$251 Cheap Flights from Guayaquil (GYE) to Santiago (SCL)

View $251 flight on Mon, May 4, 2026Opens in a new window

Popular airlines from Jose Joaquin de Olmedo Intl. Airport (GYE) to Santiago Intl. Airport (SCL)

  • notification illustration

    Be in the know

    Get alerts if flight prices drop or rise*
  • deals illustration

    Book smarter

    Save up to 30% on select hotels after you book a flight*
  • trophy illustration

    Earn twice

    Earn your airline miles on top of our OneKeyCash
    Learn about One Key

Cheap Flights from Guayaquil to Santiago (GYE-SCL)

Prices were available within the past 7 days and start at $251 for one-way flights and $367 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

LATAM Airlines Group
Thu, Apr 30 - Fri, May 15
GYE
Guayaquil
SCL
Santiago
$367 Roundtrip, found 6 days ago
$367
Roundtrip
found 6 days ago
Select LATAM Airlines Group flight, departing Thu, Apr 30 from Guayaquil to Santiago, returning Fri, May 15, priced at $367 found 6 days ago
LATAM Airlines Group
Wed, Dec 17 - Tue, Mar 17
GYE
Guayaquil
SCL
Santiago
$373 Roundtrip, found 6 days ago
$373
Roundtrip
found 6 days ago
Select LATAM Airlines Group flight, departing Wed, Dec 17 from Guayaquil to Santiago, returning Tue, Mar 17, priced at $373 found 6 days ago
LATAM Airlines Group
Sun, Dec 21 - Tue, Mar 17
GYE
Guayaquil
SCL
Santiago
$378 Roundtrip, found 6 days ago
$378
Roundtrip
found 6 days ago
Select LATAM Airlines Group flight, departing Sun, Dec 21 from Guayaquil to Santiago, returning Tue, Mar 17, priced at $378 found 6 days ago
LATAM Airlines Group
Mon, Apr 13 - Sun, Apr 26
GYE
Guayaquil
SCL
Santiago
$387 Roundtrip, found 6 days ago
$387
Roundtrip
found 6 days ago
Select LATAM Airlines Group flight, departing Mon, Apr 13 from Guayaquil to Santiago, returning Sun, Apr 26, priced at $387 found 6 days ago
LATAM Airlines Group
Mon, Apr 13 - Sun, Apr 26
GYE
Guayaquil
SCL
Santiago
$396 Roundtrip, found 6 days ago
$396
Roundtrip
found 6 days ago
Select LATAM Airlines Group flight, departing Mon, Apr 13 from Guayaquil to Santiago, returning Sun, Apr 26, priced at $396 found 6 days ago
LATAM Airlines Group
Mon, Apr 13 - Sun, Apr 26
GYE
Guayaquil
SCL
Santiago
$404 Roundtrip, found 6 days ago
$404
Roundtrip
found 6 days ago
Select LATAM Airlines Group flight, departing Mon, Apr 13 from Guayaquil to Santiago, returning Sun, Apr 26, priced at $404 found 6 days ago
Copa
Thu, Apr 30 - Fri, May 15
GYE
Guayaquil
SCL
Santiago
$407 Roundtrip, found 6 days ago
$407
Roundtrip
found 6 days ago
Select Copa flight, departing Thu, Apr 30 from Guayaquil to Santiago, returning Fri, May 15, priced at $407 found 6 days ago
LATAM Airlines Group
Thu, Apr 30 - Fri, May 15
GYE
Guayaquil
SCL
Santiago
$408 Roundtrip, found 6 days ago
$408
Roundtrip
found 6 days ago
Select LATAM Airlines Group flight, departing Thu, Apr 30 from Guayaquil to Santiago, returning Fri, May 15, priced at $408 found 6 days ago
LATAM Airlines Group
Wed, Dec 17 - Tue, Mar 17
GYE
Guayaquil
SCL
Santiago
$414 Roundtrip, found 6 days ago
$414
Roundtrip
found 6 days ago
Select LATAM Airlines Group flight, departing Wed, Dec 17 from Guayaquil to Santiago, returning Tue, Mar 17, priced at $414 found 6 days ago
avianca
Wed, Dec 31 - Fri, Apr 24
GYE
Guayaquil
SCL
Santiago
$424 Roundtrip, found 6 days ago
$424
Roundtrip
found 6 days ago
Select avianca flight, departing Wed, Dec 31 from Guayaquil to Santiago, returning Fri, Apr 24, priced at $424 found 6 days ago

Find the cheapest month to fly from Guayaquil (GYE) to Santiago (SCL)

November is typically the cheapest month to fly

From $324 - $495 per traveler.

Alternative airports near Santiago

Prices were available within the past 7 days. Prices and availability are subject to change.

