$178 Cheap Flights from Medellín (MDE) to Santiago (SCL)

View $178 flight on Mon, Dec 8, 2025Opens in a new window

Popular airlines from Jose Maria Cordova Intl. Airport (MDE) to Santiago Intl. Airport (SCL)

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Cheap Flights from Medellín to Santiago (MDE-SCL)

Prices were available within the past 7 days and start at $178 for one-way flights and $284 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Jetsmart SPA
Sun, Dec 7 - Mon, Dec 15
MDE
Medellin
SCL
Santiago
$284 Roundtrip, found 2 days ago
$284
Roundtrip
found 2 days ago
Select Jetsmart SPA flight, departing Sun, Dec 7 from Medellin to Santiago, returning Mon, Dec 15, priced at $284 found 2 days ago
Jetsmart SPA
Mon, Dec 15 - Wed, Dec 24
MDE
Medellin
SCL
Santiago
$284 Roundtrip, found 3 days ago
$284
Roundtrip
found 3 days ago
Select Jetsmart SPA flight, departing Mon, Dec 15 from Medellin to Santiago, returning Wed, Dec 24, priced at $284 found 3 days ago
Jetsmart SPA
Mon, Dec 1 - Mon, Dec 8
MDE
Medellin
SCL
Santiago
$308 Roundtrip, found 3 days ago
$308
Roundtrip
found 3 days ago
Select Jetsmart SPA flight, departing Mon, Dec 1 from Medellin to Santiago, returning Mon, Dec 8, priced at $308 found 3 days ago
Jetsmart SPA
Mon, Dec 15 - Fri, Jan 2
MDE
Medellin
SCL
Santiago
$318 Roundtrip, found 6 days ago
$318
Roundtrip
found 6 days ago
Select Jetsmart SPA flight, departing Mon, Dec 15 from Medellin to Santiago, returning Fri, Jan 2, priced at $318 found 6 days ago
Jetsmart SPA
Sat, Dec 6 - Fri, Dec 12
MDE
Medellin
SCL
Santiago
$323 Roundtrip, found 2 days ago
$323
Roundtrip
found 2 days ago
Select Jetsmart SPA flight, departing Sat, Dec 6 from Medellin to Santiago, returning Fri, Dec 12, priced at $323 found 2 days ago
Jetsmart SPA
Mon, Dec 8 - Wed, Dec 17
MDE
Medellin
SCL
Santiago
$329 Roundtrip, found 2 days ago
$329
Roundtrip
found 2 days ago
Select Jetsmart SPA flight, departing Mon, Dec 8 from Medellin to Santiago, returning Wed, Dec 17, priced at $329 found 2 days ago
Jetsmart SPA
Sat, Dec 6 - Fri, Dec 12
MDE
Medellin
SCL
Santiago
$337 Roundtrip, found 2 days ago
$337
Roundtrip
found 2 days ago
Select Jetsmart SPA flight, departing Sat, Dec 6 from Medellin to Santiago, returning Fri, Dec 12, priced at $337 found 2 days ago
Jetsmart SPA
Mon, Jan 5 - Mon, Jan 12
MDE
Medellin
SCL
Santiago
$342 Roundtrip, found 1 day ago
$342
Roundtrip
found 1 day ago
Select Jetsmart SPA flight, departing Mon, Jan 5 from Medellin to Santiago, returning Mon, Jan 12, priced at $342 found 1 day ago
Copa
Sun, Dec 7 - Mon, Dec 15
MDE
Medellin
SCL
Santiago
$376 Roundtrip, found 2 days ago
$376
Roundtrip
found 2 days ago
Select Copa flight, departing Sun, Dec 7 from Medellin to Santiago, returning Mon, Dec 15, priced at $376 found 2 days ago
avianca
Thu, Aug 21 - Mon, Aug 25
MDE
Medellin
SCL
Santiago
$479 Roundtrip, found 1 day ago
$479
Roundtrip
found 1 day ago
Select avianca flight, departing Thu, Aug 21 from Medellin to Santiago, returning Mon, Aug 25, priced at $479 found 1 day ago

Find the cheapest month to fly from Medellín (MDE) to Santiago (SCL)

March is typically the cheapest month to fly

From $321 - $560 per traveler.

Graph displaying average flight prices per month

Flights from Medellín (MDE) to Santiago (SCL)
Origin airport
José María Córdova Intl.
Destination airport
Arturo Merino Benitez
Airlines serving
Copa, Jetsmart SPA, LATAM Airlines Group, avianca
Roundtrip price
$283
Distance
2750 mi

Medellín to Santiago Flights

The cheapest times to fly from Medellín to Santiago

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Medellín to Santiago are during the month of December. You can find some of the cheapest flights from Medellín to Santiago with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Medellín to Santiago

Sunday is one of the best days to book for cheap flights from Medellín to Santiago: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Medellín to Santiago

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Medellín to Santiago in 2025. You can also book with separate airlines for your outbound and return journeys, from $178 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Medellín to Santiago flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Medellín to Santiago airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Frequently asked questions

