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21c Museum Hotel Louisville

4.5 star property
Luxury hotel with a full-service spa and a 24-hour fitness center

Choose dates to view prices

Travelers find art and luxury at 21c Museum Hotel Louisville. Enjoy rejuvenating massages at the spa, breakfast and dinner at Proof on Main, a 24-hour gym, and dry cleaning services. Attentive staff handle every need to ensure guests look their best.

Reviews

9.2 out of 10
Wonderful

Popular amenities

  • Spa
  • Bar
  • Room service

Room options

Available filters for rooms
Showing 12 of 12 rooms

View all photos for Deluxe Double Room, 2 Double Beds

Deluxe Double Room, 2 Double Beds | Premium bedding, down comforters, minibar, in-room safe

Deluxe Double Room, 2 Double Beds

9.6 out of 10
Exceptional
(30 reviews)

Highlights

Soundproofed
Air conditioning
Connecting rooms available
Free cribs/infant beds
HDTV
Hypo-allergenic bedding
Blackout drapes/curtains
Down duvet
  • 335 sq ft
  • Sleeps 4
  • 2 Double Beds

View all photos for Luxury Double Room, 2 Double Beds

Luxury Double Room, 2 Double Beds | Premium bedding, down comforters, minibar, in-room safe

Luxury Double Room, 2 Double Beds

9.0 out of 10
Wonderful
(2 reviews)

Highlights

Soundproofed
Air conditioning
Connecting rooms available
Free cribs/infant beds
HDTV
Hypo-allergenic bedding
Blackout drapes/curtains
Down duvet
  • 435 sq ft
  • City view
  • Sleeps 4
  • 2 Double Beds

View all photos for Deluxe Room, 1 King Bed

Deluxe Room, 1 King Bed | Premium bedding, down comforters, minibar, in-room safe

Deluxe Room, 1 King Bed

9.6 out of 10
Exceptional
(65 reviews)

Highlights

Soundproofed
Air conditioning
Connecting rooms available
Free cribs/infant beds
HDTV
Hypo-allergenic bedding
Blackout drapes/curtains
Down duvet
  • 350 sq ft
  • Sleeps 3
  • 1 King Bed

View all photos for Luxury Room, 1 King Bed

Luxury Room, 1 King Bed | Premium bedding, down comforters, minibar, in-room safe

Luxury Room, 1 King Bed

9.0 out of 10
Wonderful
(32 reviews)

Highlights

Soundproofed
Air conditioning
Connecting rooms available
Free cribs/infant beds
HDTV
Hypo-allergenic bedding
Blackout drapes/curtains
Down duvet
  • 455 sq ft
  • City view
  • Sleeps 3
  • 1 King Bed

View all photos for Suite, Corner

Suite, Corner | Premium bedding, down comforters, minibar, in-room safe

Suite, Corner

Highlights

Soundproofed
Air conditioning
Connecting rooms available
Free cribs/infant beds
HDTV
Hypo-allergenic bedding
Blackout drapes/curtains
Down duvet
  • 660 sq ft
  • City view
  • Sleeps 3
  • 1 King Bed

View all photos for Room (Asleep in the Cyclone)

Room (Asleep in the Cyclone) | Premium bedding, down comforters, minibar, in-room safe

Room (Asleep in the Cyclone)

Highlights

Soundproofed
Air conditioning
Connecting rooms available
Free cribs/infant beds
HDTV
Hypo-allergenic bedding
Blackout drapes/curtains
Down duvet
  • 500 sq ft
  • Sleeps 3
  • 1 King Bed

View all photos for Suite (Atrium)

Suite (Atrium) | Premium bedding, down comforters, minibar, in-room safe

Suite (Atrium)

Highlights

Soundproofed
Air conditioning
Connecting rooms available
Free cribs/infant beds
HDTV
Hypo-allergenic bedding
Blackout drapes/curtains
Down duvet
  • 580 sq ft
  • Sleeps 3
  • 1 King Bed

View all photos for Room, Balcony

Room, Balcony | Premium bedding, down comforters, minibar, in-room safe

Room, Balcony

10.0 out of 10
Exceptional
(1 review)

Highlights

Furnished balcony or patio
Soundproofed
Air conditioning
Connecting rooms available
Free cribs/infant beds
HDTV
Hypo-allergenic bedding
Blackout drapes/curtains
  • 315 sq ft
  • City view
  • Sleeps 3
  • 1 King Bed