Select flight to Arturo Merino Benitez SCL. Cheapest and Closest option available. Average driving time to city center is 17 minutes. Flights from $672
SCL
Arturo Merino Benitez
CheapestClosest
Average driving time to city center17 min
Flights from $672
Flights from Guayaquil (GYE) to Santiago (SCL)
Origin airport
Jose Joaquin de Olmedo Intl.
Destination airport
Arturo Merino Benitez
Airlines serving
Copa, LATAM Airlines Group, avianca
Roundtrip price
$367
Distance
2237 mi
Average flight time
4 hours 47 mins

Guayaquil to Santiago Flights

The cheapest times to fly from Guayaquil to Santiago

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Guayaquil to Santiago are during the month of April. You can find some of the cheapest flights from Guayaquil to Santiago with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Guayaquil to Santiago

Sunday is one of the best days to book for cheap flights from Guayaquil to Santiago: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Guayaquil to Santiago

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Guayaquil to Santiago in 2026. You can also book with separate airlines for your outbound and return journeys, from $251 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Guayaquil to Santiago flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Guayaquil to Santiago airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Frequently asked questions

How much does a flight from Jose Joaquin de Olmedo Intl. Airport (GYE) to Arturo Merino Benitez Airport (SCL) cost?
Grab a cheap one-way flight from $251 or cheap return flight from $367 from Jose Joaquin de Olmedo Intl. Airport (GYE) to Arturo Merino Benitez Airport (SCL) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to see our cheapest flight deals on this route.
What is the cheapest month to fly from Jose Joaquin de Olmedo Intl. Airport (GYE) to Arturo Merino Benitez Airport (SCL)?
Flying in April is a good way to save, as it's the cheapest month for flights between GYE and SCL. You'll usually find the lowest prices during off-peak months.
Which airlines fly direct from Jose Joaquin de Olmedo Intl. Airport (GYE) to Arturo Merino Benitez Airport (SCL)?
Take a direct flight with LATAM Airlines and journey straight from Jose Joaquin de Olmedo Intl. Airport (GYE) to Arturo Merino Benitez Airport (SCL).
What is the cheapest airline that flies from Jose Joaquin de Olmedo Intl. Airport (GYE) to Arturo Merino Benitez Airport (SCL)?
Use the filters on Expedia to compare airlines and find the most affordable carrier that'll fly you from GYE to SCL. Then, sort your results by "Price (lowest to highest)" to score a good deal.
How many flights per day from Jose Joaquin de Olmedo Intl. Airport (GYE) to Arturo Merino Benitez Airport (SCL)?
On average, only 1 direct flight departs each day from Jose Joaquin de Olmedo Intl. Airport (GYE) to Arturo Merino Benitez Airport (SCL). Looking for more options? Use Expedia's filters to find flights with layovers and add a new destination to your journey.
What are the most popular departure times for flights from Jose Joaquin de Olmedo Intl. Airport (GYE) to Arturo Merino Benitez Airport (SCL)?
The 2 PM departures from GYE to SCL are the most sought after. Prices can be higher for these popular slots. If you want to save on your fare, pick a less crowded time to fly.
What day of the week has the most flights from GYE to SCL?
Travel on a Friday if you're looking for the best choice of flights from Jose Joaquin de Olmedo Intl. Airport (GYE) to Arturo Merino Benitez Airport (SCL).
What is the earliest flight from Jose Joaquin de Olmedo Intl. Airport (GYE) to Arturo Merino Benitez Airport (SCL)?
Catch the earliest flight at around 2:45PM UTC-5, departing from Jose Joaquin de Olmedo Intl. Airport (GYE). You'll be traveling for around 4h 48m, arriving at Arturo Merino Benitez Airport (SCL) at approximately 9:33PM UTC-3.
How long does it take to fly from Jose Joaquin de Olmedo Intl. Airport (GYE) to Arturo Merino Benitez Airport (SCL)?
Flights from GYE to SCL have an average travel time of 4 hours and 48 minutes. The total distance between the two is 2,200 mi.
What airline has the least delays from GYE to SCL?
With 100% of flights generally arriving as scheduled, Qantas has the best on-time performance for nonstop flights from Jose Joaquin de Olmedo Intl. Airport (GYE) to Arturo Merino Benitez Airport (SCL). To monitor your flight status and receive notifications if anything changes, simply head to the Expedia App.
What is the best time to fly from Jose Joaquin de Olmedo Intl. Airport (GYE) to Arturo Merino Benitez Airport (SCL)?
Opt for a flight from Jose Joaquin de Olmedo Intl. Airport (GYE) to Arturo Merino Benitez Airport (SCL) that takes off before 3 PM to reduce the risk of cancellations. Departures after this time are on average 22% more likely to be canceled.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
What airports do you fly into for Santiago from Jose Joaquin de Olmedo Intl. Airport (GYE)?
Arturo Merino Benitez Airport (SCL) is the only airport in Santiago with direct flights from Jose Joaquin de Olmedo Intl. Airport (GYE). Compare the available options and discover cheap fares on Expedia.
Is it cheaper to buy a plane ticket from Jose Joaquin de Olmedo Intl. Airport (GYE) to Arturo Merino Benitez Airport (SCL) last-minute?
Holding off until just before your trip to book your flight from GYE to SCL often results in higher prices. While you may find some last-minute offers, they're not always guaranteed. Keep your travel plans flexible for a better chance of landing a bargain.
Is it cheaper to book a GYE to SCL flight and hotel package?
Opting for a GYE to SCL flight and hotel package is generally cheaper than booking separately. With Expedia, you can enjoy the convenience of organizing your travels all in one place. Select from our wide range of accommodations and then add flights, car rentals and activities to your booking. Bundle everything together, and you could save hundreds of dollars.
Can I cancel or change the date of my flight from Jose Joaquin de Olmedo Intl. Airport (GYE) to Arturo Merino Benitez Airport (SCL)?
If you booked your GYE to SCL flight within the last 24 hours, you may be able to modify or cancel it without fees. Depending on the airline and the type of fare you have, additional charges may apply for changes after that time. Airline policies and contact information can be found in your itinerary or confirmation email. Or, head to our Customer Service portal if you'd like more information.

Explore a world of travel with Expedia

*Available to One Key members.