$89 Cheap American Airlines flights Cleveland (CLE) to St. Louis (STL)

Grab cheap round-trip American Airlines flights from $170 from CLE to STL by filtering your results from “Price (lowest to highest)” on Expedia. Or look for bargains from $89 for a one-way journey.**These prices were available on Expedia within the past 7 days, for flights departing within the next year. Prices and availability are subject to change. Additional terms apply.

January is one of the least expensive months to fly to St. Louis with American Airlines. You could also find great deals on return and one-way fares in February.

Search for cheap American Airlines flights from Hopkins Intl. Airport (CLE) to Lambert-St. Louis Intl. Airport (STL) one to three months prior to your departure day. Travelers who book domestic flights 34 to 86 days in advance can save 25% compared to those who book just 6 to 12 days ahead. Regardless of fare class and itinerary, the best day to book a domestic flight is usually Sunday and the most expensive tends to be Monday. Passengers who book on a Sunday can save 6% on average compared to those who book their travel on a Monday.**Ideal booking window recommendation is based on average round-trip ticket prices for January through November for 2024. Best day of the week to book recommendation is based on average round-trip ticket prices for January through October 2024. All data sourced from ARC’s global airline sales database.

Simply enter your dates, hit search and select “Nonstop” on Expedia to browse any direct flights from CLE to STL with American Airlines or another airline.

Search American Airlines’s earliest flights from CLE to STL by using our “Morning” and “Early Morning” filters. Not only will you get to your destination sooner, early departures also have a 20% less chance of being canceled.**Most reliable time of the day recommendation is based on January through August 2024 flight status data sourced from OAG’s global flight data platform.

American Airlines flights from Hopkins Intl. Airport (CLE) to St. Louis come in to land at Lambert-St. Louis Intl. Airport (STL). This is the main gateway here.

Depending on the ticket type you purchased, a fee will generally apply if you cancel or reschedule your booking more than 24 hours after confirmation. To secure flexible fares, select our “Changes included” or “No cancel fee” filter while searching for flights. For additional information on canceling or changing your reservation, visit “Trips,” select your flight and tick “Manage Booking.”