View all photos for Deluxe Double Room, Accessible

Designer toiletries, hair dryer, bathrobes, towels

Deluxe Double Room, Accessible

9.0 out of 10
Wonderful
(2 reviews)

Highlights

Soundproofed
Air conditioning
Connecting rooms available
Free cribs/infant beds
HDTV
Hypo-allergenic bedding
Blackout drapes/curtains
Down duvet
  • 455 sq ft
  • Sleeps 4
  • 2 Double Beds

View all photos for Deluxe Room, 1 King Bed, Accessible

Premium bedding, down comforters, minibar, in-room safe

Deluxe Room, 1 King Bed, Accessible

Highlights

Soundproofed
Air conditioning
Connecting rooms available
Free cribs/infant beds
HDTV
Hypo-allergenic bedding
Blackout drapes/curtains
Down duvet
  • 434 sq ft
  • Sleeps 3
  • 1 King Bed

View all photos for Deluxe Room, 1 King Bed, Accessible

Premium bedding, down comforters, minibar, in-room safe

Deluxe Room, 1 King Bed, Accessible

Highlights

Soundproofed
Air conditioning
Connecting rooms available
Free cribs/infant beds
HDTV
Hypo-allergenic bedding
Blackout drapes/curtains
Down duvet
  • 435 sq ft
  • Sleeps 3
  • 1 King Bed

View all photos for Apartment, 1 Double Bed (Rooftop)

Apartment, 1 Double Bed (Rooftop) | Premium bedding, down comforters, minibar, in-room safe

Apartment, 1 Double Bed (Rooftop)

Highlights

Furnished balcony or patio
Soundproofed
Air conditioning
Connecting rooms available
Free cribs/infant beds
HDTV
Hypo-allergenic bedding
Blackout drapes/curtains
  • City view
  • Sleeps 4
  • 1 Double Bed

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About the neighborhood

Map
700 W Main Street, Louisville, KY, 40202

What's nearby

  • 21c Museum Hotel - 1 min walk - 0.0 miles
  • Muhammad Ali Center - 3 min walk - 0.2 miles
  • Louisville Slugger Museum - 3 min walk - 0.2 miles
  • Kentucky International Convention Center - 8 min walk - 0.5 miles
  • KFC Yum Center - 8 min walk - 0.5 miles

Getting around

  • Louisville Intl. Airport (SDF) - 10 min drive

Restaurants

  • ‪Heine Brothers' Coffee - ‬3 min walk
  • ‪Vincenzo's Italian Restaurant - ‬5 min walk
  • ‪Mussel & Burger Bar - ‬1 min walk
  • ‪Sunergos Coffee and Espresso Bar - ‬6 min walk
  • ‪Bristol Bar and Grille - ‬2 min walk

About this property

21c Museum Hotel Louisville

Luxury boutique hotel near KFC Yum Center
Close to Louisville Slugger Museum and Kentucky International Convention Center, 21c Museum Hotel Louisville provides dry cleaning/laundry services, a bar, and a 24-hour gym. Treat yourself to a deep-tissue massage at 21c Spa, the onsite spa. The on-site restaurant, Proof on Main, offers breakfast, brunch, lunch, and dinner. In addition to a 24-hour business center, guests can connect to free in-room WiFi.
You'll also enjoy perks such as:
  • Limo/town car service, full breakfast (surcharge), and valet parking (surcharge)
  • An electric car charging station, a computer station, and a banquet hall
  • Concierge services, smoke-free premises, and massage treatment rooms
  • Guest reviews speak highly of the dining options, helpful staff, and location
Room features
All 91 rooms include comforts such as premium bedding and laptop-compatible safes, in addition to perks like laptop-friendly workspaces and air conditioning. Guest reviews speak positively of the clean rooms at the property.
Extra conveniences in all rooms include:
  • LED light bulbs and eco-friendly cleaning products
  • Bathrooms with designer toiletries and hair dryers
  • 50-inch HDTVs with premium channels
  • Wardrobes/closets, free infant beds, and daily housekeeping

Awards and affiliations

Eco-Certified Property
This property participates in Green Key Global, a program that measures the property's impact on one or more of the following: environment, community, cultural-heritage, the local economy.

