$378 Cheap Flights from Denver (DEN) to La Crosse (LSE)

View $378 flight on Fri, Dec 5, 2025Opens in a new window

Popular airlines from Denver Intl. Airport (DEN) to La Crosse, WI (LSE-La Crosse Municipal)

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Cheap Flights from Denver to La Crosse (DEN-LSE)

Prices were available within the past 7 days and start at $378 for one-way flights and $497 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

American Airlines
Wed, Dec 17 - Wed, Dec 24
DEN
Denver
LSE
La Crosse
$497 Roundtrip, found 3 days ago
$497
Roundtrip
found 3 days ago
Select American Airlines flight, departing Wed, Dec 17 from Denver to La Crosse, returning Wed, Dec 24, priced at $497 found 3 days ago
American Airlines
Thu, Dec 4 - Sun, Dec 7
DEN
Denver
LSE
La Crosse
$504 Roundtrip, found 3 days ago
$504
Roundtrip
found 3 days ago
Select American Airlines flight, departing Thu, Dec 4 from Denver to La Crosse, returning Sun, Dec 7, priced at $504 found 3 days ago
American Airlines
Fri, Dec 5 - Mon, Dec 8
DEN
Denver
LSE
La Crosse
$510 Roundtrip, found 5 days ago
$510
Roundtrip
found 5 days ago
Select American Airlines flight, departing Fri, Dec 5 from Denver to La Crosse, returning Mon, Dec 8, priced at $510 found 5 days ago
American Airlines
Sat, Dec 27 - Wed, Jan 14
DEN
Denver
LSE
La Crosse
$514 Roundtrip, found 1 day ago
$514
Roundtrip
found 1 day ago
Select American Airlines flight, departing Sat, Dec 27 from Denver to La Crosse, returning Wed, Jan 14, priced at $514 found 1 day ago
American Airlines
Tue, Nov 4 - Sat, Nov 22
DEN
Denver
LSE
La Crosse
$516 Roundtrip, found 2 hours ago
$516
Roundtrip
found 2 hours ago
Select American Airlines flight, departing Tue, Nov 4 from Denver to La Crosse, returning Sat, Nov 22, priced at $516 found 2 hours ago
American Airlines
Wed, Dec 17 - Sat, Jan 3
DEN
Denver
LSE
La Crosse
$520 Roundtrip, found 1 day ago
$520
Roundtrip
found 1 day ago
Select American Airlines flight, departing Wed, Dec 17 from Denver to La Crosse, returning Sat, Jan 3, priced at $520 found 1 day ago
American Airlines
Mon, Nov 24 - Sat, Dec 6
DEN
Denver
LSE
La Crosse
$524 Roundtrip, found 4 days ago
$524
Roundtrip
found 4 days ago
Select American Airlines flight, departing Mon, Nov 24 from Denver to La Crosse, returning Sat, Dec 6, priced at $524 found 4 days ago
American Airlines
Sat, Nov 22 - Sat, Dec 13
DEN
Denver
LSE
La Crosse
$532 Roundtrip, found 1 day ago
$532
Roundtrip
found 1 day ago
Select American Airlines flight, departing Sat, Nov 22 from Denver to La Crosse, returning Sat, Dec 13, priced at $532 found 1 day ago
American Airlines
Thu, Nov 27 - Tue, Dec 2
DEN
Denver
LSE
La Crosse
$534 Roundtrip, found 3 days ago
$534
Roundtrip
found 3 days ago
Select American Airlines flight, departing Thu, Nov 27 from Denver to La Crosse, returning Tue, Dec 2, priced at $534 found 3 days ago
American Airlines
Sat, Dec 13 - Wed, Dec 31
DEN
Denver
LSE
La Crosse
$538 Roundtrip, found 1 day ago
$538
Roundtrip
found 1 day ago
Select American Airlines flight, departing Sat, Dec 13 from Denver to La Crosse, returning Wed, Dec 31, priced at $538 found 1 day ago

Find the cheapest month to fly from Denver (DEN) to La Crosse (LSE)

November is typically the cheapest month to fly

From $425 - $984 per traveler.

