$241 Cheap Flights from Florence (FLO) to Buffalo (BUF)

View $241 flight on Mon, May 4, 2026Opens in a new window

Popular airlines from Florence, SC (FLO-Florence Regional) to Buffalo Niagara Intl. Airport (BUF)

Cheap Flights from Florence to Buffalo (FLO-BUF)

Prices were available within the past 7 days and start at $241 for one-way flights and $481 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

American Airlines
Thu, Dec 4 - Mon, Dec 8
FLO
Florence
BUF
Buffalo
$481 Roundtrip, found 16 hours ago
$481
Roundtrip
found 16 hours ago
Select American Airlines flight, departing Thu, Dec 4 from Florence to Buffalo, returning Mon, Dec 8, priced at $481 found 16 hours ago
American Airlines
Sat, Aug 9 - Fri, Aug 15
FLO
Florence
BUF
Buffalo
$498 Roundtrip, found 6 days ago
$498
Roundtrip
found 6 days ago
Select American Airlines flight, departing Sat, Aug 9 from Florence to Buffalo, returning Fri, Aug 15, priced at $498 found 6 days ago
American Airlines
Thu, Dec 4 - Mon, Dec 8
FLO
Florence
BUF
Buffalo
$505 Roundtrip, found 16 hours ago
$505
Roundtrip
found 16 hours ago
Select American Airlines flight, departing Thu, Dec 4 from Florence to Buffalo, returning Mon, Dec 8, priced at $505 found 16 hours ago
American Airlines
Fri, Aug 8 - Sat, Aug 16
FLO
Florence
BUF
Buffalo
$507 Roundtrip, found 6 days ago
$507
Roundtrip
found 6 days ago
Select American Airlines flight, departing Fri, Aug 8 from Florence to Buffalo, returning Sat, Aug 16, priced at $507 found 6 days ago
American Airlines
Fri, Aug 8 - Fri, Aug 15
FLO
Florence
BUF
Buffalo
$508 Roundtrip, found 6 days ago
$508
Roundtrip
found 6 days ago
Select American Airlines flight, departing Fri, Aug 8 from Florence to Buffalo, returning Fri, Aug 15, priced at $508 found 6 days ago
American Airlines
Fri, Aug 8 - Wed, Aug 13
FLO
Florence
BUF
Buffalo
$518 Roundtrip, found 6 days ago
$518
Roundtrip
found 6 days ago
Select American Airlines flight, departing Fri, Aug 8 from Florence to Buffalo, returning Wed, Aug 13, priced at $518 found 6 days ago
American Airlines
Fri, Aug 8 - Fri, Aug 15
FLO
Florence
BUF
Buffalo
$529 Roundtrip, found 6 days ago
$529
Roundtrip
found 6 days ago
Select American Airlines flight, departing Fri, Aug 8 from Florence to Buffalo, returning Fri, Aug 15, priced at $529 found 6 days ago
American Airlines
Thu, Dec 4 - Mon, Dec 8
FLO
Florence
BUF
Buffalo
$530 Roundtrip, found 16 hours ago
$530
Roundtrip
found 16 hours ago
Select American Airlines flight, departing Thu, Dec 4 from Florence to Buffalo, returning Mon, Dec 8, priced at $530 found 16 hours ago
American Airlines
Thu, Aug 7 - Sat, Aug 16
FLO
Florence
BUF
Buffalo
$532 Roundtrip, found 6 days ago
$532
Roundtrip
found 6 days ago
Select American Airlines flight, departing Thu, Aug 7 from Florence to Buffalo, returning Sat, Aug 16, priced at $532 found 6 days ago
American Airlines
Wed, Aug 6 - Fri, Aug 15
FLO
Florence
BUF
Buffalo
$533 Roundtrip, found 6 days ago
$533
Roundtrip
found 6 days ago
Select American Airlines flight, departing Wed, Aug 6 from Florence to Buffalo, returning Fri, Aug 15, priced at $533 found 6 days ago
American Airlines
Wed, Aug 6 - Mon, Aug 18
FLO
Florence
BUF
Buffalo
$548 Roundtrip, found 6 days ago
$548
Roundtrip
found 6 days ago
Select American Airlines flight, departing Wed, Aug 6 from Florence to Buffalo, returning Mon, Aug 18, priced at $548 found 6 days ago
American Airlines
Mon, Aug 25 - Thu, Aug 28
FLO
Florence
BUF
Buffalo
$573 Roundtrip, found 3 days ago
$573
Roundtrip
found 3 days ago
Select American Airlines flight, departing Mon, Aug 25 from Florence to Buffalo, returning Thu, Aug 28, priced at $573 found 3 days ago
American Airlines
Thu, Dec 4 - Mon, Dec 8
FLO
Florence
BUF
Buffalo
$605 Roundtrip, found 16 hours ago
$605
Roundtrip
found 16 hours ago
Select American Airlines flight, departing Thu, Dec 4 from Florence to Buffalo, returning Mon, Dec 8, priced at $605 found 16 hours ago
American Airlines
Thu, Dec 4 - Mon, Dec 8
FLO
Florence
BUF
Buffalo
$651 Roundtrip, found 16 hours ago
$651
Roundtrip
found 16 hours ago
Select American Airlines flight, departing Thu, Dec 4 from Florence to Buffalo, returning Mon, Dec 8, priced at $651 found 16 hours ago
American Airlines
Thu, Dec 4 - Mon, Dec 8
FLO
Florence
BUF
Buffalo
$660 Roundtrip, found 16 hours ago
$660
Roundtrip
found 16 hours ago
Select American Airlines flight, departing Thu, Dec 4 from Florence to Buffalo, returning Mon, Dec 8, priced at $660 found 16 hours ago
Flights from Florence (FLO) to Buffalo (BUF)
Origin airport
Florence Regional
Destination airport
Buffalo Niagara Intl.
Roundtrip price
$480
Distance
606 mi

