Title: Cheap flights from Lisbon to Siena (LIS to SAY) - Expedia.com ![](https://images.trvl-media.com/place/9821/7379d030-252a-4e26-a469-e10785470ebc.jpg?impolicy=fcrop&w=1200&h=500&q=medium) ![](https://images.trvl-media.com/place/9821/7379d030-252a-4e26-a469-e10785470ebc.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Cheap Flights from Lisbon (LIS) to Siena (SAY) ## Popular airlines from Humberto Delgado Airport (LIS) to Ampugnano Airport (SAY) - ![](https://forever.travel-assets.com/flex/flexmanager/images/2024/09/23/landing_airline_sq_logo_AA.svg) American Airlines [](https://www.expedia.com/Flights-Search?leg1=from:LIS,to:SAY,departure:4/22/2026TANYT&leg2=from:SAY,to:LIS,departure:4/29/2026TANYT&trip=roundtrip&passengers=adults:1,children:0,infantinlap:N&mode=search&pageId=0&filters=[{"preferredAirlineFilterValue":{"carrierCode":"AA"}}]) - ![](https://forever.travel-assets.com/flex/flexmanager/images/2024/09/23/landing_airline_sq_logo_UA.svg) United [](https://www.expedia.com/Flights-Search?leg1=from:LIS,to:SAY,departure:4/22/2026TANYT&leg2=from:SAY,to:LIS,departure:4/29/2026TANYT&trip=roundtrip&passengers=adults:1,children:0,infantinlap:N&mode=search&pageId=0&filters=[{"preferredAirlineFilterValue":{"carrierCode":"UA"}}]) - ![](https://forever.travel-assets.com/flex/flexmanager/images/2024/09/23/landing_airline_sq_logo_WN.svg) Southwest Airlines [](https://www.expedia.com/Flights-Search?leg1=from:LIS,to:SAY,departure:4/22/2026TANYT&leg2=from:SAY,to:LIS,departure:4/29/2026TANYT&trip=roundtrip&passengers=adults:1,children:0,infantinlap:N&mode=search&pageId=0&filters=[{"preferredAirlineFilterValue":{"carrierCode":"WN"}}]) - ![](https://forever.travel-assets.com/flex/flexmanager/images/2024/09/23/landing_airline_sq_logo_DL.svg) Delta [](https://www.expedia.com/Flights-Search?leg1=from:LIS,to:SAY,departure:4/22/2026TANYT&leg2=from:SAY,to:LIS,departure:4/29/2026TANYT&trip=roundtrip&passengers=adults:1,children:0,infantinlap:N&mode=search&pageId=0&filters=[{"preferredAirlineFilterValue":{"carrierCode":"DL"}}]) - ![](https://forever.travel-assets.com/flex/flexmanager/images/2024/09/23/landing_airline_sq_logo_F9.svg) Frontier Airlines [](https://www.expedia.com/Flights-Search?leg1=from:LIS,to:SAY,departure:4/22/2026TANYT&leg2=from:SAY,to:LIS,departure:4/29/2026TANYT&trip=roundtrip&passengers=adults:1,children:0,infantinlap:N&mode=search&pageId=0&filters=[{"preferredAirlineFilterValue":{"carrierCode":"F9"}}]) - ![](https://forever.travel-assets.com/flex/flexmanager/images/2024/09/23/landing_airline_sq_logo_B6.svg) JetBlue Airways [](https://www.expedia.com/Flights-Search?leg1=from:LIS,to:SAY,departure:4/22/2026TANYT&leg2=from:SAY,to:LIS,departure:4/29/2026TANYT&trip=roundtrip&passengers=adults:1,children:0,infantinlap:N&mode=search&pageId=0&filters=[{"preferredAirlineFilterValue":{"carrierCode":"B6"}}]) - ![](https://forever.travel-assets.com/flex/flexmanager/images/2024/09/23/landing_airline_sq_logo_AS.svg) Alaska Airlines [](https://www.expedia.com/Flights-Search?leg1=from:LIS,to:SAY,departure:4/22/2026TANYT&leg2=from:SAY,to:LIS,departure:4/29/2026TANYT&trip=roundtrip&passengers=adults:1,children:0,infantinlap:N&mode=search&pageId=0&filters=[{"preferredAirlineFilterValue":{"carrierCode":"AS"}}]) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__notification.svg) ### Be in the know Get alerts if flight prices drop or rise\* - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Book smarter Save up to 30% on select hotels after you book a flight\* - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__trophy.svg) ### Earn twice Earn your airline miles on top of our OneKeyCash [Learn about One Key](https://www.expedia.com/welcome-one-key) ## Frequently asked questions ### How much does a flight from Lisbon (LIS-Humberto Delgado) to Siena (SAY-Ampugnano) cost? ### What is the cheapest month to fly from Lisbon (LIS-Humberto Delgado) to Siena (SAY-Ampugnano)? ### Which airlines fly direct from Lisbon (LIS-Humberto Delgado) to Siena (SAY-Ampugnano)? ### How do I find cheap flights from Lisbon (LIS-Humberto Delgado) to Siena (SAY-Ampugnano)? ### What is the best time to fly from Lisbon (LIS-Humberto Delgado) to Siena (SAY-Ampugnano)? ### What is the earliest flight from Lisbon (LIS-Humberto Delgado) to Siena (SAY-Ampugnano)? ### Can you fly business or first class from Lisbon (LIS-Humberto Delgado) to Siena (SAY-Ampugnano)? ### How do I earn miles on a Lisbon (LIS-Humberto Delgado) to Siena (SAY-Ampugnano) flight with Expedia? ### Is it cheaper to buy a plane ticket from Lisbon (LIS-Humberto Delgado) to Siena (SAY-Ampugnano) at the last minute? ### Is it cheaper to book a Lisbon (LIS-Humberto Delgado) to Siena (SAY-Ampugnano) flight and hotel package? ### Can I cancel or change the date of my flight from Lisbon (LIS-Humberto Delgado) to Siena (SAY-Ampugnano)? ## Travel information | Origin airport | Humberto Delgado | | ------------------- | ---------------- | | Destination airport | Ampugnano | | Distance | 1103 mi | \*Flight schedules are subject to change. \*Available to One Key members. ## Explore a world of travel with Expedia - 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