$201 Cheap Flights from Ithaca (ITH) to Knoxville (TYS)

View $201 flight on Wed, Apr 15, 2026Opens in a new window

Popular airlines from Ithaca, NY (ITH-Tompkins Regional) to McGhee Tyson Airport (TYS)

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Cheap Flights from Ithaca to Knoxville (ITH-TYS)

Prices were available within the past 7 days and start at $201 for one-way flights and $279 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Delta
Tue, Apr 14 - Wed, Apr 22
ITH
Ithaca
TYS
Knoxville
$279 Roundtrip, found 3 days ago
$279
Roundtrip
found 3 days ago
Select Delta flight, departing Tue, Apr 14 from Ithaca to Knoxville, returning Wed, Apr 22, priced at $279 found 3 days ago
Delta
Tue, Apr 14 - Wed, Apr 29
ITH
Ithaca
TYS
Knoxville
$320 Roundtrip, found 2 days ago
$320
Roundtrip
found 2 days ago
Select Delta flight, departing Tue, Apr 14 from Ithaca to Knoxville, returning Wed, Apr 29, priced at $320 found 2 days ago
Delta
Sat, Apr 18 - Wed, Apr 22
ITH
Ithaca
TYS
Knoxville
$329 Roundtrip, found 3 days ago
$329
Roundtrip
found 3 days ago
Select Delta flight, departing Sat, Apr 18 from Ithaca to Knoxville, returning Wed, Apr 22, priced at $329 found 3 days ago
Delta
Tue, Mar 10 - Tue, Mar 24
ITH
Ithaca
TYS
Knoxville
$335 Roundtrip, found 2 days ago
$335
Roundtrip
found 2 days ago
Select Delta flight, departing Tue, Mar 10 from Ithaca to Knoxville, returning Tue, Mar 24, priced at $335 found 2 days ago
United
Sun, Apr 5 - Sat, Apr 18
ITH
Ithaca
TYS
Knoxville
$339 Roundtrip, found 2 days ago
$339
Roundtrip
found 2 days ago
Select United flight, departing Sun, Apr 5 from Ithaca to Knoxville, returning Sat, Apr 18, priced at $339 found 2 days ago
United
Tue, Mar 24 - Sat, Mar 28
ITH
Ithaca
TYS
Knoxville
$344 Roundtrip, found 2 days ago
$344
Roundtrip
found 2 days ago
Select United flight, departing Tue, Mar 24 from Ithaca to Knoxville, returning Sat, Mar 28, priced at $344 found 2 days ago
United
Fri, Apr 17 - Wed, Apr 29
ITH
Ithaca
TYS
Knoxville
$344 Roundtrip, found 2 days ago
$344
Roundtrip
found 2 days ago
Select United flight, departing Fri, Apr 17 from Ithaca to Knoxville, returning Wed, Apr 29, priced at $344 found 2 days ago
United
Mon, Mar 23 - Sat, Mar 28
ITH
Ithaca
TYS
Knoxville
$349 Roundtrip, found 2 days ago
$349
Roundtrip
found 2 days ago
Select United flight, departing Mon, Mar 23 from Ithaca to Knoxville, returning Sat, Mar 28, priced at $349 found 2 days ago
United
Fri, Apr 17 - Sat, May 2
ITH
Ithaca
TYS
Knoxville
$349 Roundtrip, found 2 days ago
$349
Roundtrip
found 2 days ago
Select United flight, departing Fri, Apr 17 from Ithaca to Knoxville, returning Sat, May 2, priced at $349 found 2 days ago
United
Mon, Apr 13 - Sat, May 2
ITH
Ithaca
TYS
Knoxville
$354 Roundtrip, found 2 days ago
$354
Roundtrip
found 2 days ago
Select United flight, departing Mon, Apr 13 from Ithaca to Knoxville, returning Sat, May 2, priced at $354 found 2 days ago

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Alternative airports near Knoxville

Prices were available within the past 7 days. Prices and availability are subject to change.

