$107 Cheap Flights from Cusco (CUZ) to Santiago (SCL)

View $107 flight on Wed, Oct 15, 2025Opens in a new window

Popular airlines from Alejandro Velasco Astete Intl. Airport (CUZ) to Santiago Intl. Airport (SCL)

Cheap Flights from Cusco to Santiago (CUZ-SCL)

Prices were available within the past 7 days and start at $107 for one-way flights and $243 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

LATAM Airlines Group
Fri, Nov 28 - Wed, Dec 3
CUZ
Cusco
SCL
Santiago
$243 Roundtrip, found 6 days ago
$243
Roundtrip
found 6 days ago
Select LATAM Airlines Group flight, departing Fri, Nov 28 from Cusco to Santiago, returning Wed, Dec 3, priced at $243 found 6 days ago
LATAM Airlines Group
Fri, Oct 17 - Sun, Oct 26
CUZ
Cusco
SCL
Santiago
$246 Roundtrip, found 3 days ago
$246
Roundtrip
found 3 days ago
Select LATAM Airlines Group flight, departing Fri, Oct 17 from Cusco to Santiago, returning Sun, Oct 26, priced at $246 found 3 days ago
LATAM Airlines Group
Sat, Dec 6 - Thu, Dec 11
CUZ
Cusco
SCL
Santiago
$247 Roundtrip, found 5 days ago
$247
Roundtrip
found 5 days ago
Select LATAM Airlines Group flight, departing Sat, Dec 6 from Cusco to Santiago, returning Thu, Dec 11, priced at $247 found 5 days ago
LATAM Airlines Group
Fri, Nov 28 - Wed, Dec 3
CUZ
Cusco
SCL
Santiago
$250 Roundtrip, found 6 days ago
$250
Roundtrip
found 6 days ago
Select LATAM Airlines Group flight, departing Fri, Nov 28 from Cusco to Santiago, returning Wed, Dec 3, priced at $250 found 6 days ago
LATAM Airlines Group
Fri, Nov 28 - Wed, Dec 3
CUZ
Cusco
SCL
Santiago
$252 Roundtrip, found 6 days ago
$252
Roundtrip
found 6 days ago
Select LATAM Airlines Group flight, departing Fri, Nov 28 from Cusco to Santiago, returning Wed, Dec 3, priced at $252 found 6 days ago
LATAM Airlines Group
Fri, Dec 12 - Mon, Dec 15
CUZ
Cusco
SCL
Santiago
$257 Roundtrip, found 6 days ago
$257
Roundtrip
found 6 days ago
Select LATAM Airlines Group flight, departing Fri, Dec 12 from Cusco to Santiago, returning Mon, Dec 15, priced at $257 found 6 days ago
LATAM Airlines Group
Fri, Oct 17 - Sun, Oct 26
CUZ
Cusco
SCL
Santiago
$262 Roundtrip, found 3 days ago
$262
Roundtrip
found 3 days ago
Select LATAM Airlines Group flight, departing Fri, Oct 17 from Cusco to Santiago, returning Sun, Oct 26, priced at $262 found 3 days ago
LATAM Airlines Group
Fri, Oct 17 - Sun, Oct 26
CUZ
Cusco
SCL
Santiago
$265 Roundtrip, found 3 days ago
$265
Roundtrip
found 3 days ago
Select LATAM Airlines Group flight, departing Fri, Oct 17 from Cusco to Santiago, returning Sun, Oct 26, priced at $265 found 3 days ago
SKY AIRLINE
Fri, Dec 12 - Mon, Dec 15
CUZ
Cusco
SCL
Santiago
$276 Roundtrip, found 6 days ago
$276
Roundtrip
found 6 days ago
Select SKY AIRLINE flight, departing Fri, Dec 12 from Cusco to Santiago, returning Mon, Dec 15, priced at $276 found 6 days ago
Jetsmart SPA
Wed, Oct 22 - Sun, Oct 26
CUZ
Cusco
SCL
Santiago
$321 Roundtrip, found 1 day ago
$321
Roundtrip
found 1 day ago
Select Jetsmart SPA flight, departing Wed, Oct 22 from Cusco to Santiago, returning Sun, Oct 26, priced at $321 found 1 day ago

Find the cheapest month to fly from Cusco (CUZ) to Santiago (SCL)

November is typically the cheapest month to fly

From $219 - $453 per traveler.

