$201 Cheap Flights from Ithaca (ITH) to Knoxville (TYS)

View $201 flight on Tue, Apr 28, 2026Opens in a new window

Popular airlines from Ithaca, NY (ITH-Tompkins Regional) to McGhee Tyson Airport (TYS)

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Cheap Flights from Ithaca to Knoxville (ITH-TYS)

Prices were available within the past 7 days and start at $201 for one-way flights and $548 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

United
Fri, Mar 20 - Tue, Mar 24
ITH
Ithaca
TYS
Knoxville
$548 Roundtrip, found 6 days ago
$548
Roundtrip
found 6 days ago
Select United flight, departing Fri, Mar 20 from Ithaca to Knoxville, returning Tue, Mar 24, priced at $548 found 6 days ago

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Frequently asked questions

How much does a flight from Ithaca, NY (ITH-Tompkins Regional) to Knoxville, TN (TYS-McGhee Tyson) cost?
You can find cheap one-way flights from $201 and cheap return flights from $548 Ithaca, NY (ITH-Tompkins Regional) to Knoxville, TN (TYS-McGhee Tyson) with Expedia. Return flights typically cost between $284 and $1383. Flight prices vary based on the month and day of the week you want to travel, as well as the airline and how far in advance you book your ticket. Filter your search on Expedia by "Price (lowest to highest)" to see the cheapest fares first, and use the Price Tracking tool to receive alerts when Ithaca, NY (ITH-Tompkins Regional) to Knoxville, TN (TYS-McGhee Tyson) ticket fares go up or down.*Typical price ranges based on flights available on Expedia in the last year. Prices include multi-airline options.
What is the cheapest month to fly from Ithaca, NY (ITH-Tompkins Regional) to Knoxville, TN (TYS-McGhee Tyson)?
The cheapest month to fly from ITH to TYS is March when demand is low. Traveling in off-peak or shoulder months is usually a good way to secure cheap tickets, just remember to avoid flying during holidays if you're able to. Use the calendar view in your search to see which months have low fares on this route.
Which airlines fly direct from Ithaca, NY (ITH-Tompkins Regional) to Knoxville, TN (TYS-McGhee Tyson)?
Enter ITH to TYS and your travel dates, then apply the 'Nonstop' filter to see only direct flights.
What is the cheapest airline that flies from Ithaca, NY (ITH-Tompkins Regional) to Knoxville, TN (TYS-McGhee Tyson)?
Delta is one of the cheapest airlines offering connecting flights from Ithaca, NY (ITH) to Knoxville, TN (TYS), with round-trip tickets starting from around $284. This flight includes a layover in John F. Kennedy Intl. (JFK). Use Expedia's search tool to compare the prices and schedules of airlines that fly this route to find the best option for your plans and budget.*Prices based on flights available on Expedia in the last year.
How do I find cheap flights from Ithaca, NY (ITH-Tompkins Regional) to Knoxville, TN (TYS-McGhee Tyson)?
To find a cheap flight from Ithaca, NY (ITH-Tompkins Regional) to Knoxville, TN (TYS-McGhee Tyson), be flexible with your dates. Traveling outside of peak vacation months and booking a mid-week flight can help you save. Early morning and late night flights are often more affordable, too. Expedia allows you to compare flight times, airlines and routes all in one place to find low fares. You can also set up Price Tracking and receive alerts when fares go up or down.
What is the best time to fly from Ithaca, NY (ITH-Tompkins Regional) to Knoxville, TN (TYS-McGhee Tyson)?
The best time to fly is usually mid-week (Tuesday or Wednesday) and during early morning hours as flights tend to be cheaper, less crowded, and generally more on-time. Avoid major holidays and peak vacation seasons for smoother travel. Combining off-peak days and hours often gives the best combination of cost, comfort, and convenience.
What is the earliest flight from Ithaca, NY (ITH-Tompkins Regional) to Knoxville, TN (TYS-McGhee Tyson)?
The earliest flight from Ithaca, NY (ITH-Tompkins Regional) to Knoxville, TN (TYS-McGhee Tyson) typically leaves at around 5:25 AM, operated by Delta. This seasonal service is active in January, allowing you to maximize your time in Knoxville. To compare early flights on Expedia, select the "Early Morning" and "Morning" filters in your search.
