$294 Cheap Flights from Medellín (MDE) to Buffalo (BUF)

View $294 flight on Thu, Dec 11, 2025Opens in a new window

Popular airlines from Jose Maria Cordova Intl. Airport (MDE) to Buffalo Niagara Intl. Airport (BUF)

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Cheap Flights from Medellín to Buffalo (MDE-BUF)

Prices were available within the past 7 days and start at $294 for one-way flights and $587 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

JetBlue Airways
Thu, Mar 5 - Thu, Mar 12
MDE
Medellin
BUF
Buffalo
$587 Roundtrip, found 6 days ago
$587
Roundtrip
found 6 days ago
Select JetBlue Airways flight, departing Thu, Mar 5 from Medellin to Buffalo, returning Thu, Mar 12, priced at $587 found 6 days ago
United
Tue, Aug 11 - Mon, Aug 17
MDE
Medellin
BUF
Buffalo
$623 Roundtrip, found 3 days ago
$623
Roundtrip
found 3 days ago
Select United flight, departing Tue, Aug 11 from Medellin to Buffalo, returning Mon, Aug 17, priced at $623 found 3 days ago
American Airlines
Thu, Nov 13 - Mon, Nov 17
MDE
Medellin
BUF
Buffalo
$623 Roundtrip, found 5 days ago
$623
Roundtrip
found 5 days ago
Select American Airlines flight, departing Thu, Nov 13 from Medellin to Buffalo, returning Mon, Nov 17, priced at $623 found 5 days ago
Copa
Tue, Aug 11 - Mon, Aug 17
MDE
Medellin
BUF
Buffalo
$631 Roundtrip, found 3 days ago
$631
Roundtrip
found 3 days ago
Select Copa flight, departing Tue, Aug 11 from Medellin to Buffalo, returning Mon, Aug 17, priced at $631 found 3 days ago
JetBlue Airways
Thu, Mar 5 - Thu, Mar 12
MDE
Medellin
BUF
Buffalo
$635 Roundtrip, found 6 days ago
$635
Roundtrip
found 6 days ago
Select JetBlue Airways flight, departing Thu, Mar 5 from Medellin to Buffalo, returning Thu, Mar 12, priced at $635 found 6 days ago
avianca
Thu, Nov 13 - Mon, Nov 17
MDE
Medellin
BUF
Buffalo
$642 Roundtrip, found 5 days ago
$642
Roundtrip
found 5 days ago
Select avianca flight, departing Thu, Nov 13 from Medellin to Buffalo, returning Mon, Nov 17, priced at $642 found 5 days ago
United
Tue, Aug 11 - Mon, Aug 17
MDE
Medellin
BUF
Buffalo
$642 Roundtrip, found 3 days ago
$642
Roundtrip
found 3 days ago
Select United flight, departing Tue, Aug 11 from Medellin to Buffalo, returning Mon, Aug 17, priced at $642 found 3 days ago
JetBlue Airways
Thu, Nov 13 - Mon, Nov 17
MDE
Medellin
BUF
Buffalo
$644 Roundtrip, found 5 days ago
$644
Roundtrip
found 5 days ago
Select JetBlue Airways flight, departing Thu, Nov 13 from Medellin to Buffalo, returning Mon, Nov 17, priced at $644 found 5 days ago
United
Tue, Aug 11 - Mon, Aug 17
MDE
Medellin
BUF
Buffalo
$648 Roundtrip, found 3 days ago
$648
Roundtrip
found 3 days ago
Select United flight, departing Tue, Aug 11 from Medellin to Buffalo, returning Mon, Aug 17, priced at $648 found 3 days ago
LATAM Airlines Group
Tue, Aug 11 - Mon, Aug 17
MDE
Medellin
BUF
Buffalo
$650 Roundtrip, found 3 days ago
$650
Roundtrip
found 3 days ago
Select LATAM Airlines Group flight, departing Tue, Aug 11 from Medellin to Buffalo, returning Mon, Aug 17, priced at $650 found 3 days ago

