Title: The Best 5 Star Hotels in St. Ann, MO from $149 | Expedia.com [St. Ann Travel Guide](https://expedia.com/St-Ann.dx7051)[Hotels in St. Ann](https://expedia.com/St-Ann-Hotels.d7051.Travel-Guide-Hotels)[Vacation Rentals in St. Ann](https://expedia.com/St-Ann-Vacation-Rentals.d7051.Travel-Guide-VacationRentals)[Flights to St. Ann](https://expedia.com/Cheap-Flights-To-St-Ann.d7051.Travel-Guide-Flights)[Things to do in St. Ann](https://expedia.com/Things-To-Do-In-St-Ann.d7051.Travel-Guide-Activities)[Car Rentals in St. Ann](https://expedia.com/Car-Rentals-In-St-Ann.d7051.Car-Rental-Guide)[St. Ann Vacation Packages](https://expedia.com/St-Ann.d7051.Destination-Travel-Guides) ![Default HTG hotel image](https://a.travel-assets.com/travel-assets-manager/fallback-images-brand/bex_lodging_v2.jpg?impolicy=fcrop&w=1200&h=500&q=medium) ![](https://a.travel-assets.com/travel-assets-manager/fallback-images-brand/bex_lodging_v2.jpg?impolicy=fcrop&w=1200&h=500&q=medium) ## Check availability on St. Ann 5 Star Hotels Tonight [Mar 24 - Mar 25](https://www.expedia.com/Hotel-Search?regionId=7051&startDate=2026-03-24&endDate=2026-03-25&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Mar 25 - Mar 26](https://www.expedia.com/Hotel-Search?regionId=7051&startDate=2026-03-25&endDate=2026-03-26&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Mar 27 - Mar 29](https://www.expedia.com/Hotel-Search?regionId=7051&startDate=2026-03-27&endDate=2026-03-29&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Apr 3 - Apr 5](https://www.expedia.com/Hotel-Search?regionId=7051&startDate=2026-04-03&endDate=2026-04-05&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Our top choices for St. Ann 5-star hotels ![Meeting facility](https://images.trvl-media.com/lodging/1000000/10000/6200/6132/a54897ef.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/10000/6200/6132/3f20ce75.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Meeting facility](https://images.trvl-media.com/lodging/1000000/10000/6200/6132/1817cdae.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Daily buffet breakfast for a fee](https://images.trvl-media.com/lodging/1000000/10000/6200/6132/f50e8b2b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Ritz-Carlton, St. Louis [](https://www.expedia.com/St-Louis-Hotels-The-Ritz-Carlton.h6132.Hotel-Information) Clayton 9.2/10 Wonderful (561 reviews) "Excellent hotel with various restaurants and expansive lobby area.. staff very attentive." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Diane M $499 nightly $583 total Mar 29 - Mar 30 Total with taxes and fees [](https://www.expedia.com/St-Louis-Hotels-The-Ritz-Carlton.h6132.Hotel-Information) ![Terrace/patio](https://images.trvl-media.com/lodging/3000000/2860000/2851500/2851438/ef7a5612.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Rooftop bar](https://images.trvl-media.com/lodging/3000000/2860000/2851500/2851438/5b370fff.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Couples treatment rooms, hot tub, body treatments, aromatherapy](https://images.trvl-media.com/lodging/3000000/2860000/2851500/2851438/56a41562.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Couples treatment rooms, hot tub, body treatments, aromatherapy](https://images.trvl-media.com/lodging/3000000/2860000/2851500/2851438/941b0ba8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Four Seasons Hotel St Louis [](https://www.expedia.com/St-Louis-Hotels-Four-Seasons-Hotel-St-Louis.h2851438.Hotel-Information) Downtown St. Louis 9.4/10 Exceptional (1,001 reviews) "The heated pool was great for the kids and the staff great" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Jacob $325 nightly $380 total Mar 30 - Mar 31 Total with taxes and fees [](https://www.expedia.com/St-Louis-Hotels-Four-Seasons-Hotel-St-Louis.h2851438.Hotel-Information) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in ](https://expedia.com/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2F5Star-St-Ann-Hotels.s50-0-d7051.Travel-Guide-Filter-Hotels)[ Sign up, it's free ](https://expedia.com/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2F5Star-St-Ann-Hotels.s50-0-d7051.Travel-Guide-Filter-Hotels) ## Explore similar 4-star hotels Many 4-star hotels have the same amenities as 5-star hotels. See all 4-star hotels in St. Ann. ![21C Museum Hotel St Louis ](https://images.trvl-media.com/lodging/90000000/89170000/89164600/89164592/bd7064dc_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### 21C Museum Hotel St Louis 1528 Locust street St. Louis MO $138 nightly $162 total Apr 5 - Apr 6 Total with taxes and fees 9/10 Wonderful! (1,684 reviews) [](https://expedia.com/St-Louis-Hotels-21C-Museum-Hotel-St-Louis.h89164592.Hotel-Information) ![Hyatt Regency St. Louis at The Arch](https://images.trvl-media.com/lodging/1000000/20000/14900/14877/c1e52387_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Hyatt