$179 Cheap Flights from Medellín (MDE) to Santiago (SCL)

Bundle Your Flight + Hotel & Save!

Featured airlines

Top nine airline logos for desktop

    Plan, book, fly with confidence
  • trending down icon
    Be in the know
    Get alerts if flight prices drop or rise*
  • bex rewards loyalty icon
    Book smarter
    Save up to 30% on select hotels after you book a flight*
  • one key icon
    Earn twice
    Earn your airline miles on top of our OneKeyCash

Cheap Flights from Medellín to Santiago (MDE-SCL)

Prices were available within the past 7 days and start at $179 for one-way flights and $287 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

avianca
avianca
avianca
avianca
Copa
LATAM Airlines Group
LATAM Airlines Group
Copa
avianca
avianca
Flights from Medellín (MDE) to Santiago (SCL)
Origin airport
José María Córdova Intl.
Destination airport
Arturo Merino Benitez
Airlines serving
Copa, Hahn Air Technologies, LATAM Airlines Group, avianca
Roundtrip price
$287
Distance
2750 mi
Average flight time
5 hours 8 mins

Medellín to Santiago Flights

Whether you’re looking for a grand adventure or just want to get away for a last-minute break, flights from Medellín to Santiago offer the perfect respite. Not only does exploring Santiago provide the chance to make some magical memories, dip into delectable dishes, and tour the local landmarks, but the cheap airfare means you won’t bust your budget. So no matter whether your ideal itinerary involves flying one way, non-stop, or round trip, you’re bound to find flights that match your schedule on Expedia, and at prices that won’t shock your wallet.

Bagging a cheap flight from Medellín to Santiago may mean more dollars to spend on for one-of-a-kind souvenirs when you arrive, but it doesn’t mean you have to skimp on your travel experience, as Expedia offers a sizzling selection of cheap airlines that’ll put you in your happy place on their planes, whether that’s getting lost in a hair-raising airport thriller, dreaming on the passing landscape over a glass of bubbly, or jotting down your vacation bucket list at 38,000 feet. There’s also bound to be plenty of opportunities to snap a few photos of the high life that will make your friends green with envy. After all, enjoying the journey is part of the fun.

With so many affordable flights and so many wonderful adventures awaiting you, there’s no reason to put off booking a fantastic flight from to today. So don’t leave it to the last minute to make your dream trip a reality: pack your bags with your go-to travel accessories, put together your list of must-see attractions and can’t-miss activities, and get ready to broaden your horizons – with Expedia, the wonders of Santiago are only a plane trip away. Book your travel arrangements with us today!

If you would like to book flights to Santiago more flexibly many prefer to purchase one-way tickets with options to take different airlines. A one way ticket to Santiago is $179 now!

Frequently asked questions

How much is a one-way flight from MDE to Arturo Merino Benitez Airport (SCL)?
Make your next booking with Expedia and you could pick up one-way Medellin flights to Santiago from just $179. This was the lowest price found for this particular route with a departure date during the next three months — an Avianca flight, taking off from Medellin Airport on June 2 2024 and arriving at Nuevo Pudahuel Airport. The price was updated on April 21 2024 and has not changed since. Can’t wait to snap up your own bargain? Great offers are the click of a button away.
Is it cheaper to buy a plane ticket from MDE to Arturo Merino Benitez Airport (SCL) last minute?
Booking your journey from MDE to SCL last minute could save you cash if you happen to find a terrific deal. However, fares usually don’t drop in price closer to the departure date. If you wait around, flights could also be booked out or the best seats taken (we hope you like the middle seat!). If you’d rather not hedge your bets, book well in advance of when you want to leave. In fact, some of the best deals are available on Expedia up to 12 months in advance. If your favorite airline hasn’t released tickets yet, check back regularly as offers are constantly updated on Expedia.
What is the cheapest airline flying from Medellin Airport to Santiago International Airport in the next 90 days?
Based on airfares found on Expedia with a departure date within the next 90 days, Avianca is the cheapest airline flying from Medellin to Santiago. The fare between these destinations starts from $179. This flight leaves MDE on June 2 2024 and lands at Arturo Merino Benitez Airport (SCL). The price was last updated on April 21 2024 and has not changed since.
What's the cheapest price for a flight from Jose Maria Cordova Intl. Airport (MDE) to Arturo Merino Benitez Airport (SCL) next month?
With a one-way flight from Medellin to Santiago on sale for just $204, you’ll have extra cash to splash on awesome adventures. This deal was found after searching all available flights on Expedia within the next 30 days. This particular service sets off from Jose Maria Cordova Intl. Airport (MDE) on May 2 2024, touches down at Nuevo Pudahuel Airport and is with LATAM Airlines Group. Pricing information was last updated on April 21 2024 and has not changed since.
What airports do you fly into for Santiago from Medellin?
Arturo Merino Benitez Airport (SCL), San Felipe (SSD) and Valparaiso (VAP-Rodelillo Airfield) are your choices when setting off from Medellin to Santiago. Around 10 mi west of the center of Santiago, Arturo Merino Benitez Airport (SCL) is the city’s main gateway. Think about things such as flight schedules and the distance to your hotel before deciding where you fly into. Palacio de la Moneda and San Cristobal Hill are two leading attractions to visit when you arrive.
Can I change the date of my flight from Medellin Airport to Nuevo Pudahuel Airport?
You can easily make changes to your MDE to SCL trip via the Expedia Trips portal. But before you begin, review the conditions and rules in your itinerary to see what the airline will allow you to do and if charges apply. Some carriers charge a change fee per person, plus any difference in prices. But if you booked in the last 24 hours, you may be able to cancel for free and arrange new flights. You can also head to our Customer Service portal for more handy information and to chat with our Virtual Agent.
*Available to One Key members.