How long does it take to fly from Ithaca, NY (ITH-Tompkins Regional) to Knoxville, TN (TYS-McGhee Tyson)?
Flying from ITH to TYS with a connection usually takes about 4 hours 20 minutes, traveling roughly 613 miles. Keep in mind that actual flight times can vary due to wind patterns, weather, and air traffic.
Can you fly business or first class from Ithaca, NY (ITH-Tompkins Regional) to Knoxville, TN (TYS-McGhee Tyson)?
First class seats are offered on the ITH to TYS route with Delta Air Lines.
How do I earn miles on a Ithaca, NY (ITH-Tompkins Regional) to Knoxville, TN (TYS-McGhee Tyson) flight with Expedia?
It's easy to earn miles on a Ithaca, NY (ITH-Tompkins Regional) to Knoxville, TN (TYS-McGhee Tyson) flight when you book with Expedia. Before you confirm your booking, simply select your frequent flyer program and enter your program number. As a member of One Key™, you can also earn OneKeyCash™* on top of your airline miles when you book with Expedia.*Excludes taxes and fees. OneKeyCash is not redeemable for cash and can only be used on Expedia and other participating brands.
What airports do you fly into for Knoxville from Tompkins Regional (ITH)?
If you're planning to travel to Knoxville from Tompkins Regional (ITH), you can fly into McGhee Tyson (TYS) Some flights may connect through major hubs like John F. Kennedy Intl. (JFK), Washington Dulles Intl. (IAD) before reaching Knoxville. Compare routes and airports on Expedia to find the best flight options for your travel plans.
Is it cheaper to buy a plane ticket from Ithaca, NY (ITH-Tompkins Regional) to Knoxville, TN (TYS-McGhee Tyson) at the last minute?
Typically, booking a last minute flight from Ithaca, NY (ITH-Tompkins Regional) to Knoxville, TN (TYS-McGhee Tyson) will be more expensive than booking in advance. As the departure date approaches, there are usually fewer seats available which can drive up the cost. However, if there's some wiggle room with your travel dates and times, you could bag a cheap last-minute fare.
Is it cheaper to book a Ithaca, NY (ITH-Tompkins Regional) to Knoxville, TN (TYS-McGhee Tyson) flight and hotel package?
Securing a Ithaca, NY (ITH-Tompkins Regional) to Knoxville, TN (TYS-McGhee Tyson) flight and hotel package is usually cheaper than booking separately. With Expedia, you can enjoy the ease of organizing your travels all in one place. Select from our extensive range of stays and then add flights, activities and car rentals to your booking. Bundle everything together, and you could save hundreds of dollars.
Can I cancel or change the date of my flight from Ithaca, NY (ITH-Tompkins Regional) to Knoxville, TN (TYS-McGhee Tyson)?
If you booked your Ithaca, NY (ITH-Tompkins Regional) to Knoxville, TN (TYS-McGhee Tyson) flight within the last 24 hours, you may be able to modify or cancel it without any fees. Depending on the airline and the type of ticket you have, additional charges may apply for changes beyond this timeframe. Airline policies and contact information can be found in your itinerary or confirmation email. Or, head to our Customer Service portal if you'd like more information.

Travel information

Origin airport
Tompkins Regional
Destination airport
McGhee Tyson
Roundtrip price
$548
Distance
612 mi

Book with confidence

Ithaca to Knoxville Flights

The cheapest times to fly from Ithaca to Knoxville

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Ithaca to Knoxville are during the month of March. You can find some of the cheapest flights from Ithaca to Knoxville with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Ithaca to Knoxville

Sunday is one of the best days to book for cheap flights from Ithaca to Knoxville: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Ithaca to Knoxville

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Ithaca to Knoxville in 2026. You can also book with separate airlines for your outbound and return journeys, from $201 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Ithaca to Knoxville flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Ithaca to Knoxville airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Ithaca to Knoxville Flights

*Flight schedules are subject to change.

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*Available to One Key members.