Regency St. Louis at The Arch 315 Chestnut St St. Louis MO $159 nightly $188 total Apr 2 - Apr 3 Total with taxes and fees 8.4/10 Very Good! (3,990 reviews) [](https://expedia.com/St-Louis-Hotels-Hyatt-Regency-St-Louis-At-The-Arch.h14877.Hotel-Information) ![Renaissance St. Louis Airport Hotel](https://images.trvl-media.com/lodging/1000000/10000/4700/4672/a81cbeae_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Renaissance St. Louis Airport Hotel 9801 Natural Bridge Road St. Louis MO $127 nightly $149 total Apr 3 - Apr 4 Total with taxes and fees 8.4/10 Very Good! (1,069 reviews) [](https://expedia.com/St-Louis-Hotels-Renaissance-St-Louis-Airport-Hotel.h4672.Hotel-Information) Still don't see what you're looking for? [See all properties in St. Ann.](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=3%2F25%2F2026&endDate=3%2F26%2F2026®ionId=7051&star=50) You can also use these popular filters to refine your search. [Pool](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=3%2F25%2F2026&endDate=3%2F26%2F2026®ionId=7051&star=50&star=50&amenities=POOL)[Spa](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=3%2F25%2F2026&endDate=3%2F26%2F2026®ionId=7051&star=50&star=50&amenities=SPA_ON_SITE)[Hot tub](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=3%2F25%2F2026&endDate=3%2F26%2F2026®ionId=7051&star=50&star=50&amenities=HOT_TUB)[Breakfast included](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=3%2F25%2F2026&endDate=3%2F26%2F2026®ionId=7051&star=50&star=50&amenities=FREE_BREAKFAST)[Waterpark](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=3%2F25%2F2026&endDate=3%2F26%2F2026®ionId=7051&star=50&star=50&amenities=WATER_PARK) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. ## Top St. Ann Hotel Reviews ## Find out more about St. Ann Ready to experience the next standard in luxury? We know you're thinking about it. Indulge yourself on your next leisure time. There's no reason to delay a getaway to St. Ann any longer. You'll join the multitudes of vacationers who have made St. Ann so fashionable in the last year. Besides that, you'll find that these hotels are kept in fantastic condition and provide a fine place to lay your head at night. Don't wait any longer. Our 5-star hotels in St. Ann are the perfect places to relax in during your next chunk of time off. ### Book the Best St. Ann 5-Star Hotels Don't be afraid to live the high life while you're on vacation, along with the best conditions. High-end restaurants, concierges, and pillow-fluffing are all at the ready. You're sure to find exactly the accommodation you need. Besides that, you'll find that these hotels are kept in fantastic condition and provide a fine place to lay your head at night. What creature comforts do you want in your lodging? A mud wrap treatment that will leave you feeling outstanding? 24-hour room service, so you can order that berry tart in the wee hours of the morning? A rejuvenating facial treatment to help your cares fall away? Want to see for yourself? Plenty of visitors recommend this location. You won't sleep and order room service the entire time, though. We've got you covered. From doing a bit of shopping to embracing the great outdoors, you'll never be bored on this retreat. Whatever you plan to do, the 5-star hotels in St. Ann are the perfect place to rest up after an exciting day. ### Make Your Escape The results are in, and St. Ann 5-star hotels are the place to be when you book your next vacation. Additionally, these accommodations are highly rated -- 90% of visitors recommended 5-star hotels in St. Ann! It's time to plan your next great escape -- Expedia can help you land a great deal on accommodation. Decide on one of our St. Ann 5-star hotels today and dive into in the lap of luxury when you're ready. ## Frequently asked questions ### What are the best 5-star hotels in St. Ann? ### How much does it cost to stay in a 5-star hotel in St. Ann? > - Search for the lowest price per night from $149 ### What makes a hotel 5 stars in St. Ann? ## Explore a world of travel with Expedia - Lodging - Flights - Packages - Cars - [Hotels near Lambert-St. Louis Intl. ](https://www.expedia.com/Lambert-St-Louis-Intl-Airport-Hotels.0-aSTL-0.Travel-Guide-Filter-Hotels) - [4 Star Hotels in Edmundson ](https://www.expedia.com/4Star-Edmundson-St-Louis-Hotels.s40-n8173-0.Travel-Guide-Filter-Hotels) - [Flights from Lambert-St. Louis Intl. ](https://www.expedia.com/lp/airports/stl/flights-from-lambert-st-louis-intl-airport) - [Flights from Chicago (ORD) to St. Louis (STL) ](https://www.expedia.com/lp/flights/ord/stl/chicago-to-st-louis) - [Flights from Dallas (DFW) to St. Louis (STL) ](https://www.expedia.com/lp/flights/dfw/stl/dallas-to-st-louis) - 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