$422 Cheap Flights from St. Louis (STL) to Tupelo (TUP)

View $422 flight on Sun, Sep 14, 2025Opens in a new window

Popular airlines from St. Louis Lambert Intl. Airport (STL) to Tupelo, MS (TUP-Tupelo Regional)

Cheap Flights from St. Louis to Tupelo (STL-TUP)

Prices were available within the past 7 days and start at $422 for one-way flights and $343 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

United
Mon, Sep 29 - Tue, Oct 14
STL
St. Louis
TUP
Tupelo
$343 Roundtrip, found 18 hours ago
$343
Roundtrip
found 18 hours ago
Select United flight, departing Mon, Sep 29 from St. Louis to Tupelo, returning Tue, Oct 14, priced at $343 found 18 hours ago
United
Wed, Sep 3 - Mon, Sep 22
STL
St. Louis
TUP
Tupelo
$353 Roundtrip, found 18 hours ago
$353
Roundtrip
found 18 hours ago
Select United flight, departing Wed, Sep 3 from St. Louis to Tupelo, returning Mon, Sep 22, priced at $353 found 18 hours ago
United
Sat, Aug 30 - Sat, Sep 13
STL
St. Louis
TUP
Tupelo
$363 Roundtrip, found 18 hours ago
$363
Roundtrip
found 18 hours ago
Select United flight, departing Sat, Aug 30 from St. Louis to Tupelo, returning Sat, Sep 13, priced at $363 found 18 hours ago
United
Sat, Sep 13 - Thu, Oct 2
STL
St. Louis
TUP
Tupelo
$372 Roundtrip, found 18 hours ago
$372
Roundtrip
found 18 hours ago
Select United flight, departing Sat, Sep 13 from St. Louis to Tupelo, returning Thu, Oct 2, priced at $372 found 18 hours ago
United
Mon, Sep 29 - Sat, Oct 11
STL
St. Louis
TUP
Tupelo
$373 Roundtrip, found 18 hours ago
$373
Roundtrip
found 18 hours ago
Select United flight, departing Mon, Sep 29 from St. Louis to Tupelo, returning Sat, Oct 11, priced at $373 found 18 hours ago
United
Tue, Sep 30 - Mon, Oct 20
STL
St. Louis
TUP
Tupelo
$382 Roundtrip, found 18 hours ago
$382
Roundtrip
found 18 hours ago
Select United flight, departing Tue, Sep 30 from St. Louis to Tupelo, returning Mon, Oct 20, priced at $382 found 18 hours ago
United
Sun, Aug 31 - Sat, Sep 13
STL
St. Louis
TUP
Tupelo
$385 Roundtrip, found 18 hours ago
$385
Roundtrip
found 18 hours ago
Select United flight, departing Sun, Aug 31 from St. Louis to Tupelo, returning Sat, Sep 13, priced at $385 found 18 hours ago
United
Tue, Sep 23 - Tue, Oct 14
STL
St. Louis
TUP
Tupelo
$388 Roundtrip, found 18 hours ago
$388
Roundtrip
found 18 hours ago
Select United flight, departing Tue, Sep 23 from St. Louis to Tupelo, returning Tue, Oct 14, priced at $388 found 18 hours ago
United
Sat, Sep 27 - Sat, Oct 11
STL
St. Louis
TUP
Tupelo
$393 Roundtrip, found 18 hours ago
$393
Roundtrip
found 18 hours ago
Select United flight, departing Sat, Sep 27 from St. Louis to Tupelo, returning Sat, Oct 11, priced at $393 found 18 hours ago
United
Sun, Aug 31 - Mon, Sep 15
STL
St. Louis
TUP
Tupelo
$395 Roundtrip, found 18 hours ago
$395
Roundtrip
found 18 hours ago
Select United flight, departing Sun, Aug 31 from St. Louis to Tupelo, returning Mon, Sep 15, priced at $395 found 18 hours ago

Alternative airports near Tupelo

Prices were available within the past 7 days. Prices and availability are subject to change.

