$131 Cheap Flights from Medford (MFR) to Sioux Falls (FSD)

View $131 flight on Tue, Nov 4, 2025Opens in a new window

Popular airlines from Rogue Valley Intl. Airport (MFR) to Sioux Falls Regional Airport (FSD)

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Cheap Flights from Medford to Sioux Falls (MFR-FSD)

Prices were available within the past 7 days and start at $131 for one-way flights and $261 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Delta
Tue, Nov 4 - Sat, Nov 8
MFR
Medford
FSD
Sioux Falls
$261 Roundtrip, found 1 day ago
$261
Roundtrip
found 1 day ago
Select Delta flight, departing Tue, Nov 4 from Medford to Sioux Falls, returning Sat, Nov 8, priced at $261 found 1 day ago
Delta
Thu, Dec 25 - Tue, Jan 6
MFR
Medford
FSD
Sioux Falls
$279 Roundtrip, found 7 hours ago
$279
Roundtrip
found 7 hours ago
Select Delta flight, departing Thu, Dec 25 from Medford to Sioux Falls, returning Tue, Jan 6, priced at $279 found 7 hours ago
United
Sat, Oct 11 - Sat, Oct 18
MFR
Medford
FSD
Sioux Falls
$285 Roundtrip, found 5 days ago
$285
Roundtrip
found 5 days ago
Select United flight, departing Sat, Oct 11 from Medford to Sioux Falls, returning Sat, Oct 18, priced at $285 found 5 days ago
United
Sat, Oct 11 - Sat, Oct 18
MFR
Medford
FSD
Sioux Falls
$290 Roundtrip, found 5 days ago
$290
Roundtrip
found 5 days ago
Select United flight, departing Sat, Oct 11 from Medford to Sioux Falls, returning Sat, Oct 18, priced at $290 found 5 days ago
United
Fri, Oct 10 - Fri, Oct 17
MFR
Medford
FSD
Sioux Falls
$294 Roundtrip, found 5 days ago
$294
Roundtrip
found 5 days ago
Select United flight, departing Fri, Oct 10 from Medford to Sioux Falls, returning Fri, Oct 17, priced at $294 found 5 days ago
Delta
Mon, Nov 3 - Sat, Nov 8
MFR
Medford
FSD
Sioux Falls
$295 Roundtrip, found 1 day ago
$295
Roundtrip
found 1 day ago
Select Delta flight, departing Mon, Nov 3 from Medford to Sioux Falls, returning Sat, Nov 8, priced at $295 found 1 day ago
United
Fri, Oct 10 - Fri, Oct 17
MFR
Medford
FSD
Sioux Falls
$313 Roundtrip, found 5 days ago
$313
Roundtrip
found 5 days ago
Select United flight, departing Fri, Oct 10 from Medford to Sioux Falls, returning Fri, Oct 17, priced at $313 found 5 days ago
Delta
Tue, Nov 4 - Wed, Nov 5
MFR
Medford
FSD
Sioux Falls
$315 Roundtrip, found 1 day ago
$315
Roundtrip
found 1 day ago
Select Delta flight, departing Tue, Nov 4 from Medford to Sioux Falls, returning Wed, Nov 5, priced at $315 found 1 day ago
Alaska Airlines
Mon, Nov 3 - Thu, Nov 13
MFR
Medford
FSD
Sioux Falls
$359 Roundtrip, found 1 day ago
$359
Roundtrip
found 1 day ago
Select Alaska Airlines flight, departing Mon, Nov 3 from Medford to Sioux Falls, returning Thu, Nov 13, priced at $359 found 1 day ago
American Airlines
Tue, Dec 16 - Wed, Dec 31
MFR
Medford
FSD
Sioux Falls
$489 Roundtrip, found 7 hours ago
$489
Roundtrip
found 7 hours ago
Select American Airlines flight, departing Tue, Dec 16 from Medford to Sioux Falls, returning Wed, Dec 31, priced at $489 found 7 hours ago

