Book Santee Bed & Breakfast

Start date: Check-in selected.
To Date
End date: Check-out
  • Bundle & Save

    Get more, spend less whenever you see Bundle & Save deals
  • OneKeyCash

    Earn OneKeyCash on all your eligible bookings
  • Upfront pricing

    We are not like the others - we include taxes and fees

Check prices for these dates

Next weekend
In two weeks
In one month
In two months
No exact matches found, but these alternatives could be just right

Recommended hotels in Santee

Tru By Hilton Santee

Tru By Hilton Santee
2.5 star property
Santee
9.2 out of 10, Wonderful, (647)
"Nice place to stay"
Canada
Tanya
$105 nightly
The price is $117
Jan 4 - Jan 5, 2026
Total with taxes and fees
Tru By Hilton Santee

Baymont by Wyndham Santee

Baymont by Wyndham Santee
2.5 star property
Santee
8.0 out of 10, Very Good, (1421)
"Very friendly staff. "
United States
Ramil
$80 nightly
The price is $89
Dec 23 - Dec 24
Total with taxes and fees
Baymont by Wyndham Santee

Fairfield Inn & Suites by Marriott Santee

Fairfield Inn & Suites by Marriott Santee
2.5 star property
Santee
9.8 out of 10, Exceptional, (1003)
"Staff very friendly, room super clean"
United States
Karine
$121 nightly
The price is $134
Jan 4 - Jan 5, 2026
Total with taxes and fees
Fairfield Inn & Suites by Marriott Santee

Holiday Inn Santee by IHG

Holiday Inn Santee by IHG
3.0 star property
Santee
8.2 out of 10, Very Good, (975)
"Was able to walk to convenience store and other dinning alternatives. Safe secure building"
United States
Joan
$108 nightly
The price is $120
Dec 28 - Dec 29
Total with taxes and fees
Holiday Inn Santee by IHG

Hampton Inn Santee-I-95

Hampton Inn Santee-I-95
2.5 star property
Santee
9.6 out of 10, Exceptional, (1005)
"Rooms are clean, friendly staff and easy to get off and back on the highway. "
United States
Michelle
$134 nightly
The price is $149
Jan 18 - Jan 19, 2026
Total with taxes and fees
Hampton Inn Santee-I-95

Best Western Plus Santee Inn

Best Western Plus Santee Inn
2.5 star property
Santee
8.8 out of 10, Excellent, (1002)
"Nice rooms and very good breakfast items."
United States
Stephen
$118 nightly
The price is $131
Dec 29 - Dec 30
Total with taxes and fees
Best Western Plus Santee Inn

Comfort Inn & Suites Santee

Comfort Inn & Suites Santee
2.5 star property
Santee
8.0 out of 10, Very Good, (1002)
"Staff was pleasant and helpful with restaurant information, room clean. "
United States
Mark
$105 nightly
The price is $117
Jan 4 - Jan 5, 2026
Total with taxes and fees
Comfort Inn & Suites Santee

Travelodge by Wyndham Santee

Travelodge by Wyndham Santee
2.0 star property
Santee
7.0 out of 10, Good, (678)
"The room was very nice. It was newly renovated and I loved the upgrade. The beds were comfortable and warm. We didn’t eat breakfast because we were meeting someone for breakfast. "
United States
Alice
$61 nightly
The price is $68
Jan 5 - Jan 6, 2026
Total with taxes and fees
Travelodge by Wyndham Santee

Tranquil Getaways W/Heated Pool and Fishing

Tranquil Getaways W/Heated Pool and Fishing
Elloree
8.4 out of 10, Very Good, (6)
"Great property the pool was so fun! Mostly stayed on the property and lounged around for a nice relaxing stay!"
United States
Tori P.
$191 nightly
The price is $212
Jan 2 - Jan 3, 2026
Total with taxes and fees
Tranquil Getaways W/Heated Pool and Fishing

Kindred Spirits Retreat at Lake Marion - Pet Friendly Getaway Minutes from I-95!

Kindred Spirits Retreat at Lake Marion - Pet Friendly Getaway Minutes from I-95!
Santee
10.0 out of 10, Exceptional, (37)
"Amazing host, comfy furniture, the fenced in yard was perfect for our fur babies! Hope to stay here again. 1.2 miles away from I-95! "
United States
Lauren B.
$356 nightly
The price is $395
Dec 27 - Dec 28
Total with taxes and fees
Kindred Spirits Retreat at Lake Marion - Pet Friendly Getaway Minutes from I-95!

Peaceful Condo on Lake Marion in Santee, SC. Time to play golf and go fishing!

Peaceful Condo on Lake Marion in Santee, SC. Time to play golf and go fishing!
Santee
10.0 out of 10, Exceptional, (11)
"Nice place great location "
United States
Jeffrey H.
$395 nightly
The price is $438
Jan 12 - Jan 13, 2026
Total with taxes and fees
Peaceful Condo on Lake Marion in Santee, SC. Time to play golf and go fishing!

