$595 Cheap Flights from Myrtle Beach (MYR) to La Crosse (LSE)

View $595 flight on Sun, Aug 24, 2025Opens in a new window

Popular airlines from Myrtle Beach Intl. Airport (MYR) to La Crosse, WI (LSE-La Crosse Municipal)

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Cheap Flights from Myrtle Beach to La Crosse (MYR-LSE)

Prices were available within the past 7 days and start at $595 for one-way flights and $551 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

American Airlines
Fri, Oct 31 - Sat, Nov 15
MYR
Myrtle Beach
LSE
La Crosse
$551 Roundtrip, found 15 hours ago
$551
Roundtrip
found 15 hours ago
Select American Airlines flight, departing Fri, Oct 31 from Myrtle Beach to La Crosse, returning Sat, Nov 15, priced at $551 found 15 hours ago
American Airlines
Sat, Nov 8 - Tue, Nov 11
MYR
Myrtle Beach
LSE
La Crosse
$561 Roundtrip, found 15 hours ago
$561
Roundtrip
found 15 hours ago
Select American Airlines flight, departing Sat, Nov 8 from Myrtle Beach to La Crosse, returning Tue, Nov 11, priced at $561 found 15 hours ago
American Airlines
Fri, Oct 31 - Mon, Nov 17
MYR
Myrtle Beach
LSE
La Crosse
$571 Roundtrip, found 15 hours ago
$571
Roundtrip
found 15 hours ago
Select American Airlines flight, departing Fri, Oct 31 from Myrtle Beach to La Crosse, returning Mon, Nov 17, priced at $571 found 15 hours ago
American Airlines
Sat, Nov 8 - Thu, Nov 13
MYR
Myrtle Beach
LSE
La Crosse
$581 Roundtrip, found 15 hours ago
$581
Roundtrip
found 15 hours ago
Select American Airlines flight, departing Sat, Nov 8 from Myrtle Beach to La Crosse, returning Thu, Nov 13, priced at $581 found 15 hours ago
American Airlines
Wed, Sep 10 - Thu, Sep 25
MYR
Myrtle Beach
LSE
La Crosse
$591 Roundtrip, found 15 hours ago
$591
Roundtrip
found 15 hours ago
Select American Airlines flight, departing Wed, Sep 10 from Myrtle Beach to La Crosse, returning Thu, Sep 25, priced at $591 found 15 hours ago
American Airlines
Thu, Nov 6 - Thu, Nov 13
MYR
Myrtle Beach
LSE
La Crosse
$601 Roundtrip, found 15 hours ago
$601
Roundtrip
found 15 hours ago
Select American Airlines flight, departing Thu, Nov 6 from Myrtle Beach to La Crosse, returning Thu, Nov 13, priced at $601 found 15 hours ago
American Airlines
Thu, Sep 11 - Thu, Sep 25
MYR
Myrtle Beach
LSE
La Crosse
$611 Roundtrip, found 15 hours ago
$611
Roundtrip
found 15 hours ago
Select American Airlines flight, departing Thu, Sep 11 from Myrtle Beach to La Crosse, returning Thu, Sep 25, priced at $611 found 15 hours ago
American Airlines
Mon, Sep 22 - Sat, Oct 11
MYR
Myrtle Beach
LSE
La Crosse
$621 Roundtrip, found 15 hours ago
$621
Roundtrip
found 15 hours ago
Select American Airlines flight, departing Mon, Sep 22 from Myrtle Beach to La Crosse, returning Sat, Oct 11, priced at $621 found 15 hours ago
American Airlines
Sat, Nov 8 - Thu, Nov 27
MYR
Myrtle Beach
LSE
La Crosse
$631 Roundtrip, found 15 hours ago
$631
Roundtrip
found 15 hours ago
Select American Airlines flight, departing Sat, Nov 8 from Myrtle Beach to La Crosse, returning Thu, Nov 27, priced at $631 found 15 hours ago
American Airlines
Wed, Sep 10 - Sat, Sep 27
MYR
Myrtle Beach
LSE
La Crosse
$641 Roundtrip, found 15 hours ago
$641
Roundtrip
found 15 hours ago
Select American Airlines flight, departing Wed, Sep 10 from Myrtle Beach to La Crosse, returning Sat, Sep 27, priced at $641 found 15 hours ago
American Airlines
Thu, Dec 25 - Sat, Jan 10
MYR
Myrtle Beach
LSE
La Crosse
$642 Roundtrip, found 17 hours ago
$642
Roundtrip
found 17 hours ago
Select American Airlines flight, departing Thu, Dec 25 from Myrtle Beach to La Crosse, returning Sat, Jan 10, priced at $642 found 17 hours ago
American Airlines
Mon, Dec 8 - Wed, Dec 24
MYR
Myrtle Beach
LSE
La Crosse
$645 Roundtrip, found 17 hours ago
$645
Roundtrip
found 17 hours ago
Select American Airlines flight, departing Mon, Dec 8 from Myrtle Beach to La Crosse, returning Wed, Dec 24, priced at $645 found 17 hours ago
American Airlines
Thu, Nov 6 - Thu, Nov 27
MYR
Myrtle Beach
LSE
La Crosse
$651 Roundtrip, found 15 hours ago
$651
Roundtrip
found 15 hours ago
Select American Airlines flight, departing Thu, Nov 6 from Myrtle Beach to La Crosse, returning Thu, Nov 27, priced at $651 found 15 hours ago
American Airlines
Fri, Dec 12 - Wed, Dec 24
MYR
Myrtle Beach
LSE
La Crosse
$652 Roundtrip, found 17 hours ago
$652
Roundtrip
found 17 hours ago
Select American Airlines flight, departing Fri, Dec 12 from Myrtle Beach to La Crosse, returning Wed, Dec 24, priced at $652 found 17 hours ago
American Airlines
Thu, Sep 11 - Sat, Sep 27
MYR
Myrtle Beach
LSE
La Crosse
$661 Roundtrip, found 15 hours ago
$661
Roundtrip
found 15 hours ago
Select American Airlines flight, departing Thu, Sep 11 from Myrtle Beach to La Crosse, returning Sat, Sep 27, priced at $661 found 15 hours ago
American Airlines
Sun, Nov 9 - Sat, Nov 29
MYR
Myrtle Beach
LSE
La Crosse
$666 Roundtrip, found 17 hours ago
$666
Roundtrip
found 17 hours ago
Select American Airlines flight, departing Sun, Nov 9 from Myrtle Beach to La Crosse, returning Sat, Nov 29, priced at $666 found 17 hours ago
American Airlines
Fri, Sep 5 - Fri, Sep 19
MYR
Myrtle Beach
LSE
La Crosse
$668 Roundtrip, found 15 hours ago
$668
Roundtrip
found 15 hours ago
Select American Airlines flight, departing Fri, Sep 5 from Myrtle Beach to La Crosse, returning Fri, Sep 19, priced at $668 found 15 hours ago
American Airlines
Mon, Sep 22 - Thu, Oct 9
MYR
Myrtle Beach
LSE
La Crosse
$671 Roundtrip, found 15 hours ago
$671
Roundtrip
found 15 hours ago
Select American Airlines flight, departing Mon, Sep 22 from Myrtle Beach to La Crosse, returning Thu, Oct 9, priced at $671 found 15 hours ago

