$457 Cheap American Airlines flights San Antonio (SAT) to Florence (FLR)

You'll find affordable round-trip American Airlines flights from $667 from SAT to FLR by sorting your results from "Price (lowest to highest)" on Expedia. Or look for options from $457 for a one-way trip.**These prices were available on Expedia within the past 7 days, for flights departing within the next year. Prices and availability are subject to change. Additional terms apply.

Landing the best American Airlines deals from SAT to FLR often comes down to booking at the right time. You can save 17% on international flights when you book 18 to 29 days before takeoff instead of four to five months ahead. As an added bonus, you can pocket 17% on average by buying your fare on a Sunday rather than a Friday, which is usually the most expensive day to book.* It's smart to kick off your flight search about one month before your departure date.*Ideal booking window recommendation is based on average round-trip ticket prices for January through November for 2024. Best day of the week to book recommendation is based on average round-trip ticket prices for January through October 2024. All data sourced from ARC's global airline sales database.

Search American Airlines's earliest flights from SAT to FLR by selecting our "Early Morning" and "Morning" filters. Not only will you get to your destination sooner, early departures also experience 20% fewer cancellations.**Most reliable time of the day recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.