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Property amenities

Internet

  • Available in all rooms: Free WiFi and wired internet
  • Available in some public areas: Free WiFi and wired internet

Parking and transportation

  • Electric car charging station on site
  • Limo/town car service
  • Valet parking on site (USD 32 per night; includes in/out privileges)
  • Wheelchair-accessible parking available

Food and drink

  • Full breakfast available for a fee 7:00 AM to 10:00 AM on weekdays and 8:00 AM to 1:00 PM on weekends; USD 5 to 25 per person
  • A bar/lounge
  • A restaurant
  • Coffee and tea in common areas

Restaurants on site

  • Proof on Main

Things to do

  • 24-hour gym
  • Full-service spa
  • Yoga classes

Family friendly

  • In-room crib
  • Laundry facilities
  • Rollaway/extra bed (surcharge)
  • Soundproofed rooms

Conveniences

  • 24-hour front desk
  • ATM
  • Gift shop/newsstand
  • Laundry facilities
  • Luggage storage
  • Safe at front desk

Guest services

  • Concierge services
  • Dry cleaning/laundry service
  • Housekeeping (daily)
  • Multilingual staff
  • Porter/bellhop
  • Tour and ticket assistance

Business services

  • 24-hour business center
  • 5,000 square feet of conference space
  • Computer station
  • Meeting rooms

Full-service spa

  • 2 treatment rooms
  • Deep-tissue massages
  • Hot stone massages
  • In-room massages
  • Prenatal massages
  • Sauna
  • Spa open daily
  • Sports massages
  • Steam room
  • Swedish massages

Accessibility

  • If you have requests for specific accessibility needs, please contact the property using the information on the reservation confirmation received after booking.
  • Assistive listening devices
  • Braille/raised signage
  • Elevator
  • Wheelchair accessibility
  • Wheelchair accessible (may have limitations)
  • Wheelchair-accessible parking
  • Wheelchair-accessible path of travel
  • Wheelchair-accessible registration desk

More

  • 1 building
  • 4 floors
  • At least 80% lighting from LEDs
  • Banquet hall
  • Biodegradable coffee stirrers available
  • Biodegradable drinking straws available
  • Built in 2006
  • Comprehensive food waste policy
  • Double-glazed windows
  • Eco-friendly cleaning products used
  • No plastic coffee stirrers
  • No plastic drinking straws
  • No plastic soft drink bottles
  • No plastic water bottles
  • Reusable cups
  • Reusable tableware
  • Smoking not allowed
  • Vegan dining options

Room amenities

Bedroom

  • Blackout drapes
  • Down comforter
  • Free crib
  • Hypo-allergenic bedding
  • Premium bedding
  • Rollaway/extra bed (surcharge)

Bathroom

  • Bathrobes
  • Designer toiletries
  • Hair dryer
  • Private bathroom
  • Shampoo
  • Soap
  • Toilet paper
  • Toothbrush and toothpaste (on request)
  • Towels provided

Entertainment

  • 50-inch LCD TV with premium cable channels
  • iPod dock

Food and drink

  • Champagne service
  • Espresso maker
  • Free bottled water
  • Limited room service
  • Minibar

More

  • Air conditioning (climate-controlled)
  • Cleaning products are eco-friendly
  • Connecting rooms available
  • Desk
  • Eco-friendly toiletries
  • Free local calls
  • Iron/ironing board
  • Laptop workspace
  • Laptop-compatible safe
  • LED lighting
  • Soundproofed rooms
  • Water-efficient showers

Policies

Check-in

Check-in start time: 4 PM; Check-in end time: midnight
Contactless check-in available
Minimum check-in age: 21

Check-out

Check-out before 11 AM
Contactless check-out available

Special check-in instructions

Front desk staff will greet guests on arrival at the property

Access methods

Staffed front desk

Pets

Pets allowed for an extra charge of USD 40.00 per accommodation, per stay
Service animals are welcome, and are exempt from fees
Up to 50 lbs per pet
Food and water bowls are available

Children and extra beds

Children are welcome
Rollaway/extra beds are available for USD 30.0 per night
Free cribs are available on request at the property

Property payment types

Important information

Fees

You'll be asked to pay the following charges at the property. Fees may include applicable taxes:

  • Service fee: USD 5.00 per accommodation, per stay

We have included all charges provided to us by the property.

