$194 Cheap American Airlines flights New Orleans (MSY) to Sioux Falls (FSD)

Use the "Price (lowest to highest)" filter on Expedia to look for cheap American Airlines return flights from $259 from MSY to FSD. Affordable one-way options from $194 are available too.**These prices were available on Expedia within the past 7 days, for flights departing within the next year. Prices and availability are subject to change. Additional terms apply.

Search for cheap American Airlines flights from Louis Armstrong New Orleans Intl. Airport (MSY) to Sioux Falls Regional Airport (FSD) one to three months before your departure date. Travelers who book domestic flights 34 to 86 days in advance can save 25% compared to those who book just 6 to 12 days ahead. No matter the fare type and journey, the best day of the week to book a domestic flight is generally Sunday and the most expensive day is typically Monday. Passengers who book on a Sunday can save 6% on average compared to those who book on a Monday.**Ideal booking window recommendation is based on average round-trip ticket prices for January through November for 2024. Best day of the week to book recommendation is based on average round-trip ticket prices for January through October 2024. All data sourced from ARC's global airline sales database.

Sort your results by "Early Morning" and "Morning" to find the earliest departures from MSY to FSD. Heading off early means you're less likely to experience cancellations.**Most reliable time of the day recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.