$126 Cheap Delta flights Portland (PDX) to Knoxville (TYS)

Finding cheap one-way Delta Air Lines flights from PDX to TYS from $126 on Expedia couldn't be easier --- just filter by "Price (lowest to highest)." Alternatively, check out our affordable round-trip fares from $251 for your next exciting vacation.**These prices were available on Expedia within the past 7 days, for flights departing within the next year. Prices and availability are subject to change. Additional terms apply.

Look for affordable Delta Air Lines flights from Portland Intl. Airport (PDX) to McGhee Tyson Airport (TYS) one to three months prior to your departure day. Travelers who book domestic flights 34 to 86 days in advance can save 25% compared to those who book just 6 to 12 days ahead. No matter the fare class and itinerary, the best day of the week to book a domestic flight is usually Sunday and the most expensive tends to be Monday. Passengers who book on a Sunday can save 6% on average compared to those who book on a Monday.**Ideal booking window recommendation is based on average round-trip ticket prices for January through November for 2024. Best day of the week to book recommendation is based on average round-trip ticket prices for January through October 2024. All data sourced from ARC's global airline sales database.

Search Delta Air Lines's earliest flights from PDX to TYS by using our "Morning" and "Early Morning" filters. Not only will you get to your destination sooner, early departures are also 20% less likely to be canceled.**Most reliable time of the day recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.

Delta Air Lines makes traveling from PDX to TYS more enjoyable with a rewarding loyalty program and an excellent in-flight experience. You even have the chance to collect points with Delta SkyMiles. Be sure to sign up to our free One Key™ rewards program to earn OneKeyCash™*, which can be redeemed on future travel.*OneKeyCash™ disclaimer - OneKeyCash™ is not redeemable for cash and can only be used on Expedia, Hotels.com and Vrbo.