Optional extras

  • Fee for full breakfast: approximately USD 5 to 25 per person
  • Valet parking fee: USD 32 per night (in/out privileges)
  • Pet fee: USD 40.00 per accommodation, per stay
  • Service animals are exempt from fees
  • Rollaway bed fee: USD 30.0 per night

The above list may not be comprehensive. Fees and deposits may not include tax and are subject to change.

You need to know

Extra-person charges may apply and vary depending on property policy
Government-issued photo identification and a credit card may be required at check-in for incidental charges
Special requests are subject to availability upon check-in and may incur additional charges; special requests cannot be guaranteed
The name on the credit card used at check-in to pay for incidentals must be the primary name on the guestroom reservation
This property accepts credit cards; cash is not accepted
This property uses eco-friendly cleaning products
Safety features at this property include a carbon monoxide detector, a fire extinguisher, a smoke detector, a security system, a first aid kit, and window guards
This property affirms that it follows the cleaning and disinfection practices of ALLSAFE (Accor Hotels)

We should mention

Reservations are required for massage services; reservations can be made by contacting the property prior to arrival, using the contact information on the booking confirmation
The property has connecting/adjoining rooms, which are subject to availability and can be requested by contacting the property using the number on the booking confirmation
This property welcomes guests of all sexual orientations and gender identities (LGBTQ+ friendly)

Property is also known as

21c Hotel Louisville
21c Hotel Museum
21c Louisville Hotel
21c Museum
21c Museum Hotel
21c Museum Hotel Louisville
21c Museum Louisville
Louisville 21c Hotel
Louisville 21c Museum
Museum Hotel 21c
21c Museum Hotel Louisville MGallery
21c Museum Louisville MGallery
Hotel 21c Museum Hotel Louisville - MGallery Louisville
Louisville 21c Museum Hotel Louisville - MGallery Hotel
21c Museum Hotel Louisville - MGallery Louisville
Hotel 21c Museum Hotel Louisville - MGallery
21c Museum Hotel MGallery
21c Museum MGallery
21c Museum Hotel Louisville
21c Museum Louisville Mgallery
21c Museum Louisville
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21c Museum Hotel Louisville MGallery
21c Museum Hotel Louisville Louisville
21c Museum Hotel Louisville Hotel Louisville

Frequently asked questions

Is 21c Museum Hotel Louisville pet-friendly?

Yes, this hotel allows pets with a maximum weight of up to 50 lbs per pet. There's a fee of USD 40.00 per accommodation, per stay. Service animals are exempt from fees.

How much does it cost to stay at 21c Museum Hotel Louisville?

As of Nov 20, 2025, prices found for a 1-night stay for 2 adults at 21c Museum Hotel Louisville on Nov 23, 2025 start from $179.0, excluding taxes and fees. This price is based on the lowest nightly price found in the last 24 hours for stays in the next 30 days. Prices are subject to change. Choose your dates for more accurate prices.

How much is parking?

Valet parking is available for USD 32 per night.

What time is check-in at 21c Museum Hotel Louisville?

Check-in start time: 4 PM; Check-in end time: midnight.

What time is check-out at 21c Museum Hotel Louisville?

Check-out is at 11 AM.

Where is 21c Museum Hotel Louisville located?

Located in Downtown Louisville, this luxury hotel is steps from Ohio River Valley and Louisville Slugger Museum. Kentucky International Convention Center and KFC Yum Center are also within 15 minutes.

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Reviews

21c Museum Hotel Louisville Reviews

9.2

Wonderful

9.6

Cleanliness

9.0

Location

9.4

Staff & service

9.2

Eco-friendliness

9.6

Property conditions & facilities
Rating 10 - Excellent. 760 out of 1001 reviews
Rating 8 - Good. 137 out of 1001 reviews
Rating 6 - Okay. 61 out of 1001 reviews
Rating 4 - Poor. 23 out of 1001 reviews
Rating 2 - Terrible. 20 out of 1001 reviews

Reviews

10/10 Excellent

Erica

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Loved our stay, would definitely plan to come back if we are ever in the area again.
Stayed 1 night in Oct 2025

10/10 Excellent

Jeannette

Liked: Cleanliness, staff & service, property conditions & facilities
Great stay overall.
Stayed 2 nights in Sep 2025

