$174 Cheap Flights from Des Moines (DSM) to McAllen (MFE)

View $174 flight on Tue, Apr 14, 2026Opens in a new window

Popular airlines from Des Moines International Airport (DSM) to Miller Intl. Airport (MFE)

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Cheap Flights from Des Moines to McAllen (DSM-MFE)

Prices were available within the past 7 days and start at $174 for one-way flights and $301 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Delta
Tue, Apr 21 - Tue, Apr 28
DSM
Des Moines
MFE
McAllen
$301 Roundtrip, found 4 days ago
$301
Roundtrip
found 4 days ago
Select Delta flight, departing Tue, Apr 21 from Des Moines to McAllen, returning Tue, Apr 28, priced at $301 found 4 days ago
American Airlines
Fri, Sep 25 - Tue, Sep 29
DSM
Des Moines
MFE
McAllen
$310 Roundtrip, found 2 days ago
$310
Roundtrip
found 2 days ago
Select American Airlines flight, departing Fri, Sep 25 from Des Moines to McAllen, returning Tue, Sep 29, priced at $310 found 2 days ago
United
Wed, May 6 - Sat, May 9
DSM
Des Moines
MFE
McAllen
$311 Roundtrip, found 6 hours ago
$311
Roundtrip
found 6 hours ago
Select United flight, departing Wed, May 6 from Des Moines to McAllen, returning Sat, May 9, priced at $311 found 6 hours ago
American Airlines
Sat, Apr 18 - Sun, Apr 19
DSM
Des Moines
MFE
McAllen
$315 Roundtrip, found 15 hours ago
$315
Roundtrip
found 15 hours ago
Select American Airlines flight, departing Sat, Apr 18 from Des Moines to McAllen, returning Sun, Apr 19, priced at $315 found 15 hours ago
United
Wed, May 6 - Sat, May 9
DSM
Des Moines
MFE
McAllen
$316 Roundtrip, found 6 hours ago
$316
Roundtrip
found 6 hours ago
Select United flight, departing Wed, May 6 from Des Moines to McAllen, returning Sat, May 9, priced at $316 found 6 hours ago
American Airlines
Fri, May 1 - Fri, May 8
DSM
Des Moines
MFE
McAllen
$319 Roundtrip, found 11 hours ago
$319
Roundtrip
found 11 hours ago
Select American Airlines flight, departing Fri, May 1 from Des Moines to McAllen, returning Fri, May 8, priced at $319 found 11 hours ago
United
Fri, Sep 25 - Tue, Sep 29
DSM
Des Moines
MFE
McAllen
$320 Roundtrip, found 2 days ago
$320
Roundtrip
found 2 days ago
Select United flight, departing Fri, Sep 25 from Des Moines to McAllen, returning Tue, Sep 29, priced at $320 found 2 days ago
American Airlines
Fri, Apr 3 - Fri, Apr 10
DSM
Des Moines
MFE
McAllen
$324 Roundtrip, found 12 hours ago
$324
Roundtrip
found 12 hours ago
Select American Airlines flight, departing Fri, Apr 3 from Des Moines to McAllen, returning Fri, Apr 10, priced at $324 found 12 hours ago
United
Wed, May 6 - Sat, May 9
DSM
Des Moines
MFE
McAllen
$328 Roundtrip, found 6 hours ago
$328
Roundtrip
found 6 hours ago
Select United flight, departing Wed, May 6 from Des Moines to McAllen, returning Sat, May 9, priced at $328 found 6 hours ago
United
Thu, Mar 26 - Sat, Apr 4
DSM
Des Moines
MFE
McAllen
$333 Roundtrip, found 4 days ago
$333
Roundtrip
found 4 days ago
Select United flight, departing Thu, Mar 26 from Des Moines to McAllen, returning Sat, Apr 4, priced at $333 found 4 days ago

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Alternative airports near McAllen

Prices were available within the past 7 days. Prices and availability are subject to change.

