$107 Cheap Flights from Lyon (LYS) to Brussels (BRU)

View $107 flight on Tue, Sep 23, 2025Opens in a new window

Popular airlines from Saint-Exupery Airport (LYS) to Brussels Airport (BRU)

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Cheap Flights from Lyon to Brussels (LYS-BRU)

Prices were available within the past 7 days and start at $107 for one-way flights and $208 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Vueling Airlines
Sun, Sep 21 - Mon, Sep 22
LYS
Lyon
BRU
Brussels
$208 Roundtrip, found 1 day ago
$208
Roundtrip
found 1 day ago
Select Vueling Airlines flight, departing Sun, Sep 21 from Lyon to Brussels, returning Mon, Sep 22, priced at $208 found 1 day ago
Vueling Airlines
Sun, Sep 28 - Fri, Oct 3
LYS
Lyon
BRU
Brussels
$214 Roundtrip, found 1 day ago
$214
Roundtrip
found 1 day ago
Select Vueling Airlines flight, departing Sun, Sep 28 from Lyon to Brussels, returning Fri, Oct 3, priced at $214 found 1 day ago
Vueling Airlines
Sun, Sep 21 - Mon, Sep 22
LYS
Lyon
BRU
Brussels
$214 Roundtrip, found 1 day ago
$214
Roundtrip
found 1 day ago
Select Vueling Airlines flight, departing Sun, Sep 21 from Lyon to Brussels, returning Mon, Sep 22, priced at $214 found 1 day ago
Brussels Airlines
Thu, Sep 18 - Thu, Sep 25
LYS
Lyon
BRU
Brussels
$219 Roundtrip, found 3 days ago
$219
Roundtrip
found 3 days ago
Select Brussels Airlines flight, departing Thu, Sep 18 from Lyon to Brussels, returning Thu, Sep 25, priced at $219 found 3 days ago
Brussels Airlines
Thu, Sep 11 - Sun, Sep 14
LYS
Lyon
BRU
Brussels
$220 Roundtrip, found 6 days ago
$220
Roundtrip
found 6 days ago
Select Brussels Airlines flight, departing Thu, Sep 11 from Lyon to Brussels, returning Sun, Sep 14, priced at $220 found 6 days ago
Brussels Airlines
Sun, Sep 28 - Fri, Oct 3
LYS
Lyon
BRU
Brussels
$222 Roundtrip, found 1 day ago
$222
Roundtrip
found 1 day ago
Select Brussels Airlines flight, departing Sun, Sep 28 from Lyon to Brussels, returning Fri, Oct 3, priced at $222 found 1 day ago
Scandinavian Airlines
Thu, Sep 18 - Thu, Sep 25
LYS
Lyon
BRU
Brussels
$237 Roundtrip, found 3 days ago
$237
Roundtrip
found 3 days ago
Select Scandinavian Airlines flight, departing Thu, Sep 18 from Lyon to Brussels, returning Thu, Sep 25, priced at $237 found 3 days ago
Iberia
Mon, Jan 26 - Wed, Jan 28
LYS
Lyon
BRU
Brussels
$237 Roundtrip, found 1 day ago
$237
Roundtrip
found 1 day ago
Select Iberia flight, departing Mon, Jan 26 from Lyon to Brussels, returning Wed, Jan 28, priced at $237 found 1 day ago
TAP Portugal
Mon, Jan 26 - Wed, Jan 28
LYS
Lyon
BRU
Brussels
$244 Roundtrip, found 1 day ago
$244
Roundtrip
found 1 day ago
Select TAP Portugal flight, departing Mon, Jan 26 from Lyon to Brussels, returning Wed, Jan 28, priced at $244 found 1 day ago
Vueling Airlines
Sun, Sep 28 - Fri, Oct 3
LYS
Lyon
BRU
Brussels
$245 Roundtrip, found 1 day ago
$245
Roundtrip
found 1 day ago
Select Vueling Airlines flight, departing Sun, Sep 28 from Lyon to Brussels, returning Fri, Oct 3, priced at $245 found 1 day ago
Flights from Lyon (LYS) to Brussels (BRU)
Origin airport
Saint-Exupery
Destination airport
Brussels - National
Airlines serving
Aer Lingus, Austrian Airlines, British Airways, Brussels Airlines, Iberia, KLM, KM Malta Airlines, LOT-Polish Airlines, Lufthansa, Scandinavian Airlines, Vueling Airlines
Roundtrip price
$207
Distance
358 mi
Average flight time
1 hour 25 mins

Lyon to Brussels Flights

The cheapest times to fly from Lyon to Brussels

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Lyon to Brussels are during the month of September. You can find some of the cheapest flights from Lyon to Brussels with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Lyon to Brussels

