$164 Cheap Flights from Des Moines (DSM) to McAllen (MFE)

View $164 flight on Tue, Dec 16, 2025Opens in a new window

Popular airlines from Des Moines International Airport (DSM) to Miller Intl. Airport (MFE)

Cheap Flights from Des Moines to McAllen (DSM-MFE)

Prices were available within the past 7 days and start at $164 for one-way flights and $259 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

American Airlines
Fri, Dec 5 - Wed, Dec 10
DSM
Des Moines
MFE
McAllen
$259 Roundtrip, just found
$259
Roundtrip
just found
Select American Airlines flight, departing Fri, Dec 5 from Des Moines to McAllen, returning Wed, Dec 10, priced at $259 just found
United
Wed, Jan 7 - Wed, Jan 14
DSM
Des Moines
MFE
McAllen
$259 Roundtrip, found 4 days ago
$259
Roundtrip
found 4 days ago
Select United flight, departing Wed, Jan 7 from Des Moines to McAllen, returning Wed, Jan 14, priced at $259 found 4 days ago
Delta
Sat, Feb 14 - Thu, Feb 19
DSM
Des Moines
MFE
McAllen
$261 Roundtrip, found 5 days ago
$261
Roundtrip
found 5 days ago
Select Delta flight, departing Sat, Feb 14 from Des Moines to McAllen, returning Thu, Feb 19, priced at $261 found 5 days ago
United
Wed, Feb 25 - Sat, Feb 28
DSM
Des Moines
MFE
McAllen
$264 Roundtrip, found 7 hours ago
$264
Roundtrip
found 7 hours ago
Select United flight, departing Wed, Feb 25 from Des Moines to McAllen, returning Sat, Feb 28, priced at $264 found 7 hours ago
United
Wed, Dec 3 - Tue, Dec 9
DSM
Des Moines
MFE
McAllen
$265 Roundtrip, found 9 hours ago
$265
Roundtrip
found 9 hours ago
Select United flight, departing Wed, Dec 3 from Des Moines to McAllen, returning Tue, Dec 9, priced at $265 found 9 hours ago
Delta
Wed, Jan 7 - Tue, Jan 20
DSM
Des Moines
MFE
McAllen
$269 Roundtrip, found 1 hour ago
$269
Roundtrip
found 1 hour ago
Select Delta flight, departing Wed, Jan 7 from Des Moines to McAllen, returning Tue, Jan 20, priced at $269 found 1 hour ago
United
Wed, Dec 3 - Tue, Dec 9
DSM
Des Moines
MFE
McAllen
$274 Roundtrip, found 9 hours ago
$274
Roundtrip
found 9 hours ago
Select United flight, departing Wed, Dec 3 from Des Moines to McAllen, returning Tue, Dec 9, priced at $274 found 9 hours ago
American Airlines
Tue, Feb 10 - Sat, Feb 14
DSM
Des Moines
MFE
McAllen
$284 Roundtrip, found 6 days ago
$284
Roundtrip
found 6 days ago
Select American Airlines flight, departing Tue, Feb 10 from Des Moines to McAllen, returning Sat, Feb 14, priced at $284 found 6 days ago
Delta
Tue, Feb 10 - Sat, Feb 14
DSM
Des Moines
MFE
McAllen
$289 Roundtrip, found 6 days ago
$289
Roundtrip
found 6 days ago
Select Delta flight, departing Tue, Feb 10 from Des Moines to McAllen, returning Sat, Feb 14, priced at $289 found 6 days ago
United
Tue, Feb 10 - Sat, Feb 14
DSM
Des Moines
MFE
McAllen
$293 Roundtrip, found 6 days ago
$293
Roundtrip
found 6 days ago
Select United flight, departing Tue, Feb 10 from Des Moines to McAllen, returning Sat, Feb 14, priced at $293 found 6 days ago

Find the cheapest month to fly from Des Moines (DSM) to McAllen (MFE)

May is typically the cheapest month to fly

From $204 - $495 per traveler.

