Title: Flights to Cusco from Panama City from $321 (PTY to CUZ) - Expedia.com ![](https://images.trvl-media.com/place/941/190db430-5bf6-40e0-9c05-c84acc9cd781.jpg?impolicy=fcrop&w=1200&h=500&q=medium) ![](https://images.trvl-media.com/place/941/190db430-5bf6-40e0-9c05-c84acc9cd781.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # $321 Cheap Flights from Panama City (PTY) to Cusco (CUZ) [View $321 flight on Wed, Nov 25, 2026](https://expedia.com/Flights-Search?trip=oneway&leg1=from:PTY,to:CUZ,departure:11/25/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:320.75&airProductToken=AQppCjIIwawBEgI1ORjvxAEgwTMo1Y2eAzC0jp4DOFNAAFgBagdDTEFTU0lDcghTRU9CMkJSOQozCMGsARIDMTA1GMEzIILNASiRmJ4DMNSZngM4U0ABWAFqB0NMQVNTSUNyCFNFT0IyQlI5EgwIARABGAEqAkFWMgAYASIECAEQASgCKAMoBDAB) ## Popular airlines from Tocumen Intl. Airport (PTY) to Alejandro Velasco Astete Intl. Airport (CUZ) - ![](https://forever.travel-assets.com/flex/flexmanager/images/2024/09/23/landing_airline_sq_logo_AV.svg) Avianca [](https://www.expedia.com/Flights-Search?leg1=from:PTY,to:CUZ,departure:4/4/2026TANYT&leg2=from:CUZ,to:PTY,departure:4/11/2026TANYT&trip=roundtrip&passengers=adults:1,children:0,infantinlap:N&mode=search&pageId=0&filters=[{"preferredAirlineFilterValue":{"carrierCode":"AV"}}]) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__notification.svg) ### Be in the know Get alerts if flight prices drop or rise\* - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Book smarter Save up to 30% on select hotels after you book a flight\* - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__trophy.svg) ### Earn twice Earn your airline miles on top of our OneKeyCash [Learn about One Key](https://www.expedia.com/welcome-one-key) ## Cheap Flights from Panama City to Cusco (PTY-CUZ) Prices were available within the past 7 days and start at $321 for one-way flights and $591 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply. All deals One way Roundtrip ![avianca](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/av.gif) Wed, Nov 25 - Thu, Dec 3 PTY Panama City CUZ Cusco $591 Roundtrip found 5 days ago [](https://expedia.com/Flights-Search?trip=roundtrip&leg1=from:PTY,to:CUZ,departure:11/25/2026TANYT&leg2=from:CUZ,to:PTY,departure:12/3/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:590.62&airProductToken=AQppCjIIwawBEgI1NxjvxAEgwTMoupGeAzCekp4DOFNAAFgBagdDTEFTU0lDcghTRU9CMkJSOQozCMGsARIDMTA1GMEzIILNASiRmJ4DMNSZngM4U0ABWAFqB0NMQVNTSUNyCFNFT0IyQlI5CmkKMwjBrAESAzEwNBiCzQEgwTMokuueAzDk7J4DOFNAAFgBagdDTEFTU0lDcghTRU9CMkJSOQoyCMGsARICNTgYwTMg78QBKNXxngMwvvKeAzhTQAFYAWoHQ0xBU1NJQ3IIU0VPQjJCUjkSDAgBEAEYASoCQVYyABgBIgQIARABKAIoAygEMAE) ![avianca](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/av.gif) Mon, Nov 2 - Sun, Nov 8 PTY Panama City CUZ Cusco $602 Roundtrip found 3 hours ago [](https://expedia.com/Flights-Search?trip=roundtrip&leg1=from:PTY,to:CUZ,departure:11/2/2026TANYT&leg2=from:CUZ,to:PTY,departure:11/8/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:601.32&airProductToken=AQppCjIIwawBEgI0MRjvxAEgwTMo24ecAzDEiJwDOFNAAFgBagdDTEFTU0lDcghTRU9CMkJSOQozCMGsARIDMTA1GMEzIILNASiRipwDMNSLnAM4U0ABWAFqB0NMQVNTSUNyCFNFT0IyQlI5CmgKMgjBrAESAjgwGILNASDBMyjVz5wDMKLRnAM4U0AAWAFqB0NMQVNTSUNyCFNFT0IyQlI5CjIIwawBEgI1OBjBMyDvxAEotdicAzCe2ZwDOFNAAVgBagdDTEFTU0lDcghTRU9CMkJSORIKCAEQARgBKgJBVhgBIgQIARABKAIoAygEMAE) ![avianca](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/av.gif) Wed, Nov 25 - Thu, Dec 3 PTY Panama City CUZ Cusco $608 Roundtrip found 5 days ago [](https://expedia.com/Flights-Search?trip=roundtrip&leg1=from:PTY,to:CUZ,departure:11/25/2026TANYT&leg2=from:CUZ,to:PTY,departure:12/3/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:607.82&airProductToken=AQplCjAIwawBEgI1NxjvxAEgwTMoupGeAzCekp4DOFBAAFgBagVMSUdIVHIIUEVPQjFCUkIKMQjBrAESAzEwNRjBMyCCzQEokZieAzDUmZ4DOFBAAVgBagVMSUdIVHIIUEVPQjFCUkIKZQoxCMGsARIDMTA0GILNASDBMyiS654DMOTsngM4UEAAWAFqBUxJR0hUcghQRU9CMUJSQgowCMGsARICNTgYwTMg78QBKNXxngMwvvKeAzhQQAFYAWoFTElHSFRyCFBFT0IxQlJCEgwIARABGAEqAkFWMgAYASIECAEQASgCKAMoBDAB) ![avianca](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/av.gif) Wed, Nov 25 - Thu, Dec 3 PTY Panama City CUZ Cusco $614 Roundtrip found 5 days ago [](https://expedia.com/Flights-Search?trip=roundtrip&leg1=from:PTY,to:CUZ,departure:11/25/2026TANYT&leg2=from:CUZ,to:PTY,departure:12/3/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:613.42&airProductToken=AQplCjAIwawBEgI1ORjvxAEgwTMo1Y2eAzC0jp4DOFBAAFgBagVMSUdIVHIIUEVPQjFCUkIKMQjBrAESAzEwNRjBMyCCzQEokZieAzDUmZ4DOFBAAVgBagVMSUdIVHIIUEVPQjFCUkISDAgBEAEYASoCQVYyABgBIgQIARABKAIoAygEMAE) ![avianca](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/av.gif) Wed, Nov 25 - Thu, Dec 3 PTY Panama City CUZ Cusco $615 Roundtrip found 5 days ago [](https://expedia.com/Flights-Search?trip=roundtrip&leg1=from:PTY,to:CUZ,departure:11/25/2026TANYT&leg2=from:CUZ,to:PTY,departure:12/3/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:614.22&airProductToken=AQppCjIIwawBEgI1ORjvxAEgwTMo1Y2eAzC0jp4DOFNAAFgBagdDTEFTU0lDcghTRU9CMkJSOQozCMGsARIDMTA1GMEzIILNASiRmJ4DMNSZngM4U0ABWAFqB0NMQVNTSUNyCFNFT0IyQlI5EgwIARABGAEqAkFWMgAYASIECAEQASgCKAMoBDAB) ![avianca](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/av.gif) Mon, Nov 2 - Sun, Nov 8 PTY Panama City CUZ Cusco $619 Roundtrip found 3 hours ago [](https://expedia.com/Flights-Search?trip=roundtrip&leg1=from:PTY,to:CUZ,departure:11/2/2026TANYT&leg2=from:CUZ,to:PTY,departure:11/8/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:618.52&airProductToken=AQplCjAIwawBEgI0MRjvxAEgwTMo24ecAzDEiJwDOFBAAFgBagVMSUdIVHIIUEVPQjFCUkIKMQjBrAESAzEwNRjBMyCCzQEokYqcAzDUi5wDOFBAAVgBagVMSUdIVHIIUEVPQjFCUkIKZAowCMGsARICODAYgs0BIMEzKNXPnAMwotGcAzhQQABYAWoFTElHSFRyCFBFT0IxQlJCCjAIwawBEgI1OBjBMyDvxAEotdicAzCe2ZwDOFBAAVgBagVMSUdIVHIIUEVPQjFCUkISCggBEAEYASoCQVYYASIECAEQASgCKAMoBDAB) ![avianca](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/av.gif) Mon, Nov 