Frequently asked questions

How much does a flight from Jose Maria Cordova Intl. Airport (MDE) to Buffalo Niagara Intl. Airport (BUF) cost?
Snag a cheap one-way flight from $294 or cheap return flight from $587 from Jose Maria Cordova Intl. Airport (MDE) to Buffalo Niagara Intl. Airport (BUF) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to see our cheapest flight deals on this route.
What is the cheapest month to fly from Jose Maria Cordova Intl. Airport (MDE) to Buffalo Niagara Intl. Airport (BUF)?
The cheapest month to fly from MDE to BUF is March, when demand is low. Off-peak months are usually when airlines offer lower prices between these airports.
What is the cheapest airline that flies from Jose Maria Cordova Intl. Airport (MDE) to Buffalo Niagara Intl. Airport (BUF)?
Expedia's filter tool lets you easily compare airlines, flight times and baggage options all in one place. Select your preferences, then sort by "Price (lowest to highest)" to find out which carrier offers the cheapest MDE to BUF flight.
How many flights per day from Jose Maria Cordova Intl. Airport (MDE) to Buffalo Niagara Intl. Airport (BUF)?
Direct flights from Jose Maria Cordova Intl. Airport (MDE) to Buffalo Niagara Intl. Airport (BUF) aren't available daily, so you'll have to take a flight with a layover. Explore your options with Expedia's filter tool. Enter your dates and pick either "1 Stop" or "2+ Stops."
What day of the week has the most flights from MDE to BUF?
You'll typically find Tuesday the quietest day for flights, while Fridays tend to be the busiest.* However this can vary from season to season and during public holidays or peak travel times.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Jose Maria Cordova Intl. Airport (MDE) to Buffalo Niagara Intl. Airport (BUF)?
Opt for a flight from Jose Maria Cordova Intl. Airport (MDE) to Buffalo Niagara Intl. Airport (BUF) that leaves before 3 PM to reduce the risk of delays and cancellations. Later departures are on average 22% more likely to be canceled.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Jose Maria Cordova Intl. Airport (MDE) to Buffalo Niagara Intl. Airport (BUF) last-minute?
Booking your ticket from MDE to BUF shortly before your getaway is usually more expensive. But if you're flexible with your itinerary, you could snag a cheap last-minute fare.
Is it cheaper to book a MDE to BUF flight and hotel package?
You can save money by securing a MDE to BUF flight and hotel package compared to booking separately. In fact, travelers could save hundreds of dollars by bundling with Expedia. And it's simple to manage everything in one convenient place. Once you've selected your ideal flights and accommodations, consider adding extras like tours, activities and car rentals.
Can I cancel or change the date of my flight from Jose Maria Cordova Intl. Airport (MDE) to Buffalo Niagara Intl. Airport (BUF)?
Typically, you're able to reschedule or cancel your MDE to BUF flight. However, there may be additional fees, especially if you made your booking more than 24 hours ago. Check your itinerary for the airline's guidelines and fees on flight changes, or if you need more information, visit our Customer Service portal.

Travel information

Origin airport
José María Córdova Intl.
Destination airport
Buffalo Niagara Intl.
Airlines serving
American Airlines, Copa, Delta, JetBlue Airways, LATAM Airlines Group, United
Roundtrip price
$586
Distance
2547 mi

Book with confidence

Medellín to Buffalo Flights

The cheapest times to fly from Medellín to Buffalo

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Medellín to Buffalo are during the month of March. You can find some of the cheapest flights from Medellín to Buffalo with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Medellín to Buffalo

Sunday is one of the best days to book for cheap flights from Medellín to Buffalo: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Medellín to Buffalo

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Medellín to Buffalo in 2025. You can also book with separate airlines for your outbound and return journeys, from $294 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Medellín to Buffalo flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Medellín to Buffalo airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Medellín to Buffalo Flights

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*Available to One Key members.