10/10 Excellent

Clark and Margaret

Liked: Cleanliness, amenities, property conditions & facilities
Room clean , comfortable and quiet.
Stayed 1 night in Nov 2025

10/10 Excellent

Jan Elliott

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Excellent in every way. The art museum was an added bonus!!!
Stayed 3 nights in Nov 2025

10/10 Excellent

Glenn

Liked: Cleanliness, amenities, property conditions & facilities
Room comfortable and clean. Staff very helpful and friendly. Loved the art!
Stayed 1 night in Nov 2025

10/10 Excellent

Shelley

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
We only stayed 1 night, but everything was excellent
Stayed 1 night in Oct 2025

10/10 Excellent

Robin

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
21c Museum Hotel is a fun and unique experience. Beautiful rooms and centrally located to shops, restaurants and distilleries in Louisville.
Stayed 2 nights in Oct 2025

10/10 Excellent

Jennifer

Liked: Cleanliness, staff & service, property conditions & facilities
Room was very clean and staff were very friendly.
Stayed 1 night in Sep 2025

10/10 Excellent

earl

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Perfect location for walking Louisville
Stayed 4 nights in Oct 2025

8/10 Good

ABBEY

Liked: Cleanliness
Bed was comfortable, room was large, bathroom was OK. Staff was kind. Wish the breakfast opened earlier on Sunday.
Stayed 3 nights in Oct 2025

8/10 Good

mirtha

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Good location
Stayed 2 nights in Oct 2025

10/10 Excellent

Jennifer

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Amazing location and great hotel. Staff was great. Restaurant was delicious. Great location on Main Street!!
Stayed 4 nights in Sep 2025

8/10 Good

Richard

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Breakfast had a good variety but in some cases a little over cooked. Right on whiskey row, plenty of dining options
Stayed 3 nights in Oct 2025

10/10 Excellent

Kimberley

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Fun place to stay! Eclectic, unique and eccentric decor. Really enjoyed the location and convenient, walkable access.
Stayed 3 nights in Sep 2025

10/10 Excellent

Vaunalee

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
We had a great stay and very much enjoyed the art and the atmosphere.
Stayed 2 nights in Aug 2025

10/10 Excellent

Eric

Liked: Cleanliness, staff & service, property conditions & facilities
The art museum is pretty cool. Staff were super nice.
Stayed 5 nights in Sep 2025

10/10 Excellent

Andrea

Liked: Cleanliness, staff & service, property conditions & facilities
Love my stay at this unique musuem hotel!
Stayed 1 night in Aug 2025

10/10 Excellent

Heather

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Nice property. Room was comfortable, easy check in and check out. Staff were pleasant and atmosphere was cool.
Stayed 2 nights in Sep 2025

10/10 Excellent

Jeffrey

Liked: Cleanliness, staff & service, property conditions & facilities
I would definitely stay again at this chic hotel chain
Stayed 1 night in Sep 2025

10/10 Excellent

Thomas

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Excellent place to stay.
Stayed 1 night in Jun 2025

10/10 Excellent

Melissa

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
We've wanted to stay at a 21c Museum hotel. We love the concept. And the room was large and well appointed. Staff was A+. We highly recommend when visiting Louisville.
Stayed 1 night in Oct 2025

8/10 Good

Thomas

Liked: Cleanliness, amenities, property conditions & facilities
Front desk and valets were great. But our room wasn't serviced, which makes the stay less comfortable.
Stayed 2 nights in Oct 2025

10/10 Excellent

Jessica

Liked: Cleanliness, staff & service, property conditions & facilities
Shout out to the valet staff, super friendly and helpful and truly made the weekend great.
Stayed 3 nights in Sep 2025

10/10 Excellent

Michael Sheridan

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Very cool art in a perfect location, walkable to so many great venues. Very friendly, helpful staff. The adjacent restaurant, Proof, was cool and delicious. The rooms were well appointed with in room safe, mini fridge, nice shower and comfortable beds. We would definitely stay here again.
Stayed 2 nights in Sep 2025

10/10 Excellent

Stephanie

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Loved the strange art. I thought the building maintained the character I was expecting by the name and the reviews. Gym was actually better than the reviews.
Stayed 2 nights in Oct 2025