$253 Cheap Flights from Medellín (MDE) to Antofagasta (ANF)

View $253 flight on Sat, May 30, 2026Opens in a new window

Popular airlines from Jose Maria Cordova Intl. Airport (MDE) to Antofagasta (ANF-Cerro Moreno Intl.)

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Cheap Flights from Medellín to Antofagasta (MDE-ANF)

Prices were available within the past 7 days and start at $253 for one-way flights and $609 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

LATAM Airlines Group
Thu, Dec 11 - Sun, Dec 14
MDE
Medellin
ANF
Antofagasta
$609 Roundtrip, found 5 days ago
$609
Roundtrip
found 5 days ago
Select LATAM Airlines Group flight, departing Thu, Dec 11 from Medellin to Antofagasta, returning Sun, Dec 14, priced at $609 found 5 days ago
LATAM Airlines Group
Thu, Dec 11 - Sun, Dec 14
MDE
Medellin
ANF
Antofagasta
$615 Roundtrip, found 5 days ago
$615
Roundtrip
found 5 days ago
Select LATAM Airlines Group flight, departing Thu, Dec 11 from Medellin to Antofagasta, returning Sun, Dec 14, priced at $615 found 5 days ago
LATAM Airlines Group
Thu, Dec 11 - Sun, Dec 14
MDE
Medellin
ANF
Antofagasta
$645 Roundtrip, found 4 days ago
$645
Roundtrip
found 4 days ago
Select LATAM Airlines Group flight, departing Thu, Dec 11 from Medellin to Antofagasta, returning Sun, Dec 14, priced at $645 found 4 days ago
LATAM Airlines Group
Thu, Dec 11 - Sun, Dec 14
MDE
Medellin
ANF
Antofagasta
$647 Roundtrip, found 5 days ago
$647
Roundtrip
found 5 days ago
Select LATAM Airlines Group flight, departing Thu, Dec 11 from Medellin to Antofagasta, returning Sun, Dec 14, priced at $647 found 5 days ago
LATAM Airlines Group
Thu, Dec 11 - Sun, Dec 14
MDE
Medellin
ANF
Antofagasta
$653 Roundtrip, found 5 days ago
$653
Roundtrip
found 5 days ago
Select LATAM Airlines Group flight, departing Thu, Dec 11 from Medellin to Antofagasta, returning Sun, Dec 14, priced at $653 found 5 days ago
LATAM Airlines Group
Thu, Dec 11 - Mon, Dec 15
MDE
Medellin
ANF
Antofagasta
$657 Roundtrip, found 5 days ago
$657
Roundtrip
found 5 days ago
Select LATAM Airlines Group flight, departing Thu, Dec 11 from Medellin to Antofagasta, returning Mon, Dec 15, priced at $657 found 5 days ago
LATAM Airlines Group
Thu, Dec 11 - Mon, Dec 15
MDE
Medellin
ANF
Antofagasta
$663 Roundtrip, found 5 days ago
$663
Roundtrip
found 5 days ago
Select LATAM Airlines Group flight, departing Thu, Dec 11 from Medellin to Antofagasta, returning Mon, Dec 15, priced at $663 found 5 days ago
LATAM Airlines Group
Thu, Dec 11 - Sun, Dec 14
MDE
Medellin
ANF
Antofagasta
$666 Roundtrip, found 4 days ago
$666
Roundtrip
found 4 days ago
Select LATAM Airlines Group flight, departing Thu, Dec 11 from Medellin to Antofagasta, returning Sun, Dec 14, priced at $666 found 4 days ago
LATAM Airlines Group
Thu, Dec 11 - Sun, Dec 14
MDE
Medellin
ANF
Antofagasta
$678 Roundtrip, found 5 days ago
$678
Roundtrip
found 5 days ago
Select LATAM Airlines Group flight, departing Thu, Dec 11 from Medellin to Antofagasta, returning Sun, Dec 14, priced at $678 found 5 days ago
LATAM Airlines Group
Tue, Dec 23 - Sat, Jan 3
MDE
Medellin
ANF
Antofagasta
$681 Roundtrip, found 1 day ago
$681
Roundtrip
found 1 day ago
Select LATAM Airlines Group flight, departing Tue, Dec 23 from Medellin to Antofagasta, returning Sat, Jan 3, priced at $681 found 1 day ago

