$42 Cheap Flights from La Serena (LSC) to Antofagasta (ANF)

View $42 flight on Thu, Jan 8, 2026Opens in a new window

Popular airlines from La Serena (LSC-La Florida) to Antofagasta (ANF-Cerro Moreno Intl.)

Cheap Flights from La Serena to Antofagasta (LSC-ANF)

Prices were available within the past 7 days and start at $42 for one-way flights and $78 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

LATAM Airlines Group
Thu, Jan 8 - Tue, Jan 20
LSC
La Serena
ANF
Antofagasta
$78 Roundtrip, found 3 days ago
$78
Roundtrip
found 3 days ago
Select LATAM Airlines Group flight, departing Thu, Jan 8 from La Serena to Antofagasta, returning Tue, Jan 20, priced at $78 found 3 days ago
LATAM Airlines Group
Wed, Feb 4 - Wed, Feb 11
LSC
La Serena
ANF
Antofagasta
$80 Roundtrip, found 2 hours ago
$80
Roundtrip
found 2 hours ago
Select LATAM Airlines Group flight, departing Wed, Feb 4 from La Serena to Antofagasta, returning Wed, Feb 11, priced at $80 found 2 hours ago
LATAM Airlines Group
Thu, Jan 8 - Tue, Jan 20
LSC
La Serena
ANF
Antofagasta
$83 Roundtrip, found 3 days ago
$83
Roundtrip
found 3 days ago
Select LATAM Airlines Group flight, departing Thu, Jan 8 from La Serena to Antofagasta, returning Tue, Jan 20, priced at $83 found 3 days ago
SKY AIRLINE
Wed, Jan 7 - Tue, Jan 20
LSC
La Serena
ANF
Antofagasta
$84 Roundtrip, found 6 days ago
$84
Roundtrip
found 6 days ago
Select SKY AIRLINE flight, departing Wed, Jan 7 from La Serena to Antofagasta, returning Tue, Jan 20, priced at $84 found 6 days ago
Jetsmart SPA
Wed, Feb 4 - Wed, Feb 11
LSC
La Serena
ANF
Antofagasta
$85 Roundtrip, found 2 hours ago
$85
Roundtrip
found 2 hours ago
Select Jetsmart SPA flight, departing Wed, Feb 4 from La Serena to Antofagasta, returning Wed, Feb 11, priced at $85 found 2 hours ago
Jetsmart SPA
Thu, Jan 8 - Tue, Jan 20
LSC
La Serena
ANF
Antofagasta
$87 Roundtrip, found 3 days ago
$87
Roundtrip
found 3 days ago
Select Jetsmart SPA flight, departing Thu, Jan 8 from La Serena to Antofagasta, returning Tue, Jan 20, priced at $87 found 3 days ago
LATAM Airlines Group
Thu, Jan 8 - Tue, Jan 20
LSC
La Serena
ANF
Antofagasta
$88 Roundtrip, found 3 days ago
$88
Roundtrip
found 3 days ago
Select LATAM Airlines Group flight, departing Thu, Jan 8 from La Serena to Antofagasta, returning Tue, Jan 20, priced at $88 found 3 days ago
LATAM Airlines Group
Wed, Jan 7 - Tue, Jan 20
LSC
La Serena
ANF
Antofagasta
$89 Roundtrip, found 6 days ago
$89
Roundtrip
found 6 days ago
Select LATAM Airlines Group flight, departing Wed, Jan 7 from La Serena to Antofagasta, returning Tue, Jan 20, priced at $89 found 6 days ago
Jetsmart SPA
Thu, Jan 8 - Tue, Jan 20
LSC
La Serena
ANF
Antofagasta
$92 Roundtrip, found 3 days ago
$92
Roundtrip
found 3 days ago
Select Jetsmart SPA flight, departing Thu, Jan 8 from La Serena to Antofagasta, returning Tue, Jan 20, priced at $92 found 3 days ago
Jetsmart SPA
Thu, Jan 8 - Tue, Jan 20
LSC
La Serena
ANF
Antofagasta
$93 Roundtrip, found 3 days ago
$93
Roundtrip
found 3 days ago
Select Jetsmart SPA flight, departing Thu, Jan 8 from La Serena to Antofagasta, returning Tue, Jan 20, priced at $93 found 3 days ago
Flights from La Serena (LSC) to Antofagasta (ANF)
Origin airport
La Florida
Destination airport
Cerro Moreno Intl.
Airlines serving
LATAM Airlines Group, SKY AIRLINE
Roundtrip price
$78
Distance
449 mi
Average flight time
1 hour 21 mins

La Serena to Antofagasta Flights

The cheapest times to fly from La Serena to Antofagasta

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from La Serena to Antofagasta are during the month of January. You can find some of the cheapest flights from La Serena to Antofagasta with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from La Serena to Antofagasta

