$109 Cheap Flights from Des Moines (DSM) to McAllen (MFE)

View $109 flight on Wed, Feb 25, 2026Opens in a new window

Popular airlines from Des Moines International Airport (DSM) to Miller Intl. Airport (MFE)

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Cheap Flights from Des Moines to McAllen (DSM-MFE)

Prices were available within the past 7 days and start at $109 for one-way flights and $219 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

American Airlines
Sat, Oct 18 - Sat, Oct 25
DSM
Des Moines
MFE
McAllen
$219 Roundtrip, found 3 days ago
$219
Roundtrip
found 3 days ago
Select American Airlines flight, departing Sat, Oct 18 from Des Moines to McAllen, returning Sat, Oct 25, priced at $219 found 3 days ago
Delta
Wed, Dec 3 - Wed, Feb 25
DSM
Des Moines
MFE
McAllen
$225 Roundtrip, found 5 days ago
$225
Roundtrip
found 5 days ago
Select Delta flight, departing Wed, Dec 3 from Des Moines to McAllen, returning Wed, Feb 25, priced at $225 found 5 days ago
Delta
Wed, Oct 29 - Tue, Nov 11
DSM
Des Moines
MFE
McAllen
$227 Roundtrip, found 3 days ago
$227
Roundtrip
found 3 days ago
Select Delta flight, departing Wed, Oct 29 from Des Moines to McAllen, returning Tue, Nov 11, priced at $227 found 3 days ago
Delta
Wed, Oct 29 - Sat, Nov 8
DSM
Des Moines
MFE
McAllen
$228 Roundtrip, found 3 days ago
$228
Roundtrip
found 3 days ago
Select Delta flight, departing Wed, Oct 29 from Des Moines to McAllen, returning Sat, Nov 8, priced at $228 found 3 days ago
Delta
Thu, Oct 30 - Tue, Nov 11
DSM
Des Moines
MFE
McAllen
$242 Roundtrip, found 3 days ago
$242
Roundtrip
found 3 days ago
Select Delta flight, departing Thu, Oct 30 from Des Moines to McAllen, returning Tue, Nov 11, priced at $242 found 3 days ago
Delta
Thu, Oct 30 - Sat, Nov 8
DSM
Des Moines
MFE
McAllen
$243 Roundtrip, found 3 days ago
$243
Roundtrip
found 3 days ago
Select Delta flight, departing Thu, Oct 30 from Des Moines to McAllen, returning Sat, Nov 8, priced at $243 found 3 days ago
American Airlines
Wed, Dec 3 - Wed, Feb 25
DSM
Des Moines
MFE
McAllen
$245 Roundtrip, found 5 days ago
$245
Roundtrip
found 5 days ago
Select American Airlines flight, departing Wed, Dec 3 from Des Moines to McAllen, returning Wed, Feb 25, priced at $245 found 5 days ago
United
Tue, Feb 3 - Fri, Feb 6
DSM
Des Moines
MFE
McAllen
$246 Roundtrip, found 5 days ago
$246
Roundtrip
found 5 days ago
Select United flight, departing Tue, Feb 3 from Des Moines to McAllen, returning Fri, Feb 6, priced at $246 found 5 days ago
Delta
Wed, Dec 3 - Sun, Dec 14
DSM
Des Moines
MFE
McAllen
$248 Roundtrip, found 5 days ago
$248
Roundtrip
found 5 days ago
Select Delta flight, departing Wed, Dec 3 from Des Moines to McAllen, returning Sun, Dec 14, priced at $248 found 5 days ago
Delta
Sat, Dec 6 - Sun, Dec 14
DSM
Des Moines
MFE
McAllen
$249 Roundtrip, found 5 days ago
$249
Roundtrip
found 5 days ago
Select Delta flight, departing Sat, Dec 6 from Des Moines to McAllen, returning Sun, Dec 14, priced at $249 found 5 days ago

Find the cheapest month to fly from Des Moines (DSM) to McAllen (MFE)

May is typically the cheapest month to fly

From $204 - $527 per traveler.
Flights from Des Moines (DSM) to McAllen (MFE)
Origin airport
Des Moines Intl.
Destination airport
Miller Intl.
Airlines serving
American Airlines, Delta, United
Roundtrip price
$218
Distance
1092 mi

Des Moines to McAllen Flights

The cheapest times to fly from Des Moines to McAllen

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Des Moines to McAllen are during the month of October. You can find some of the cheapest flights from Des Moines to McAllen with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Des Moines to McAllen

Sunday is one of the best days to book for cheap flights from Des Moines to McAllen: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Des Moines to McAllen

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Des Moines to McAllen in 2025. You can also book with separate airlines for your outbound and return journeys, from $109 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Des Moines to McAllen flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Des Moines to McAllen airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Frequently asked questions

How much does a flight from Des Moines Intl. Airport (DSM) to Miller Intl. Airport (MFE) cost?
Get a cheap one-way flight from $109 or cheap return flight from $219 from Des Moines Intl. Airport (DSM) to Miller Intl. Airport (MFE) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to see our cheapest flight offers on this route.
What is the cheapest month to fly from Des Moines Intl. Airport (DSM) to Miller Intl. Airport (MFE)?
Traveling in October may help you find better deals, as it's the cheapest month for flights between DSM and MFE. You'll often find the lowest fares during off-peak months.
What is the cheapest airline that flies from Des Moines Intl. Airport (DSM) to Miller Intl. Airport (MFE)?
Use the filter tool on Expedia to compare airlines and find the cheapest carrier that'll take you from DSM to MFE. Then, sort your results by "Price (lowest to highest)" to pick up a great deal.
How many flights per day from Des Moines Intl. Airport (DSM) to Miller Intl. Airport (MFE)?
Direct flights from Des Moines Intl. Airport (DSM) to Miller Intl. Airport (MFE) aren't available daily, so you'll need to take a flight with a layover. Explore your options with our filter tool. Enter your travel dates and pick either "1 Stop" or "2+ Stops."
What day of the week has the most flights from DSM to MFE?
Friday is typically the busiest day for flights, while Tuesday tends to be the quietest.* Keep in mind that flight schedules can change depending on a number of factors, including the carrier and season.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Des Moines Intl. Airport (DSM) to Miller Intl. Airport (MFE)?
Choose a flight from Des Moines Intl. Airport (DSM) to Miller Intl. Airport (MFE) that leaves before 3 PM to reduce the risk of cancellations. Departures after this time have a 22% higher chance of being canceled, on average.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Des Moines Intl. Airport (DSM) to Miller Intl. Airport (MFE) last-minute?
Holding off until right before your break to book your flight from DSM to MFE often results in higher prices. While you may come across some last-minute discounts, there's no guarantee. Be flexible with your itinerary for a better chance of landing a bargain.
Is it cheaper to book a DSM to MFE flight and hotel package?
Compared with arranging hotels and flights separately, booking a DSM to MFE flight and hotel package with Expedia could lead to significant savings. Better still, having it all in one place will take the hassle out of planning your trip. Simply pick your flights and choose from our wide range of hotels, then personalize your trip with extras like car rentals and activities.
Can I cancel or change the date of my flight from Des Moines Intl. Airport (DSM) to Miller Intl. Airport (MFE)?
Typically, you can cancel or reschedule your DSM to MFE flight. However, additional fees may apply, especially if you booked more than 24 hours ago. Double-check your itinerary for the airline's rules and fees on flight changes, or if you'd like further information, go to our Customer Service portal.

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*Available to One Key members.