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Flights from Medellín (MDE) to Antofagasta (ANF)
Origin airport
José María Córdova Intl.
Destination airport
Cerro Moreno Intl.
Airlines serving
LATAM Airlines Group
Roundtrip price
$609
Distance
2073 mi

Medellín to Antofagasta Flights

The cheapest times to fly from Medellín to Antofagasta

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Medellín to Antofagasta are during the month of December. You can find some of the cheapest flights from Medellín to Antofagasta with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Medellín to Antofagasta

Sunday is one of the best days to book for cheap flights from Medellín to Antofagasta: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Medellín to Antofagasta

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Medellín to Antofagasta in 2025. You can also book with separate airlines for your outbound and return journeys, from $253 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Medellín to Antofagasta flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Medellín to Antofagasta airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Frequently asked questions

How much does a flight from Jose Maria Cordova Intl. Airport (MDE) to Cerro Moreno Intl. Airport (ANF) cost?
Lock in a cheap one-way flight from $253 or cheap return flight from $609 from Jose Maria Cordova Intl. Airport (MDE) to Cerro Moreno Intl. Airport (ANF) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to find our cheapest flight deals on this route.
What is the cheapest month to fly from Jose Maria Cordova Intl. Airport (MDE) to Cerro Moreno Intl. Airport (ANF)?
Traveling in December may help you find better deals, as it's the cheapest month for flights between MDE and ANF. You'll usually find the lowest fares during the off-season.
What is the cheapest airline that flies from Jose Maria Cordova Intl. Airport (MDE) to Cerro Moreno Intl. Airport (ANF)?
To find the cheapest airline that'll fly you from MDE to ANF, use Expedia's filter tool. Tailor your search based on your travel needs, such as preferred carriers and number of stops. You can then sort your results by "Price (lowest to highest)" to see the cheapest fares upfront.
How many flights per day from Jose Maria Cordova Intl. Airport (MDE) to Cerro Moreno Intl. Airport (ANF)?
You'll have to take a flight with a layover if you're traveling from Jose Maria Cordova Intl. Airport (MDE) to Cerro Moreno Intl. Airport (ANF). There are no daily direct flights on this route. However, simply filter your search to include one or two stops to discover an option that works for you.
What day of the week has the most flights from MDE to ANF?
Generally you'll find the largest variety of flight choices on a Friday. Tuesdays are often the quietest.* However, this can vary based on the airline, season and other factors.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Jose Maria Cordova Intl. Airport (MDE) to Cerro Moreno Intl. Airport (ANF)?
Book a flight from Jose Maria Cordova Intl. Airport (MDE) to Cerro Moreno Intl. Airport (ANF) that leaves before 3 PM to reduce the likelihood of delays. Later departures are on average 22% more likely to be canceled.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Jose Maria Cordova Intl. Airport (MDE) to Cerro Moreno Intl. Airport (ANF) last-minute?
Booking your flight from MDE to ANF right before your journey is usually more expensive. However, if you're flexible with your departure dates and times, you could snag a cheap last-minute fare.
Is it cheaper to book a MDE to ANF flight and hotel package?
Compared with arranging flights and hotels separately, booking a MDE to ANF flight and hotel package with Expedia could result in significant savings. Better yet, managing everything in one place takes the hassle out of travel planning. Simply pick your flights and choose from our extensive range of stays, then customize your trip with extras like tours, car rentals and activities.
Can I cancel or change the date of my flight from Jose Maria Cordova Intl. Airport (MDE) to Cerro Moreno Intl. Airport (ANF)?
If you booked your MDE to ANF flight within the last 24 hours, you may be able to cancel or modify it without any fees. Depending on the airline and the type of fare you purchased, additional charges may apply for changes beyond this timeframe. Airline policies and contact information can be found in your itinerary or confirmation email. Or, visit our Customer Service portal if you want more information.

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*Available to One Key members.