San Sisto

Travel Guide

Villa di Piazzano - Small Luxury Hotel of the World

Villa di Piazzano - Small Luxury Hotel of the World

5 out of 5
Localita Piazzano, C.P. 6 Cortona AR
$629 nightly
The price is $701 total per night from Oct 9 to Oct 10
$701 total
Oct 9 - Oct 10
Total with taxes and fees
Book a stay at this luxury hotel in Cortona. Enjoy free WiFi, free parking, and room service. Our guests praise the helpful staff in our reviews. Popular attractions ...
9.8/10 Exceptional! (251 reviews)
"Stunning little hotel with the most beautiful setting, gardens and pool. The room was exceptionally appointed clean. The best part of the stay was the restaurant. The best meals we had on our entire trip. Definitely recommend hiring e-bikes and riding up to Cortona!"

Reviewed on Sep 20, 2026

Villa di Piazzano - Small Luxury Hotel of the World
Giotto Hotel & Spa

Giotto Hotel & Spa

4 out of 5
Via Fontebella 41 Assisi PG
$122 nightly
The price is $143 total per night from Sep 30 to Oct 1
$143 total
Sep 30 - Oct 1
Total with taxes and fees
Book a stay at this spa hotel in Assisi. Enjoy free WiFi, a full-service spa, and 3 restaurants. Our guests praise the helpful staff in our reviews. Popular ...
9/10 Wonderful! (837 reviews)
"Great views !!"

Reviewed on Sep 17, 2026

Giotto Hotel & Spa
La Meridiana Bleisure Hotel

La Meridiana Bleisure Hotel

4 out of 5
42 del Discobolo St. Perugia PG
$93 nightly
The price is $109 total per night from Oct 25 to Oct 26
$109 total
Oct 25 - Oct 26
Total with taxes and fees
Book a stay at this family-friendly hotel in Perugia. Enjoy free breakfast, free parking, and an outdoor pool. Our guests praise the helpful staff in our reviews. ...
La Meridiana Bleisure Hotel
See all 3,586 properties in San Sisto
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
TH Perugia - Castello di Monterone

TH Perugia - Castello di Monterone

Strada Montevile 3 Perugia PG
Book a stay at this luxury residence in Perugia. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular ...
9.8/10 Exceptional! (325 reviews)
"Fantastic view of the valley. Rooms were clean, staff was friendly, and when else do you get to stay in a castle?! Roof top access as well, with some tables and chairs for lounging up top, weather permitting. Id give 6/5 stars if I could."

Reviewed on Sep 28, 2026

TH Perugia - Castello di Monterone
Aethos Hotel Saragano

Aethos Hotel Saragano

Via Milano 20 Gualdo Cattaneo PG
Book a stay at this spa aparthotel in Gualdo Cattaneo. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Sanctuary of Madonna della Valle ...
9.4/10 Exceptional! (39 reviews)
"Très tranquille, qualité de la chambre etait superbe, de plus le service du restaurant etait très chaleureux et professionnel. Nourriture très fraîche"

Reviewed on Sep 10, 2026

Aethos Hotel Saragano
Big estate with private indoor & outdoor pool, gym, billiard in Umbria

Big estate with private indoor & outdoor pool, gym, billiard in Umbria

Gaglietole di Collazzone FL
Book a stay at this family-friendly villa in Collazzone. Enjoy free WiFi, private pools, and a fitness center. Popular attractions Sanctuary of Madonna della ...
9.8/10 Exceptional! (45 reviews)
"Stefano was an exceptional host—friendly, welcoming, and incredibly helpful throughout our stay. The villa exceeded all of our expectations. Every bedroom had its own private bathroom, which made it perfect for our group, and the kitchen was fully equipped with everything we needed, from making our ..."

Reviewed on Jul 23, 2026

Big estate with private indoor & outdoor pool, gym, billiard in Umbria
See all properties in San Sisto
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Things to do

Perugia: Old Town Walking Tour, Piazza IV Novembre

Perugia: Old Town Walking Tour, Piazza IV Novembre

$34
per adult
Perugia: Old Town Walking Tour, Piazza IV Novembre
From Rome: Explore Assisi, Civita di Bagnoregio & Orvieto

Rome Day Tour to Assisi, Civita di Bagnoregio & Orvieto

$113
per adult
88% of travellers recommend
Rome Day Tour to Assisi, Civita di Bagnoregio & Orvieto
Pic nic Deluxe Assisi and wine tasting 5 wines

