$134 Cheap Flights from Key West (EYW) to Buffalo (BUF)

View $134 flight on Thu, Dec 25, 2025Opens in a new window

Popular airlines from Key West Intl. Airport (EYW) to Buffalo Niagara Intl. Airport (BUF)

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Cheap Flights from Key West to Buffalo (EYW-BUF)

Prices were available within the past 7 days and start at $134 for one-way flights and $264 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

United
Tue, Nov 4 - Tue, Nov 11
EYW
Key West
BUF
Buffalo
$264 Roundtrip, found 3 days ago
$264
Roundtrip
found 3 days ago
Select United flight, departing Tue, Nov 4 from Key West to Buffalo, returning Tue, Nov 11, priced at $264 found 3 days ago
American Airlines
Fri, Dec 5 - Mon, Dec 8
EYW
Key West
BUF
Buffalo
$269 Roundtrip, found 1 hour ago
$269
Roundtrip
found 1 hour ago
Select American Airlines flight, departing Fri, Dec 5 from Key West to Buffalo, returning Mon, Dec 8, priced at $269 found 1 hour ago
Delta
Thu, Jan 15 - Sun, Jan 18
EYW
Key West
BUF
Buffalo
$269 Roundtrip, found 10 hours ago
$269
Roundtrip
found 10 hours ago
Select Delta flight, departing Thu, Jan 15 from Key West to Buffalo, returning Sun, Jan 18, priced at $269 found 10 hours ago
American Airlines
Tue, Nov 4 - Tue, Nov 11
EYW
Key West
BUF
Buffalo
$276 Roundtrip, found 3 days ago
$276
Roundtrip
found 3 days ago
Select American Airlines flight, departing Tue, Nov 4 from Key West to Buffalo, returning Tue, Nov 11, priced at $276 found 3 days ago
American Airlines
Sat, Feb 14 - Sat, Feb 21
EYW
Key West
BUF
Buffalo
$286 Roundtrip, found 4 hours ago
$286
Roundtrip
found 4 hours ago
Select American Airlines flight, departing Sat, Feb 14 from Key West to Buffalo, returning Sat, Feb 21, priced at $286 found 4 hours ago
American Airlines
Sat, Feb 14 - Sat, Feb 21
EYW
Key West
BUF
Buffalo
$293 Roundtrip, found 4 hours ago
$293
Roundtrip
found 4 hours ago
Select American Airlines flight, departing Sat, Feb 14 from Key West to Buffalo, returning Sat, Feb 21, priced at $293 found 4 hours ago
American Airlines
Wed, Dec 17 - Thu, Jan 1
EYW
Key West
BUF
Buffalo
$301 Roundtrip, found 2 hours ago
$301
Roundtrip
found 2 hours ago
Select American Airlines flight, departing Wed, Dec 17 from Key West to Buffalo, returning Thu, Jan 1, priced at $301 found 2 hours ago
American Airlines
Wed, Mar 4 - Wed, Apr 8
EYW
Key West
BUF
Buffalo
$309 Roundtrip, found 2 days ago
$309
Roundtrip
found 2 days ago
Select American Airlines flight, departing Wed, Mar 4 from Key West to Buffalo, returning Wed, Apr 8, priced at $309 found 2 days ago
Delta
Thu, Jan 15 - Sun, Jan 18
EYW
Key West
BUF
Buffalo
$314 Roundtrip, found 10 hours ago
$314
Roundtrip
found 10 hours ago
Select Delta flight, departing Thu, Jan 15 from Key West to Buffalo, returning Sun, Jan 18, priced at $314 found 10 hours ago
JetBlue Airways
Thu, Apr 9 - Mon, Apr 13
EYW
Key West
BUF
Buffalo
$553 Roundtrip, found 1 day ago
$553
Roundtrip
found 1 day ago
Select JetBlue Airways flight, departing Thu, Apr 9 from Key West to Buffalo, returning Mon, Apr 13, priced at $553 found 1 day ago

Find the cheapest month to fly from Key West (EYW) to Buffalo (BUF)

November is typically the cheapest month to fly

From $219 - $885 per traveler.