2 - Sun, Nov 8 PTY Panama City CUZ Cusco $620 Roundtrip found 3 hours ago [](https://expedia.com/Flights-Search?trip=roundtrip&leg1=from:PTY,to:CUZ,departure:11/2/2026TANYT&leg2=from:CUZ,to:PTY,departure:11/8/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:619.62&airProductToken=AQppCjIIwawBEgI0MRjvxAEgwTMo24ecAzDEiJwDOFNAAFgBagdDTEFTU0lDcghTRU9CMkJSOQozCMGsARIDMTA1GMEzIILNASiRipwDMNSLnAM4U0ABWAFqB0NMQVNTSUNyCFNFT0IyQlI5EgoIARABGAEqAkFWGAEiBAgBEAEoAigDKAQwAQ) ![avianca](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/av.gif) Wed, Nov 25 - Thu, Dec 3 PTY Panama City CUZ Cusco $625 Roundtrip found 2 days ago [](https://expedia.com/Flights-Search?trip=roundtrip&leg1=from:PTY,to:CUZ,departure:11/25/2026TANYT&leg2=from:CUZ,to:PTY,departure:12/3/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:624.62&airProductToken=AQplCjAIwawBEgI1ORjvxAEgwTMo1Y2eAzC0jp4DOFBAAFgBagVMSUdIVHIIUEVPQjFCUkIKMQjBrAESAzEwNRjBMyCCzQEokZieAzDUmZ4DOFBAAVgBagVMSUdIVHIIUEVPQjFCUkISCggBEAEYASoCQVYYASIECAEQASgCKAMoBDAB) ![avianca](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/av.gif) Wed, Nov 25 - Thu, Dec 3 PTY Panama City CUZ Cusco $626 Roundtrip found 2 days ago [](https://expedia.com/Flights-Search?trip=roundtrip&leg1=from:PTY,to:CUZ,departure:11/25/2026TANYT&leg2=from:CUZ,to:PTY,departure:12/3/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:625.52&airProductToken=AQppCjIIwawBEgI1ORjvxAEgwTMo1Y2eAzC0jp4DOFNAAFgBagdDTEFTU0lDcghTRU9CMkJSOQozCMGsARIDMTA1GMEzIILNASiRmJ4DMNSZngM4U0ABWAFqB0NMQVNTSUNyCFNFT0IyQlI5EgoIARABGAEqAkFWGAEiBAgBEAEoAigDKAQwAQ) ![avianca](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/av.gif) Thu, Apr 23 - Thu, Apr 30 PTY Panama City CUZ Cusco $662 Roundtrip found 2 days ago [](https://expedia.com/Flights-Search?trip=roundtrip&leg1=from:PTY,to:CUZ,departure:4/23/2026TANYT&leg2=from:CUZ,to:PTY,departure:4/30/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:661.32&airProductToken=AQplCjAIwawBEgI0MRjvxAEgwTMolY2LAzD0jYsDOE9AAFgBagVMSUdIVHIIT0VPQjFCUkIKMQjBrAESAzEwNRjBMyCCzQEo7I6LAzC0kIsDOE9AAVgBagVMSUdIVHIIT0VPQjFCUkIKZQoxCMGsARIDMTA0GILNASDBMyjy4YsDML_jiwM4UEAAWAFqBUxJR0hUcghQRU9CMUJSQgowCMGsARICNTYYwTMg78QBKP_qiwMw4-uLAzhQQAFYAWoFTElHSFRyCFBFT0IxQlJCEgoIARABGAEqAkFWGAEiBAgBEAEoAigDKAQwAQ) ## Frequently asked questions ### How much does a flight from Panama City (PTY-Tocumen Intl.) to Cusco (CUZ-Alejandro Velasco Astete Intl.) cost? ### What is the cheapest month to fly from Panama City (PTY-Tocumen Intl.) to Cusco (CUZ-Alejandro Velasco Astete Intl.)? ### Which airlines fly direct from Panama City (PTY-Tocumen Intl.) to Cusco (CUZ-Alejandro Velasco Astete Intl.)? ### What is the cheapest airline that flies from Panama City (PTY-Tocumen Intl.) to Cusco (CUZ-Alejandro Velasco Astete Intl.)? ### How do I find cheap flights from Panama City (PTY-Tocumen Intl.) to Cusco (CUZ-Alejandro Velasco Astete Intl.)