Select flight to McGhee Tyson TYS. Cheapest and Closest option available. Average driving time to city center is 22 minutes. Flights from $715
TYS
McGhee Tyson
CheapestClosest
Average driving time to city center22 min
Flights from $715

Frequently asked questions

How much does a flight from Tompkins Regional Airport (ITH) to McGhee Tyson Airport (TYS) cost?
Grab a cheap one-way flight from $201 or cheap return flight from $279 from Tompkins Regional Airport (ITH) to McGhee Tyson Airport (TYS) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to see our cheapest flight offers on this route.
What is the cheapest month to fly from Tompkins Regional Airport (ITH) to McGhee Tyson Airport (TYS)?
Traveling in April is a good way to save, as it's the cheapest month for flights between ITH and TYS. You'll typically find the lowest prices during the off-season.
What is the cheapest airline that flies from Tompkins Regional Airport (ITH) to McGhee Tyson Airport (TYS)?
To find the cheapest airline that'll fly you from ITH to TYS, use Expedia's filter tool. Customize your search based on what's important to you, such as preferred carriers and number of stops. You can then sort your results by "Price (lowest to highest)" to see the cheapest flights first.
How many flights per day from Tompkins Regional Airport (ITH) to McGhee Tyson Airport (TYS)?
You'll have to hop on a flight with a layover if you're traveling from Tompkins Regional Airport (ITH) to McGhee Tyson Airport (TYS). Direct flights don't operate daily on this route. However, simply filter your search to include one or two stops to discover the best option for your trip.
What day of the week has the most flights from ITH to TYS?
You'll generally find Tuesday the quietest day for flights, while Fridays are often the busiest.* However this can vary from season to season and during public holidays or peak travel times.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Tompkins Regional Airport (ITH) to McGhee Tyson Airport (TYS)?
Opt for a flight from Tompkins Regional Airport (ITH) to McGhee Tyson Airport (TYS) that leaves before 3 PM to reduce the likelihood of delays and cancellations. Later departures have a 22% higher chance of being canceled, on average.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Tompkins Regional Airport (ITH) to McGhee Tyson Airport (TYS) last-minute?
Booking your flight from ITH to TYS shortly before your journey is usually more expensive. However, if there's some wiggle room with your travel times and dates, you could land a cheap last-minute fare.
Is it cheaper to book an ITH to TYS flight and hotel package?
Compared with arranging flights and hotels separately, booking an ITH to TYS flight and hotel package with Expedia could lead to significant savings. Better yet, having everything in one easy place will take the hassle out of planning your trip. Simply pick your flights and select from our wide range of stays, then personalize your trip with other add-ons like tours and car rentals.
Can I cancel or change the date of my flight from Tompkins Regional Airport (ITH) to McGhee Tyson Airport (TYS)?
If you reserved your ITH to TYS flight within the last 24 hours, you may be able to modify or cancel it at no cost. Depending on the airline and the type of ticket you purchased, additional charges may apply for changes after that time. Airline policies and contact information can be found in your itinerary or confirmation email. Or, visit our Customer Service portal for further details.

Travel information

Origin airport
Tompkins Regional
Destination airport
McGhee Tyson
Roundtrip price
$279
Distance
612 mi

Book with confidence

Ithaca to Knoxville Flights

The cheapest times to fly from Ithaca to Knoxville

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Ithaca to Knoxville are during the month of April. You can find some of the cheapest flights from Ithaca to Knoxville with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Ithaca to Knoxville

Sunday is one of the best days to book for cheap flights from Ithaca to Knoxville: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Ithaca to Knoxville

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Ithaca to Knoxville in 2026. You can also book with separate airlines for your outbound and return journeys, from $201 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Ithaca to Knoxville flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Ithaca to Knoxville airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Ithaca to Knoxville Flights

*Flight schedules are subject to change.

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