Find hotels near Saint Francis Healthcare System, Cape Girardeau from $65

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Compare 222 hotels close to Saint Francis Healthcare System with room rates, reviews, and availability. Most hotels are fully refundable.

Lobby
Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center

3.0 star property
1.9 mi from Saint Francis Healthcare System
9.6 out of 10, Exceptional, (1000)
"Great place and staff, very accommodating!"
United States
Megan
$90 nightly
The price is $102
Dec 11 - Dec 12
Total with taxes and fees
Drury Plaza Hotel Cape Girardeau Conference Center
Room, 2 Queen Beds
Tru By Hilton Cape Girardeau

Tru By Hilton Cape Girardeau

2.5 star property
1.9 mi from Saint Francis Healthcare System
9.6 out of 10, Exceptional, (97)
"It was a nice stay"
United States
Douglas
$87 nightly
The price is $99
Dec 14 - Dec 15
Total with taxes and fees
Tru By Hilton Cape Girardeau
Lobby
Quality Inn

Quality Inn

2.5 star property
0.5 mi from Saint Francis Healthcare System
7.2 out of 10, Good, (678)
"Overall was wonderful customer service and breakfast"
United States
Stephanie
$58 nightly
The price is $65
Dec 9 - Dec 10
Total with taxes and fees
Quality Inn
Desk, free WiFi
Town House Inn Cape Giradreau

Town House Inn Cape Giradreau

2.5 star property
1.7 mi from Saint Francis Healthcare System
6.0 out of 10, (206)
"Along a main street but not a lot of noise, especially in the rooms. Rooms exit to the outdoors."
United States
Gary
$73 nightly
The price is $82
Dec 7 - Dec 8
Total with taxes and fees
Town House Inn Cape Giradreau
Courtyard
Hampton Inn Cape Girardeau I 55 East

Hampton Inn Cape Girardeau I 55 East

2.5 star property
2.3 mi from Saint Francis Healthcare System
9.6 out of 10, Exceptional, (780)
"Excellent stay"
United States
Christina
$99 nightly
The price is $112
Dec 21 - Dec 22
Total with taxes and fees
Hampton Inn Cape Girardeau I 55 East
Business center
Drury Inn & Suites Cape Girardeau

Drury Inn & Suites Cape Girardeau

3.0 star property
2.2 mi from Saint Francis Healthcare System
9.4 out of 10, Exceptional, (1008)
"I do love this hotel chain. Another great visit!"
United States
Mark
$90 nightly
The price is $102
Dec 7 - Dec 8
Total with taxes and fees
Drury Inn & Suites Cape Girardeau
Standard Room, 1 Queen Bed, Non Smoking, Garden View | Free WiFi
Rockwood Inn

Rockwood Inn

2.0 star property
2.5 mi from Saint Francis Healthcare System
10.0 out of 10, Exceptional, (18)
"We came into town for a concert and had a blast! The hotel was super comfy, and the staff were friendly. The rooms were very clean and the decor was beautiful! "
United States
Vanessa
$150 nightly
The price is $170
Dec 4 - Dec 5
Total with taxes and fees
Rockwood Inn
Exterior
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

2.5 star property
2.2 mi from Saint Francis Healthcare System
9.4 out of 10, Exceptional, (1001)
"It was right off the interstate with lots of restaurant options "
United States
Kelly
$95 nightly
The price is $107
Dec 22 - Dec 23
Total with taxes and fees
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
Lobby
Courtyard by Marriott Cape Girardeau Downtown

Courtyard by Marriott Cape Girardeau Downtown

3.0 star property
3.3 mi from Saint Francis Healthcare System
9.6 out of 10, Exceptional, (466)
"The staff was very helpful and friendly. The rooms were modern and clean. The downtown location was perfect for us. "
United States
Deborah
$110 nightly
The price is $124
Dec 14 - Dec 15
Total with taxes and fees
Courtyard by Marriott Cape Girardeau Downtown
Lobby
Fairfield Inn & Suites by Marriott Cape Girardeau

Fairfield Inn & Suites by Marriott Cape Girardeau

2.5 star property
2.9 mi from Saint Francis Healthcare System
9.4 out of 10, Exceptional, (138)
"Nice hotel, clean and comfortable "
United States
Laura
$88 nightly
The price is $99
Dec 11 - Dec 12
Total with taxes and fees
Fairfield Inn & Suites by Marriott Cape Girardeau
Lobby
Pear Tree Inn Cape Girardeau Near the Medical Center

Pear Tree Inn Cape Girardeau Near the Medical Center

2.5 star property
2.1 mi from Saint Francis Healthcare System
9.0 out of 10, Wonderful, (1009)
"I liked how comfortable the beds and pillows were."
United States
Christine
$70 nightly
The price is $79
Dec 7 - Dec 8
Total with taxes and fees
Pear Tree Inn Cape Girardeau Near the Medical Center
Lobby sitting area
The Riverview

The Riverview

4.0 star property
3.3 mi from Saint Francis Healthcare System
9.4 out of 10, Exceptional, (464)
"Place was nice and safe"
United States
ryan
$107 nightly
The price is $121
Dec 4 - Dec 5
Total with taxes and fees
The Riverview
Property amenity
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