Find the cheapest month to fly from Medford (MFR) to Sioux Falls (FSD)

April is typically the cheapest month to fly

From $219 - $1,379 per traveler.
Flights from Medford (MFR) to Sioux Falls (FSD)
Origin airport
Rogue Valley Intl.
Destination airport
Sioux Falls Regional
Airlines serving
Alaska Airlines, American Airlines, Delta, United
Roundtrip price
$261
Distance
1318 mi

Medford to Sioux Falls Flights

The cheapest times to fly from Medford to Sioux Falls

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Medford to Sioux Falls are during the month of November. You can find some of the cheapest flights from Medford to Sioux Falls with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Medford to Sioux Falls

Sunday is one of the best days to book for cheap flights from Medford to Sioux Falls: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Medford to Sioux Falls

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Medford to Sioux Falls in 2025. You can also book with separate airlines for your outbound and return journeys, from $131 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Medford to Sioux Falls flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Medford to Sioux Falls airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Frequently asked questions

How much does a flight from Rogue Valley Intl. Airport (MFR) to Sioux Falls Regional Airport (FSD) cost?
Snag a cheap one-way flight from $131 or cheap return flight from $261 from Rogue Valley Intl. Airport (MFR) to Sioux Falls Regional Airport (FSD) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to see our cheapest flight offers on this route.
What is the cheapest month to fly from Rogue Valley Intl. Airport (MFR) to Sioux Falls Regional Airport (FSD)?
Planning your trip for November is a good way to save, as it's the cheapest month for flights between MFR and FSD. You'll often find the lowest prices during off-peak months.
What is the cheapest airline that flies from Rogue Valley Intl. Airport (MFR) to Sioux Falls Regional Airport (FSD)?
To find the cheapest airline flying from MFR to FSD, use Expedia's filter tool. Customize your search based on what's important to you, such as preferred carriers and flight duration. You can then sort your results by "Price (lowest to highest)" to discover the cheapest flight right away.
How many flights per day from Rogue Valley Intl. Airport (MFR) to Sioux Falls Regional Airport (FSD)?
You'll need to hop on a flight with a layover if you're traveling from Rogue Valley Intl. Airport (MFR) to Sioux Falls Regional Airport (FSD). There are no daily direct flights on this route. However, just filter your search to include one or two stops to discover an option that works for you.
What day of the week has the most flights from MFR to FSD?
Friday is typically the busiest day for flights, while Tuesday is often the quietest.* Keep in mind that flight schedules can change based on various factors, such as the time of year and carrier.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Rogue Valley Intl. Airport (MFR) to Sioux Falls Regional Airport (FSD)?
To avoid possible delays on the Rogue Valley Intl. Airport (MFR) to Sioux Falls Regional Airport (FSD) route, travel before 3 PM. Later departures are 22% more likely to be canceled.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Rogue Valley Intl. Airport (MFR) to Sioux Falls Regional Airport (FSD) last-minute?
Booking your ticket from MFR to FSD shortly before your getaway is generally more expensive. But if you're flexible with your itinerary, you could land a cheap last-minute fare.
Is it cheaper to book a MFR to FSD flight and hotel package?
Securing a MFR to FSD flight and hotel package is typically cheaper than booking separately. With Expedia, you can enjoy the ease of organizing your travels in one place. Pick from our impressive range of hotels and then add flights, car rentals and activities to your booking. Bundle it all together, and you could save hundreds of dollars.
Can I cancel or change the date of my flight from Rogue Valley Intl. Airport (MFR) to Sioux Falls Regional Airport (FSD)?
If you reserved your MFR to FSD flight in the last 24 hours, you may be able to modify or cancel it without any fees. Depending on the airline and the fare type you purchased, additional charges may apply for changes beyond that time. Airline policies and contact information can be found in your itinerary or confirmation email. Or, head to our Customer Service portal if you'd like more information.

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*Available to One Key members.