Alternative airports near La Crosse

Prices were available within the past 7 days. Prices and availability are subject to change.

Select flight to La Crosse Municipal LSE. Cheapest and Closest option available. Average driving time to city center is 12 minutes. Flights from $532
LSE
La Crosse Municipal
CheapestClosest
Average driving time to city center12 min
Flights from $532
Flights from Denver (DEN) to La Crosse (LSE)
Origin airport
Denver Intl.
Destination airport
La Crosse Municipal
Airlines serving
American Airlines
Roundtrip price
$497
Distance
742 mi

Denver to La Crosse Flights

The cheapest times to fly from Denver to La Crosse

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Denver to La Crosse are during the month of December. You can find some of the cheapest flights from Denver to La Crosse with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Denver to La Crosse

Sunday is one of the best days to book for cheap flights from Denver to La Crosse: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Denver to La Crosse

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Denver to La Crosse in 2025. You can also book with separate airlines for your outbound and return journeys, from $378 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Denver to La Crosse flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Denver to La Crosse airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Frequently asked questions

How much does a flight from Denver Intl. Airport (DEN) to La Crosse Municipal Airport (LSE) cost?
Secure a cheap one-way flight from $378 or cheap return flight from $497 from Denver Intl. Airport (DEN) to La Crosse Municipal Airport (LSE) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to find our cheapest flight offers on this route.
What is the cheapest month to fly from Denver Intl. Airport (DEN) to La Crosse Municipal Airport (LSE)?
Traveling in December can help you save, as it's the cheapest month for flights between DEN and LSE. You'll usually find the lowest prices during off-peak months.
What is the cheapest airline that flies from Denver Intl. Airport (DEN) to La Crosse Municipal Airport (LSE)?
Use the filter tool on Expedia to compare different airlines and find the most affordable carrier that'll fly you from DEN to LSE. Then, sort your results by "Price (lowest to highest)" to snag a good deal.
How many flights per day from Denver Intl. Airport (DEN) to La Crosse Municipal Airport (LSE)?
There aren't any daily nonstop flights available from Denver Intl. Airport (DEN) to La Crosse Municipal Airport (LSE). But you can opt for flights with layovers. Filter your search results on Expedia to include one or more stops, and you'll be soaring above the clouds in no time at all.
What day of the week has the most flights from DEN to LSE?
Generally you'll find the greatest selection of flight options on a Friday. Tuesdays are often the quietest.* However, this can vary based on the airline, time of year and other factors.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Denver Intl. Airport (DEN) to La Crosse Municipal Airport (LSE)?
To avoid possible delays on the Denver Intl. Airport (DEN) to La Crosse Municipal Airport (LSE) route, fly before 3 PM. Later flights have a 22% higher chance of cancellation.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Denver Intl. Airport (DEN) to La Crosse Municipal Airport (LSE) last-minute?
Booking your ticket from DEN to LSE shortly before your getaway is typically more expensive. But if there's some wiggle room with your travel times and dates, you could score a cheap last-minute fare.
Is it cheaper to book a DEN to LSE flight and hotel package?
You'll generally save money by booking a DEN to LSE flight and hotel package compared to booking separately. In fact, travelers could save hundreds of dollars by bundling with Expedia. And it's easy to manage everything in one convenient place. After selecting your ideal accommodations and flights, consider adding extras such as tours, car rentals and activities.
Can I cancel or change the date of my flight from Denver Intl. Airport (DEN) to La Crosse Municipal Airport (LSE)?
If you reserved your DEN to LSE flight in the last 24 hours, you may be able to cancel or modify it without fees. Depending on the airline and the type of fare you purchased, additional charges may apply for changes after that time. Airline policies and contact information can be found in your itinerary or confirmation email. Or, visit our Customer Service portal if you'd like more information.

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*Available to One Key members.