Red Roof Inn Santee

Red Roof Inn Santee
2.0 star property
Santee
6.6 out of 10, (638)
"A good option if traveling with pets. The hotel is clean and well maintained but dated. "
United States
Karen
$70 nightly
The price is $78
Dec 23 - Dec 24
Total with taxes and fees
Red Roof Inn Santee

Super 8 by Wyndham Santee

Super 8 by Wyndham Santee
2.0 star property
Santee
6.8 out of 10, (441)
"The staff was very friendly and helpful. Room was clean and beds were so comfortable. "
United States
Kathy
$75 nightly
The price is $83
Dec 23 - Dec 24
Total with taxes and fees
Super 8 by Wyndham Santee

Quality Inn & Suites Santee I-95

Quality Inn & Suites Santee I-95
2.5 star property
Santee
6.0 out of 10, (455)
"exellent service"
United States
Mirjana
$59 nightly
The price is $66
Dec 29 - Dec 30
Total with taxes and fees
Quality Inn & Suites Santee I-95

Ramada by Wyndham Santee I-95

Ramada by Wyndham Santee I-95
2.0 star property
Santee
6.2 out of 10, (543)
"The grounds and property were clean and you could tell they take pride in what they're offering."
United States
Eric
$80 nightly
The price is $88
Dec 30 - Dec 31
Total with taxes and fees
Ramada by Wyndham Santee I-95

Econo Lodge Santee

Econo Lodge Santee
2.0 star property
Santee
6.4 out of 10, (309)
"Last minute arrangements stay was quiet and peaceful "
United States
Iasia
$63 nightly
The price is $70
Jan 7 - Jan 8, 2026
Total with taxes and fees
Econo Lodge Santee

Fairfield Inn by Marriott Orangeburg

Fairfield Inn by Marriott Orangeburg
2.5 star property
Orangeburg
8.4 out of 10, Very Good, (700)
"The staff was great and the room was clean."
United States
Juillet
$84 nightly
The price is $93
Dec 30 - Dec 31
Total with taxes and fees
Fairfield Inn by Marriott Orangeburg

Tru by Hilton Orangeburg

Tru by Hilton Orangeburg
2.5 star property
Orangeburg
9.2 out of 10, Wonderful, (1002)
"Wonderful stay"
United States
Josephine
$106 nightly
The price is $117
Jan 5 - Jan 6, 2026
Total with taxes and fees
Tru by Hilton Orangeburg

Spark by Hilton Orangeburg

Spark by Hilton Orangeburg
2.5 star property
Orangeburg
7.8 out of 10, Good, (1004)
"Great place and pet friendly. Rooms are clean and comfortable."
United States
Penny
$87 nightly
The price is $97
Dec 25 - Dec 26
Total with taxes and fees
Spark by Hilton Orangeburg

Best Inn of Manning

Best Inn of Manning
2.5 star property
Manning
8.0 out of 10, Very Good, (9)
"Clean, comfortable, and efficient stay with friendly helpful staff and great value for your money."
United States
Loren
$73 nightly
The price is $81
Dec 24 - Dec 25
Total with taxes and fees
Best Inn of Manning
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Save an average of 15% on thousands of hotels when you're signed in

Top Santee Hotel Reviews

Find out more about Santee

Santee B&B information

Number of reviews
12,864
Accommodation
0 B&B
Lowest Price
$66
Highest Price
$438

Frequently asked questions

What is the nightly rate for a Bed and Breakfast in Santee?
Prices for B&Bs in Santee often vary, but you can find a great deal from $66 with Expedia. All sorts of factors affect price, such as location and the time of year. It usually costs more to stay at Santee B&Bs over the weekend too. Travelers can find the best deals by being flexible with their dates, and by using our filters to sort prices from low to high.
When is the best time to book a Bed & Breakfast in Santee?
The best time to book a B&B in Santee is during the spring months of March to May, when the weather is pleasantly warm, and outdoor activities are in full swing. This season attracts visitors looking for both relaxation and adventure, with opportunities for hiking, biking, and exploring the beautiful landscapes of the area. As temperatures typically range from the mid-50s to the low 80s Fahrenheit, you can comfortably enjoy the numerous parks and natural sites nearby.

April stands out as the most popular month to visit Santee, offering a lively atmosphere and vibrant community events. It's an ideal time for outdoor enthusiasts to experience the blooming flora and fauna, while also taking advantage of the local attractions. The pleasant weather sets the superb backdrop for exploring parks like Santee Lakes, where you can enjoy picnicking, fishing, or simply soaking in the scenery.

If you're seeking a more budget-friendly option, consider visiting in November. This month provides a quieter experience, allowing you to appreciate the tranquility of Santee while still enjoying mild temperatures. You can revel in local culture, explore less crowded attractions, and take advantage of potential off-season deals.
What is the difference between a Santee B&B and a hotel?
Every Santee B&B has its own unique feel. Whether it's a cozy reading space or a sunlit breakfast nook to enjoy your morning cup of coffee, the quaint details are what make bed and breakfasts a home away from home. Travelers can look forward to personal touches, thoughtful amenities and of course a scrumptious breakfast at Santee B&Bs.

Explore a world of travel with Expedia