$357 Cheap Flights from Myrtle Beach (MYR) to Cheyenne (CYS)

View $357 flight on Fri, Oct 24, 2025Opens in a new window

Popular airlines from Myrtle Beach Intl. Airport (MYR) to Cheyenne, WY (CYS-Cheyenne Regional)

Cheap Flights from Myrtle Beach to Cheyenne (MYR-CYS)

Prices were available within the past 7 days and start at $357 for one-way flights and for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Frequently asked questions

How much does a flight from Myrtle Beach Intl. Airport (MYR) to Cheyenne Regional Airport (CYS) cost?
Lock in a cheap one-way flight from $357 or cheap return flight from Myrtle Beach Intl. Airport (MYR) to Cheyenne Regional Airport (CYS) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to find our cheapest flight deals on this route.
What is the cheapest month to fly from Myrtle Beach Intl. Airport (MYR) to Cheyenne Regional Airport (CYS)?
The cheapest month to fly from MYR to CYS is , when there's less demand. Off-peak season is generally when airlines offer better prices between these airports.
What is the cheapest airline that flies from Myrtle Beach Intl. Airport (MYR) to Cheyenne Regional Airport (CYS)?
Use the filter tool on Expedia to compare airlines and find the most affordable carrier that'll fly you from MYR to CYS. Then, sort your results by "Price (lowest to highest)" to score a great deal.
How many flights per day from Myrtle Beach Intl. Airport (MYR) to Cheyenne Regional Airport (CYS)?
You'll need to catch a flight with a layover if you're traveling from Myrtle Beach Intl. Airport (MYR) to Cheyenne Regional Airport (CYS). Direct flights don't operate daily on this route. However, simply filter your search to include one or more stops to discover the best option for your trip.
What day of the week has the most flights from MYR to CYS?
You'll typically find Tuesday the quietest day for flights, while Fridays tend to be the busiest.* However this can vary from season to season and during peak travel times or public holidays.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Myrtle Beach Intl. Airport (MYR) to Cheyenne Regional Airport (CYS)?
Book a flight from Myrtle Beach Intl. Airport (MYR) to Cheyenne Regional Airport (CYS) that leaves before 3 PM to reduce the risk of delays and cancellations. Later departures are on average 22% more likely to be canceled.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Myrtle Beach Intl. Airport (MYR) to Cheyenne Regional Airport (CYS) last-minute?
Holding off until right before your break to book a flight from MYR to CYS often results in higher prices. While you may find some last-minute discounts, there's no guarantee. Keep your travel schedule open to boost your chances of scoring a bargain.
Is it cheaper to book a MYR to CYS flight and hotel package?
You'll typically save money by securing a MYR to CYS flight and hotel package compared to booking separately. In fact, travelers could save hundreds of dollars by bundling with Expedia. And it's simple to manage everything in one place. Once you've selected your ideal flights and accommodations, you can add extras such as activities, tours and car rentals.
Can I cancel or change the date of my flight from Myrtle Beach Intl. Airport (MYR) to Cheyenne Regional Airport (CYS)?
If you reserved your MYR to CYS flight in the last 24 hours, you may be able to modify or cancel it without any fees. Depending on the airline and the type of ticket you have, additional charges may apply for changes beyond this timeframe. Airline policies and contact information can be found in your itinerary or confirmation email. Or, go to our Customer Service portal for more details.

Travel information

Origin airport
Myrtle Beach Intl.
Destination airport
Cheyenne Regional
Distance
1504 mi

Book with confidence

Myrtle Beach to Cheyenne Flights

The cheapest times to fly from Myrtle Beach to Cheyenne

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Myrtle Beach to Cheyenne are during the month of . You can find some of the cheapest flights from Myrtle Beach to Cheyenne with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Myrtle Beach to Cheyenne

Sunday is one of the best days to book for cheap flights from Myrtle Beach to Cheyenne: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Myrtle Beach to Cheyenne

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Myrtle Beach to Cheyenne in 2025. You can also book with separate airlines for your outbound and return journeys, from $357 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Myrtle Beach to Cheyenne flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Myrtle Beach to Cheyenne airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Myrtle Beach to Cheyenne Flights

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*Available to One Key members.