29, 2026
Hotel Klaus

Find out more about Opelousas

Everything you need to know about Opelousas vacation rentals

Whether you’re excited for the perfect family vacation, a romantic getaway for two, or the ultimate city break, we’ve got the Opelousas vacation rental for you. At Expedia, you can take your pick from private vacation homes, apartments, condos, resorts, cabins, villas, motels. The list goes on, and on …and on.

There’s just as wide a choice of amenities, too. Maybe you’re dreaming of your own pool, long evenings in a hot tub, or watching the kids laugh through the day at a waterpark. Maybe you just want a quiet retreat in a pet-friendly apartment. Well, we can help you find it. Hunt out the perfect Opelousas vacation rental for you by simply entering your desired dates. Then check your favorite filters to narrow down your search.

Opelousas vacation rentals: An excellent choice for every season

Whenever you want to travel, a warm welcome awaits you in Opelousas. If you’re looking for a little peace, consider booking during the quieter low season months. For more hustle and bustle, you may prefer to visit Opelousas in high season.

Prices vary throughout the year. Your chosen location, property type, and amenities will impact the cost of your trip, too. The selection of properties we have chosen for you start as low as $89 per night. Rates vary depending on your travel dates, location, and amenities so make a search and you might find even better deals!

How to find incredible deals on Opelousas rentals

At Expedia, we put the best Opelousas vacation rentals in one place. All you need to do is take your pick. And as we offer book now, pay later options, as well as free cancellation on some properties, you can plan your trip with total peace of mind. You’ll always find a great deal with Expedia.

To find some top Opelousas rental deals, enter your travel dates, and sort your search results by price. You can also filter by budget, so you only see accommodation in your ballpark. Next, add any filters you want—and just like that, you’ve built your dream Opelousas vacation.

If you’re looking for a little inspiration, browse our latest incredible offers, or use the map to view all accommodation in and around Opelousas. And to unlock even more fantastic deals, bundle your accommodation, flights, and car rental together to save and book with Expedia in complete confidence.

Frequently Asked Questions

Can I find vacation rentals in Opelousas?

Yes, we give you a choice of vacation rentals in Opelousas close to Louisiana Orphan Train Museum, or you can select a more remote option if you're looking for extra privacy while you relax. Opelousas is known for its casinos and cafes. Make sure you have time to check out the art and churches during your trip.

What are some of the best vacation rentals that Opelousas has to offer?

Enclave 1 Bedroom Suites: This vacation home rental near Opelousas has air-conditioning and free WiFi to help you feel perfectly comfortable in your new surroundings. Amenities like a coffee maker and free parking are also available for your convenience.

How many vacation rentals are there in Opelousas?

Choose from 5 Expedia vacation rentals in Opelousas for a memorable vacation.

What’s there to see and do in Opelousas?

Cultural attractions include Louisiana Orphan Train Museum and Fireman's Museum, whereas South Park is one spot to enjoy nature. Evangeline Downs Racetrack & Casino and Opelousas Historic District are other places to visit while you're in town.

What are vacation rentals like in Opelousas?

Vacation rentals are privately owned accommodations you can reserve for several days or more in Opelousas. Vacation rentals feature amenities such as kitchens and laundry facilities to help you enjoy your stay. If you're concerned about cleanliness, a vacation rental can provide a sense of safety away from public hotel elevators and busy lobbies while still allowing you to travel. You'll also get more space in a vacation rental than in a traditional hotel, which is another reason why a vacation rental is a great option for a small group gathering.

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