$680 Cheap Flights from Charleston (CHS) to Tupelo (TUP)

View $680 flight on Sun, Nov 23, 2025Opens in a new window

Popular airlines from Charleston Intl. Airport (CHS) to Tupelo, MS (TUP-Tupelo Regional)

Cheap Flights from Charleston to Tupelo (CHS-TUP)

Prices were available within the past 7 days and start at $680 for one-way flights and $560 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

United
Thu, Nov 20 - Mon, Nov 24
CHS
Charleston
TUP
Tupelo
$560 Roundtrip, found 4 days ago
$560
Roundtrip
found 4 days ago
Select United flight, departing Thu, Nov 20 from Charleston to Tupelo, returning Mon, Nov 24, priced at $560 found 4 days ago
United
Fri, Nov 21 - Mon, Nov 24
CHS
Charleston
TUP
Tupelo
$570 Roundtrip, found 4 days ago
$570
Roundtrip
found 4 days ago
Select United flight, departing Fri, Nov 21 from Charleston to Tupelo, returning Mon, Nov 24, priced at $570 found 4 days ago
United
Wed, Nov 19 - Mon, Nov 24
CHS
Charleston
TUP
Tupelo
$587 Roundtrip, found 4 days ago
$587
Roundtrip
found 4 days ago
Select United flight, departing Wed, Nov 19 from Charleston to Tupelo, returning Mon, Nov 24, priced at $587 found 4 days ago
American Airlines
Wed, Dec 24 - Sun, Dec 28
CHS
Charleston
TUP
Tupelo
$588 Roundtrip, found 5 hours ago
$588
Roundtrip
found 5 hours ago
Select American Airlines flight, departing Wed, Dec 24 from Charleston to Tupelo, returning Sun, Dec 28, priced at $588 found 5 hours ago
American Airlines
Wed, Dec 24 - Sun, Dec 28
CHS
Charleston
TUP
Tupelo
$657 Roundtrip, found 5 hours ago
$657
Roundtrip
found 5 hours ago
Select American Airlines flight, departing Wed, Dec 24 from Charleston to Tupelo, returning Sun, Dec 28, priced at $657 found 5 hours ago
American Airlines
Wed, Dec 24 - Sun, Dec 28
CHS
Charleston
TUP
Tupelo
$666 Roundtrip, found 5 hours ago
$666
Roundtrip
found 5 hours ago
Select American Airlines flight, departing Wed, Dec 24 from Charleston to Tupelo, returning Sun, Dec 28, priced at $666 found 5 hours ago
American Airlines
Wed, Dec 24 - Sun, Dec 28
CHS
Charleston
TUP
Tupelo
$731 Roundtrip, found 5 hours ago
$731
Roundtrip
found 5 hours ago
Select American Airlines flight, departing Wed, Dec 24 from Charleston to Tupelo, returning Sun, Dec 28, priced at $731 found 5 hours ago
American Airlines
Wed, Dec 24 - Sun, Dec 28
CHS
Charleston
TUP
Tupelo
$735 Roundtrip, found 5 hours ago
$735
Roundtrip
found 5 hours ago
Select American Airlines flight, departing Wed, Dec 24 from Charleston to Tupelo, returning Sun, Dec 28, priced at $735 found 5 hours ago
American Airlines
Wed, Dec 24 - Sun, Dec 28
CHS
Charleston
TUP
Tupelo
$739 Roundtrip, found 5 hours ago
$739
Roundtrip
found 5 hours ago
Select American Airlines flight, departing Wed, Dec 24 from Charleston to Tupelo, returning Sun, Dec 28, priced at $739 found 5 hours ago
American Airlines
Wed, Dec 24 - Sun, Dec 28
CHS
Charleston
TUP
Tupelo
$800 Roundtrip, found 5 hours ago
$800
Roundtrip
found 5 hours ago
Select American Airlines flight, departing Wed, Dec 24 from Charleston to Tupelo, returning Sun, Dec 28, priced at $800 found 5 hours ago
American Airlines
Wed, Dec 24 - Sun, Dec 28
CHS
Charleston
TUP
Tupelo
$828 Roundtrip, found 5 hours ago
$828
Roundtrip
found 5 hours ago
Select American Airlines flight, departing Wed, Dec 24 from Charleston to Tupelo, returning Sun, Dec 28, priced at $828 found 5 hours ago
United
Wed, Dec 24 - Sun, Dec 28
CHS
Charleston
TUP
Tupelo
$1,808 Roundtrip, found 5 hours ago
$1,808
Roundtrip
found 5 hours ago
Select United flight, departing Wed, Dec 24 from Charleston to Tupelo, returning Sun, Dec 28, priced at $1,808 found 5 hours ago

