$126 Cheap Delta flights New Orleans (MSY) to Knoxville (TYS)

You'll discover affordable return Delta Air Lines flights from $234 from MSY to TYS by sorting your results from "Price (lowest to highest)" on Expedia. Or look for bargains from $126 for a one-way trip.**These prices were available on Expedia within the past 7 days, for flights departing within the next year. Prices and availability are subject to change. Additional terms apply.

Look for cheap Delta Air Lines flights from Louis Armstrong New Orleans Intl. Airport (MSY) to McGhee Tyson Airport (TYS) one to three months prior to your day of departure. Travelers who book domestic flights 34 to 86 days in advance can save 25% compared to those who book just 6 to 12 days ahead. No matter the fare class and journey, the ideal day to book a domestic flight is generally Sunday and the most expensive tends to be Monday. Passengers who book on a Sunday can save 6% on average compared to those who book their travel on a Monday.**Ideal booking window recommendation is based on average round-trip ticket prices for January through November for 2024. Best day of the week to book recommendation is based on average round-trip ticket prices for January through October 2024. All data sourced from ARC's global airline sales database.

To find the earliest departure from MSY to TYS with Delta Air Lines, sort your results by "Morning" and "Early Morning." Booking an early flight usually means cancellations are less likely.**Most reliable time of the day recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.

Delta Air Lines makes traveling from MSY to TYS more comfortable with a rewarding loyalty program and an excellent in-flight experience. You could even start earning points with Delta SkyMiles. Don't forget to join Expedia's free One Key™ rewards program to earn OneKeyCash™*, which can be redeemed on future bookings.*OneKeyCash™ disclaimer - OneKeyCash™ is not redeemable for cash and can only be used on Expedia, Hotels.com and Vrbo.