Pic nic Deluxe Assisi and wine tasting 5 wines

$51
per adult
Pic nic Deluxe Assisi and wine tasting 5 wines
Pic nic Deluxe Assisi for 2 and wine tasting 5 wines

Pic nic Deluxe Assisi for 2 and wine tasting 5 wines

$44
per adult
Pic nic Deluxe Assisi for 2 and wine tasting 5 wines
Cannara: Herbal Liqueur tasting with food pairing

Cannara: Herbal Liqueur tasting with food pairing

$34
per adult
Cannara: Herbal Liqueur tasting with food pairing
Assisi: Wine tasting, gourmet pairing, walk in the vineyards

Assisi: Wine tasting, gourmet pairing, walk in the vineyards

$29
per adult
100% of travellers recommend
Assisi: Wine tasting, gourmet pairing, walk in the vineyards
See all activities in San Sisto

Frequently asked questions

Is San Sisto worth visiting?
San Sisto is worth visiting for its standout attractions, including the Perugina Chocolate Factory, which offers a unique experience. Travelers also benefit from practical transit access via train, making exploration convenient. For those who prefer to cook, local grocers are available for self-catering.
When is the best time to visit San Sisto?
The best time to visit San Sisto is from May through September, when the climate is typically most pleasant for travelers. For fewer crowds and better value, consider visiting during the quieter months of December through March, which offer a cooler season to explore the area.
What is a good itinerary length for San Sisto?
A good itinerary length for San Sisto is one day to visit the Perugina Chocolate Factory, where you can take a Baci Perugina Chocolate tour and enjoy an Umbrian food tasting. If you prefer a more unhurried experience to fully savor the offerings, a two-day trip would be ideal. See San Sisto Activities.
How do you get around San Sisto?
In San Sisto, travelers can primarily get around using the train, with Perugia Silvestrini Station serving as a key access point. This makes train travel a practical option for exploring the local area. For reaching destinations not covered by train, rideshare services offer an additional convenient way to travel.
What are the top things to do in and around San Sisto?
In San Sisto, travelers can take a Baci Perugina Chocolate tour and enjoy Umbrian food tasting.
Can I book a refundable hotel in San Sisto?
Yes, Expedia offers many flexible booking options, and you can look for refundable hotels in San Sisto by entering your dates and using the refundable or fully refundable filter. Always check the hotel's cancellation policy before you book, since terms can vary by hotel, and visit Expedia help center for further details.
Why book a trip to San Sisto with Expedia?
Expedia makes it easier to plan your San Sisto trip with travel tools, flexible search options, and bookable trip components all in one place. You can organize your plans in one account and use Expedia to help build a trip that fits your budget and travel style. Find out more about how by visiting Expedia's Trip Planner page.
Should I stay in a hotel or vacation rental in San Sisto?
The best choice depends on your travel style. Hotels in San Sisto can be a good fit for convenience, on-site amenities, and shorter stays, while vacation rentals may offer more space, privacy, and home-style amenities for longer trips, families, or groups. With Expedia, you can compare both options side by side, read traveler reviews, and filter by amenities to find the right fit for your trip.
How can I manage my San Sisto trip on Expedia?
Once you've booked your San Sisto trip, you can manage it through your Expedia account or the Expedia app. You can view your itinerary, access booking details, make eligible changes, and check for updates in My Trips. The Expedia app can also help you stay organized while you travel.
What if I need help during my San Sisto trip?
Expedia offers customer support before, during, and after your San Sisto trip. If your plans change or something unexpected happens, you can review your booking in My Trips and use Expedia help center channels for help with eligible changes, cancellations, or travel issues.
How can Expedia help me plan my first trip to San Sisto?
If it's your first trip to San Sisto, Expedia can help you plan by bringing together stays, flights, activities, traveler reviews, and trip-planning tools in one place. With Expedia's Trip Planner you can compare options, read reviews from other travelers, and build an itinerary that matches your interests and budget.
How can I save on my San Sisto hotel booking with Expedia?
Join One Key™ for free to unlock instant discounts with Member Prices on select hotels. You can also earn and use OneKeyCash™* on eligible bookings on Expedia. Booking in advance is usually another great way to save on your San Sisto hotel.

*Excludes taxes and fees. OneKeyCash is not redeemable for cash and can only be used on Expedia and other participating brands.

Cities near San Sisto

A historic street with ornate street lamps, a fountain, and outdoor cafes.

Perugia

A historic town with a prominent tower, lush green hills, and distant mountains.

Corciano

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