? ### What is the best time to fly from Panama City (PTY-Tocumen Intl.) to Cusco (CUZ-Alejandro Velasco Astete Intl.)? ### What is the earliest flight from Panama City (PTY-Tocumen Intl.) to Cusco (CUZ-Alejandro Velasco Astete Intl.)? ### What are the most popular departure times for flights from Panama City (PTY-Tocumen Intl.) to Cusco (CUZ-Alejandro Velasco Astete Intl.)? ### How long does it take to fly from Panama City (PTY-Tocumen Intl.) to Cusco (CUZ-Alejandro Velasco Astete Intl.)? ### Can you fly business or first class from Panama City (PTY-Tocumen Intl.) to Cusco (CUZ-Alejandro Velasco Astete Intl.)? ### How do I earn miles on a Panama City (PTY-Tocumen Intl.) to Cusco (CUZ-Alejandro Velasco Astete Intl.) flight with Expedia? ### What airports do you fly into for Cusco from Tocumen Intl. (PTY)? ### Is it cheaper to buy a plane ticket from Panama City (PTY-Tocumen Intl.) to Cusco (CUZ-Alejandro Velasco Astete Intl.) at the last minute? ### Is it cheaper to book a Panama City (PTY-Tocumen Intl.) to Cusco (CUZ-Alejandro Velasco Astete Intl.) flight and hotel package? ### Can I cancel or change the date of my flight from Panama City (PTY-Tocumen Intl.) to Cusco (CUZ-Alejandro Velasco Astete Intl.)? ## Travel information | Origin airport | Tocumen Intl. | | ------------------- | ------------------------------ | | Destination airport | Alejandro Velasco Astete Intl. | | Airlines serving | avianca | | Roundtrip price | $591 | | Distance | 1643 mi | ## Book with confidence # Panama City to Cusco Flights The cheapest times to fly from Panama City to Cusco On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Panama City to Cusco are during the month of November. You can find some of the cheapest flights from Panama City to Cusco with Expedia's search tool and vast selection of airlines. The best time to book a flight from Panama City to Cusco Sunday is one of the best days to book for cheap flights from Panama City to Cusco: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance. How to find cheap round-trip tickets from Panama City to Cusco Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Panama City to Cusco in 2026\. You can also book with separate airlines for your outbound and return journeys, from $321 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference\*. This is available for a small fee, and is free to One Key Gold and Platinum tier members. Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Panama City to Cusco flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps. You could also save big by booking one of Expedia's [vacation packages](https://www.expedia.com/package-deals). Bundling together your Panama City to Cusco airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures. \*Terms apply. Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023\. 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