How much does a flight from Jose Maria Cordova Intl. Airport (MDE) to Arturo Merino Benitez Airport (SCL) cost?
Score cheap return tickets from Jose Maria Cordova Intl. Airport (MDE) to Arturo Merino Benitez Airport (SCL) starting from $1583. Grab a seat and take off on your trip. This information is based on the cheapest price found on Expedia for this return journey departing within the next three months. This airfare is for a Avianca flight leaving MDE on July 13 2025 and touching down at SCL. The price was last updated on July 2 2025 and has not changed since.
What is the cheapest month to fly from MDE to SCL?
The cheapest flights from MDE to SCL are usually during off-peak season, when demand is lower. To save money, avoid flying during public holidays, school breaks and major local events.
Which airlines fly direct from Jose Maria Cordova Intl. Airport (MDE) to Arturo Merino Benitez Airport (SCL)?
You can fly nonstop from Jose Maria Cordova Intl. Airport (MDE) to Arturo Merino Benitez Airport (SCL) on a JetSMART flight.
What is the cheapest airline that flies from MDE to SCL?
With fares starting at $877 for a one-way journey from MDE to SCL, Avianca is currently the cheapest airline flying this route. This fare is based on the lowest price found on Expedia departing within the next three months. The flight takes off from MDE on August 8 2025. Prices were last updated on July 2 2025 and have not changed since.
How many flights per day from Jose Maria Cordova Intl. Airport (MDE) to Arturo Merino Benitez Airport (SCL)?
On average, there is just 1 nonstop flight taking off from Jose Maria Cordova Intl. Airport (MDE) to Arturo Merino Benitez Airport (SCL) every day. If this doesn't work for you, consider flights with a layover. Just customize your search results on Expedia to include one stop or more to find the next best option.
What are the most popular departure times for flights from Jose Maria Cordova Intl. Airport (MDE) to Arturo Merino Benitez Airport (SCL)?
More travelers fly between MDE and SCL at 1 PM than at any other time. Looking for a quieter experience? Travel outside of rush hours and you could save on your ticket as well.
What day of the week has the most flights from MDE to SCL?
Jet off on a Friday if you're after the best selection of flights from Jose Maria Cordova Intl. Airport (MDE) to Arturo Merino Benitez Airport (SCL).
What is the earliest flight from Jose Maria Cordova Intl. Airport (MDE) to Arturo Merino Benitez Airport (SCL)?
Hop on the earliest flight at around 1:13PM UTC-5, departing from Jose Maria Cordova Intl. Airport (MDE). You'll be flying for about 6h 8m, coming in to land at Arturo Merino Benitez Airport (SCL) at approximately 9:21PM UTC-3.
How long does it take to fly from Jose Maria Cordova Intl. Airport (MDE) to Arturo Merino Benitez Airport (SCL)?
Flights from MDE to SCL have an average travel time of 5 hours and 59 minutes. The distance between these two airports is 2,800 mi.
What airline has the least delays from MDE to SCL?
With 82% of flights usually arriving on schedule, JetSMART has the best on-time performance for direct flights from Jose Maria Cordova Intl. Airport (MDE) to Arturo Merino Benitez Airport (SCL). To check your flight status and get notifications about any changes, head to the Expedia App.
What is the best time to fly from Jose Maria Cordova Intl. Airport (MDE) to Arturo Merino Benitez Airport (SCL)?
To avoid possible delays on the Jose Maria Cordova Intl. Airport (MDE) to Arturo Merino Benitez Airport (SCL) route, aim to fly before 3 PM. Later departures have a 22% higher chance of cancellation.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
What airports do you fly into for Santiago from Jose Maria Cordova Intl. Airport (MDE)?
Arturo Merino Benitez Airport (SCL) is the only airport in Santiago with direct flights from Jose Maria Cordova Intl. Airport (MDE). Consider the available options and find affordable fares on Expedia.
Is it cheaper to buy a plane ticket from Jose Maria Cordova Intl. Airport (MDE) to Arturo Merino Benitez Airport (SCL) last-minute?
Waiting until just before your trip to book a ticket from MDE to SCL generally means paying more. While you may find some last-minute discounts, they're not always guaranteed. Be flexible with your itinerary to maximize your chances of landing a bargain.
Is it cheaper to book a MDE to SCL flight and hotel package?
Securing a MDE to SCL flight and hotel package is generally cheaper than booking separately. With Expedia, you can enjoy the convenience of organizing your trip all in one place. Select from our extensive range of hotels and then add car rentals, activities and flights to your booking. Bundle it all together, and you could save hundreds of dollars.
Can I cancel or change the date of my flight from Jose Maria Cordova Intl. Airport (MDE) to Arturo Merino Benitez Airport (SCL)?
If you booked your MDE to SCL flight in the last 24 hours, you may be able to modify or cancel it without any fees. Depending on the airline and the type of ticket you have, additional charges may apply for changes beyond that time. Airline policies and contact information can be found in your itinerary or confirmation email. Or, go to our Customer Service portal for more information.

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