Select flight to Miller Intl. MFE. Cheapest and Closest option available. Average driving time to city center is 4 minutes. Flights from $349
MFE
Miller Intl.
CheapestClosest
Average driving time to city center4 min
Flights from $349

Frequently asked questions

How much does a flight from Des Moines, IA (DSM-Des Moines Intl.) to McAllen, TX (MFE-Miller Intl.) cost?
You can find cheap one-way flights from $174 and cheap return flights from $301 Des Moines, IA (DSM-Des Moines Intl.) to McAllen, TX (MFE-Miller Intl.) with Expedia. One-way flights generally range between $187 and $885, and roundtrip flights usually range from $349 to $1281. Flight prices vary based on the month and day of the week you want to travel, as well as the airline and how far in advance you book your ticket. Filter your search on Expedia by "Price (lowest to highest)" to see the cheapest fares first, and use the Price Tracking tool to receive alerts when Des Moines, IA (DSM-Des Moines Intl.) to McAllen, TX (MFE-Miller Intl.) ticket fares go up or down.*Typical price ranges based on flights available on Expedia in the last year. Prices include multi-airline options.
What is the cheapest month to fly from Des Moines, IA (DSM-Des Moines Intl.) to McAllen, TX (MFE-Miller Intl.)?
March is the cheapest month to fly from Des Moines, IA (DSM) to McAllen, TX (MFE), with average round-trip fares around $342. This price is about 24% lower than the average throughout the year, as travel demand tends to dip after the winter months. Other affordable months to consider are April and May.*Averages based on flights available on Expedia in the last year.
Which airlines fly direct from Des Moines, IA (DSM-Des Moines Intl.) to McAllen, TX (MFE-Miller Intl.)?
Enter DSM to MFE and your travel dates, then apply the 'Nonstop' filter to see only direct flights.
What is the cheapest airline that flies from Des Moines, IA (DSM-Des Moines Intl.) to McAllen, TX (MFE-Miller Intl.)?
American Airlines is one of the cheapest airlines offering connecting flights from Des Moines (DSM) to McAllen (MFE), with round-trip tickets starting from around $196.37 with a layover in O'Hare Intl. (ORD). Use Expedia's search tool to compare the prices and schedules of airlines that fly this route to find the best option for your plans and budget.*Prices based on flights available on Expedia in the last year.
How do I find cheap flights from Des Moines, IA (DSM-Des Moines Intl.) to McAllen, TX (MFE-Miller Intl.)?
To find a cheap flight from Des Moines, IA (DSM-Des Moines Intl.) to McAllen, TX (MFE-Miller Intl.), be flexible with your dates. Traveling outside of peak vacation months and booking a mid-week flight can help you save. Early morning and late night flights are often more affordable, too. Expedia allows you to compare flight times, airlines and routes all in one place to find low fares. You can also set up Price Tracking and receive alerts when fares go up or down.
What is the best time to fly from Des Moines, IA (DSM-Des Moines Intl.) to McAllen, TX (MFE-Miller Intl.)?
The best time to fly from Des Moines (DSM) to McAllen (MFE) is in March or April, with average return flight prices around $342. March is particularly appealing as it marks the beginning of spring, making it a great time to visit Texas.*Prices based on flights available on Expedia in the last year.
What is the earliest flight from Des Moines, IA (DSM-Des Moines Intl.) to McAllen, TX (MFE-Miller Intl.)?
The earliest flight from Des Moines International Airport (DSM) to Miller International Airport (MFE) departs at 5:00 AM local time, operated by American Airlines. This seasonal service is active in January, November, and December, giving you an early start to your trip to McAllen. To compare early flights on Expedia, select the "Early Morning" and "Morning" filters in your search.
What are the most popular departure times for flights from Des Moines, IA (DSM-Des Moines Intl.) to McAllen, TX (MFE-Miller Intl.)?
The most popular departure times for flights from Des Moines (DSM) to McAllen (MFE) are in the early morning, from 3am to 6am. About 24% of passengers prefer this time window. Many major carriers, including American Airlines, Delta and United Airlines, offer flights during this window. This timing works well because it allows you to arrive in McAllen with plenty of time to enjoy your day.
How long does it take to fly from Des Moines, IA (DSM-Des Moines Intl.) to McAllen, TX (MFE-Miller Intl.)?
Flights from DSM to MFE with one stop typically take around 5 hours, covering approximately 1,093 miles. Keep in mind that actual flight times can vary due to wind patterns, weather, and air traffic.
Can you fly business or first class from Des Moines, IA (DSM-Des Moines Intl.) to McAllen, TX (MFE-Miller Intl.)?
First class seats are offered on the DSM to MFE route. First class cabins are available on:

  • American Airlines
  • Delta Air Lines
  • United Airlines

How do I earn miles on a Des Moines, IA (DSM-Des Moines Intl.) to McAllen, TX (MFE-Miller Intl.) flight with Expedia?
It's easy to earn miles on a Des Moines, IA (DSM-Des Moines Intl.) to McAllen, TX (MFE-Miller Intl.) flight when you book with Expedia. Before you confirm your booking, simply select your frequent flyer program and enter your program number. As a member of One Key™, you can also earn OneKeyCash™* on top of your airline miles when you book with Expedia.*Excludes taxes and fees. OneKeyCash is not redeemable for cash and can only be used on Expedia and other participating brands.
What airports do you fly into for McAllen from Des Moines Intl. (DSM)?
From Des Moines Intl. (DSM), you can fly into Miller Intl. (MFE) to reach McAllen. Some flights may connect through major hubs like O'Hare Intl. (ORD), Denver Intl. (DEN), Hartsfield-Jackson Atlanta Intl. (ATL) before reaching McAllen. Compare routes and airports on Expedia to find the best flight options for your travel plans.
Is it cheaper to buy a plane ticket from Des Moines, IA (DSM-Des Moines Intl.) to McAllen, TX (MFE-Miller Intl.) at the last minute?
Typically, booking a last minute flight from Des Moines, IA (DSM-Des Moines Intl.) to McAllen, TX (MFE-Miller Intl.) will be more expensive than booking in advance. As the departure date approaches, there are usually fewer seats available which can drive up the cost. However, if there's some wiggle room with your travel dates and times, you could bag a cheap last-minute fare.
Is it cheaper to book a Des Moines, IA (DSM-Des Moines Intl.) to McAllen, TX (MFE-Miller Intl.) flight and hotel package?
Securing a Des Moines, IA (DSM-Des Moines Intl.) to McAllen, TX (MFE-Miller Intl.) Mcallen Vacation Packages is usually cheaper than booking separately. With Expedia, you can enjoy the ease of organizing your travels all in one place. Select from our extensive range of stays and then add flights, activities and car rentals to your booking. Bundle everything together, and you could save hundreds of dollars.
Can I cancel or change the date of my flight from Des Moines, IA (DSM-Des Moines Intl.) to McAllen, TX (MFE-Miller Intl.)?
If you booked your Des Moines, IA (DSM-Des Moines Intl.) to McAllen, TX (MFE-Miller Intl.) flight within the last 24 hours, you may be able to modify or cancel it without any fees. Depending on the airline and the type of ticket you have, additional charges may apply for changes beyond this timeframe. Airline policies and contact information can be found in your itinerary or confirmation email. Or, head to our Customer Service portal if you'd like more information.

Travel information

Origin airport
Des Moines Intl.
Destination airport
Miller Intl.
Airlines serving
American Airlines, Delta, United
Roundtrip price
$301
Distance
1092 mi

Book with confidence

Des Moines to McAllen Flights

The cheapest times to fly from Des Moines to McAllen

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Des Moines to McAllen are during the month of April. You can find some of the cheapest flights from Des Moines to McAllen with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Des Moines to McAllen

Sunday is one of the best days to book for cheap flights from Des Moines to McAllen: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Des Moines to McAllen

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Des Moines to McAllen in 2026. You can also book with separate airlines for your outbound and return journeys, from $174 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Des Moines to McAllen flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Des Moines to McAllen airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Des Moines to McAllen Flights

*Flight schedules are subject to change.

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*Available to One Key members.