$255 Cheap Flights from Panama City (ECP) to Columbia (COU)

View $255 flight on Mon, Oct 6, 2025Opens in a new window

Popular airlines from Northwest Florida Beaches Intl. Airport (ECP) to Columbia, MO (COU-Columbia Regional)

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Cheap Flights from Panama City to Columbia (ECP-COU)

Prices were available within the past 7 days and start at $255 for one-way flights and $464 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

American Airlines
Fri, Sep 26 - Mon, Sep 29
ECP
Panama City
COU
Columbia
$464 Roundtrip, found 4 days ago
$464
Roundtrip
found 4 days ago
Select American Airlines flight, departing Fri, Sep 26 from Panama City to Columbia, returning Mon, Sep 29, priced at $464 found 4 days ago
American Airlines
Tue, Oct 7 - Sat, Oct 25
ECP
Panama City
COU
Columbia
$480 Roundtrip, found 3 days ago
$480
Roundtrip
found 3 days ago
Select American Airlines flight, departing Tue, Oct 7 from Panama City to Columbia, returning Sat, Oct 25, priced at $480 found 3 days ago
American Airlines
Tue, Oct 7 - Tue, Oct 21
ECP
Panama City
COU
Columbia
$486 Roundtrip, found 3 days ago
$486
Roundtrip
found 3 days ago
Select American Airlines flight, departing Tue, Oct 7 from Panama City to Columbia, returning Tue, Oct 21, priced at $486 found 3 days ago
American Airlines
Wed, Oct 1 - Sat, Oct 18
ECP
Panama City
COU
Columbia
$490 Roundtrip, found 3 days ago
$490
Roundtrip
found 3 days ago
Select American Airlines flight, departing Wed, Oct 1 from Panama City to Columbia, returning Sat, Oct 18, priced at $490 found 3 days ago
American Airlines
Wed, Nov 19 - Mon, Dec 8
ECP
Panama City
COU
Columbia
$507 Roundtrip, found 3 days ago
$507
Roundtrip
found 3 days ago
Select American Airlines flight, departing Wed, Nov 19 from Panama City to Columbia, returning Mon, Dec 8, priced at $507 found 3 days ago
American Airlines
Sat, Oct 4 - Mon, Oct 6
ECP
Panama City
COU
Columbia
$513 Roundtrip, found 3 days ago
$513
Roundtrip
found 3 days ago
Select American Airlines flight, departing Sat, Oct 4 from Panama City to Columbia, returning Mon, Oct 6, priced at $513 found 3 days ago
American Airlines
Thu, Oct 2 - Sat, Oct 18
ECP
Panama City
COU
Columbia
$517 Roundtrip, found 3 days ago
$517
Roundtrip
found 3 days ago
Select American Airlines flight, departing Thu, Oct 2 from Panama City to Columbia, returning Sat, Oct 18, priced at $517 found 3 days ago
American Airlines
Thu, Oct 9 - Wed, Oct 29
ECP
Panama City
COU
Columbia
$523 Roundtrip, found 3 days ago
$523
Roundtrip
found 3 days ago
Select American Airlines flight, departing Thu, Oct 9 from Panama City to Columbia, returning Wed, Oct 29, priced at $523 found 3 days ago
American Airlines
Sun, Oct 5 - Sat, Oct 18
ECP
Panama City
COU
Columbia
$524 Roundtrip, found 3 days ago
$524
Roundtrip
found 3 days ago
Select American Airlines flight, departing Sun, Oct 5 from Panama City to Columbia, returning Sat, Oct 18, priced at $524 found 3 days ago
United
Wed, Oct 8 - Fri, Oct 24
ECP
Panama City
COU
Columbia
$575 Roundtrip, found 3 days ago
$575
Roundtrip
found 3 days ago
Select United flight, departing Wed, Oct 8 from Panama City to Columbia, returning Fri, Oct 24, priced at $575 found 3 days ago
Flights from Panama City (ECP) to Columbia (COU)
Origin airport
Northwest Florida Beaches Intl.
Destination airport
Columbia Regional
Roundtrip price
$464
Distance
688 mi

Panama City to Columbia Flights

The cheapest times to fly from Panama City to Columbia

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Panama City to Columbia are during the month of September. You can find some of the cheapest flights from Panama City to Columbia with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Panama City to Columbia

Sunday is one of the best days to book for cheap flights from Panama City to Columbia: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Panama City to Columbia

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Panama City to Columbia in 2025. You can also book with separate airlines for your outbound and return journeys, from $255 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Panama City to Columbia flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Panama City to Columbia airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Frequently asked questions

How much does a flight from Northwest Florida Beaches Intl. Airport (ECP) to Columbia Regional Airport (COU) cost?
Grab a cheap one-way flight from $255 or cheap return flight from $464 from Northwest Florida Beaches Intl. Airport (ECP) to Columbia Regional Airport (COU) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to see our cheapest flight deals on this route.
What is the cheapest month to fly from Northwest Florida Beaches Intl. Airport (ECP) to Columbia Regional Airport (COU)?
September is the cheapest month to fly from ECP to COU. Traveling during an off-peak travel window is often the key to landing a great deal.
What is the cheapest airline that flies from Northwest Florida Beaches Intl. Airport (ECP) to Columbia Regional Airport (COU)?
Expedia's filter tool lets you easily compare airlines, flight times and fares all in one place. Choose your preferences, then sort by "Price (lowest to highest)" to find the carrier with the cheapest ECP to COU flight.
How many flights per day from Northwest Florida Beaches Intl. Airport (ECP) to Columbia Regional Airport (COU)?
You'll need to hop on a flight with a layover if you're traveling from Northwest Florida Beaches Intl. Airport (ECP) to Columbia Regional Airport (COU). Direct flights don't operate daily on this route. However, simply filter your search to include one or more stops to find the best option for your trip.
What day of the week has the most flights from ECP to COU?
Friday is generally the busiest day for flights, while Tuesday is often the quietest.* Keep in mind that flight schedules can change depending on a range of factors, such as the season and airline.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Northwest Florida Beaches Intl. Airport (ECP) to Columbia Regional Airport (COU)?
To arrive at Columbia Regional Airport (COU) without delays, select a flight that takes off from Northwest Florida Beaches Intl. Airport (ECP) before 3 PM. The chance of cancellations is 22% higher, on average, for departures after this time.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Northwest Florida Beaches Intl. Airport (ECP) to Columbia Regional Airport (COU) last-minute?
Booking your ticket from ECP to COU right before your getaway is usually more expensive. But if you're flexible with your departure dates and times, you could snag a cheap last-minute fare.
Is it cheaper to book an ECP to COU flight and hotel package?
Opting for an ECP to COU flight and hotel package tends to be cheaper than booking separately. With Expedia, you can enjoy the convenience of organizing your travels all in one place. Select from our wide range of accommodations and then add activities, car rentals and flights to your booking. Bundle everything together, and you could save hundreds of dollars.
Can I cancel or change the date of my flight from Northwest Florida Beaches Intl. Airport (ECP) to Columbia Regional Airport (COU)?
You can usually reschedule or cancel your ECP to COU flight. However, for bookings made more than 24 hours ago, additional charges may apply. Refer to your airline's policies in your itinerary to see what changes are allowed and if any costs are involved. You'll also find further details on our Customer Service portal.

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*Available to One Key members.