$538 Cheap Flights from Medellín (MDE) to Sioux Falls (FSD)

View $538 flight on Wed, Apr 15, 2026Opens in a new window

Popular airlines from Jose Maria Cordova Intl. Airport (MDE) to Sioux Falls Regional Airport (FSD)

Cheap Flights from Medellín to Sioux Falls (MDE-FSD)

Prices were available within the past 7 days and start at $538 for one-way flights and for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Flights from Medellín (MDE) to Sioux Falls (FSD)
Origin airport
José María Córdova Intl.
Destination airport
Sioux Falls Regional
Distance
2890 mi

Medellín to Sioux Falls Flights

The cheapest times to fly from Medellín to Sioux Falls

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Medellín to Sioux Falls are during the month of . You can find some of the cheapest flights from Medellín to Sioux Falls with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Medellín to Sioux Falls

Sunday is one of the best days to book for cheap flights from Medellín to Sioux Falls: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Medellín to Sioux Falls

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Medellín to Sioux Falls in 2025. You can also book with separate airlines for your outbound and return journeys, from $538 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Medellín to Sioux Falls flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Medellín to Sioux Falls airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Frequently asked questions

How much does a flight from Jose Maria Cordova Intl. Airport (MDE) to Sioux Falls Regional Airport (FSD) cost?
Secure a cheap one-way flight from $538 or cheap return flight from Jose Maria Cordova Intl. Airport (MDE) to Sioux Falls Regional Airport (FSD) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to find our cheapest flight deals on this route.
What is the cheapest month to fly from Jose Maria Cordova Intl. Airport (MDE) to Sioux Falls Regional Airport (FSD)?
Traveling in is a good way to save, as it's the cheapest month for flights between MDE and FSD. You'll typically find the lowest fares during the off-season.
What is the cheapest airline that flies from Jose Maria Cordova Intl. Airport (MDE) to Sioux Falls Regional Airport (FSD)?
Use the filter tool on Expedia to compare different airlines and find the most affordable carrier that'll take you from MDE to FSD. Then, sort your results by "Price (lowest to highest)" to score a good deal.
How many flights per day from Jose Maria Cordova Intl. Airport (MDE) to Sioux Falls Regional Airport (FSD)?
There aren't any daily direct flights from Jose Maria Cordova Intl. Airport (MDE) to Sioux Falls Regional Airport (FSD). But you can choose flights with layovers. Filter your search on Expedia to include one or more stops, and you'll be cruising above the clouds in no time.
What day of the week has the most flights from MDE to FSD?
You'll usually find Tuesday the quietest day for flights, while Fridays are often the busiest.* However this can vary from season to season and during public holidays or peak travel times.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Jose Maria Cordova Intl. Airport (MDE) to Sioux Falls Regional Airport (FSD)?
To land at Sioux Falls Regional Airport (FSD) on schedule, pick a flight that leaves Jose Maria Cordova Intl. Airport (MDE) before 3 PM. The chance of cancellations is 22% higher, on average, for departures after this time.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Jose Maria Cordova Intl. Airport (MDE) to Sioux Falls Regional Airport (FSD) last-minute?
Holding off until just before your departure to book a ticket from MDE to FSD generally means paying more. Although you may find some last-minute offers, they aren't always guaranteed. Keep your travel plans flexible to boost your chances of snagging a bargain.
Is it cheaper to book a MDE to FSD flight and hotel package?
You can save money by booking a MDE to FSD flight and hotel package compared to booking separately. In fact, travelers could save hundreds of dollars by bundling with Expedia. And it's simple to manage everything in one convenient place. After selecting your ideal accommodations and flights, you can add extras like tours, activities and car rentals.
Can I cancel or change the date of my flight from Jose Maria Cordova Intl. Airport (MDE) to Sioux Falls Regional Airport (FSD)?
It's usually possible to cancel or reschedule your MDE to FSD flight. However, if it's been more than 24 hours since booking, additional fees may apply. Check your airline's policies in your itinerary to see what changes are allowed and whether any costs are involved. You'll also find further details on our Customer Service portal.

Explore a world of travel with Expedia

*Available to One Key members.