Florence to Buffalo Flights

The cheapest times to fly from Florence to Buffalo

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Florence to Buffalo are during the month of December. You can find some of the cheapest flights from Florence to Buffalo with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Florence to Buffalo

Sunday is one of the best days to book for cheap flights from Florence to Buffalo: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Florence to Buffalo

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Florence to Buffalo in 2025. You can also book with separate airlines for your outbound and return journeys, from $241 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Florence to Buffalo flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Florence to Buffalo airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Frequently asked questions

How much does a flight from Florence Regional Airport (FLO) to Buffalo Niagara Intl. Airport (BUF) cost?
Discover the latest flight deals from FLO to BUF by entering your preferred travel dates and searching on Expedia. Easily compare prices by departure date if you have flexibility with your schedule and use handy filters to explore prices for your preferred journey. As a member of One Key™, our free loyalty program, you can use Price Tracking to watch fares and receive notifications if prices go up or down.
What is the cheapest month to fly from FLO to BUF?
The cheapest flights from FLO to BUF are usually during off-peak season, when demand is lower. To save money, avoid flying during public holidays, school breaks and major local events.
What is the cheapest airline that flies from FLO to BUF?
Use the filter tool on Expedia to compare airlines and find the cheapest carrier that'll take you from FLO to BUF. Sort your results by "Price (lowest to highest)" to snap up a great deal.
How many flights per day from Florence Regional Airport (FLO) to Buffalo Niagara Intl. Airport (BUF)?
You'll need to hop on a flight with a layover if you're traveling from Florence Regional Airport (FLO) to Buffalo Niagara Intl. Airport (BUF). There are no daily direct flights on this route. However, simply filter your search to include one or two stops to find the best option for your trip.
What day of the week has the most flights from FLO to BUF?
You'll typically find Tuesday the quietest day for flights, while Fridays tend to be the busiest.* However this can change from season to season and during peak travel times or public holidays.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Florence Regional Airport (FLO) to Buffalo Niagara Intl. Airport (BUF)?
Select a flight from Florence Regional Airport (FLO) to Buffalo Niagara Intl. Airport (BUF) that leaves before 3 PM to reduce the risk of delays and cancellations. Later departures have a 22% higher chance of being canceled, on average.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Florence Regional Airport (FLO) to Buffalo Niagara Intl. Airport (BUF) last-minute?
Waiting until just before your trip to book your flight from FLO to BUF generally means paying more. While you may come across some last-minute deals, they aren't always guaranteed. Be flexible with your travel plans for the best chance of landing a bargain.
Is it cheaper to book a FLO to BUF flight and hotel package?
Booking a FLO to BUF flight and hotel package is typically cheaper than booking separately. With Expedia, you can enjoy the convenience of organizing your trip all in one place. Select from our extensive range of hotels and then add car rentals, activities and flights to your booking. Bundle it all together, and you could save hundreds of dollars.
Can I cancel or change the date of my flight from Florence Regional Airport (FLO) to Buffalo Niagara Intl. Airport (BUF)?
In most cases, you're able to reschedule or cancel your FLO to BUF flight. However, there may be additional fees, especially if your booking was made over 24 hours ago. Double-check your itinerary for the airline's policies and fees on flight changes, or if you want further information, go to our Customer Service portal.

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*Available to One Key members.