Frequently asked questions

How much does a flight from Charleston Intl. Airport (CHS) to Tupelo Regional Airport (TUP) cost?
Snag a cheap one-way flight from $680 or cheap return flight from $560 from Charleston Intl. Airport (CHS) to Tupelo Regional Airport (TUP) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to see our cheapest flight deals on this route.
What is the cheapest month to fly from Charleston Intl. Airport (CHS) to Tupelo Regional Airport (TUP)?
Traveling in November can help you save, as it's the cheapest month for flights between CHS and TUP. You'll typically find the lowest prices during off-peak months.
What is the cheapest airline that flies from Charleston Intl. Airport (CHS) to Tupelo Regional Airport (TUP)?
Use the filters on Expedia to compare different airlines and find the most affordable carrier that'll fly you from CHS to TUP. Then, sort your results by "Price (lowest to highest)" to pick up a good deal.
How many flights per day from Charleston Intl. Airport (CHS) to Tupelo Regional Airport (TUP)?
You'll need to take a flight with a layover when traveling from Charleston Intl. Airport (CHS) to Tupelo Regional Airport (TUP). Direct flights don't operate daily on this route. However, just filter your search to include one or two stops to find the best option for your trip.
What day of the week has the most flights from CHS to TUP?
Friday is generally the busiest day for flights, while Tuesday is often the quietest.* Remember that flight schedules can change based on a number of factors, such as the carrier and season.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Charleston Intl. Airport (CHS) to Tupelo Regional Airport (TUP)?
To touch down at Tupelo Regional Airport (TUP) on schedule, book a flight that takes off from Charleston Intl. Airport (CHS) before 3 PM. The likelihood of cancellations is 22% higher, on average, for departures after this hour.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Charleston Intl. Airport (CHS) to Tupelo Regional Airport (TUP) last-minute?
Waiting until just before your trip to book a ticket from CHS to TUP often results in higher prices. While you might find some last-minute offers, they aren't always guaranteed. Allow some flexibility in your schedule for the best chance of landing a bargain.
Is it cheaper to book a CHS to TUP flight and hotel package?
Opting for a CHS to TUP flight and hotel package tends to be cheaper than booking separately. With Expedia, you can enjoy the ease of organizing your travels all in one place. Choose from our impressive range of stays and then add flights, activities and car rentals to your booking. Bundle everything together, and you could save hundreds of dollars.
Can I cancel or change the date of my flight from Charleston Intl. Airport (CHS) to Tupelo Regional Airport (TUP)?
Typically, you can cancel or modify your CHS to TUP flight. However, additional charges may apply, especially if you made your booking over 24 hours ago. Check your itinerary for the airline's fees and rules on flight changes, or if you'd like further details, head to our Customer Service portal.

Travel information

Origin airport
Charleston Intl.
Destination airport
Tupelo Regional
Roundtrip price
$560
Distance
511 mi

Book with confidence

Charleston to Tupelo Flights

The cheapest times to fly from Charleston to Tupelo

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Charleston to Tupelo are during the month of November. You can find some of the cheapest flights from Charleston to Tupelo with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Charleston to Tupelo

Sunday is one of the best days to book for cheap flights from Charleston to Tupelo: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Charleston to Tupelo

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Charleston to Tupelo in 2025. You can also book with separate airlines for your outbound and return journeys, from $680 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Charleston to Tupelo flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Charleston to Tupelo airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Charleston to Tupelo Flights

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*Available to One Key members.