Select flight to Tupelo Regional TUP. Cheapest and Closest option available. Average driving time to city center is 8 minutes. Flights from $462
TUP
Tupelo Regional
CheapestClosest
Average driving time to city center8 min
Flights from $462
Flights from St. Louis (STL) to Tupelo (TUP)
Origin airport
Lambert-St. Louis Intl.
Destination airport
Tupelo Regional
Roundtrip price
$343
Distance
321 mi

St. Louis to Tupelo Flights

The cheapest times to fly from St. Louis to Tupelo

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from St. Louis to Tupelo are during the month of September. You can find some of the cheapest flights from St. Louis to Tupelo with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from St. Louis to Tupelo

Sunday is one of the best days to book for cheap flights from St. Louis to Tupelo: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from St. Louis to Tupelo

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from St. Louis to Tupelo in 2025. You can also book with separate airlines for your outbound and return journeys, from $422 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap St. Louis to Tupelo flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your St. Louis to Tupelo airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Frequently asked questions

How much does a flight from Lambert-St. Louis Intl. Airport (STL) to Tupelo Regional Airport (TUP) cost?
Secure a cheap one-way flight from $422 or cheap return flight from $343 from Lambert-St. Louis Intl. Airport (STL) to Tupelo Regional Airport (TUP) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to find our cheapest flight offers on this route.
What is the cheapest month to fly from Lambert-St. Louis Intl. Airport (STL) to Tupelo Regional Airport (TUP)?
The cheapest month to fly from STL to TUP is September, when demand is low. Off-peak months are usually when airlines offer lower prices between these airports.
What is the cheapest airline that flies from Lambert-St. Louis Intl. Airport (STL) to Tupelo Regional Airport (TUP)?
To find the cheapest airline that'll fly you from STL to TUP, use Expedia's filter tool. Customize your search based on your travel style, such as preferred carriers and ideal departure window. You can then sort your results by "Price (lowest to highest)" to see the cheapest flights first.
How many flights per day from Lambert-St. Louis Intl. Airport (STL) to Tupelo Regional Airport (TUP)?
You'll have to book a flight with a layover if you're traveling from Lambert-St. Louis Intl. Airport (STL) to Tupelo Regional Airport (TUP). Direct flights don't operate daily on this route. However, just filter your search to include one or more stops to discover an option that works for you.
What day of the week has the most flights from STL to TUP?
Friday is generally the busiest day for flights, while Tuesday tends to be the quietest.* Keep in mind that flight schedules can vary depending on a range of factors, such as the season and airline.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Lambert-St. Louis Intl. Airport (STL) to Tupelo Regional Airport (TUP)?
To avoid possible delays on the Lambert-St. Louis Intl. Airport (STL) to Tupelo Regional Airport (TUP) route, fly before 3 PM. Flights after this time have a 22% higher chance of cancellation.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Lambert-St. Louis Intl. Airport (STL) to Tupelo Regional Airport (TUP) last-minute?
Waiting until just before your trip to book a flight from STL to TUP often results in higher prices. While you might find some last-minute discounts, they aren't always guaranteed. Allow some flexibility in your schedule for a better chance of snagging a bargain.
Is it cheaper to book a STL to TUP flight and hotel package?
Securing a STL to TUP flight and hotel package is typically cheaper than booking separately. With Expedia, you can enjoy the convenience of organizing your travels all in one place. Pick from our wide range of hotels and then add activities, flights and car rentals to your booking. Bundle everything together, and you could save hundreds of dollars.
Can I cancel or change the date of my flight from Lambert-St. Louis Intl. Airport (STL) to Tupelo Regional Airport (TUP)?
Typically, you can cancel or modify your STL to TUP flight. However, there may be additional charges, especially if you booked over 24 hours ago. Check your itinerary for the airline's policies and fees on flight changes, or if you want further information, go to our Customer Service portal.

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*Available to One Key members.