Sunday is one of the best days to book for cheap flights from La Serena to Antofagasta: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from La Serena to Antofagasta

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from La Serena to Antofagasta in 2026. You can also book with separate airlines for your outbound and return journeys, from $42 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap La Serena to Antofagasta flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your La Serena to Antofagasta airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Frequently asked questions

How much does a flight from La Florida Airport (LSC) to Cerro Moreno Intl. Airport (ANF) cost?
Secure a cheap one-way flight from $42 or cheap return flight from $78 from La Florida Airport (LSC) to Cerro Moreno Intl. Airport (ANF) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to see our cheapest flight offers on this route.
What is the cheapest month to fly from La Florida Airport (LSC) to Cerro Moreno Intl. Airport (ANF)?
The cheapest month to fly from LSC to ANF is January, when there's less demand. Off-peak season is usually when airlines offer lower prices between these airports.
Which airlines fly direct from La Florida Airport (LSC) to Cerro Moreno Intl. Airport (ANF)?
Avoid the detours and travel nonstop from La Florida Airport (LSC) to Cerro Moreno Intl. Airport (ANF) with 3 carriers, including:

  • JetSMART
  • LATAM Airlines
  • Sky Airline

What is the cheapest airline that flies from La Florida Airport (LSC) to Cerro Moreno Intl. Airport (ANF)?
The cheapest airline to offer flights between La Florida Airport (LSC) and Cerro Moreno Intl. Airport (ANF) will change depending on when you plan to fly. However, you'll typically find that low-cost carriers like LATAM Airlines and Sky Airline provide some of the most affordable options. Use Expedia's filter tool to compare airlines in one place and find the right LSC to ANF flight for your budget.
How many flights per day from La Florida Airport (LSC) to Cerro Moreno Intl. Airport (ANF)?
When departing from La Florida Airport (LSC), you can take your pick from an average of 3 daily nonstop flights to Cerro Moreno Intl. Airport (ANF).
What are the most popular departure times for flights from La Florida Airport (LSC) to Cerro Moreno Intl. Airport (ANF)?
The 9 AM departures from LSC to ANF are the busiest. They can also be more expensive. If you're looking to save, pick a less crowded time to fly.
What day of the week has the most flights from LSC to ANF?
If you depart on a Thursday, you'll get the widest range of choices for flights from La Florida Airport (LSC) to Cerro Moreno Intl. Airport (ANF).
What is the earliest flight from La Florida Airport (LSC) to Cerro Moreno Intl. Airport (ANF)?
Hop on the earliest flight at around 9:38AM UTC-3, heading out of La Florida Airport (LSC). You'll be flying for approximately 1h 18m, arriving at Cerro Moreno Intl. Airport (ANF) at approximately 10:56AM UTC-3.
How long does it take to fly from La Florida Airport (LSC) to Cerro Moreno Intl. Airport (ANF)?
It takes around 1 hour and 19 minutes to fly the 450 mi from LSC to ANF.
What airline has the least delays from LSC to ANF?
Sky Airline has the best performance for on-time direct flights from La Florida Airport (LSC) to Cerro Moreno Intl. Airport (ANF), with an on-time score of 88%. Use the Expedia App to see your flight status before you head off and get real-time alerts about any trip changes.
What is the best time to fly from La Florida Airport (LSC) to Cerro Moreno Intl. Airport (ANF)?
Select a flight from La Florida Airport (LSC) to Cerro Moreno Intl. Airport (ANF) that leaves before 3 PM to reduce the risk of cancellations. Departures after this time have a 22% higher chance of being canceled, on average.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
What airports do you fly into for Antofagasta from La Florida Airport (LSC)?
If you're boarding a direct flight from La Florida Airport (LSC) to Antofagasta, Cerro Moreno Intl. Airport (ANF) is the only airport you can land at.
Is it cheaper to buy a plane ticket from La Florida Airport (LSC) to Cerro Moreno Intl. Airport (ANF) last-minute?
Last-minute fares from LSC to ANF are typically more expensive. To secure the lowest rates, start searching for flights ahead of time. That said, if your travel plans are flexible, it's possible to score a cheap ticket right before your trip.
Is it cheaper to book a LSC to ANF flight and hotel package?
Compared with arranging flights and hotels separately, booking a LSC to ANF flight and hotel package with Expedia could result in significant savings. Better yet, having everything in one place takes the hassle out of planning your trip. Simply secure your flights and choose from our wide range of hotels, then customize your trip with extras like activities, tours and car rentals.
Can I cancel or change the date of my flight from La Florida Airport (LSC) to Cerro Moreno Intl. Airport (ANF)?
It's usually possible to reschedule or cancel your LSC to ANF flight. However, if it's been more than 24 hours since booking, additional charges may apply. Check your airline's policies in your itinerary to see what changes are allowed and if any costs are involved. You'll also find further details on our Customer Service portal.

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*Available to One Key members.