3.0 star property
2.6 mi from Saint Francis Healthcare System
8.8 out of 10, Excellent, (658)
"Great place "
United States
GUY
$84 nightly
The price is $91
Dec 4 - Dec 5
Total with taxes and fees
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
Lobby
Comfort Suites Jackson-Cape Girardeau

Comfort Suites Jackson-Cape Girardeau

2.5 star property
2.6 mi from Saint Francis Healthcare System
8.2 out of 10, Very Good, (739)
"Dirty "
United States
Jon
$80 nightly
The price is $86
Dec 28 - Dec 29
Total with taxes and fees
Comfort Suites Jackson-Cape Girardeau
Exterior
Candlewood Suites Cape Girardeau by IHG

Candlewood Suites Cape Girardeau by IHG

2.5 star property
3 mi from Saint Francis Healthcare System
8.0 out of 10, Very Good, (875)
"Great room"
United States
Kevin
$70 nightly
The price is $85
Dec 7 - Dec 8
Total with taxes and fees
Candlewood Suites Cape Girardeau by IHG
Lobby
Drury Inn & Suites Jackson MO

Drury Inn & Suites Jackson MO

3.0 star property
7.7 mi from Saint Francis Healthcare System
9.6 out of 10, Exceptional, (1013)
"Breakfast was great- staff was welcoming. Will stay there again."
United States
Laura
$83 nightly
The price is $88
Dec 4 - Dec 5
Total with taxes and fees
Drury Inn & Suites Jackson MO
Economy Single Room, 1 Queen Bed, Kitchenette | Free WiFi, bed sheets
Town House Inn

Town House Inn

2.5 star property
5.8 mi from Saint Francis Healthcare System
7.6 out of 10, Good, (422)
"Room was clean and had a refrigerator and microwave for use if needed."
United States
Sherry
$63 nightly
The price is $69
Jan 1 - Jan 2, 2026
Total with taxes and fees
Town House Inn
Lobby
Pear Tree Inn Cape Girardeau West

Pear Tree Inn Cape Girardeau West

2.5 star property
2.2 mi from Saint Francis Healthcare System
9.0 out of 10, Wonderful, (1001)
"Great stay"
United States
Heather
$70 nightly
The price is $79
Dec 7 - Dec 8
Total with taxes and fees
Pear Tree Inn Cape Girardeau West
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Saint Francis Healthcare System Hotel Reviews

Pear Tree Inn Cape Girardeau Near the Medical Center

Pear Tree Inn Cape Girardeau Near the Medical Center

10/10 Excellent
"I liked how comfortable the beds and pillows were."
Christine 4-night trip
Posted 2 days ago
Pear Tree Inn Cape Girardeau Near the Medical Center

Hotels near other Saint Francis Healthcare System attractions

Southeast Missouri State University

4.4/5 (137 reviews)
Take a campus tour or just explore the area of Southeast Missouri State University, during your trip to Cape Girardeau. While in this family-friendly area, you can savor the top-notch restaurants.
See properties

Cape Splash Family Aquatic Center

Bring the family to Cape Splash Family Aquatic Center and enjoy this exciting amusement park in Cape Girardeau. While in this family-friendly area, you can savor the top-notch restaurants.
See properties

Frequently asked questions

What's the area like around Saint Francis Healthcare System?
Saint Francis Healthcare System is located in Cape Girardeau. This family-friendly area is known for its array of dining options. You'll find 61 hotels and other accommodations within a few miles for a convenient home base.
What's the best place to stay close to Saint Francis Healthcare System?
Quality Inn is one of the top choices for your stay based on our traveler data, and this hotel offers free breakfast and an outdoor pool. It's located just a short 0.5 mi (0.8 km) from Saint Francis Healthcare System. Other good options within a few miles include Drury Plaza Hotel Cape Girardeau Conference Center and Pear Tree Inn Cape Girardeau West.
How many hotels should I expect to find near Saint Francis Healthcare System?
Expedia has 61 hotels and other accommodations a few miles from Saint Francis Healthcare System.
If I need to cancel the hotel reservation for my stay near Saint Francis Healthcare System, will I receive a refund?
Yes, the majority of room reservations are fully refundable if cancelled before the accommodation's cancellation deadline, which often is within 24-48 hours of the scheduled arrival. If you booked a non-refundable reservation, you might be able to cancel it and get a refund within 24 hours of booking. Enter dates in and click on "Search", then use the filter option "fully refundable" to get the best deals available near Saint Francis Healthcare System.
Where can I learn more about changing or cancelling my trip in the area near Saint Francis Healthcare System?
To find more details about updating your stay near Saint Francis Healthcare System or cancelling it, go to https://www.expedia.com/service/.
What can I see and do near Saint Francis Healthcare System?
You might spend a leisurely day outdoors at Cape Rock Park and Fort D Historic Site. Cape Splash Family Aquatic Center, Cape Girardeau Conservation Nature Center, and Lazy L Safari Park are fun stops for the whole family while you're in town. You might plan a visit to Show Me Center or eDen Spa & Salon while you're in the area.