Alternative airports near La Crosse

Prices were available within the past 7 days. Prices and availability are subject to change.

Select flight to La Crosse Municipal LSE. Cheapest and Closest option available. Average driving time to city center is 12 minutes. Flights from $721
LSE
La Crosse Municipal
CheapestClosest
Average driving time to city center12 min
Flights from $721
Flights from Myrtle Beach (MYR) to La Crosse (LSE)
Origin airport
Myrtle Beach Intl.
Destination airport
La Crosse Municipal
Airlines serving
American Airlines
Roundtrip price
$550
Distance
966 mi

Myrtle Beach to La Crosse Flights

The cheapest times to fly from Myrtle Beach to La Crosse

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Myrtle Beach to La Crosse are during the month of October. You can find some of the cheapest flights from Myrtle Beach to La Crosse with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Myrtle Beach to La Crosse

Sunday is one of the best days to book for cheap flights from Myrtle Beach to La Crosse: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Myrtle Beach to La Crosse

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Myrtle Beach to La Crosse in 2025. You can also book with separate airlines for your outbound and return journeys, from $595 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Myrtle Beach to La Crosse flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Myrtle Beach to La Crosse airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Frequently asked questions

How much does a flight from Myrtle Beach Intl. Airport (MYR) to La Crosse Municipal Airport (LSE) cost?
Snag a cheap one-way flight from $595 or cheap return flight from $551 from Myrtle Beach Intl. Airport (MYR) to La Crosse Municipal Airport (LSE) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to see our cheapest flight offers on this route.
What is the cheapest month to fly from Myrtle Beach Intl. Airport (MYR) to La Crosse Municipal Airport (LSE)?
The cheapest month to fly from MYR to LSE is October, when there's less demand. Off-peak season is usually when airlines offer better prices between these airports.
What is the cheapest airline that flies from Myrtle Beach Intl. Airport (MYR) to La Crosse Municipal Airport (LSE)?
To find the cheapest airline flying from MYR to LSE, use Expedia's filter tool. Tailor your search based on what's important to you, such as preferred carriers and flight duration. You can then sort your results by "Price (lowest to highest)" to see the most affordable options first.
How many flights per day from Myrtle Beach Intl. Airport (MYR) to La Crosse Municipal Airport (LSE)?
Direct flights from Myrtle Beach Intl. Airport (MYR) to La Crosse Municipal Airport (LSE) aren't available daily, so you'll need to take a flight with a layover. Explore your options with Expedia's filters. Enter your travel details and choose either "1 Stop" or "2+ Stops."
What day of the week has the most flights from MYR to LSE?
Generally you'll find the most flight options available on a Friday. Tuesdays are often the quietest.* But this can vary based on the season, carrier and other factors.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Myrtle Beach Intl. Airport (MYR) to La Crosse Municipal Airport (LSE)?
Book a flight from Myrtle Beach Intl. Airport (MYR) to La Crosse Municipal Airport (LSE) that leaves before 3 PM to reduce the risk of delays and cancellations. Departures after this time have a 22% higher chance of being canceled, on average.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Myrtle Beach Intl. Airport (MYR) to La Crosse Municipal Airport (LSE) last-minute?
Booking your ticket from MYR to LSE just before your trip is usually more expensive. However, if you're flexible with your travel times and dates, you could snag a cheap last-minute fare.
Is it cheaper to book a MYR to LSE flight and hotel package?
Compared with arranging flights and hotels separately, booking a MYR to LSE flight and hotel package with Expedia could result in significant savings. What's more, having everything in one convenient place will take the stress out of planning your trip. Simply secure your flights and choose from our wide range of hotels, then tailor your trip with extras like car rentals and activities.
Can I cancel or change the date of my flight from Myrtle Beach Intl. Airport (MYR) to La Crosse Municipal Airport (LSE)?
If you reserved your MYR to LSE flight within the last 24 hours, you may be able to modify or cancel it without any fees. Depending on the airline and the ticket type you purchased, additional charges may apply for changes after that time. Airline policies and contact information can be found in your itinerary or confirmation email. Or, go to our Customer Service portal if you'd like more information.

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*Available to One Key members.