$336 Cheap Flights from Des Moines (DSM) to Manhattan (MHK)

View $336 flight on Wed, Jan 21, 2026Opens in a new window

Popular airlines from Des Moines International Airport (DSM) to Manhattan, KS (MHK-Manhattan Regional)

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Cheap Flights from Des Moines to Manhattan (DSM-MHK)

Prices were available within the past 7 days and start at $336 for one-way flights and $565 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

American Airlines
Mon, Dec 1 - Wed, Dec 17
DSM
Des Moines
MHK
Manhattan
$565 Roundtrip, found 5 days ago
$565
Roundtrip
found 5 days ago
Select American Airlines flight, departing Mon, Dec 1 from Des Moines to Manhattan, returning Wed, Dec 17, priced at $565 found 5 days ago
American Airlines
Wed, Jan 21 - Mon, Jan 26
DSM
Des Moines
MHK
Manhattan
$630 Roundtrip, found 5 days ago
$630
Roundtrip
found 5 days ago
Select American Airlines flight, departing Wed, Jan 21 from Des Moines to Manhattan, returning Mon, Jan 26, priced at $630 found 5 days ago
American Airlines
Tue, Jan 20 - Sat, Jan 24
DSM
Des Moines
MHK
Manhattan
$659 Roundtrip, found 5 days ago
$659
Roundtrip
found 5 days ago
Select American Airlines flight, departing Tue, Jan 20 from Des Moines to Manhattan, returning Sat, Jan 24, priced at $659 found 5 days ago
American Airlines
Wed, Jan 21 - Mon, Jan 26
DSM
Des Moines
MHK
Manhattan
$667 Roundtrip, found 5 days ago
$667
Roundtrip
found 5 days ago
Select American Airlines flight, departing Wed, Jan 21 from Des Moines to Manhattan, returning Mon, Jan 26, priced at $667 found 5 days ago
American Airlines
Wed, Dec 3 - Sat, Dec 20
DSM
Des Moines
MHK
Manhattan
$677 Roundtrip, found 5 days ago
$677
Roundtrip
found 5 days ago
Select American Airlines flight, departing Wed, Dec 3 from Des Moines to Manhattan, returning Sat, Dec 20, priced at $677 found 5 days ago
American Airlines
Mon, Dec 1 - Wed, Dec 17
DSM
Des Moines
MHK
Manhattan
$682 Roundtrip, found 5 days ago
$682
Roundtrip
found 5 days ago
Select American Airlines flight, departing Mon, Dec 1 from Des Moines to Manhattan, returning Wed, Dec 17, priced at $682 found 5 days ago
American Airlines
Tue, Jan 20 - Mon, Jan 26
DSM
Des Moines
MHK
Manhattan
$685 Roundtrip, found 5 days ago
$685
Roundtrip
found 5 days ago
Select American Airlines flight, departing Tue, Jan 20 from Des Moines to Manhattan, returning Mon, Jan 26, priced at $685 found 5 days ago
American Airlines
Tue, Jan 20 - Tue, Jan 27
DSM
Des Moines
MHK
Manhattan
$699 Roundtrip, found 5 days ago
$699
Roundtrip
found 5 days ago
Select American Airlines flight, departing Tue, Jan 20 from Des Moines to Manhattan, returning Tue, Jan 27, priced at $699 found 5 days ago
American Airlines
Fri, Nov 28 - Sat, Dec 20
DSM
Des Moines
MHK
Manhattan
$703 Roundtrip, found 5 days ago
$703
Roundtrip
found 5 days ago
Select American Airlines flight, departing Fri, Nov 28 from Des Moines to Manhattan, returning Sat, Dec 20, priced at $703 found 5 days ago
American Airlines
Tue, Nov 11 - Sat, Nov 15
DSM
Des Moines
MHK
Manhattan
$705 Roundtrip, found 6 days ago
$705
Roundtrip
found 6 days ago
Select American Airlines flight, departing Tue, Nov 11 from Des Moines to Manhattan, returning Sat, Nov 15, priced at $705 found 6 days ago

Frequently asked questions

How much does a flight from Des Moines Intl. Airport (DSM) to Manhattan Regional Airport (MHK) cost?
Secure a cheap one-way flight from $336 or cheap return flight from $565 from Des Moines Intl. Airport (DSM) to Manhattan Regional Airport (MHK) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to find our cheapest flight deals on this route.
What is the cheapest month to fly from Des Moines Intl. Airport (DSM) to Manhattan Regional Airport (MHK)?
December is the most affordable month to fly from DSM to MHK. Traveling during an off-peak travel window is often the key to finding better deals on flights.
What is the cheapest airline that flies from Des Moines Intl. Airport (DSM) to Manhattan Regional Airport (MHK)?
Expedia's filter tool lets you easily compare airlines, flight times and baggage options all in one place. Tailor the search to your trip, then sort by "Price (lowest to highest)" to find the carrier with the cheapest DSM to MHK flight.
How many flights per day from Des Moines Intl. Airport (DSM) to Manhattan Regional Airport (MHK)?
You'll have to take a flight with a layover if you're traveling from Des Moines Intl. Airport (DSM) to Manhattan Regional Airport (MHK). Direct flights don't operate daily on this route. However, just filter your search to include one or more stops to discover the best option for your trip.
What day of the week has the most flights from DSM to MHK?
You'll usually find Tuesday the quietest day for flights, while Fridays are often the busiest.* However this can vary from season to season and during public holidays or peak travel times.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Des Moines Intl. Airport (DSM) to Manhattan Regional Airport (MHK)?
Select a flight from Des Moines Intl. Airport (DSM) to Manhattan Regional Airport (MHK) that leaves before 3 PM to reduce the risk of delays and cancellations. Departures later than this have a 22% higher chance of being canceled, on average.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Des Moines Intl. Airport (DSM) to Manhattan Regional Airport (MHK) last-minute?
Booking your plane ticket from DSM to MHK shortly before your trip is generally more expensive. However, if you're flexible with your departure times and dates, you could grab a cheap last-minute fare.
Is it cheaper to book a DSM to MHK flight and hotel package?
You'll generally save money by securing a DSM to MHK flight and hotel package compared to booking separately. In fact, you could save hundreds of dollars by bundling with Expedia. And it's easy to manage it all in one place. After choosing your preferred accommodations and flights, consider adding extras including tours, activities and car rentals.
Can I cancel or change the date of my flight from Des Moines Intl. Airport (DSM) to Manhattan Regional Airport (MHK)?
Generally, it's possible to cancel or reschedule your DSM to MHK flight. However, for bookings made more than 24 hours ago, additional charges may apply. Check your airline's policies in your itinerary to see what changes are allowed and whether any costs are involved. You'll also find further details on our Customer Service portal.

Travel information

Origin airport
Des Moines Intl.
Destination airport
Manhattan Regional
Roundtrip price
$564
Distance
229 mi

Book with confidence

Des Moines to Manhattan Flights

The cheapest times to fly from Des Moines to Manhattan

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Des Moines to Manhattan are during the month of December. You can find some of the cheapest flights from Des Moines to Manhattan with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Des Moines to Manhattan

Sunday is one of the best days to book for cheap flights from Des Moines to Manhattan: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Des Moines to Manhattan

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Des Moines to Manhattan in 2025. You can also book with separate airlines for your outbound and return journeys, from $336 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Des Moines to Manhattan flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Des Moines to Manhattan airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Des Moines to Manhattan Flights

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*Available to One Key members.