Frequently asked questions

How much does a flight from Key West Intl. Airport (EYW) to Buffalo Niagara Intl. Airport (BUF) cost?
Lock in a cheap one-way flight from $134 or cheap return flight from $264 from Key West Intl. Airport (EYW) to Buffalo Niagara Intl. Airport (BUF) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to find our cheapest flight offers on this route.
What is the cheapest month to fly from Key West Intl. Airport (EYW) to Buffalo Niagara Intl. Airport (BUF)?
The cheapest month to fly from EYW to BUF is November, when there's less demand. Off-peak months are typically when better flight deals are available between these airports.
What is the cheapest airline that flies from Key West Intl. Airport (EYW) to Buffalo Niagara Intl. Airport (BUF)?
Use the filters on Expedia to compare different airlines and find the cheapest carrier that'll take you from EYW to BUF. Then, sort your results by "Price (lowest to highest)" to snap up a good deal.
How many flights per day from Key West Intl. Airport (EYW) to Buffalo Niagara Intl. Airport (BUF)?
Direct flights from Key West Intl. Airport (EYW) to Buffalo Niagara Intl. Airport (BUF) aren't available daily, so you'll need to take a flight with a layover. Explore your options with our filter tool. Enter your travel details and choose either "1 Stop" or "2+ Stops."
What day of the week has the most flights from EYW to BUF?
Generally you'll find the greatest selection of flight options on a Friday. Tuesdays are often the quietest.* But this can vary depending on the airline, time of year and other factors.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Key West Intl. Airport (EYW) to Buffalo Niagara Intl. Airport (BUF)?
To avoid possible delays on the Key West Intl. Airport (EYW) to Buffalo Niagara Intl. Airport (BUF) route, fly before 3 PM. Departures after this hour are 22% more likely to be canceled.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Key West Intl. Airport (EYW) to Buffalo Niagara Intl. Airport (BUF) last-minute?
Holding off until just before your departure to book a ticket from EYW to BUF generally means paying more. While you may come across some last-minute discounts, they're not always guaranteed. Allow some flexibility in your schedule to boost your chances of snagging a bargain.
Is it cheaper to book an EYW to BUF flight and hotel package?
You can save money by booking an EYW to BUF flight and hotel package compared to booking separately. In fact, travelers could save hundreds of dollars by bundling with Expedia. And it's simple to manage everything in one convenient place. After choosing your preferred accommodations and flights, consider adding extras including activities, tours and car rentals.
Can I cancel or change the date of my flight from Key West Intl. Airport (EYW) to Buffalo Niagara Intl. Airport (BUF)?
In most cases, you're able to cancel or reschedule your EYW to BUF flight. However, there may be additional charges, especially if you made your booking over 24 hours ago. Check your itinerary for the airline's fees and rules on flight changes, or if you'd like more details, go to our Customer Service portal.

Travel information

Travel information

Origin airport
Key West Intl.
Destination airport
Buffalo Niagara Intl.
Airlines serving
American Airlines, Delta, United
Roundtrip price
$264
Distance
1281 mi

Book with confidence

Book with confidence

Key West to Buffalo Flights

The cheapest times to fly from Key West to Buffalo

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Key West to Buffalo are during the month of November. You can find some of the cheapest flights from Key West to Buffalo with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Key West to Buffalo

Sunday is one of the best days to book for cheap flights from Key West to Buffalo: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Key West to Buffalo

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Key West to Buffalo in 2025. You can also book with separate airlines for your outbound and return journeys, from $134 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Key West to Buffalo flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Key West to Buffalo airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Key West to Buffalo Flights

Explore a world of travel with Expedia

Explore a world of travel with Expedia

*Available to One Key members.