Sunday is one of the best days to book for cheap flights from Lyon to Brussels: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Lyon to Brussels

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Lyon to Brussels in 2025. You can also book with separate airlines for your outbound and return journeys, from $107 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Lyon to Brussels flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Lyon to Brussels airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Frequently asked questions

How much does a flight from Saint-Exupery Airport (LYS) to Brussels - National Airport (BRU) cost?
Grab a cheap one-way flight from $107 or cheap return flight from $208 from Saint-Exupery Airport (LYS) to Brussels - National Airport (BRU) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to see our cheapest flight offers on this route.
What is the cheapest month to fly from Saint-Exupery Airport (LYS) to Brussels - National Airport (BRU)?
September is the most affordable month to fly from LYS to BRU. Planning your trip for the off-season is often the key to scoring lower fares.
Which airlines fly direct from Saint-Exupery Airport (LYS) to Brussels - National Airport (BRU)?
When flying out of Saint-Exupery Airport (LYS), you can take a direct flight to Brussels - National Airport (BRU) with Brussels Airlines.
What is the cheapest airline that flies from Saint-Exupery Airport (LYS) to Brussels - National Airport (BRU)?
Expedia's filter tool lets you easily compare travel time, airlines and fares all in one place. Customize the search to your preferences, then sort by "Price (lowest to highest)" to see which carrier offers the cheapest LYS to BRU flight.
How many flights per day from Saint-Exupery Airport (LYS) to Brussels - National Airport (BRU)?
On average, just 1 direct flight departs daily from Saint-Exupery Airport (LYS) to Brussels - National Airport (BRU). Need other options? Use our filter tool to discover flights with layovers and add a new stop to your trip.
What are the most popular departure times for flights from Saint-Exupery Airport (LYS) to Brussels - National Airport (BRU)?
More travelers fly between LYS and BRU at 7 AM than at any other point in the day. Prefer a quieter experience? Pick a flight outside the busiest times and there's a chance you'll save on your ticket as well.
What day of the week has the most flights from LYS to BRU?
If you fly on a Friday, you'll get the greatest range of choices for flights from Saint-Exupery Airport (LYS) to Brussels - National Airport (BRU).
What is the earliest flight from Saint-Exupery Airport (LYS) to Brussels - National Airport (BRU)?
The earliest flight departing from Saint-Exupery Airport (LYS) is at around 7:00AM UTC+1. Board this flight and you'll reach Brussels - National Airport (BRU) at approximately 8:25AM UTC+1. The overall travel time is 1h 25m.
How long does it take to fly from Saint-Exupery Airport (LYS) to Brussels - National Airport (BRU)?
The average flight time from LYS to BRU is 1 hour and 25 minutes, covering a total distance of 360 mi.
What airline has the least delays from LYS to BRU?
With 100% of flights generally landing on schedule, Thai Airways International has the best on-time performance for direct flights from Saint-Exupery Airport (LYS) to Brussels - National Airport (BRU). To check your flight status and get notified if anything changes, use the Expedia App.
What is the best time to fly from Saint-Exupery Airport (LYS) to Brussels - National Airport (BRU)?
To reach Brussels - National Airport (BRU) on time, pick a flight that takes off from Saint-Exupery Airport (LYS) before 3 PM. The chance of cancellations is 22% higher, on average, for departures after this hour.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
What airports do you fly into for Brussels from Saint-Exupery Airport (LYS)?
Compare your flight options from Saint-Exupery Airport (LYS) to Brussels - National Airport (BRU). This is the only Brussels airport you can arrive at if you're taking a direct flight.
Is it cheaper to buy a plane ticket from Saint-Exupery Airport (LYS) to Brussels - National Airport (BRU) last-minute?
Booking your ticket from LYS to BRU right before your journey is typically more expensive. However, if you're flexible with your schedule, you could land a cheap last-minute fare.
Is it cheaper to book a LYS to BRU flight and hotel package?
Compared with arranging flights and hotels separately, booking a LYS to BRU flight and hotel package with Expedia could result in significant savings. What's more, having everything in one easy place takes the hassle out of planning your trip. Simply secure your flights and select from our extensive range of stays, then tailor your trip with extras like tours and car rentals.
Can I cancel or change the date of my flight from Saint-Exupery Airport (LYS) to Brussels - National Airport (BRU)?
If you booked your LYS to BRU flight within the last 24 hours, you may be able to modify or cancel it without any fees. Depending on the airline and the ticket type you purchased, additional charges may apply for changes beyond this timeframe. Airline policies and contact information can be found in your itinerary or confirmation email. Or, go to our Customer Service portal for further details.

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*Available to One Key members.