Frequently asked questions

How much does a flight from Alejandro Velasco Astete Intl. Airport (CUZ) to Arturo Merino Benitez Airport (SCL) cost?
Lock in a cheap one-way flight from $107 or cheap return flight from $243 from Alejandro Velasco Astete Intl. Airport (CUZ) to Arturo Merino Benitez Airport (SCL) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to see our cheapest flight offers on this route.
What is the cheapest month to fly from Alejandro Velasco Astete Intl. Airport (CUZ) to Arturo Merino Benitez Airport (SCL)?
The cheapest month to fly from CUZ to SCL is November, when demand is low. Off-peak months are generally when better flight deals are available between these airports.
Which airlines fly direct from Alejandro Velasco Astete Intl. Airport (CUZ) to Arturo Merino Benitez Airport (SCL)?
Take a direct flight with LATAM Airlines and fly straight from Alejandro Velasco Astete Intl. Airport (CUZ) to Arturo Merino Benitez Airport (SCL).
What is the cheapest airline that flies from Alejandro Velasco Astete Intl. Airport (CUZ) to Arturo Merino Benitez Airport (SCL)?
To find the cheapest airline that'll fly you from CUZ to SCL, use Expedia's filter tool. Tailor your search based on what's important to you, such as preferred carriers and seat class. You can then sort your results by "Price (lowest to highest)" to see the cheapest flights first.
How many flights per day from Alejandro Velasco Astete Intl. Airport (CUZ) to Arturo Merino Benitez Airport (SCL)?
On average, there is just 1 direct flight operating from Alejandro Velasco Astete Intl. Airport (CUZ) to Arturo Merino Benitez Airport (SCL) every day. If this doesn't work for you, think about flights with layovers. Just customize your search on Expedia to include one or more stops to find a better alternative.
What are the most popular departure times for flights from Alejandro Velasco Astete Intl. Airport (CUZ) to Arturo Merino Benitez Airport (SCL)?
Flights between CUZ and SCL are their busiest at 9 AM. If you're after a quieter trip and potentially cheaper fares, look for a departure that's outside typical rush times.
What day of the week has the most flights from CUZ to SCL?
Jet off on a Friday if you're looking for the best choice of flights from Alejandro Velasco Astete Intl. Airport (CUZ) to Arturo Merino Benitez Airport (SCL).
What is the earliest flight from Alejandro Velasco Astete Intl. Airport (CUZ) to Arturo Merino Benitez Airport (SCL)?
Alejandro Velasco Astete Intl. Airport (CUZ)'s earliest flight to Arturo Merino Benitez Airport (SCL) departs at approximately 9:10AM UTC-5. With a travel duration of 3h 20m, you'll touch down at around 2:30PM UTC-3.
How long does it take to fly from Alejandro Velasco Astete Intl. Airport (CUZ) to Arturo Merino Benitez Airport (SCL)?
It usually takes 3 hours and 20 minutes to cover the 1,400 mi from CUZ to SCL.
What airline has the least delays from CUZ to SCL?
With 90% of flights generally landing on schedule, LATAM Airlines has the best on-time performance for nonstop flights from Alejandro Velasco Astete Intl. Airport (CUZ) to Arturo Merino Benitez Airport (SCL). To check your flight status and get notified about any changes, use the Expedia App.
What is the best time to fly from Alejandro Velasco Astete Intl. Airport (CUZ) to Arturo Merino Benitez Airport (SCL)?
To avoid possible delays on the Alejandro Velasco Astete Intl. Airport (CUZ) to Arturo Merino Benitez Airport (SCL) route, aim to fly before 3 PM. Departures after this time have a 22% higher chance of cancellation.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
What airports do you fly into for Santiago from Alejandro Velasco Astete Intl. Airport (CUZ)?
Arturo Merino Benitez Airport (SCL) is the only airport in Santiago with direct flights from Alejandro Velasco Astete Intl. Airport (CUZ). Explore your options and discover cheap fares on Expedia.
Is it cheaper to buy a plane ticket from Alejandro Velasco Astete Intl. Airport (CUZ) to Arturo Merino Benitez Airport (SCL) last-minute?
Booking your ticket from CUZ to SCL just before your getaway is generally more expensive. However, if you're flexible with your travel times and dates, you could snag a cheap last-minute fare.
Is it cheaper to book a CUZ to SCL flight and hotel package?
You'll generally save money by securing a CUZ to SCL flight and hotel package compared to booking separately. In fact, you could save hundreds of dollars by bundling with Expedia. And it's simple to manage it all in one place. After selecting your ideal flights and accommodations, consider adding extras such as car rentals, activities and tours.
Can I cancel or change the date of my flight from Alejandro Velasco Astete Intl. Airport (CUZ) to Arturo Merino Benitez Airport (SCL)?
Typically, you can cancel or reschedule your CUZ to SCL flight. However, there may be additional fees, especially if your booking was made over 24 hours ago. Double-check your itinerary for the airline's rules and fees on flight changes, or if you want further information, head to our Customer Service portal.

Travel information

Travel information

Origin airport
Alejandro Velasco Astete Intl.
Destination airport
Arturo Merino Benitez
Airlines serving
Jetsmart SPA, LATAM Airlines Group, SKY AIRLINE
Roundtrip price
$243
Distance
1373 mi
Average flight time
3 hours 20 mins

Book with confidence

Book with confidence

Cusco to Santiago Flights

The cheapest times to fly from Cusco to Santiago

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Cusco to Santiago are during the month of November. You can find some of the cheapest flights from Cusco to Santiago with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Cusco to Santiago

Sunday is one of the best days to book for cheap flights from Cusco to Santiago: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Cusco to Santiago

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Cusco to Santiago in 2025. You can also book with separate airlines for your outbound and return journeys, from $107 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Cusco to Santiago flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Cusco to Santiago airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Cusco to Santiago Flights

Explore a world of travel with Expedia

Explore a world of travel with Expedia

*Available to One Key members.