Alternative airports near McAllen

Prices were available within the past 7 days. Prices and availability are subject to change.

Select flight to Miller Intl. MFE. Cheapest and Closest option available. Average driving time to city center is 4 minutes. Flights from $334
MFE
Miller Intl.
CheapestClosest
Average driving time to city center4 min
Flights from $334

Frequently asked questions

How much does a flight from Des Moines Intl. Airport (DSM) to Miller Intl. Airport (MFE) cost?
Get a cheap one-way flight from $164 or cheap return flight from $259 from Des Moines Intl. Airport (DSM) to Miller Intl. Airport (MFE) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to see our cheapest flight offers on this route.
What is the cheapest month to fly from Des Moines Intl. Airport (DSM) to Miller Intl. Airport (MFE)?
Traveling in December may help you find better deals, as it's the cheapest month for flights between DSM and MFE. You'll often find the lowest fares during off-peak months.
What is the cheapest airline that flies from Des Moines Intl. Airport (DSM) to Miller Intl. Airport (MFE)?
Use the filter tool on Expedia to compare airlines and find the cheapest carrier that'll take you from DSM to MFE. Then, sort your results by "Price (lowest to highest)" to pick up a great deal.
How many flights per day from Des Moines Intl. Airport (DSM) to Miller Intl. Airport (MFE)?
Direct flights from Des Moines Intl. Airport (DSM) to Miller Intl. Airport (MFE) aren't available daily, so you'll need to take a flight with a layover. Explore your options with our filter tool. Enter your travel dates and pick either "1 Stop" or "2+ Stops."
What day of the week has the most flights from DSM to MFE?
Friday is typically the busiest day for flights, while Tuesday tends to be the quietest.* Keep in mind that flight schedules can change depending on a number of factors, including the carrier and season.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Des Moines Intl. Airport (DSM) to Miller Intl. Airport (MFE)?
Choose a flight from Des Moines Intl. Airport (DSM) to Miller Intl. Airport (MFE) that leaves before 3 PM to reduce the risk of cancellations. Departures after this time have a 22% higher chance of being canceled, on average.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Des Moines Intl. Airport (DSM) to Miller Intl. Airport (MFE) last-minute?
Holding off until right before your break to book your flight from DSM to MFE often results in higher prices. While you may come across some last-minute discounts, there's no guarantee. Be flexible with your itinerary for a better chance of landing a bargain.
Is it cheaper to book a DSM to MFE flight and hotel package?
Compared with arranging hotels and flights separately, booking a DSM to MFE flight and hotel package with Expedia could lead to significant savings. Better still, having it all in one place will take the hassle out of planning your trip. Simply pick your flights and choose from our wide range of hotels, then personalize your trip with extras like car rentals and activities.
Can I cancel or change the date of my flight from Des Moines Intl. Airport (DSM) to Miller Intl. Airport (MFE)?
Typically, you can cancel or reschedule your DSM to MFE flight. However, additional fees may apply, especially if you booked more than 24 hours ago. Double-check your itinerary for the airline's rules and fees on flight changes, or if you'd like further information, go to our Customer Service portal.

Travel information

Origin airport
Des Moines Intl.
Destination airport
Miller Intl.
Airlines serving
American Airlines, Delta, United
Roundtrip price
$258
Distance
1092 mi

Book with confidence

Des Moines to McAllen Flights

The cheapest times to fly from Des Moines to McAllen

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Des Moines to McAllen are during the month of December. You can find some of the cheapest flights from Des Moines to McAllen with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Des Moines to McAllen

Sunday is one of the best days to book for cheap flights from Des Moines to McAllen: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Des Moines to McAllen

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Des Moines to McAllen in 2025. You can also book with separate airlines for your outbound and return journeys, from $164 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Des Moines to McAllen flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Des Moines to McAllen airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Des Moines to McAllen Flights

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*Available to One Key members.